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Coincident but Distinct Messages of Midbrain Dopamine and Striatal Tonically Active Neurons

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Morris, Genela, Arkadir, David, Nevet, Alon, Vaadia, Eilon, Bergman, Hagai·2004·Neuron

DOI 10.1016/j.neuron.2004.06.012

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Abstract

Midbrain dopamine and striatal tonically active neurons (TANs, presumed acetylcholine interneurons) signal behavioral significance of environmental events. Since striatal dopamine and acetylcholine affect plasticity of cortico-striatal transmission and are both crucial to learning, they may serve as teachers in the basal ganglia circuits. We recorded from both neuronal populations in monkeys performing a probabilistic instrumental conditioning task. Both neuronal types respond robustly to reward-related events. Although different events yielded responses with different latencies, the responses of the two populations coincided, indicating integration at the target level. Yet, while the dopamine neurons' response reflects mismatch between expectation and outcome in the positive domain, the TANs are invariant to reward predictability. Finally, TAN pairs are synchronized, compared to a minority of dopamine neuron pairs. We conclude that the striatal cholinergic and dopaminergic systems carry distinct messages by different means, which can be integrated differently to shape the basal ganglia responses to reward-related events.

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Authors: Morris, G., Arkadir, D., Nevet, A., Vaadia, E., & Bergman, H.
Affiliations: Hebrew University of Jerusalem (IL)
Corresponding author: Morris, Genela
ORCID: Morris, Genela
Arkadir, David
Nevet, Alon
Vaadia, Eilon
Bergman, Hagai
Venue: Neuron
Publisher: Elsevier BV
Published: 2004-07
Volume: 43
Issue: 1
Pages: 133-143
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2004.06.012
OpenAlex: W2154145851
Semantic Scholar: fd94217912e9b183da7428af2af0960f198fcd3c
Cited by: 574
References: 75
Citations by year: 2026: 13 · 2025: 15 · 2024: 11 · 2023: 14 · 2022: 24 · 2021: 21 · 2020: 49 · 2019: 32 · 2018: 24 · 2017: 22 · 2016: 32 · 2015: 31 · 2014: 29 · 2013: 18 · 2012: 20
FWCI: 9.83
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3303 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: midbrain dopamine, basal ganglia, reward prediction, neuronal synchronization, signal integration
MeSH terms: Acetylcholine, Action Potentials, Animals, Behavior, Animal, Dopamine, Female, Interneurons, Learning, Macaca mulatta, Male, Mesencephalon, Neural Pathways, Synaptic Transmission, Neuronal Plasticity, Reaction Time, Reward, Substantia Nigra, Neostriatum

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Coincident but Distinct Messages of Midbrain Dopamine and Striatal Tonically Active Neurons

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