Metabolic syndrome as a risk factor for Alzheimer's disease: Is Aβ a crucial factor in both pathologies?

Astrocyte-endothelial interactions at the blood-brain barrier

Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595 · see citing works

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404 · see citing works

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

Haass, C., & Selkoe, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2101 · Cited by 4,744 · see citing works

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) · Nature · doi:10.1038/349704a0 · Cited by 4,659 · see citing works

Adipokines in inflammation and metabolic disease

Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625 · see citing works

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619 · see citing works

Alzheimer’s disease

Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569 · see citing works

The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects

Blessed, G., Tomlinson, B. E., & Roth, M. (1968) · British Journal of Psychiatry · doi:10.1192/bjp.114.512.797 · Cited by 4,117 · see citing works

Inflammatory Mechanisms in Obesity

Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754 · see citing works

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Rozovsky, I., Trommer, B., Viola, K. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6448 · Cited by 3,506 · see citing works

A central role for JNK in obesity and insulin resistance

Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359 · see citing works

Candidate gene for the chromosome 1 familial Alzheimer’s disease locus

Levy-Lahad, E., Wasco, W., Poorkaj, P., Romano, D. M., Oshima, J., Pettingell, W. H., Yu, C.-E., Jondro, P. D., Schmidt, S. D., Wang, K., et al. (1995) · Science · doi:10.1126/science.7638622 · Cited by 2,577 · see citing works

Elevated C-reactive protein levels in overweight and obese adults

Visser, M. (1999) · JAMA · doi:10.1001/jama.282.22.2131 · Cited by 2,494 · see citing works

Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation

Bélanger, M., Allaman, I., & Magistretti, P. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.016 · Cited by 2,313 · see citing works

Diabetes mellitus and the risk of dementia: The Rotterdam Study

Ott, A., Stolk, R. P., van Harskamp, F., Pols, H. A. P., Hofman, A., & Breteler, M. M. B. (1999) · Neurology · doi:10.1212/wnl.53.9.1937 · Cited by 2,175 · see citing works

The Metabolic Syndrome

Cornier, M.-A., Dabelea, D., Hernandez, T. L., Lindstrom, R. C., Steig, A. J., Stob, N. R., Van Pelt, R. E., Wang, H., & Eckel, R. H. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0024 · Cited by 2,162 · see citing works

Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

Shankar, G. M., Bloodgood, B. L., Townsend, M., Walsh, D. M., Selkoe, D. J., & Sabatini, B. L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4970-06.2007 · Cited by 1,592 · see citing works

Regulation of NMDA receptor trafficking by amyloid-β

Snyder, E. M., Nong, Y., Almeida, C. G., Paul, S., Moran, T., Choi, E. Y., Nairn, A. C., Salter, M. W., Lombroso, P. J., Gouras, G. K., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1503 · Cited by 1,561 · see citing works

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

Borchelt, D. R., Thinakaran, G., Eckman, C. B., Lee, M. K., Davenport, F., Ratovitsky, T., Prada, C.-M., Kim, G., Seekins, S., Yager, D., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80230-5 · Cited by 1,478 · see citing works

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

Duff, K., Eckman, C., Zehr, C., Yu, X., Prada, C.-M., Pérez‐Tur, J., Hutton, M., Buée, L., Harigaya, Y., Yager, D., et al. (1996) · Nature · doi:10.1038/383710a0 · Cited by 1,453 · see citing works

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

Esch, F. S., Keim, P. S., Beattie, E. C., Blacher, R. W., Culwell, A. R., Oltersdorf, T., McClure, D., & Ward, P. J. (1990) · Science · doi:10.1126/science.2111583 · Cited by 1,403 · see citing works

Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo

Farris, W., Mansourian, S., Chang, Y., Lindsley, L., Eckman, E., Frosch, M., Eckman, C., Tanzi, R., Selkoe, D., & Guénette, S. (2003) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0230450100 · Cited by 1,361 · see citing works

Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

Chartier-Harlin, M.-C., Crawford, F., Houlden, H., Warren, A., Hughes, D., Fidani, L., Goate, A., Rossor, M., Roques, P., Hardy, J., et al. (1991) · Nature · doi:10.1038/353844a0 · Cited by 1,214 · see citing works

Alzheimer’s disease is type 3 diabetes—Evidence reviewed

de la Monte, S. M., & Wands, J. R. (2008) · Journal of Diabetes Science and Technology · doi:10.1177/193229680800200619 · Cited by 1,158 · see citing works

A mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease

Murrell, J. R., Farlow, M. R., Ghetti, B. F., & Benson, M. D. (1991) · Science · doi:10.1126/science.1925564 · Cited by 1,122 · see citing works

The metabolic syndrome, inflammation, and risk of cognitive decline

Yaffe, K. (2004) · JAMA · doi:10.1001/jama.292.18.2237 · Cited by 1,025 · see citing works

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

Loo, D. T., Copani, A., Pike, C. J., Whittemore, E. R., Walencewicz, A. J., & Cotman, C. W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7951 · Cited by 1,022 · see citing works

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

Mattson, M. P. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.4.1081 · Cited by 1,006 · cited 1× · see citing works

Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?

Klein, W. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01749-5 · Cited by 989 · see citing works

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

Wischik, C. M., Novak, M., Thøgersen, H. C., Edwards, P. C., Runswick, M. J., Jakes, R., Walker, J. E., Milstein, C., Roth, M., & Klug, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.12.4506 · Cited by 939 · see citing works

Adult mouse astrocytes degrade amyloid-β in vitro and in situ

Wyss-Coray, T., Loike, J. D., Brionne, T. C., Lu, E., Anankov, R., Yan, F., Silverstein, S. C., & Husemann, J. (2003) · Nature Medicine · doi:10.1038/nm838 · Cited by 909 · see citing works

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

Sisodia, S. S., Koo, E. H., Beyreuther, K. T., Unterbeck, A., & Price, D. L. (1990) · Science · doi:10.1126/science.1691865 · Cited by 894 · see citing works

Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly

Cleveland, D. W., Hwo, S. Y., & Kirschner, M. W. (1977) · Journal of Molecular Biology · doi:10.1016/0022-2836(77)90214-5 · Cited by 881 · see citing works

ApoE Promotes the Proteolytic Degradation of Aβ

Jiang, Q., Lee, C. Y. D., Mandrekar, S., Wilkinson, B., Cramer, P., Zelcer, N., Mann, K., Lamb, B., Willson, T. M., Collins, J. L., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.010 · Cited by 876 · see citing works

