The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Coincident but Distinct Messages of Midbrain Dopamine and Striatal Tonically Active Neurons
Open accessAbstract
Midbrain dopamine and striatal tonically active neurons (TANs, presumed acetylcholine interneurons) signal behavioral significance of environmental events. Since striatal dopamine and acetylcholine affect plasticity of cortico-striatal transmission and are both crucial to learning, they may serve as teachers in the basal ganglia circuits. We recorded from both neuronal populations in monkeys performing a probabilistic instrumental conditioning task. Both neuronal types respond robustly to reward-related events. Although different events yielded responses with different latencies, the responses of the two populations coincided, indicating integration at the target level. Yet, while the dopamine neurons' response reflects mismatch between expectation and outcome in the positive domain, the TANs are invariant to reward predictability. Finally, TAN pairs are synchronized, compared to a minority of dopamine neuron pairs. We conclude that the striatal cholinergic and dopaminergic systems carry distinct messages by different means, which can be integrated differently to shape the basal ganglia responses to reward-related events.
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“However, on closer inspection, dopamine responses in such elaborate tasks constitute standard reward prediction-error signals2,33,59,66,69,75,151–153.”
From Dopamine reward prediction-error signalling: A two-component response (2016) · cites this paper as [59]
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Cites
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BackgroundNeuronal Spike Trains and Stochastic Point Processes
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Research works printed but not linked: 2
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Dopamine in motivational control: rewarding, aversive, and alerting
Bromberg-Martin, E. S., Matsumoto, M., & Hikosaka, O. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.022 · Cited by 2,396
Habits, Rituals, and the Evaluative Brain
Graybiel, A. M. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112851 · Cited by 1,697
Behavioral Theories and the Neurophysiology of Reward
Schultz, W. (2006) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070229 · Cited by 1,637
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Schultz, W. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135722 · Cited by 1,415
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Metadata
- Authors
- Morris, G., Arkadir, D., Nevet, A., Vaadia, E., & Bergman, H.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Morris, Genela
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2004-07
- Volume
- 43
- Issue
- 1
- Pages
- 133-143
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2154145851
- Semantic Scholar
- fd94217912e9b183da7428af2af0960f198fcd3c
- Cited by
- 574
- References
- 75
- Citations by year
- 2026: 13 · 2025: 15 · 2024: 11 · 2023: 14 · 2022: 24 · 2021: 21 · 2020: 49 · 2019: 32 · 2018: 24 · 2017: 22 · 2016: 32 · 2015: 31 · 2014: 29 · 2013: 18 · 2012: 20
- FWCI
- 9.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- midbrain dopamine, basal ganglia, reward prediction, neuronal synchronization, signal integration
- MeSH terms
- Acetylcholine, Action Potentials, Animals, Behavior, Animal, Dopamine, Female, Interneurons, Learning, Macaca mulatta, Male, Mesencephalon, Neural Pathways, Synaptic Transmission, Neuronal Plasticity, Reaction Time, Reward, Substantia Nigra, Neostriatum
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