Behavioral Phenotyping Strategies for Mutant Mice

Developments of a water-maze procedure for studying spatial learning in the rat

Morris, R. (1984) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(84)90007-4 · Cited by 7,180

Untitled work

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The use of a plus-maze to measure anxiety in the mouse

Lister, R. G. (1987) · Psychopharmacology · doi:10.1007/bf00177912 · Cited by 2,617

Applications of the Morris water maze in the study of learning and memory

D’Hooge, R., & Deyn, P. P. D. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00067-4 · Cited by 2,083

Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

Roberson, E. D., Scearce-Levie, K., Palop, J. J., Yan, F., Cheng, I. H., Wu, T., Gerstein, H., Yu, G.-Q., & Mucke, L. (2007) · Science · doi:10.1126/science.1141736 · Cited by 1,892

Genetics of Mouse Behavior: Interactions with Laboratory Environment

Crabbe, J. C., Wahlsten, D., & Dudek, B. C. (1999) · Science · doi:10.1126/science.284.5420.1670 · Cited by 1,666

Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review

Geyer, M. A., Krebs-Thomson, K., Braff, D. L., & Swerdlow, N. R. (2001) · Psychopharmacology · doi:10.1007/s002130100811 · Cited by 1,484

Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia

Barlow, C., Hirotsune, S., Paylor, R. E., Liyanage, M., Eckhaus, M., Collins, F. S., Shiloh, Y., Crawley, J. N., Ried, T., Tagle, D. A., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80086-0 · Cited by 1,465

Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies

Crawley, J. N., Belknap, J. K., Collins, A. C., Crabbe, J. C., Frankel, W. N., Henderson, N. D., HITZEMANN, R. J., Maxson, S. C., Miner, L. L., Silva, A. J., et al. (1997) · Psychopharmacology · doi:10.1007/s002130050327 · Cited by 1,372

Schemas and Memory Consolidation.

Tse, D., Langston, R. F., Kakeyama, M., Bethus, I., Spooner, P. A., Wood, E. R., Witter, M. P., & Morris, R. G. M. (2007) · Science · doi:10.1126/science.1135935 · Cited by 1,244

Brain Fires in Autism Spectrum Disorders

Theoharides, T. C., & Stewart, J. M. (2016) · clinics in Mother and Child Health · doi:10.4172/2090-7214.1000226

Untapped resources for pharmacogenomic discovery in psychiatry.

Crowley, J. J., Sullivan, P. F., & McLeod, H. L. (2008) · PubMed

Mutant and Transgenic Tools in Modeling Schizophrenia

Desbonnet, L., Tomiyama, K., Koshikawa, N., O’Tuathaigh, C. M. P., & Waddington, J. L. (2009) · Neuromethods · doi:10.1007/978-1-60761-474-6_12

Conditional Gene Targeting: A Refined Method for Genetic Studies in Neurosciences

Beil, J., Mansuy, I. M., & Buch, T. (2013) · Neuromethods · doi:10.1007/978-1-62703-517-0_1

Characterization of Williams-Beuren Syndrome Mouse Models: Linking Genes with Cognition and Behaviour

Lam, E. (2012) · TSpace (University of Toronto)

Emotional regulation and the limbic system associated membrane protein.

Catania, E. H. (2008) · Europe PMC (PubMed Central)

The Effects of Synthetic and Dietary Therapeutics on Learning, Memory, Motor Coordination, and Seizure in an Angelman Syndrome Mouse Model

Ciarlone, S. L. (2016) · Digital Commons - University of South Florida (University of South Florida)

Fibroblast growth factor signaling in the developing serotonergic system and anxiety-related behavior

Brooks, L. R. (2014) · CU Scholar (University of Colorado Boulder)

Reanalyzing Explorative Behavior in the Open Field Test New Insights from a New Application that Phenotypes Mice Exploratory Behavior

Tsoory, M., Fainzilber, M., & Panayotis, N. (2014)

Growing uncultured bacteria from the human gut microbiome: potential influence of the hidden majority on host physiology, including mental health.