Intranasal insulin improves cognition and modulates β-amyloid in early AD

Reger, M. A., Watson, G. S., Green, P. S., Wilkinson, C. W., Baker, L. D., Cholerton, B., Fishel, M. A., Plymate, S. R., Breitner, J. C. S., DeGroodt, W., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000265401.62434.36 · Cited by 830 · see citing works

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

Bomfim, T. R., Forny‐Germano, L., Sathler, L. B., Brito‐Moreira, J., Houzel, J., Decker, H., Silverman, M. A., Kazi, H., Melo, H. M., McClean, P. L., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci57256 · Cited by 830 · see citing works

Normal and Abnormal Biology of the Beta-Amyloid Precursor Protein

Selkoe, D. J. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.002421 · Cited by 827 · see citing works

Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation

Qiu, W. Q., Walsh, D. M., Ye, Z., Vekrellis, K., Zhang, J., Podlisny, M. B., Rosner, M. R., Safavi, A., Hersh, L. B., & Selkoe, D. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32730 · Cited by 812 · see citing works

GSK3 inhibitors: development and therapeutic potential

Cohen, P., & Goedert, M. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1415 · Cited by 788 · see citing works

Molecular mechanisms of neurodegeneration in Alzheimer's disease

Crews, L., & Masliah, E. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq160 · Cited by 772 · cited 2× · see citing works

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer’s disease indicate possible resistance to IGF-1 and insulin signalling

Moloney, A. M., Griffin, R. J., Timmons, S., O’Connor, R., Ravid, R., & O’Neill, C. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.04.002 · Cited by 764 · see citing works

Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory

Turner, P. R., O’Connor, K., Tate, W. P., & Abraham, W. C. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00089-3 · Cited by 751 · see citing works

The Blood-Brain Barrier in Brain Homeostasis and Neurological Diseases

Weiss, N., Miller, F., Cazaubon, S., & Couraud, P.-O. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.10.022 · Cited by 731 · see citing works

Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer’s disease: Link to brain reductions in acetylcholine

Rivera, E. J., Goldin, A., Fulmer, N., Tavares, R., Wands, J. R., & de la Monte, S. M. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-8304 · Cited by 723 · see citing works

β-Amyloid Stimulation of Microglia and Monocytes Results in TNFα-Dependent Expression of Inducible Nitric Oxide Synthase and Neuronal Apoptosis

Combs, C. K., Karlo, J. C., Kao, S.-C., & Landreth, G. E. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01179.2001 · Cited by 721 · see citing works

Definition of Metabolic Syndrome

Grundy, S. M., Brewer, H. B., Cleeman, J. I., Smith, S. C., & Lenfant, C. J. M. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000111245.75752.c6 · Cited by 718 · see citing works

Early inflammation and dementia: A 25‐year follow‐up of the Honolulu‐Asia aging study

Schmidt, R., Schmidt, H., Curb, J. D., Masaki, K., White, L. R., & Launer, L. J. (2002) · Annals of Neurology · doi:10.1002/ana.10265 · Cited by 710 · see citing works

The role of microglia in amyloid clearance from the AD brain

Lee, C. Y. D., & Landreth, G. E. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0433-4 · Cited by 701 · see citing works

Intranasal insulin improves memory in humans

Benedict, C., Hallschmid, M., Hatke, A., Schultes, B., Fehm, H. L., Born, J., & Kern, W. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.04.003 · Cited by 699 · see citing works

Association of diabetes mellitus and dementia, the Rotterdam study

Ott, A., Stolk, R. P., Hofman, A., van Harskamp, F., Grobbee, D. E., & Breteler, M. M. B. (1996) · Diabetologia · doi:10.1007/s001250050588 · Cited by 677 · see citing works

Transport Pathways for Clearance of Human Alzheimer's Amyloid β-Peptide and Apolipoproteins E and J in the Mouse Central Nervous System

Bell, R. D., Sagare, A. P., Friedman, A. E., Bedi, G. S., Holtzman, D. M., Deane, R., & Zlokovic, B. V. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600419 · Cited by 670 · see citing works

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

De Felice, F. G., Vieira, M. N. N., Bomfim, T. R., Decker, H., Velasco, P. T., Lambert, M. P., Viola, K. L., Zhao, W.-Q., Ferreira, S. T., & Klein, W. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809158106 · Cited by 657 · see citing works

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

Felice, F. G. D., & Ferreira, S. T. (2014) · Diabetes · doi:10.2337/db13-1954 · Cited by 647 · see citing works

Diet‐induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

Ho, L., Qin, W., Pompl, P., Xiang, Z.-M., Wang, J., Zhao, Z., Peng, Y., Cambareri, G., Rocher, A., Mobbs, C., et al. (2004) · The FASEB Journal · doi:10.1096/fj.03-0978fje · Cited by 646 · see citing works

Mechanisms of tau-induced neurodegeneration

Iqbal, K., Liu, F., Gong, C.-X., Alonso, A. D. C., & Grundke-Iqbal, I. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0486-3 · Cited by 628 · see citing works

Proteolytic processing and cell biological functions of the amyloid precursor protein

Strooper, B. D., & Annaert, W. G. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.11.1857 · Cited by 628 · see citing works

Structure and novel exons of the human .tau. gene

Andreadis, A., Brown, W. M., & Kosik, K. S. (1992) · Biochemistry · doi:10.1021/bi00158a027 · Cited by 625 · see citing works

β-Amyloid Peptides Induce Mitochondrial Dysfunction and Oxidative Stress in Astrocytes and Death of Neurons through Activation of NADPH Oxidase

Abramov, A. Y., Canevari, L., & Duchen, M. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4042-03.2004 · Cited by 587 · see citing works

Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure.

