ApoE Promotes the Proteolytic Degradation of Aβ

Jiang, Qingguang, Lee, C.Y. Daniel, Mandrekar, Shweta, Wilkinson, Brandy, Cramer, Paige, Zelcer, Noam, Mann, Karen, Lamb, Bruce +9 more·2008·Neuron

DOI 10.1016/j.neuron.2008.04.010

Cited by (876)

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Campos-Peña, Victoria, Toral-Rios, Danira, Becerril-Pérez, Fernando, Sánchez-Torres, Carmen, Delgado-Namorado, Yair, Torres-Ossorio, Elimar, Franco-Bocanegra, Diana, Carvajal, Karla · 2017 · Antioxidants & Redox Signaling
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K. Baranger, S. Rivera, F. Liechti, D. Grandgirard, J. Bigas, Jesus Seco, T. Tarragó, S. Leib, M. Khrestchatisky · 2014 · Progress in Brain Research
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Friederike Fritze, Uwe Ehrt, Hogne Sønnesyn, Martin Wilhelm Kurz, Tibor Hortobágyi, Sabine Piepenstock Nore, Clive G. Ballard, Dag Aarsland · 2010 · International Journal of Geriatric Psychiatry
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Choi, Jinkuk, Gao, Jie, Kim, Jaekwang, Hong, Cynthia, Kim, Jungsu, Tontonoz, Peter · 2015 · Science Translational Medicine
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Yujie Cui, Mingwei Huang, Yingbo He, Shuyan Zhang, Yongzhang Luo · 2011 · American Journal Of Pathology
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Rupinder Kaur Sodhi, Nirmal Singh · 2013 · PLoS ONE
Neuropsychiatric symptoms and Apolipoprotein E: Associations with eventual Alzheimer’s disease development
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Li‐Feng‐Rong Qi, Shuai Liu, Yu-Ci Liu, Ping Li, Xiaojun Xu · 2021 · International Journal of Molecular Sciences
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Fan, Jianjia, Zhao, Rui Qi, Parro, Cameron, Zhao, Wenchen, Chou, Hsien-Ya, Robert, Jerome, Deeb, Tarek Z., Raynoschek, Carina, Barichievy, Samantha, Engkvist, Ola et al. · 2018 · Journal of Lipid Research
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Lei Fan, Xiaoxia Qiu, Zhiyuan Zhu, Jianlu Lv, Jian Lu, Fei Mao, Jin Zhu, Jiaying Wang, Xiaowei Guan, Jing Chen et al. · 2019 · Acta Pharmacologica Sinica
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Yawu Liu, Teemu I. Paajanen, Eric Westman, Yi Zhang, Lars‐Olof Wahlund, Andrew Simmons, Catherine Tunnard, Tomasz Sobów, Petroula Proitsi, John F. Powell et al. · 2010 · Dementia and Geriatric Cognitive Disorders
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Guilaine K. Boyce, Emily B. Button, S.V. Sonja, Cheryl Lea Wellington · 2017 · Journal of Biomedical Research
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Hong, Ingie, Kang, Taewook, Yoo, YongCheol, Park, Royun, Lee, Junuk, Lee, Sukwon, Kim, Jeongyeon, Song, Boemjong, Kim, Se-Young, Moon, Minho et al. · 2013 · Journal of Alzheimer s Disease
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S. Hunter, T. Arendt, C. Brayne · 2013 · Molecular Neurobiology
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Xiaodan Guo, Jianlu Lv, Jian Lu, Lei Fan, Xi Huang, Lihong Hu, Jiaying Wang, Xu Shen · 2017 · Neuropharmacology
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Jiu Chen, Hao Shu, Zan Wang, Duan Liu, Yongmei Shi, Xiangrong Zhang, Zhijun Zhang · 2014 · Journal of Alzheimer s Disease
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Minagawa, Hirohisa, Watanabe, Atsushi, Akatsu, Hiroyasu, Adachi, Kayo, Ohtsuka, Chigumi, Terayama, Yasuo, Hosono, Takashi, Takahashi, Satoshi, Wakita, Hideaki, Jung, Cha-Gyun et al. · 2010 · Journal of Biological Chemistry
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Christine Thai, Yen Ying Lim, Victor L. Villemagne, Simon Matthew Laws, David J. Ames, Kathryn A. Ellis, Stephanie Ruth Rainey‐Smith, Ralph Nigel Martins, Colin Louis Masters, Christopher C. Rowe et al. · 2015 · PLoS ONE
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Antara T. Rao, Nuo Chen, Min Joo Kim, Jessica R. Blumenfeld, Oscar Yip, Zherui Liang, David M. Shostak, Yanxia Hao, Maxine R. Nelson, Nicole Koutsodendris et al. · 2024 · Cell stem cell
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Sadequl Islam, A. Noorani, Yang Sun, Makoto Michikawa, Kun Zou · 2025 · Frontiers in Aging Neuroscience
Staging anti-inflammatory therapy in Alzheimer’s disease
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High‐affinity multivalent interactions between apolipoprotein E and the oligomers of amyloid‐β
Shamasree Ghosh, Timir Baran Sil, Subhrajyoti Dolai, Kanchan Garai · 2019 · FEBS Journal
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Cha‐Gyun Jung, Hirofumi Horike, Byung‐Yoon Cha, Kyung‐Ok Uhm, Rena Yamauchi, Takamasa Yamaguchi, Takashi Hosono, Kagami Iida, Je‐Tae Woo, Makoto Michikawa · 2010 · Biological and Pharmaceutical Bulletin