The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Role of NMDA Receptors in Dopamine Neurons for Plasticity and Addictive Behaviors
Open accessAbstract
Summary A single exposure to drugs of abuse produces an NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) of AMPA receptor (AMPAR) currents in DA neurons; however, the importance of LTP for various aspects of drug addiction is unclear. To test the role of NMDAR-dependent plasticity in addictive behavior, we genetically inactivated functional NMDAR signaling exclusively in DA neurons (KO mice). Inactivation of NMDARs results in increased AMPAR-mediated transmission that is indistinguishable from the increases associated with a single cocaine exposure, yet locomotor responses to multiple drugs of abuse were unaltered in the KO mice. The initial phase of locomotor sensitization to cocaine is intact; however, the delayed sensitization that occurs with prolonged cocaine withdrawal did not occur. Conditioned behavioral responses for cocaine-testing environment were also absent in the KO mice. These findings provide evidence for a role of NMDAR signaling in DA neurons for specific behavioral modifications associated with drug seeking behaviors.
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Cites
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“The mesolimbic DA circuit, consisting of midbrain DA neurons in the ventral tegmental area (VTA), that project to the nucleus accumbens (NAc) and prefrontal cortex, plays a key role in reward and motivation and is a major target of abused drugs (Wise, 2004).”
BackgroundAMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588
The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory.
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“…because it had not been reported following genetic inactivation of NMDAR in other cell types (Iwasato et al., 2000; Nakazawa et al., 2002; Tsien et al., 1996); however, since the submission of this manuscript, two other studies have reported increased synaptic AMPAR currents similar to…”
BackgroundMethodResultInfluentialDopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens
Nicola, S. M., Surmeier, D. J., & Malenka, R. C. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.185 · Cited by 931
The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity
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Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic
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Self-citationBurst firing in midbrain dopaminergic neurons
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Cited by
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Dopamine in motivational control: rewarding, aversive, and alerting
Bromberg-Martin, E. S., Matsumoto, M., & Hikosaka, O. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.022 · Cited by 2,396
Synaptic plasticity and addiction
Kauer, J. A., & Malenka, R. C. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2234 · Cited by 1,397
Neuronal Reward and Decision Signals: From Theories to Data
Schultz, W. (2015) · Physiological Reviews · doi:10.1152/physrev.00023.2014 · Cited by 1,126
Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling
Lüscher, C., & Malenka, R. C. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.017 · Cited by 1,105
Metadata
- Authors
- Zweifel, L. S., Argilli, E., Bonci, A., & Palmiter, R. D.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 59
- Issue
- 3
- Pages
- 486-496
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1975626677
- Cited by
- 210
- References
- 13
- FWCI
- 7.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zweifel, L. S., Argilli, E., Bonci, A., & Palmiter, R. D. (2008). Role of NMDA Receptors in Dopamine Neurons for Plasticity and Addictive Behaviors. Neuron. https://doi.org/10.1016/j.neuron.2008.05.028
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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