Schweers, O., Schönbrunn, E., Marx, A., & Mandelkow�, E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)51080-8 · Cited by 569 · see citing works

Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2

Neve, R. L., Harris, P. K. W., Kosik, K. S., Kurnit, D. M., & Donlon, T. A. (1986) · Molecular Brain Research · doi:10.1016/0169-328x(86)90033-1 · Cited by 565 · see citing works

Structural Insights and Biological Effects of Glycogen Synthase Kinase 3-specific Inhibitor AR-A014418

Bhat, R. V., Xue, Y., von Berg, S., Hellberg, S., Ormö, M., Nilsson, Y., Radesäter, A., Jerning, E., Markgren, P.-O., Borgegård, T., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306268200 · Cited by 557 · see citing works

Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease

Deane, R., Bell, R. D., Sagare, A. P., & Zloković, B. V. (2009) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152709787601867 · Cited by 549 · see citing works

The Role of Metabolic Disorders in Alzheimer Disease and Vascular Dementia: Two Roads Converged

Craft, S. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.27 · Cited by 547 · see citing works

Insulin, insulin-degrading enzyme and amyloid-β peptide in Alzheimer's disease: review and hypothesis

Qiu, W. Q., & Folstein, M. F. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.01.004 · Cited by 538 · see citing works

-Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

Ma, Q.-L., Yang, F., Rosario, E. R., Ubeda, O. J., Beech, W., Gant, D. J., Chen, P. P., Hudspeth, B., Chen, C., Zhao, Y., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1071-09.2009 · Cited by 536 · see citing works

Vascular risk factors, incidence of MCI, and rates of progression to dementia

Solfrizzi, V., Panza, F., Colacicco, A. M., D’Introno, A., Capurso, C., Torres, F., Grigoletto, F., Maggi, S., Del Parigi, A., Reiman, E. M., et al. (2004) · Neurology · doi:10.1212/01.wnl.0000144281.38555.e3 · Cited by 530 · see citing works

Is Diabetes Associated With Cognitive Impairment and Cognitive Decline Among Older Women?

Gregg, E. W. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.2.174 · Cited by 521 · see citing works

Brain Endothelial Cell-Cell Junctions: How to “Open” the Blood Brain Barrier

Stamatovic, S. M., Keep, R. F., & Andjelkovic, A. V. (2008) · Current Neuropharmacology · doi:10.2174/157015908785777210 · Cited by 516 · see citing works

A Cell Surface Receptor Complex for Fibrillar β-Amyloid Mediates Microglial Activation

Bamberger, M. E., Harris, M. E., McDonald, D. R., Husemann, J., & Landreth, G. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02665.2003 · Cited by 501 · see citing works

Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

Nakamura, T., Furuhashi, M., Li, P., Cao, H., Tuncman, G., Sonenberg, N., Görgün, C. Z., & Hotamışlıgil, G. S. (2010) · Cell · doi:10.1016/j.cell.2010.01.001 · Cited by 498 · see citing works

Neurons Regulate Extracellular Levels of Amyloid β-Protein via Proteolysis by Insulin-Degrading Enzyme

Vekrellis, K., Ye, Z., Qiu, W. Q., Walsh, D. M., Hartley, D. M., Chesneau, V., Rosner, M. R., & Selkoe, D. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-05-01657.2000 · Cited by 495 · see citing works

Stimulation of β-Amyloid Precursor Protein Trafficking by Insulin Reduces Intraneuronal β-Amyloid and Requires Mitogen-Activated Protein Kinase Signaling

Gasparini, L., Gouras, G. K., Wang, R., Gross, R. S., Beal, M. F., Greengard, P., & Xu, H. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02561.2001 · Cited by 493 · see citing works

How does diabetes accelerate Alzheimer disease pathology?

Sims-Robinson, C., Kim, B., Rosko, A., & Feldman, E. L. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.130 · Cited by 492 · see citing works

Different Conformations of Amyloid β Induce Neurotoxicity by Distinct Mechanisms in Human Cortical Neurons

Deshpande, A. M., Mina, E. W., Glabe, C. G., & Busciglio, J. A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1189-06.2006 · Cited by 490 · see citing works

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation

Kounnas, M. Z., Moir, R. D., Rebeck, G. W., Bush, A. I., Argraves, W. S., Tanzi, R. E., Hyman, B. T., & Strickland, D. K. (1995) · Cell · doi:10.1016/0092-8674(95)90320-8 · Cited by 489 · see citing works

Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation

Schubert, M., Brazil, D. P., Burks, D. J., Kushner, J. A., Ye, J., Flint, C. L., Farhang-Fallah, J., Dikkes, P., Warot, X. M., Rio, C., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-18-07084.2003 · Cited by 488 · see citing works

Insulin Resistance and Alzheimers Disease Pathogenesis: Potential Mechanisms and Implications for Treatment

Craft, S. (2007) · Current Alzheimer Research · doi:10.2174/156720507780362137 · Cited by 487 · see citing works

Brain metabolic dysfunction at the core of Alzheimer's disease

de la Monte, S. M., & Tong, M. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.012 · Cited by 462 · see citing works

Prevalence of dementia in Latin America, India, and China: a population-based cross-sectional survey

Rodríguez, J. J. L., Ferri, C. P., Acosta, D. M., Guerra, M., Huang, Y., Jacob, K. S., Krishnamoorthy, E. S., Salas, A., Sosa, A. L., Acosta, I., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61002-8 · Cited by 462 · see citing works

Serum insulin-like growth factor I regulates brain amyloid-β levels

Carro, E., Trejo, J. L., Gómez‐Isla, T., LeRoith, D., & Torres‐Alemán, I. (2002) · Nature Medicine · doi:10.1038/nm793 · Cited by 448 · see citing works

Insulin signaling in the central nervous system: Learning to survive

van der Heide, L. P., Ramakers, G. M. J., & Smidt, M. P. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.06.003 · Cited by 444 · see citing works

Serum insulin-like growth factor I regulates brain amyloid-β levels

Carro, E., Jl, T., Gómez‐Isla, T., LeRoith, D., & Torres‐Alemán, I. (2002) · Nature Medicine · doi:10.1038/nm1202-793 · Cited by 442 · see citing works

Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related.

Wong, C. W., Quaranta, V., & Glenner, G. G. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.24.8729 · Cited by 438 · see citing works

Expression of β amyloid protein precursor mRNAs: Recognition of a novel alternatively spliced form and quantitation in alzheimer's disease using PCR

Golde, T. E., Estus, S., Usiak, M., Younkin, L. H., & Younkin, S. G. (1990) · Neuron · doi:10.1016/0896-6273(90)90100-t · Cited by 431 · see citing works

Oligomers on the Brain: the Emerging Role of Soluble Protein Aggregates in Neurodegeneration.

