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Sez-6 Proteins Affect Dendritic Arborization Patterns and Excitability of Cortical Pyramidal Neurons
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The SEZ6 family controls synaptic connectivity and motor coordination in mice.
“The SEZ6 family controls synaptic connectivity and motor coordination in mice [18, 19], but little is known about the functions of these proteins at the molecular level.”
From Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons (2016) · cites this paper as [18]
The Abstract reports fewer excitatory synapses and impaired motor coordination in Sez-6-null mice, supporting both effects. This paper studies Sez-6 and its isoforms, however, rather than establishing that the SEZ6 family as a whole controls these outcomes. (LLM, conf=0.86)
Experimental — accuracy not yet measuredBoth mouse lines appear to have reduced levels of anxiety and/or cognitive deficits, reduced glutamatergic synapse function and reduced dendritic spine densities.
“Moreover, both mouse lines appear to have reduced levels of anxiety and/or cognitive deficits [18, 56], reduced glutamatergic synapse function and reduced dendritic spine densities [18, 58].”
From Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons (2016) · cites this paper as [18]
Both BACE1- and SEZ6-deficient mice have deficits in hippocampal learning paradigms and in motor coordination.
“Notably, both BACE1- and SEZ6-deficient mice have deficits in hippocampal learning paradigms [18, 54–56] and in motor coordination [18, 57].”
From Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons (2016) · cites this paper as [18]
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Citations
Cites
Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
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Activity-dependent regulation of dendritic growth and patterning
Wong, R. O. L., & Ghosh, A. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn941 · Cited by 635
Hayashi, M. L., Choi, S.-Y., Rao, B. S. S., Jung, H.-Y., Lee, H.-K., Zhang, D., Chattarji, S., Kirkwood, A., & Tonegawa, S. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.003 · Cited by 280
Suetsugu, M., & Mehraein, P. (1980) · Acta Neuropathologica · doi:10.1007/bf00688755 · Cited by 190
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Metadata
- Authors
- Gunnersen, J. M., Kim, M. H., Fuller, S. J., De Silva, M., Britto, J. M., Hammond, V. E., Davies, P. J., Petrou, S., Faber, E. S. L., Sah, P., & Tan, S.-S.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 56
- Issue
- 4
- Pages
- 621-639
- ISSN
- 0896-6273
- Cited by
- 139
- References
- 5
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2121 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
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