Strandwitz, P. (2016)

Collective interaction effects associated with mammalian behavioral traits reveal genetic factors connecting fear and hemostasis

Woo, H. J., & Jaques Reifman, A. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1753-4 · Cited by 1

Role of a PTP1B Pathway in the Neuropsychiatric Expression of a Mouse Maternal Immune Activation Model

Couture, P. (2019) · uO Research (University of Ottawa) · doi:10.20381/ruor-23143

Tactile discrimination learning in mice

Pacchiarini, N. (2019) · ORCA Online Research @Cardiff (Cardiff University)

Characterization of Nonmotor Symptoms in the MitoPark Mouse Model of Parkinson’s DiseasePreprint

Langley, M. R., Ghaisas, S., Palanisamy, B. N., Ay, M., Jin, H., Anantharam, V., Kanthasamy, A., & Kanthasamy, A. G. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.02.365874

Faculty Opinions recommendation of Prkcz null mice show normal learning and memory.

Giese, K.-P. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717970681.793469227

Verhaltensbiologie

Mahlke, C. (2010) · Spektrum Akademischer Verlag eBooks · doi:10.1007/978-3-8274-2369-6_9

大鼠和小鼠 - 行为表现型研究的动物模型

Teegarden, S. L. (2012) · 实验材料和方法 · doi:10.13070/mm.cn.2.122

Reference List

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Growing uncultured bacteria from the human gut microbiome

Strandwitz, P. (2016) · doi:10.17760/d20201758

JoVE Video Dataset

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Use of Data from Transgenic Animals in Safety Pharmacology

Redfern, W. S. (2023) · Springer eBooks · doi:10.1007/978-3-030-73317-9_81-1

Use of Data from Transgenic Animals in Safety Pharmacology

Redfern, W. S. (2024) · Springer eBooks · doi:10.1007/978-3-031-35529-5_81

Histopathological observations of acute toxicity effects of rodent tuber (Typhonium flagelliforme) extract in mice

Sukmara, S., Sianipar, N. F., Hadisaputri, Y. E., Assidqi, K., & So, I. G. (2025) · AIP conference proceedings · doi:10.1063/5.0249426

Upregulated SEMA3C in astrocytes contributes to Rett Syndrome phenotypesPreprint

Lyon, K. A., Paumier, A., Kandikonda, A., Melendez, A., & Allen, N. J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.10.681027

Additional file 3 of Oxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autism

Михайлович, Ч. С., Gerasimenko, M., Yuhi, T., Furuhara, K., Tsuji, C., Yokoyama, S., Nakayama, K. I., Nishiyama, M., & Higashida, H. (2021) · Figshare · doi:10.6084/m9.figshare.14525969

Additional file 2 of Oxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autism

Cherepanov, S. M., Gerasimenko, M., Yuhi, T., Furuhara, K., Tsuji, C., Yokoyama, S., Nakayama, K. I., Nishiyama, M., & Higashida, H. (2021) · Figshare · doi:10.6084/m9.figshare.14525966

Additional file 1 of Oxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autism

Михайлович, Ч. С., Gerasimenko, M., Yuhi, T., Furuhara, K., Tsuji, C., Yokoyama, S., Nakayama, K. I., Nishiyama, M., & Higashida, H. (2021) · Figshare · doi:10.6084/m9.figshare.14525963

Verhaltens- und Neurogenetik

Ehrenhofer‐Murray, A. E. (2025) · Springer eBooks · doi:10.1007/978-3-662-70328-1_14

A potential risk of plastic and plasticizer pollution: a molecular toxicological study on DIDP-exacerbated autism-like behaviors in juvenile mice

Chen, S., Qiu, Z., Peng, Q., Liu, L., Wu, Y., Li, Y., Zhang, C., Yang, X., & Ma, P. (2026) · Toxicology Research · doi:10.1093/toxres/tfaf168