Walsh, D. M., & Selkoe, D. J. (2004) · Protein and Peptide Letters · doi:10.2174/0929866043407174 · Cited by 428 · see citing works

Inflammatory process in Alzheimer's Disease

Meraz-Ríos, M. A., Toral-Rios, D., Franco-Bocanegra, D., Villeda-Hernández, J., & Campos-Peña, V. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00059 · Cited by 427 · see citing works

The toxicity in vitro of β-amyloid protein

Iversen, L. L., Mortishire‐Smith, R. J., Pollack, S. J., & Shearman, M. S. (1995) · Biochemical Journal · doi:10.1042/bj3110001 · Cited by 425 · see citing works

Clinical manifestations of cerebral amyloid angiopathy–related inflammation

Eng, J. A., Frosch, M. P., Choi, K., Rebeck, G. W., & Greenberg, S. M. (2004) · Annals of Neurology · doi:10.1002/ana.10810 · Cited by 417 · see citing works

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

Lourenco, M. V., Clarke, J. R., Frozza, R. L., Bomfim, T. R., Forny‐Germano, L., Batista, A. F., Sathler, L. B., Brito‐Moreira, J., Amaral, O. B., Silva, C. A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.002 · Cited by 415 · see citing works

Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas

Hill, J. M., Lesniak, M. A., Pert, C. B., & Roth, J. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90082-5 · Cited by 413 · see citing works

Insulin resistance and Alzheimer's disease

De La Monte, S. M. (2009) · BMB Reports · doi:10.5483/bmbrep.2009.42.8.475 · Cited by 392 · see citing works

Deficiency of ABCA1 Impairs Apolipoprotein E Metabolism in Brain

Hirsch-Reinshagen, V., Zhou, S., Burgess, B. L., Bernier, L., McIsaac, S. A., Chan, J. Y., Tansley, G. H., Cohn, J. S., Hayden, M. R., & Wellington, C. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407962200 · Cited by 385 · see citing works

Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative

Gabuzda, D., Busciglio, J., Chen, L. B., Matsudaira, P., & Yankner, B. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36875-8 · Cited by 373 · see citing works

Proteolytic Degradation of Amyloid -Protein

Saido, T., & Leissring, M. A. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006379 · Cited by 368 · see citing works

Metabolic-cognitive syndrome: A cross-talk between metabolic syndrome and Alzheimer's disease

Frisardi, V., Solfrizzi, V., Seripa, D., Capurso, C. A., Santamato, A., Sancarlo, D., Vendemiale, G., Pilotto, A., & Panza, F. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.04.007 · Cited by 357 · see citing works

Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease

Ferreira, S. T., Clarke, J. R., Bomfim, T. R., & Felice, F. G. D. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.12.010 · Cited by 354 · see citing works

Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease

Zhao, W., & Townsend, M. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.10.014 · Cited by 353 · see citing works

Microglia receptors and their implications in the response to amyloid β for Alzheimer’s disease pathogenesis

Doens, D., & Fernández, P. L. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-48 · Cited by 348 · see citing works

Microglia Function in Alzheimer’s Disease

Solito, E., & Sastre, M. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00014 · Cited by 347 · see citing works

Insulin resistance syndrome and Alzheimer's disease: Age- and obesity-related effects on memory, amyloid, and inflammation

Craft, S. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.08.021 · Cited by 347 · see citing works

Intracerebroventricular insulin enhances memory in a passive-avoidance task

Park, C. R., Seeley, R. J., Craft, S., & WOODS, S. (2000) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00220-6 · Cited by 343 · see citing works

Role for neuronal insulin resistance in neurodegenerative diseases

Schubert, M., Gautam, D., Surjo, D., Ueki, K., Baudler, S., Schubert, D., Kondo, T., Alber, J., Galldiks, N., Kustermann, E., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308724101 · Cited by 339 · see citing works

Serum inflammatory proteins and cognitive decline in older persons

Dik, M. G., Jonker, C., Hack, C. E., Smit, J. H., Comijs, H. C., & Eikelenboom, P. (2005) · Neurology · doi:10.1212/01.wnl.0000158281.08946.68 · Cited by 338 · see citing works

Metabolic Syndrome and Risk for Incident Alzheimer's Disease or Vascular Dementia

Raffaitin, C., Gin, H., Empana, J. P., Helmer, C., Berr, C., Tzourio, C., Portet, F., Dartigues, J., Alpérovitch, A., & Barberger‐Gateau, P. (2008) · Diabetes Care · doi:10.2337/dc08-0272 · Cited by 338 · see citing works

Changes in Intracellular Calcium and Glutathione in Astrocytes as the Primary Mechanism of Amyloid Neurotoxicity

Abramov, A. Y., Canevari, L., & Duchen, M. R. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05088.2003 · Cited by 337 · see citing works

Reduced Hippocampal Insulin-Degrading Enzyme in Late-Onset Alzheimer's Disease Is Associated with the Apolipoprotein E-ε4 Allele

Cook, D. G., Leverenz, J. B., McMillan, P. J., Kulstad, J. J., Ericksen, S., Roth, R. A., Schellenberg, G. D., Jin, L., Kovacina, K. S., & Craft, S. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63822-9 · Cited by 329 · see citing works

Alzheimer’s disease and insulin resistance: translating basic science into clinical applications

Felice, F. G. D. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64595 · Cited by 328 · see citing works

Cardiovascular risk factors and future risk of Alzheimer’s disease

de Bruijn, R. F. A. G., & Ikram, M. A. (2014) · BMC Medicine · doi:10.1186/s12916-014-0130-5 · Cited by 325 · see citing works

Deletion of Abca1 Increases Aβ Deposition in the PDAPP Transgenic Mouse Model of Alzheimer Disease

Wahrle, S. E., Jiang, H., Parsadanian, M., Hartman, R. E., Bales, K. R., Paul, S. M., & Holtzman, D. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508780200 · Cited by 325 · see citing works

Cardiovascular disease and Alzheimer's disease: common links

Stampfer, M. J. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01687.x · Cited by 325 · see citing works

Insulin in Central Nervous System: More than Just a Peripheral Hormone

Duarte, A. I., Moreira, P. I., & Oliveira, C. R. (2012) · Journal of Aging Research · doi:10.1155/2012/384017 · Cited by 324 · see citing works

Does insulin dysfunction play a role in Alzheimer's disease?

