Cited by 314

The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.

Structural and Mechanistic Insights into Nerve Growth Factor Interactions with the TrkA and p75 Receptors

Open access

Wehrman, Tom, He, Xiaolin, Raab, Bill, Dukipatti, Abhiram, Blau, Helen, Garcia, K. Christopher·2007·Neuron

DOI 10.1016/j.neuron.2006.09.034

Open this paper in CoChat — free account

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neuron.2006.09.034

Cites

70 of 70 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

[20] Processing of X-ray diffraction data collected in oscillation mode
Otwinowski, Z., & Minor, W. (1997) · Methods in Enzymology · doi:10.1016/s0076-6879(97)76066-x · Cited by 33,475
Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination
Brünger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., et al. (1998) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444998003254 · Cited by 15,715
Trk Receptors: Roles in Neuronal Signal Transduction
Huang, E. J., & Reichardt, L. F. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161629 · Cited by 2,537 · cited 9×
“All neurotrophins (NT-3, NT-4/5, BDNF) bind to p75, while each NT is specific for a different Trk receptor subtype (A-, B-, and C) (Huang and Reichardt, 2003; Kalb, 2005).”
BackgroundInfluential
Neurotrophins and their receptors: A convergence point for many signalling pathways
Chao, M. V. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1078 · Cited by 2,298
The trk proto-oncogene encodes a receptor for nerve growth factor
Klein, R., Jing, S., Nanduri, V., O'Rourke, E., & Barbacid, M. (1991) · Cell · doi:10.1016/0092-8674(91)90419-y · Cited by 1,401
The trk Proto-Oncogene Product: a Signal Transducing Receptor for Nerve Growth Factor
Kaplan, D. R., Hempstead, B. L., Martin-Zanca, D., Chao, M. V., & Parada, L. F. (1991) · Science · doi:10.1126/science.1850549 · Cited by 1,379
High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor
Hempstead, B. L., Martin-Zanca, D., Kaplan, D. R., Parada, L. F., & Chao, M. V. (1991) · Nature · doi:10.1038/350678a0 · Cited by 1,229
The leucine-rich repeat: a versatile binding motif
Kobe, B., & Deisenhofer, J. (1994) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(94)90090-6 · Cited by 1,202
Expression and structure of the human NGF receptor
Johnson, D., Lanahan, A., Buck, C. R., Sehgal, A., Morgan, C., Mercer, E., Bothwell, M., & Chao, M. (1986) · Cell · doi:10.1016/0092-8674(86)90619-7 · Cited by 963
Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system
Lee, K.-F., Li, E., Huber, L. J., Landis, S. C., Sharpe, A. H., Chao, M. V., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90286-l · Cited by 956
Functional Interactions of Neurotrophins and Neurotrophin Receptors
Bothwell, M. (1995) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.18.030195.001255 · Cited by 833
Induction of cell death by endogenous nerve growth factor through its p75 receptor
María Frade, J., Rodríguez-Tébar, A., & Barde, Y.-A. (1996) · Nature · doi:10.1038/383166a0 · Cited by 743
Neurotrophin Signaling Through the P75 Neurotrophin Receptor
Roux, P. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00016-3 · Cited by 717
Selective Activation of NF-κB by Nerve Growth Factor Through the Neurotrophin Receptor p75
Carter, B. D., Kaltschmidt, C., Kaltschmidt, B., Offenhäuser, N., Böhm-Matthaei, R., Baeuerle, P. A., & Barde, Y.-A. (1996) · Science · doi:10.1126/science.272.5261.542 · Cited by 658
The neurotrophin receptor p75NTR: novel functions and implications for diseases of the nervous system
Dechant, G., & Barde, Y.-A. (2002) · Nature Neuroscience · doi:10.1038/nn1102-1131 · Cited by 606
Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR
Bibel, M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.3.616 · Cited by 474
Nerve growth factor mediates signal transduction through trk homodimer receptors
Jing, S., Tapley, P., & Barbacid, M. (1992) · Neuron · doi:10.1016/0896-6273(92)90066-m · Cited by 466
An NGF-TrkA-Mediated Retrograde Signal to Transcription Factor CREB in Sympathetic Neurons
Riccio, A., Pierchala, B. A., Ciarallo, C. L., & Ginty, D. D. (1997) · Science · doi:10.1126/science.277.5329.1097 · Cited by 446
Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor
Wiesmann, C., Ultsch, M. H., Bass, S. H., & de Vos, A. M. (1999) · Nature · doi:10.1038/43705 · Cited by 415
Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells
Barker, P. A., & Shooter, E. M. (1994) · Neuron · doi:10.1016/0896-6273(94)90470-7 · Cited by 403
p75LNGFR regulates Trk signal transduction and NGF-induced neuronal differentiation in MAH cells
Verdi, J. M., Birren, S. J., Ibáñez, C. F., Persson, H., Kaplan, D. R., Benedetti, M., Chao, M. V., & Anderson, D. J. (1994) · Neuron · doi:10.1016/0896-6273(94)90327-1 · Cited by 350
Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product
Ibáñez, C. F., Ebendal, T., Barbany, G., Murray-Rust, J., Blundell, T. L., & Persson, H. (1992) · Cell · doi:10.1016/0092-8674(92)90413-7 · Cited by 327
Structure of Nerve Growth Factor Complexed with the Shared Neurotrophin Receptor p75
He, X.-L., & Garcia, K. C. (2004) · Science · doi:10.1126/science.1095190 · Cited by 323
Self-citation
High affinity nerve growth factor binding displays a faster rate of association than p140trk binding. Implications for multi-subunit polypeptide receptors.
