Increased App expression in a mouse model of Down’s syndrome disrupts NGF transport and causes cholinergic neuron degeneration
Salehi, Ahmad, Delcroix, Jean-Dominique, Belichenko, Pavel V., Zhan, Ke, Wu, Chengbiao, Valletta, Janice S., Takimoto-Kimura, Ryoko, Kleschevnikov, Alexander M., Sambamurti, Kumar, Chung, Peter P., Xia, Weiming, Villar, Angela, Campbell, William A., Kulnane, Laura Shapiro, Nixon, Ralph A., Lamb, Bruce T., Epstein, Charles J., Stokin, Gorazd B., Goldstein, Lawrence S.B., Mobley, William C.·2006·Neuron
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- Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr 682 -phosphorylated APP βCTFIm, Eunju, Jiang, Ying, Stavrides, Philip H., Darji, Sandipkumar, Erdjument-Bromage, Hediye, Neubert, Thomas A., Choi, Jun Yong, Wegiel, Jerzy, Lee, Ju-Hyun, Nixon, Ralph A. · 2023 · Science Advances
- Intracellular Aβ triggers neuron loss in the cholinergic system of the APP/PS1KI mouse model of Alzheimer's diseaseChristensen, Ditte Z., Bayer, Thomas A., Wirths, Oliver · 2010 · Neurobiology of Aging
- Amyloid precursor protein-induced axonopathies are independent of amyloid-β peptidesStokin, Gorazd B., Almenar-Queralt, Angels, Gunawardena, Shermali, Rodrigues, Elizabeth M., Falzone, Tomás, Kim, Jungsu, Lillo, Concepción, Mount, Stephanie L., Roberts, Elizabeth A., McGowan, Eileen et al. · 2008 · Human Molecular Genetics
- The human brain NGF metabolic pathway is impaired in the pre-clinical and clinical continuum of Alzheimers diseasePentz, Rowan, Iulita, M. Florencia, Ducatenzeiler, Adriana, Bennett, David A., Cuello, A. Claudio · 2021 · Molecular Psychiatry
- Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivoGunawardena, Shermali, Yang, Ge, Goldstein, Lawrence S.B. · 2013 · Human Molecular Genetics
- Impact of increased APP gene dose in Down syndrome and the Dp16 mouse modelSawa, Mariko, Overk, Cassia, Becker, Ann, Derse, Dominique, Albay, Ricardo, Weldy, Kim, Salehi, Ahmad, Beach, Thomas G., Doran, Eric, Head, Elizabeth et al. · 2022 · Alzheimer's & Dementia
- Synaptic contact number and size in stratum radiatum CA1 of APP/PS1ΔE9 transgenic miceWest, Mark J., Bach, Georg, Søderman, Andreas, Jensen, Jens Ledet · 2009 · Neurobiology of Aging
- Searching for new pharmacological targets for the treatment of Alzheimer's disease in Down syndromeCaraci, Filippo, Iulita, M. Florencia, Pentz, Rowan, Flores Aguilar, Lisi, Orciani, Chiara, Barone, Concetta, Romano, Corrado, Drago, Filippo, Cuello, A. Claudio · 2017 · European Journal of Pharmacology