Gasparini, L. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02037-0 · Cited by 314 · see citing works

Type 2 diabetes mellitus and Alzheimer’s disease

Barbagallo, M. (2014) · World Journal of Diabetes · doi:10.4239/wjd.v5.i6.889 · Cited by 313 · see citing works

Improving influence of insulin on cognitive functions in humans

Kern, W., Peters, A., Fruehwald-Schultes, B., Deininger, E., Born, J., & Fehm, H. L. (2001) · Neuroendocrinology · doi:10.1159/000054694 · Cited by 308 · see citing works

Aberrant insulin signaling in Alzheimer's disease: current knowledge

Bedse, G., Domenico, F. D., Serviddio, G., & Cassano, T. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00204 · Cited by 294 · see citing works

Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1ΔE9 mouse model of Alzheimer's disease

Toledo, E. M., & Inestrosa, N. C. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.72 · Cited by 290 · see citing works

Blood–brain-barriers in aging and in Alzheimer’s disease

Marques, F., Sousa, J. C., Sousa, N., & Palha, J. A. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-38 · Cited by 273 · see citing works

Activation of Microglia Acidifies Lysosomes and Leads to Degradation of Alzheimer Amyloid Fibrils

Majumdar, A., Cruz, D., Asamoah, N., Buxbaum, A., Sohar, I., Lobel, P., & Maxfield, F. R. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-10-0975 · Cited by 271 · see citing works

Partial Loss-of-Function Mutations in Insulin-Degrading Enzyme that Induce Diabetes also Impair Degradation of Amyloid β-Protein

Farris, W., Mansourian, S., Leissring, M. A., Eckman, E. A., Bertram, L., Eckman, C. B., Tanzi, R. E., & Selkoe, D. J. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63229-4 · Cited by 269 · see citing works

The C‐Terminus of the β Protein is Critical in Amyloidogenesisa

Jarrett, J. T., Berger, E. P., & Lansbury, P. T. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb23043.x · Cited by 260 · see citing works

β‐Amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases?

Carson, J. A., & Turner, A. J. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00855.x · Cited by 259 · see citing works

Contribution of Metabolic Syndrome Components to Cognition in Older Individuals

Dik, M. G., Jonker, C., Comijs, H. C., Deeg, D. J. H., Kok, A., Yaffe, K. S., & Penninx, B. W. J. H. (2007) · Diabetes Care · doi:10.2337/dc06-1190 · Cited by 258 · see citing works

Insulin dose–response effects on memory and plasma amyloid precursor protein in Alzheimer’s disease: interactions with apolipoprotein E genotype

Craft, S., Asthana, S., Cook, D. G., Baker, L. D., Cherrier, M. M., Purganan, K., Wait, C., Petrova, A., Latendresse, S. J., Watson, G. S., et al. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00087-2 · Cited by 255 · see citing works

Clearance mechanisms of Alzheimer's amyloid-β peptide: implications for therapeutic design and diagnostic tests

Bates, K. A., Verdile, G., Li, Q.-X., Ames, D., Hudson, P., Masters, C. L., & Martins, R. N. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.96 · Cited by 247 · see citing works

β-Amyloid-Stimulated Microglia Induce Neuron Death via Synergistic Stimulation of Tumor Necrosis Factor α and NMDA Receptors

Floden, A. M., Li, S., & Combs, C. K. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4998-04.2005 · Cited by 246 · see citing works

Degradation of Soluble Amyloid β-Peptides 1–40, 1–42, and the Dutch Variant 1–40Q by Insulin Degrading Enzyme from Alzheimer Disease and Control Brains

Pérez, A., Morelli, L., Cresto, J. C., & Castaño, E. M. (2000) · Neurochemical Research · doi:10.1023/a:1007527721160 · Cited by 240 · see citing works

Insulin Resistance in Obesity as the Underlying Cause for the Metabolic Syndrome

Gallagher, E. J., LeRoith, D., & Karnieli, E. (2010) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20212 · Cited by 236 · see citing works

Amyloid-beta induces chemokine secretion and monocyte migration across a human blood--brain barrier model.

Fiala, M., Zhang, L., Gan, X.-H., Sherry, B. A., Taub, D. D., Graves, M. C., Hama, S., Way, D., Weinand, M. E., Witte, M. H., et al. (1998) · PubMed Central · Cited by 229 · see citing works

Human neprilysin is capable of degrading amyloid β peptide not only in the monomeric form but also the pathological oligomeric form

Kanemitsu, H., Tomiyama, T., & Mori, H. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00898-x · Cited by 228 · see citing works

Growth hormone, insulin-like growth factor-1 and the aging brain

Ashpole, N. M., Sanders, J. E., Hodges, E. L., Han, Y., & Sonntag, W. E. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.10.002 · Cited by 226 · see citing works

Type 2 Diabetes and Cognitive Function in Community-Dwelling Elderly Women

Grodstein, F., Chen, J., Wilson, R. S., & Manson, J. E. (2001) · Diabetes Care · doi:10.2337/diacare.24.6.1060 · Cited by 223 · see citing works

Choroid Plexus Megalin Is Involved in Neuroprotection by Serum Insulin-Like Growth Factor I

Carro, E., Spuch, C., Trejo, J. L., Antequera, D., & Torres‐Alemán, I. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2909-05.2005 · Cited by 222 · see citing works

Staging of Alzheimer-Related Cortical Destruction

Braak, H., & Braak, E. (1997) · International Psychogeriatrics · doi:10.1017/s1041610297004973 · Cited by 217 · see citing works

Alzheimer‐associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation

Clarke, J. R., Lyra e Silva, N. M., Figueiredo, C. P., Frozza, R. L., Ledo, J. H., Beckman, D., Katashima, C. K., Razolli, D., Carvalho, B. M., Frazão, R., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201404183 · Cited by 214 · see citing works

Uptake, Degradation, and Release of Fibrillar and Soluble Forms of Alzheimer's Amyloid β-Peptide by Microglial Cells

Chung, H., Brazil, M. I., Soe, T. T., & Maxfield, F. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32301 · Cited by 212 · see citing works

Wnt-3a overcomes β-amyloid toxicity in rat hippocampal neurons

Alvarez, A. R., Godoy, J. A., Müllendorff, K., Olivares, G. H., Bronfman, M., & Inestrosa, N. C. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.02.028 · Cited by 211 · see citing works

Metabolic Syndrome and Cognitive Decline in Elderly Latinos: Findings from the Sacramento Area Latino Study of Aging Study

Yaffe, K. S., Haan, M. N., BLACKWELL, T. L., Cherkasova, E., Whitmer, R. A., & West, N. A. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01139.x · Cited by 210 · see citing works