Mahadeo, D., Kaplan, L., Chao, M. V., & Hempstead, B. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37458-6 · Cited by 320
P75NTR-live or let die
Nykjaer, A., Willnow, T. E., & Petersen, C. M. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.01.004 · Cited by 318
p75NTR Is Positively Promiscuous
Barker, P. A. (2004) · Neuron · doi:10.1016/j.neuron.2004.04.001 · Cited by 308
Neurotrophin receptor mRNA expression defines distinct populations of neurons in rat dorsal root ganglia
Wright, D. E., & Snider, W. D. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903510302 · Cited by 304
The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins
Hantzopoulos, P. A., Suri, C., Glass, D. J., Goldfarb, M. P., & Yancopoulos, G. D. (1994) · Neuron · doi:10.1016/0896-6273(94)90469-3 · Cited by 288
Structure of an Extracellular gp130 Cytokine Receptor Signaling Complex
Chow, D.-C., He, X.-L., Snow, A. L., Rose-John, S., & Garcia, K. C. (2001) · Science · doi:10.1126/science.1058308 · Cited by 261
Self-citation
Complete ablation of the neurotrophin receptor p75NTR causes defects both in the nervous and the vascular system
von Schack, D., Casademunt, E., Schweigreiter, R., Meyer, M., Bibel, M., & Dechant, G. (2001) · Nature Neuroscience · doi:10.1038/nn730 · Cited by 259
Association of the p75 Neurotrophin Receptor with TRAF6
Khursigara, G., Orlinick, J. R., & Chao, M. V. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.5.2597 · Cited by 243
The Cytoplasmic and Transmembrane Domains of the p75 and Trk A Receptors Regulate High Affinity Binding to Nerve Growth Factor
Esposito, D., Patel, P., Stephens, R. M., Perez, P., Chao, M. V., Kaplan, D. R., & Hempstead, B. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011674200 · Cited by 234
Neurotrophins and their receptors: signaling trios in complex biological systems
Teng, K. K., & Hempstead, B. L. (2004) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s00018-003-3099-3 · Cited by 222
Transgenic Mice Expressing the Intracellular Domain of the p75 Neurotrophin Receptor Undergo Neuronal Apoptosis
Majdan, M., Lachance, C., Gloster, A., Aloyz, R., Zeindler, C., Bamji, S., Bhakar, A., Belliveau, D., Fawcett, J., Miller, F. D., et al. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-18-06988.1997 · Cited by 210
Activation of Rac GTPase by p75 Is Necessary for c-jun N-Terminal Kinase-Mediated Apoptosis
Harrington, A. W., Kim, J. Y., & Yoon, S. O. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00156.2002 · Cited by 208
Nerve growth factor: structure and function
Wiesmann, C., & de Vos, A. M. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000898 · Cited by 199
p75-Mediated NF-κB Activation Enhances the Survival Response of Developing Sensory Neurons to Nerve Growth Factor
Hamanoue, M., Middleton, G., Wyatt, S., Jaffray, E., Hay, R. T., & Davies, A. M. (1999) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1999.0770 · Cited by 197
TRAF Family Proteins Interact with the Common Neurotrophin Receptor and Modulate Apoptosis Induction
Ye, X., Mehlen, P., Rabizadeh, S., VanArsdale, T., Zhang, H., Shin, H., Wang, J. J. L., Leo, E., Zapata, J., Hauser, C. A., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.30202 · Cited by 190
The zinc finger protein NRIF interacts with the neurotrophin receptor p75NTR and participates in programmed cell death
Casademunt, E. (1999) · The EMBO Journal · doi:10.1093/emboj/18.21.6050 · Cited by 189
Purification and Metabolic Effects of a Nerve Growth-promoting Protein from Snake Venom
Cohen, S. (1959) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98144-5 · Cited by 184
Long-distance retrograde neurotrophic signaling
Howe, C. L., & Mobley, W. C. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.01.010 · Cited by 179
TrkA glycosylation regulates receptor localization and activity
Watson, F. L., Porcionatto, M. A., Bhattacharyya, A., Stiles, C. D., & Segal, R. A. (1999) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199905)39:2<323::aid-neu15>3.0.co;2-4 · Cited by 163
The p75 Neurotrophin Receptor Activates Akt (Protein Kinase B) through a Phosphatidylinositol 3-Kinase-dependent Pathway
Roux, P. P., Bhakar, A. L., Kennedy, T. E., & Barker, P. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011520200 · Cited by 150
The protean actions of neurotrophins and their receptors on the life and death of neurons
Kalb, R. G. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.11.003 · Cited by 131
A potential interaction of p75 and trkA NGF receptors revealed by affinity crosslinking and immunoprecipitation
Huber, L. J., & Chao, M. V. (1995) · Journal of Neuroscience Research · doi:10.1002/jnr.490400415 · Cited by 128
HSV-1 vector-mediated gene transfer of the human nerve growth factor receptor p75hNGFR defines high-affinity NGF binding
Battleman, D., Geller, A., & Chao, M. V. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-03-00941.1993 · Cited by 127
TrkA Immunoglobulin-Like Ligand Binding Domains Inhibit Spontaneous Activation of the Receptor
Arévalo, J. C., Conde, B., Hempstead, B. L., Chao, M. V., Martín-Zanca, D., & Pérez, P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.16.5908-5916.2000 · Cited by 122
Dynamic Expression of Neurotrophin Receptors during Sensory Neuron Genesis and Differentiation
Rifkin, J. T., Todd, V. J., Anderson, L. W., & Lefcort, F. B. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9841 · Cited by 113
