Cited by 139

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Sez-6 Proteins Affect Dendritic Arborization Patterns and Excitability of Cortical Pyramidal Neurons

Gunnersen, Jenny M., Kim, Mary H., Fuller, Stephanie J., De Silva, Melanie, Britto, Joanne M., Hammond, Vicki E., Davies, Philip J., Petrou, Steve, Faber, E.S. Louise, Sah, Pankaj, Tan, Seong-Seng·2007·Neuron

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Crossref · 10.1016/j.neuron.2007.09.018

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  • The SEZ6 family controls synaptic connectivity and motor coordination in mice.

    “The SEZ6 family controls synaptic connectivity and motor coordination in mice [18, 19], but little is known about the functions of these proteins at the molecular level.”

    From Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons (2016) · cites this paper as [18]

    The Abstract reports fewer excitatory synapses and impaired motor coordination in Sez-6-null mice, supporting both effects. This paper studies Sez-6 and its isoforms, however, rather than establishing that the SEZ6 family as a whole controls these outcomes. (LLM, conf=0.86)

    Experimental — accuracy not yet measured
  • Both mouse lines appear to have reduced levels of anxiety and/or cognitive deficits, reduced glutamatergic synapse function and reduced dendritic spine densities.

    “Moreover, both mouse lines appear to have reduced levels of anxiety and/or cognitive deficits [18, 56], reduced glutamatergic synapse function and reduced dendritic spine densities [18, 58].”
  • Both BACE1- and SEZ6-deficient mice have deficits in hippocampal learning paradigms and in motor coordination.

    “Notably, both BACE1- and SEZ6-deficient mice have deficits in hippocampal learning paradigms [18, 54–56] and in motor coordination [18, 57].”

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Metadata

Authors
Gunnersen, J. M., Kim, M. H., Fuller, S. J., De Silva, M., Britto, J. M., Hammond, V. E., Davies, P. J., Petrou, S., Faber, E. S. L., Sah, P., & Tan, S.-S.
Venue
Neuron
Publisher
Elsevier BV
Published
2007-11
Volume
56
Issue
4
Pages
621-639
ISSN
0896-6273
Cited by
139
References
5
Language
en

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