The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: an update

Hoyer, S. (2002) · Journal of Neural Transmission · doi:10.1007/s007020200028 · Cited by 206 · see citing works

Metabolic syndrome as a risk factor for neurological disorders

Farooqui, A. A., Farooqui, T., Panza, F., & Frisardi, V. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0840-1 · Cited by 206 · see citing works

Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease

Pedrós, I., Petrov, D., Allgaier, M., Sureda, F. X., Barroso, E., Beas‐Zárate, C., Auladell, C., Pallàs, M., Vázquez‐Carrera, M., Casadesús, G., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.05.025 · Cited by 203 · see citing works

Insulin signaling, glucose metabolism and mitochondria: Major players in Alzheimer's disease and diabetes interrelation

Correia, S. C., Santos, R. X., Carvalho, C., Cardoso, S., Candeias, E., Santos, M. S., Oliveira, C. R., & Moreira, P. I. (2012) · Brain Research · doi:10.1016/j.brainres.2011.12.063 · Cited by 195 · see citing works

Structure and functions of the human amyloid precursor protein: The whole is more than the sum of its parts

Gralle, M., & Ferreira, S. T. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.02.001 · Cited by 191 · see citing works

Cerebral amyloid angiopathy: An overview

Yamada, M. (2000) · Neuropathology · doi:10.1046/j.1440-1789.2000.00268.x · Cited by 191 · see citing works

An Integrative View of the Role of Oxidative Stress, Mitochondria and Insulin in Alzheimer's Disease

Moreira, P. I., Duarte, A. I., Santos, M. S., Rego, A. C., & Oliveira, C. R. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0972 · Cited by 190 · see citing works

The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer’s Disease

Cole, G. M., & Frautschy, S. A. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.08.009 · Cited by 189 · see citing works

Circulating Activities of Angiotensin-Converting Enzyme, Its Homolog, Angiotensin-Converting Enzyme 2, and Neprilysin in a Family Study

Rice, G., Jones, A. L., Grant, P. J., Carter, A. M., Turner, A. J., & Hooper, N. M. (2006) · Hypertension · doi:10.1161/01.hyp.0000244543.91937.79 · Cited by 188 · see citing works

Amyloid-β Induces Chemokine Secretion and Monocyte Migration across a Human Blood-Brain Barrier Model

Fiala, M., Zhang, L., Gan, X.-H., Sherry, B. A., Taub, D. D., Graves, M. C., Hama, S., Way, D., Weinand, M. E., Witte, M. H., et al. (1998) · Molecular Medicine · doi:10.1007/bf03401753 · Cited by 187 · see citing works

β ‐Amyloid Degradation and Alzheimer′s Disease

Wang, D.-S., Dickson, D. W., & Malter, J. S. (2006) · BioMed Research International · doi:10.1155/jbb/2006/58406 · Cited by 185 · see citing works

Insulin regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase‐dependent pathway

Solano, D. C., Sironi, M., Bonfini, C., Solerte, S. B., Govoni, S. M., & Racchi, M. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.7.1015 · Cited by 175 · see citing works

Neprilysin, obesity and the metabolic syndrome

Standeven, K. F., Hess, K., Carter, A. M., Rice, G., Cordell, P. A., Balmforth, A. J., Lü, B., Scott, D. J. A., Turner, A. J., Hooper, N. M., et al. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.227 · Cited by 174 · see citing works

β-amyloid activates PARP causing astrocytic metabolic failure and neuronal death

Abeti, R., Abramov, A. Y., & Duchen, M. R. (2011) · Brain · doi:10.1093/brain/awr104 · Cited by 172 · see citing works

Ectopic fat accumulation and metabolic syndrome

Rasouli, N., Molavi, B., Elbein, S. C., & Kern, P. A. (2006) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2006.00590.x · Cited by 164 · see citing works

Protein kinase C inhibits amyloid β‐peptide neurotoxicity by acting on members of the Wnt pathway

Garrido, J., Godoy, J. A., Alvarez, A. R., Bronfman, M., & Inestrosa, N. C. (2002) · The FASEB Journal · doi:10.1096/fj.02-0327fje · Cited by 163 · see citing works

Metabolic Syndrome and Cognitive Impairment: Current Epidemiology and Possible Underlying Mechanisms

Panza, F., Frisardi, V., Capurso, C. A., Imbimbo, B. P., Vendemiale, G., Santamato, A., D’Onofrio, G., Seripa, D., Sancarlo, D., Pilotto, A., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091669 · Cited by 162 · see citing works

Hypertension enhances A <i>β</i> -induced neurovascular dysfunction, promotes <i>β</i> -secretase activity, and leads to amyloidogenic processing of APP

Faraco, G., Park, L., Zhou, P., Luo, W., Paul, S. M., Anrather, J., & Iadecola, C. (2016) · Journal of Cerebral Blood Flow &amp; Metabolism · doi:10.1038/jcbfm.2015.79 · Cited by 158 · see citing works

Adipose Tissue Inflammation in the Pathogenesis of Type 2 Diabetes

Kohlgruber, A. C., & Lynch, L. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0670-x · Cited by 157 · see citing works

Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats

Fakhrai-Rad, H. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.14.2149 · Cited by 155 · see citing works

Metabolic Alterations Induced by Sucrose Intake and Alzheimer’s Disease Promote Similar Brain Mitochondrial Abnormalities

Carvalho, C., Cardoso, S., Correia, S. C., Santos, R. X., Santos, M. S., Baldeiras, I., Oliveira, C. R., & Moreira, P. I. (2012) · Diabetes · doi:10.2337/db11-1186 · Cited by 152 · see citing works

Characterization of neuronal dystrophy induced by fibrillar amyloid β: implications for Alzheimer’s disease

Grace, E. A., Rabiner, C. A., & Busciglio, J. A. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00241-5 · Cited by 151 · see citing works

Oxidative Stress and Metabolic Syndrome: Cause or Consequence of Alzheimer's Disease?

Contreras, D. L., Carvajal, K., Toral-Ríos, D., Franco-Bocanegra, D., & Campos‐Peña, V. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/497802 · Cited by 148 · see citing works

Amyloid-β-Induced Astrocytic Phagocytosis is Mediated by CD36, CD47 and RAGE

Jones, R. S., Minogue, A. M., Connor, T. J., & Lynch, M. A. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9427-3 · Cited by 147 · see citing works

ole of apoE/Aβ Interactions in the Pathogenesis of Alzheimer's Disease and Cerebral Amyloid Angiopathy

Holtzman, D. M. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:17:2:147 · Cited by 143 · see citing works

Alzheimer’s disease: a dysfunction of the amyloid precursor protein11Published on the World Wide Web on 11 September 2000.