Characterization of a p75NTR Apoptotic Signaling Pathway Using a Novel Cellular Model
Wang, X., Bauer, J. H., Li, Y., Shao, Z., Zetoune, F. S., Cattaneo, E. F., & Vincenz, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010548200 · Cited by 113
NGF Binding to the trk Tyrosine Kinase Receptor Requires the Extracellular Immunoglobulin-like Domains
Pérez, P., Coll, P. M., Hempstead, B. L., Martı́n-Zanca, D., & Chao, M. V. (1995) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1995.1010 · Cited by 110
Neurotrophin receptor structure and interactions
Yano, H., & Chao, M. V. (2000) · Pharmaceutica Acta Helvetiae · doi:10.1016/s0031-6865(99)00036-9 · Cited by 108
Neurotrophin Signaling through the p75 Receptor Is Deficient intraf6-/- Mice
Yeiser, E. C., Rutkoski, N. J., Naito, A., Inoue, J., & Carter, B. D. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1390-04.2004 · Cited by 104
Affinity labeling and partial purification of nerve growth factor receptors from rat pheochromocytoma and human melanoma cells.
Grob, P. M., Berlot, C. H., & Bothwell, M. A. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.22.6819 · Cited by 99
p75 Co-receptors Regulate Ligand-dependent and Ligand-independent Trk Receptor Activation, in Part by Altering Trk Docking Subdomains
Zaccaro, M. C., Ivanisevic, L., Pérez, P., Meakin, S. O., & Saragovi, H. U. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104630200 · Cited by 98
Deletion of cytoplasmic sequences of the nerve growth factor receptor leads to loss of high affinity ligand binding.
Hempstead, B. L., Patil, N., Thiel, B., & Chao, M. V. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38707-1 · Cited by 96
The Extracellular Domain of p75NTR Is Necessary to Inhibit Neurotrophin-3 Signaling through TrkA
Mischel, P. S., Smith, S. G., Vining, E. R., Valletta, J. S., Mobley, W. C., & Reichardt, L. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005132200 · Cited by 94
A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions
Wehrman, T. S., Raab, W. J., Casipit, C. L., Doyonnas, R., Pomerantz, J. H., & Blau, H. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605218103 · Cited by 85
Self-citation
High Resolution Mapping of the Binding Site of TrkA for Nerve Growth Factor and TrkC for Neurotrophin-3 on the Second Immunoglobulin-like Domain of the Trk Receptors
Urfer, R., Tsoulfas, P., O'Connell, L., Hongo, J.-A., Zhao, W., & Presta, L. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5829 · Cited by 82
Anatomical evidence supporting the potential for modulation by multiple neurotrophins in the majority of adult lumbar sensory neurons
Karchewski, L. A., Kim, F. A., Johnston, J. M., McKnight, R. M., & Verge, V. M. K. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19991018)413:2<327::aid-cne11>3.0.co;2-3 · Cited by 81
Individual and Combined Effects of TrkA and p75NTR Nerve Growth Factor Receptors
Lad, S. P., Peterson, D. A., Bradshaw, R. A., & Neet, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212270200 · Cited by 80
Ternary complex with Trk, p75, and an ankyrin‐rich membrane spanning protein
Chang, M., Arévalo, J. C., & Chao, M. V. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20262 · Cited by 70
Mathematical models for ligand-receptor binding. Real sites, ghost sites.
Klotz, I. M., & Hunston, D. L. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)90927-0 · Cited by 64
Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 bind to a single leucine-rich motif of TrkB
Windisch, J. M., Marksteiner, R., Lang, M. E., Auer, B., & Schneider, R. (1995) · Biochemistry · doi:10.1021/bi00035a035 · Cited by 64
Phosphoinositide 3‐kinase regulates crosstalk between Trk A tyrosine kinase and p75NTR‐dependent sphingolipid signaling pathways
Bilderback, T. R., Gazula, V., & Dobrowsky, R. T. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00171.x · Cited by 60
A novel mutation within the extracellular domain of TrkA causes constitutive receptor activation
Arévalo, J. C., Conde, B., Hempstead, B. L., Chao, M. V., Martı́n-Zanca, D., & Pérez, P. (2001) · Oncogene · doi:10.1038/sj.onc.1204215 · Cited by 55
Characterization of Symmetric Complexes of Nerve Growth Factor and the Ectodomain of the Pan-neurotrophin Receptor, p75NTR
Aurikko, J. P., Ruotolo, B. T., Grossmann, J. G., Moncrieffe, M. C., Stephens, E., Leppänen, V., Robinson, C. V., Saarma, M., Bradshaw, R. A., & Blundell, T. L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503189200 · Cited by 46
Dimerization-dependent block of the proapoptotic effect of P75NTR
Wang, J. J. ‐., Rabizadeh, S., Tasinato, A., Sperandio, S., Ye, X., Green, M., Assa‐Munt, N., Spencer, D. M., & Bredesen, D. E. (2000) · Journal of Neuroscience Research · Cited by 44
Deletions in the Extracellular Domain of Rat TrkA Lead to an Altered Differentiative Phenotype in Neurotrophin Responsive Cells
MacDonald, J. I., & Meakin, S. O. (1996) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1996.0027 · Cited by 42
Specific neurotrophin binding to leucine‐rich motif peptides of TrkA and TrkB
Windisch, J. M., Auer, B., Marksteiner, R., Lang, M. E., & Schneider, R. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)01047-i · Cited by 34
p75 Neurotrophin receptor mediates neurotrophin activation of NF‐kappa B and induction of iNOS expression in P19 neurons
Burke, M. A., & Bothwell, M. A. (2003) · Journal of Neurobiology · doi:10.1002/neu.10174 · Cited by 28

