Thalamus and posterior temporal lobe show greater inter-network connectivity at rest and across sensory paradigms in schizophrenia
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Although a number of recent studies have examined functional connectivity at rest, few have assessed differences between connectivity both during rest and across active task paradigms. Therefore, the question of whether cortical connectivity patterns remain stable or change with task engagement continues to be unaddressed. We collected multi-scan fMRI data on healthy controls (N=53) and schizophrenia patients (N=42) during rest and across paradigms arranged hierarchically by sensory load. We measured functional network connectivity among 45 non-artifactual distinct brain networks. Then, we applied a novel analysis to assess cross paradigm connectivity patterns applied to healthy controls and patients with schizophrenia. To detect these patterns, we fit a group by task full factorial ANOVA model to the group average functional network connectivity values. Our approach identified both stable (static effects) and state-based differences (dynamic effects) in brain connectivity providing a better understanding of how individuals' reactions to simple sensory stimuli are conditioned by the context within which they are presented. Our findings suggest that not all group differences observed during rest are detectable in other cognitive states. In addition, the stable differences of heightened connectivity between multiple brain areas with thalamus across tasks underscore the importance of the thalamus as a gateway to sensory input and provide new insight into schizophrenia.
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Opposing task-related modulation of network recruitment in mentalizing networks was demonstrated using an approach in which fMRI data from two tasks collected on the same individuals was included within one sICA.
“Unlike prior studies on social cognition, semantic recall and the DMN, however, we demonstrated opposing task-related modulation of network recruitment in mentalizing networks using an approach in which fMRI data from two tasks collected on the same individuals was included within one (vs.separate) sICA, a method introduced only recently [Cetin et al., 2014;Demirci et al., 2009].”
From Specific default mode subnetworks support mentalizing as revealed through opposing network recruitment by social and semantic FMRI tasks: Mentalizing and Default-Mode Subnetworks (2015) · cites this paper as Cetin et al., 2014
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- Authors
- Çetin, M. S., Christensen, F., Abbott, C. C., Stephen, J. M., Mayer, A. R., Cañive, J. M., Bustillo, J. R., Pearlson, G. D., & Calhoun, V. D.
- Affiliations
- University of New Mexico (US)
- Mind Research Network (US)
- Yale University (US)
- Corresponding author
- Çetin, Mustafa S.
- ORCID
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 97
- Pages
- 117-126
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC4087193
- OpenAlex
- W2068924227
- Cited by
- 154
- References
- 67
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 6 · 2023: 13 · 2022: 7 · 2021: 14 · 2020: 14 · 2019: 20 · 2018: 23 · 2017: 15 · 2016: 15 · 2015: 12 · 2014: 3
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (1R01-EB006841, 1R01-EB005846, 2R01-EB000840, 1 P20 RR021938-01)
- DOE (DEFG02-08ER64581)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- schizophrenia, functional network connectivity, thalamus, posterior temporal lobe, resting-state functional connectivity, sensory load, sensory processing
- MeSH terms
- Acoustic Stimulation, Adolescent, Adult, Aged, Auditory Perception, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Photic Stimulation, Rest, Schizophrenia, Schizophrenic Psychology, Sensation, Temporal Lobe, Thalamus, Sensory Gating, Young Adult
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