Neve, R. L., McPhie, D. L., & Chen, Y. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02869-9 · Cited by 139 · see citing works

In Vivo Effects of ApoE and Clusterin on Amyloid-β Metabolism and Neuropathology

Holtzman, D. M. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:23:3:247 · Cited by 138 · see citing works

Metabolic syndrome, mild cognitive impairment and Alzheimer's disease—The emerging role of systemic low-grade inflammation and adiposity

Misiak, B., Leszek, J., & Kiejna, A. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2012.08.003 · Cited by 136 · see citing works

The WNT Inhibitor Dickkopf 1 and Bone Morphogenetic Protein 4 Rescue Adipogenesis in Hypertrophic Obesity in Humans

Gustafson, B., & Smith, U. (2012) · Diabetes · doi:10.2337/db11-1419 · Cited by 136 · see citing works

Relationship Between Serum Insulin‐Like Growth Factor‐1 Levels and Alzheimer's Disease and Vascular Dementia

Watanabe, T., Miyazaki, A., Katagiri, T., et al. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53524.x · Cited by 133 · see citing works

Metabolic syndrome, mild cognitive impairment, and progression to dementia. The Italian Longitudinal Study on Aging

Solfrizzi, V., Scafato, E., Capurso, C. A., D’Introno, A., Colacicco, A. M., Frisardi, V., Vendemiale, G., Baldereschi, M., Crepaldi, G., Carlo, A. D., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.12.012 · Cited by 131 · see citing works

Prevalence and Incidence Rates of Dementia and Cognitive Impairment No Dementia in the Mexican Population

Mejía-Arango, S., & Gutierrez, L. M. (2011) · Journal of Aging and Health · doi:10.1177/0898264311421199 · Cited by 125 · see citing works

Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer’s disease

Felice, F. G. D., & Lourenco, M. V. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00094 · Cited by 120 · see citing works

Assembly, Maturation, and Trafficking of the γ-Secretase Complex in Alzheimers Disease

Dries, D. R., & Yu, G. (2008) · Current Alzheimer Research · doi:10.2174/156720508783954695 · Cited by 120 · see citing works

Systemic inflammation and the metabolic syndrome among middle-aged community volunteers

Marsland, A. L., McCaffery, J. M., Muldoon, M. F., & Manuck, S. B. (2010) · Metabolism · doi:10.1016/j.metabol.2010.05.015 · Cited by 119 · see citing works

Mitochondrial Abnormalities in a Streptozotocin-Induced Rat Model of Sporadic Alzheimer's Disease

Correia, S. C., Santos, R. X., Santos, M. S., Casadesús, G., LaManna, J. C., Perry, G. L., Smith, M. A., & Moreira, P. I. (2013) · Current Alzheimer Research · doi:10.2174/1567205011310040006 · Cited by 116 · see citing works

Common Mechanisms of Alzheimer's Disease and Ischemic Stroke: The Role of Protein Kinase C in the Progression of Age-Related Neurodegeneration

Lucke-Wold, B. P., Turner, R. C., Logsdon, A. F., Simpkins, J. W., Alkon, D. L., Smith, K. E., Chen, Y., Tan, Z. T., Huber, J. D., & Rosen, C. L. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141422 · Cited by 114 · see citing works

Feed-forward signaling of TNF-α and NF-κB via IKK-β pathway contributes to insulin resistance and coronary arteriolar dysfunction in type 2 diabetic mice

Yang, J., Park, Y., Zhang, H., Xu, X., Laine, G. A., Dellsperger, K. C., & Zhang, C. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01199.2008 · Cited by 114 · see citing works

Whether, when and how chronic inflammation increases the risk of developing late-onset Alzheimer's disease

Eikelenboom, P., Hoozemans, J. J. M., Veerhuis, R., van Exel, E. R., Rozemüller, A. J. M., & van Gool, W. A. (2012) · Alzheimer s Research & Therapy · doi:10.1186/alzrt118 · Cited by 107 · see citing works

Ageing and dementia in low and middle income countries–Using research to engage with public and policy makers

Prince, M. J., Acosta, D. M., Albanese, E., Arizaga, R. L., Ferri, C. P., Guerra, M., Huang, Y., Jacob, K. S., Jiménez‐Velázquez, I. Z., Rodríguez, J. J. L., et al. (2008) · International Review of Psychiatry · doi:10.1080/09540260802094712 · Cited by 105 · see citing works

Neurovascular Pathways and Alzheimer Amyloid β-peptide

Zlokovic, B. V., Deane, R., Sallstrom, J., Chow, N., & Miano, J. M. (2006) · Brain Pathology · doi:10.1111/j.1750-3639.2005.tb00103.x · Cited by 104 · see citing works

Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum

Ríos, J. A., Cisternas, P., Arrese, M. A., Salesa Barja, Y., & Inestrosa, N. C. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.07.004 · Cited by 104 · see citing works

Chronic Hypertension Leads to Neurodegeneration in the TgSwDI Mouse Model of Alzheimer’s Disease

Kruyer, A., Soplop, N. H., Strickland, S., & Norris, E. H. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05524 · Cited by 104 · see citing works

Dyslipidemia and Blood-Brain Barrier Integrity in Alzheimer's Disease

Bowman, G. L., Kaye, J. A., & Quinn, J. F. (2012) · Current Gerontology and Geriatrics Research · doi:10.1155/2012/184042 · Cited by 100 · see citing works

Insulin as a Bridge between Type 2 Diabetes and Alzheimer Disease – How Anti-Diabetics Could be a Solution for Dementia

Sebastião, I., Candeias, E., Santos, M. S., Oliveira, C. R., Moreira, P. I., & Duarte, A. I. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00110 · Cited by 92 · see citing works

Metabolic Syndrome and Alzheimer's Disease: A Link to a Vascular Hypothesis?