Rôle de Scribble1 dans la formation des synapses glutamatergiques et le trafic des récepteurs NMDA

Piguel, N. H. (2010) · theses.fr (ABES) · doi:10.70675/df9c39f9zd4f5z42c6z9dcfzb990c91e9dee

Adult neurogenesis and mitochondria play a role in hippocampal plasticity in mouse models of neurodegenerative diseases

Andraini, T. (2017) · theses.fr (ABES) · doi:10.70675/d69ee7bfzfd43z49e8zac71z9d99bf4e07c2

Unraveling the physiopathological actions of the newly discovered Aη peptides in the brain

Mensch, M. (2020) · theses.fr (ABES) · doi:10.70675/476a3b23ze46ez4002z9ae4z91bd09be5c76

Brain and knee joint degeneration following anterior cruciate ligament injury in a mouse model of Alzheimer’s disease

Yao, W., Wise, B. L., Lin, Y., Fan, M., Xu, S., Ju, I.-S., Berg, J. I., Silverman, J. L., Loots, G. G., & Christiansen, B. (2026) · JBMR Plus · doi:10.1093/jbmrpl/ziag085

Behavioral phenotypes in aging: structured exploratory computational analysis of multi-assay behavioral data

Singhal, G., & Baune, B. T. (2026) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2026.1861841

Age-Associated Behavioral Alterations in Laboratory-Housed Octodon degus

Bai, H., Liu, Y., Seluanov, A., & Gorbunova, V. A. (2026) · Biology · doi:10.3390/biology15161352

Differential Dose–Response Behavioural Profiles of Diazepam, Zolpidem and Indiplon in a Two-Trial Y-Maze Paradigm in Rats

Moraru, M. V., Coman, O. A., Zugravu, A., Stoleru, S., Ghiță, C. I. V., Costescu, M., Poenaru, E., Dragomir, A.-F., Barbu, A. C., Luncă, D.-C., et al. (2026) · Pharmaceuticals · doi:10.3390/ph19081282

Preserved social development but impaired executive function in a Shank3 -deficient rat model of Phelan-McDermid syndromePreprint

Chudasama, Y., Pearson, A., Drazan, T., Bradley, S., Thurm, A., Buxbaum, J. D., & Silverman, J. L. (2026) · Research Square · doi:10.21203/rs.3.rs-10821151/v1

Baihe Zhimu Decoction ameliorates anxious depression via PI3K / AKT / mTOR pathway‐mediated neuroprotection and inhibition of hippocampal neuronal apoptosis

Yuanshan, H. A. N., He, K., Yang, H., Dai, J., Chen, R., Liu, Y., Wang, Y., Tang, L., & Zhao, H. (2026) · Animal Models and Experimental Medicine · doi:10.1002/ame2.70295

The Importance of Translational Research for Neurodevelopmental Disorders and Autism Spectrum Disorders

Silverman, J. L., Haouchine, O. Y., Roy, D., & Monsen, E. R. (2026) · Current topics in behavioral neurosciences · doi:10.1007/7854_2026_617

A Proposed Test Battery and Constellations of Specific Behavioral Paradigms to Investigate the Behavioral Phenotypes of Transgenic and Knockout Mice

Crawley, J. N., & Paylor, R. E. (1997) · Hormones and Behavior · doi:10.1006/hbeh.1997.1382 · Cited by 555

Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests1Published on the World Wide Web on 2 December 1998.1

Crawley, J. N. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01258-x · Cited by 772

Behavioral phenotyping of rodents.

Crawley, J. N. (2003) · PubMed · Cited by 102

Behavioral screening of mutant mice

Belknap, J. K. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01736-7

A Proposed Test Battery and Constellations of Speci®c Behavioral Paradigms to Investigate the Behavioral Phenotypes of Transgenic and Knockout Mice

Crawley, J. N., & Paylor, R. E. (2014)