Spike Timing-Dependent LTP/LTD Mediates Visual Experience-Dependent Plasticity in a Developing Retinotectal System
Open accessAbstract
Sensory experience plays an instructive role in the development of the nervous system. Here we showed that visual experience can induce persistent modification of developing retinotectal circuits via spike timing-dependent plasticity (STDP). Pairing light stimuli with spiking of the tectal cell induced persistent enhancement or reduction of light-evoked responses, with a dependence on the relative timing between light stimulus and postsynaptic spiking similar to that for STDP. Using precisely timed sequential three-bar stimulation to mimic a moving bar, we showed that spike timing-dependent LTP/LTD can account for the asymmetric modification of the tectal cell receptive field induced by moving bar. Furthermore, selective inhibition of signaling mediated by brain-derived neurotrophic factor and nitric oxide, which are respectively required for light-induced LTP and LTD, interfered with moving bar-induced temporally specific changes in the tectal cell responses. Together, these findings suggest that STDP can mediate sensory experience-dependent circuit refinement in the developing nervous system.
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The nature of this BDNF requirement varies depending on the induction protocol.
“A late phase of LTP has been shown to require BDNF (12–14), although the nature of this requirement varies depending on the induction protocol (15–18).”
From Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines (2008) · cites this paper as [18]
Cites
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“This form of LTP/LTD, now generally referred to as spike timing-dependent plasticity (STDP, Abbott and Nelson, 2000), has been found at excitatory synapses in many systems, including cortical slices (Markram et al., 1997; Egger et al., 1999; Feldman, 2000; Froemke and Dan, 2002), hippocampal slices…”
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- Authors
- Mu, Y., & Poo, M.-M.
- Affiliations
- University of California, Berkeley (US)
- Corresponding author
- Poo, Mu-ming
- ORCID
- Poo, Mu-ming
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2006-04
- Volume
- 50
- Issue
- 1
- Pages
- 115-125
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2167006060
- Cited by
- 164
- References
- 4
- Citations by year
- 2026: 4 · 2025: 1 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 8 · 2019: 9 · 2018: 6 · 2017: 5 · 2016: 2 · 2015: 9 · 2014: 5 · 2013: 18 · 2012: 11
- FWCI
- 5.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2664 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (R01EY014979, EY 014979)
- National Institute of Neurological Disorders and Stroke (R01NS036999, NS 36999)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- spike-timing-dependent plasticity, long-term potentiation, long-term depression, retinotectal system, brain-derived neurotrophic factor, nitric oxide, circuit refinement, sensory experience, retinal development
- MeSH terms
- Action Potentials, Animals, Carbazoles, Enzyme Inhibitors, Motion Perception, Neuronal Plasticity, Neurons, Photic Stimulation, Reaction Time, Retina, Superior Colliculi, Time Factors, Visual Pathways, Xenopus laevis, 2-Amino-5-phosphonovalerate, Long-Term Potentiation, Patch-Clamp Techniques, Excitatory Amino Acid Antagonists, NG-Nitroarginine Methyl Ester, Indole Alkaloids, Long-Term Synaptic Depression, In Vitro Techniques
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