Milionis, H. J., Florentin, M., & Giannopoulos, S. (2008) · CNS Spectrums · doi:10.1017/s1092852900016886 · Cited by 92 · see citing works

Increased Aβ production prompts the onset of glucose intolerance and insulin resistance

Jiménez-Palomares, M., Ramos‐Rodríguez, J. J., López-Acosta, J. F., Pacheco‐Herrero, M., Lechuga-Sancho, A. M., Perdomo, G., Garcı́a-Alloza, M., & Cózar‐Castellano, I. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00500.2011 · Cited by 89 · see citing works

Tau Phosphorylation by Cyclin-dependent Kinase 5/p39 during Brain Development Reduces Its Affinity for Microtubules

Takahashi, S., Saito, T., Hisanaga, S.-I., Pant, H. C., & Kulkarni, A. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211964200 · Cited by 86 · see citing works

Type 2 Diabetic and Alzheimer's Disease Mice Present Similar Behavioral, Cognitive, and Vascular Anomalies

Carvalho, C., Machado, N. J., Mota, P. C., Correia, S. C., Cardoso, S., Santos, R. X., Santos, M. S., Oliveira, C. R., & Moreira, P. I. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130005 · Cited by 85 · see citing works

Is Insulin Resistant Brain State a Central Feature of the Metabolic-Cognitive Syndrome?

Frisardi, V., Solfrizzi, V., Capurso, C. A., Imbimbo, B. P., Vendemiale, G., Seripa, D., Pilotto, A., & Panza, F. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100015 · Cited by 82 · see citing works

IGF-1-induced Processing of the Amyloid Precursor Protein Family Is Mediated by Different Signaling Pathways

Adlerz, L., Holback, S., Multhaup, G., & Iverfeldt, K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611183200 · Cited by 82 · see citing works

Amyloid-beta and Alzheimer’s disease: the role of neprilysin-2 in amyloid-beta clearance

Marr, R. A., & Hafez, D. M. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00187 · Cited by 82 · see citing works

Differential modulation of plasma β-amyloid by insulin in patients with Alzheimer disease

Kulstad, J. J., Green, P. S., Cook, D. G., Watson, G. S., Reger, M. A., Baker, L. D., Plymate, S. R., Asthana, S., Rhoads, K., Mehta, P. D., et al. (2006) · Neurology · doi:10.1212/01.wnl.0000216274.58185.09 · Cited by 82 · see citing works

Amyloid-β Induces Hepatic Insulin Resistance In Vivo via JAK2

Zhang, Y., Zhou, B. Z., Deng, B., Zhang, F., Wu, J., Wang, Y., Le, Y., & Zhai, Q. (2012) · Diabetes · doi:10.2337/db12-0670 · Cited by 81 · see citing works

Similar alternative splicing of a non-homologous domain in beta A4-amyloid protein precursor-like proteins.

Sandbrink, R., Masters, C. L., & Beyreuther, K. T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36778-9 · Cited by 78 · see citing works

Neprilysin-2 Is an Important β-Amyloid Degrading Enzyme

Hafez, D. M., Huang, J. Y., Huynh, A. M., Valtierra, S., Rockenstein, E. M., Bruno, A. M., Lu, B., DesGroseillers, L., Masliah, E., & Marr, R. A. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.11.012 · Cited by 78 · see citing works

Cognition and Neuropathology in Aging: Multidimensional Perspectives from the Rush Religious Orders Study and Rush Memory and Aging Project

Negash, S., Bennett, D. A., Wilson, R. S., Schneider, J. A., & Arnold, S. E. (2011) · Current Alzheimer Research · doi:10.2174/156720511795745302 · Cited by 78 · see citing works

Insulin resistance in the brain: An old-age or new-age problem?

Williamson, R., McNeilly, A. D., & Sutherland, C. D. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.05.007 · Cited by 77 · see citing works

Function and Dysfunction of the Presenilins

Sisodia, S. S., Kim, S. H., & Thinakaran, G. (1999) · The American Journal of Human Genetics · doi:10.1086/302475 · Cited by 76 · see citing works

Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration

van Dijk, G., van Heijningen, S., Reijne, A. C., Nyakas, C., van der Zee, E. A., & Eisel, U. L. M. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00173 · Cited by 75 · see citing works

Metabolic Syndrome and Cognitive Decline in Early Alzheimer's Disease and Healthy Older Adults

Watts, A. S., Loskutova, N., Burns, J. M., & Johnson, D. K. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121168 · Cited by 72 · see citing works

Insulin is differentially related to cognitive decline and atrophy in Alzheimer's disease and aging

Burns, J. M., Honea, R. A., Vidoni, E. D., Hutfles, L. J., Brooks, W. M., & Swerdlow, R. H. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.06.011 · Cited by 72 · see citing works

Protective effects of Akkermansia muciniphila on cognitive deficits and amyloid pathology in a mouse model of Alzheimer's disease

Ou, Z., Deng, L., Lu, Z., Wu, F., Liu, W., Huang, D., & Peng, Y. (2020) · Nutrition &amp; Diabetes · doi:10.1038/s41387-020-0115-8 · Cited by 328 · see citing works

The role of gut dysbiosis in Parkinson’s disease: mechanistic insights and therapeutic options

Wang, Q., Luo, Y., Ray Chaudhuri, K., Reynolds, R., Tan, E.-K., & Pettersson, S. (2021) · Brain · doi:10.1093/brain/awab156 · Cited by 281 · see citing works

Relationships between insulin secretion, insulin metabolism and insulin resistance in mild glucose intolerance.

Bonora, E., Manicardi, Zavaroni, I., et al. (1987) · PubMed · Cited by 56 · see citing works

Insulin resistance in adipocytes from fed and fasted obese rats: Dissociation of two insulin actions

Stevens, J., Green, M. H., Kaiser, D. L., et al. (1981) · Molecular and Cellular Biochemistry · doi:10.1007/bf02354886 · Cited by 11 · see citing works

Failure of chronic experimental hyperinsulinism to alter insulin binding to hypothalamic receptors in the rat

Melnyk, R. B., & Martin, J. M. (1984) · European Journal of Endocrinology · doi:10.1530/acta.0.1070086 · Cited by 10 · see citing works

Calorie restriction prevents the development of insulin resistance and impaired insulin signaling in skeletal muscle of ovariectomized rats

Prasannarong, M., Vichaiwong, K., & Saengsirisuwan, V. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.02.018 · Cited by 44 · see citing works

Insulin Binding and Response to Insulin of Adipocytes from Thyroxine-Treated Rats*

Heise, E. A., Joost, H., & Hasselblatt, A. (1982) · Endocrinology · doi:10.1210/endo-110-3-955 · Cited by 32 · see citing works