Cell Signaling by Receptor Tyrosine Kinases
Lemmon, M. A., & Schlessinger, J. (2010) · Cell · doi:10.1016/j.cell.2010.06.011 · Cited by 7,929
Mechanisms of receptor tyrosine kinase activation in cancer
Du, Z., & Lovly, C. M. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0782-4 · Cited by 1,066
Design of protein-binding proteins from the target structure alone
Cao, L., Coventry, B., Goreshnik, I., Huang, B., Sheffler, W., Park, J. S., Jude, K. M., Marković, I., Kadam, R. U., Verschueren, K. H. G., et al. (2022) · Nature · doi:10.1038/s41586-022-04654-9 · Cited by 577
Self-citation
Psychedelics promote plasticity by directly binding to BDNF receptor TrkB
Moliner, R., Girych, M., Brunello, C. A., Kovaleva, V., Biojone, C., Enkavi, G., Antenucci, L., Kot, E. F., Goncharuk, S. A., Kaurinkoski, K., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01316-5 · Cited by 478
The leucine-rich repeat structure
Bella, J., Hindle, K. L., McEwan, P. A., & Lovell, S. C. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8019-0 · Cited by 466

See all 314

Authors: Wehrman, T., He, X., Raab, B., Dukipatti, A., Blau, H., & Garcia, K. C.
Venue: Neuron
Publisher: Elsevier BV
Published: 2007-01
Volume: 53
Issue: 1
Pages: 25-38
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2006.09.034
OpenAlex: W2011207394
Cited by: 314
References: 70
FWCI: 9.67
Type: journal article
Language: en
Open access: bronze

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

Structural and Mechanistic Insights into Nerve Growth Factor Interactions with the TrkA and p75 Receptors

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Metadata

Record

About these checks

Data sources