Effects of prefrontal bipolar and high-definition transcranial direct current stimulation on cortical reactivity and working memory in healthy adults
Open accessAbstract
Transcranial direct current stimulation (tDCS) is a well-recognised neuromodulatory technology which has been shown to induce short-lasting changes in motor-cortical excitability. The recent and rapid expansion of tDCS into the cognitive domain, however, necessitates deeper mechanistic understanding of its neurophysiological effects over non-motor brain regions. The present study utilised transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) to probe the immediate and longer-term effects of both a bipolar (BP-tDCS) and more focal 4×1 High-Definition tDCS (HD-tDCS) montage applied over the left DLPFC on TMS-evoked potentials (TEPs) and oscillations in 19 healthy adult participants. 2-back working memory (WM) performance was also assessed as a marker of cognitive function. Region of interest (ROI) analyses taken from the F1 electrode directly adjacent to the stimulation site revealed increased P60 TEP amplitudes at this location 5min following BP-tDCS and 30min following HD-tDCS. Further global cluster based analyses of all scalp electrodes revealed widespread neuromodulatory changes following HD-tDCS, but not BP-tDCS, both five and 30min after stimulation, with reductions also detected in both beta and gamma oscillatory power over parieto-occipital channels 30min after stimulation. No significant changes in WM performance were observed following either HD-tDCS or BP-tDCS. This study highlights the capacity for single-session prefrontal anodal tDCS montages to modulate neurophysiological processes, as assessed with TMS-EEG.
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Working memory performance following NIBS has demonstrated greater effect sizes 30-40 minutes post stimulation compared to immediately following stimulation.
“working memory performance following NIBS has demonstrated greater effect sizes 30-40 minutes post stimulation compared to immediately following stimulation (Chung, Rogasch, Hoy, & Fitzgerald, 2018;Hill, Rogasch, Fitzgerald, & Hoy, 2017).”
From Investigation of neurobiological responses to theta burst stimulation during recovery from mild traumatic brain injury (mTBI) (2023) · cites this paper as Hill, Rogasch, Fitzgerald, & Hoy, 2017
Cites
Nonparametric statistical testing of EEG- and MEG-data
Maris, E., & Oostenveld, R. (2007) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.03.024 · Cited by 8,496 · see citing works
Nitsche, M. A., & Paulus, W. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00633.x · Cited by 5,656 · see citing works
MacDonald, A. W., Cohen, J. D., Stenger, V. A., & Carter, C. S. (2000) · Science · doi:10.1126/science.288.5472.1835 · Cited by 3,666 · see citing works
Beta-band oscillations—Signalling the status quo?
Engel, A. K., & Fries, P. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.02.015 · Cited by 2,953 · see citing works
Large-scale brain networks in cognition: emerging methods and principles
Bressler, S. L., & Menon, V. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.04.004 · Cited by 2,348 · see citing works
Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory
Fregni, F., Boggio, P. S., Nitsche, M., Bermpohl, F., Antal, A., Feredoes, E., Marcolin, M. A., Rigonatti, S. P., Silva, M. T. A., Paulus, W., et al. (2005) · Experimental Brain Research · doi:10.1007/s00221-005-2334-6 · Cited by 1,159 · see citing works
An efficient and accurate new method for locating the F3 position for prefrontal TMS applications
Beam, W., Borckardt, J. J., Reeves, S. T., & George, M. S. (2009) · Brain Stimulation · doi:10.1016/j.brs.2008.09.006 · Cited by 626 · see citing works
Rogasch, N. C., Thomson, R. H., Farzan, F., Fitzgibbon, B. M., Bailey, N. W., Hernandez-Pavon, J. C., Daskalakis, Z. J., & Fitzgerald, P. B. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.07.037 · Cited by 309 · see citing works
Self-citationThe role of the coil click in TMS assessed with simultaneous EEG
Nikouline, V., Ruohonen, J., & Ilmoniemi, R. J. (1999) · Clinical Neurophysiology · doi:10.1016/s1388-2457(99)00070-x · Cited by 269 · see citing works
Can noninvasive brain stimulation enhance cognition in neuropsychiatric disorders?
Demirtas-Tatlidede, A., Vahabzadeh-Hagh, A. M., & Pascual-Leone, A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.020 · Cited by 236 · see citing works
Gill, J., Shah-Basak, P. P., & Hamilton, R. (2015) · Brain Stimulation · doi:10.1016/j.brs.2014.10.018 · Cited by 224 · see citing works
Farzan, F., Vernet, M., Shafi, M. M. D., Rotenberg, A., Daskalakis, Z. J., & Pascual-Leone, A. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00073 · Cited by 173 · see citing works
Huber, R., Määttä, S., Esser, S. K., Sarasso, S., Ferrarelli, F., Watson, A., Ferreri, F., Peterson, M. J., & Tononi, G. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1636-08.2008 · Cited by 147 · see citing works
Paired Associative Stimulation Enforces the Communication between Interconnected Areas
Veniero, D., Ponzo, V., & Koch, G. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1777-13.2013 · Cited by 131 · see citing works
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Clinical utility and prospective of TMS–EEG
Tremblay, S., Rogasch, N. C., Premoli, I., Blumberger, D. M., Casarotto, S., Chen, R., Di Lazzaro, V., Farzan, F., Ferrarelli, F., Fitzgerald, P. B., et al. (2019) · Clinical Neurophysiology · doi:10.1016/j.clinph.2019.01.001 · Cited by 472 · see citing works
Self-citationEfficacy of invasive and non-invasive brain modulation interventions for addiction
Luigjes, J., Segrave, R., de Joode, N., Figee, M., & Denys, D. (2019) · Neuropsychology Review · doi:10.1007/s11065-018-9393-5 · Cited by 125 · see citing works
Coyle, H. L., Bailey, N. W., Ponsford, J., & Hoy, K. E. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114308 · Cited by 10 · see citing works
Self-citation
- Authors
- Hill, A. T., Rogasch, N. C., Fitzgerald, P. B., & Hoy, K. E.
- Affiliations
- The Alfred Hospital (AU)
- Monash University (AU)
- Corresponding author
- Hill, Aron T.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 152
- Pages
- 142-157
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2594694121
- Cited by
- 105
- References
- 14
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 5 · 2023: 11 · 2022: 14 · 2021: 15 · 2020: 9 · 2019: 14 · 2018: 16 · 2017: 6 · 2016: 1
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Own your potential (DEAKIN) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- National Health and Medical Research Council (1072057, 1082894, 1078567)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- transcranial direct current stimulation, high-definition tDCS, prefrontal cortex, dorsolateral prefrontal cortex, working memory, cortical excitability, TMS-evoked potentials, P60, beta oscillations, gamma oscillations, cortical oscillations, neuromodulation
- MeSH terms
- Adult, Cerebral Cortex, Electroencephalography, Female, Humans, Male, Memory, Short-Term, Young Adult, Transcranial Direct Current Stimulation
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