The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Coordinated Actions of the Forkhead Protein Foxp1 and Hox Proteins in the Columnar Organization of Spinal Motor Neurons
Open accessAbstract
Summary The formation of locomotor circuits depends on the spatially organized generation of motor columns that innervate distinct muscle and autonomic nervous system targets along the body axis. Within each spinal segment, multiple motor neuron classes arise from a common progenitor population, however, the mechanisms underlying their diversification remain poorly understood. Here, we show that the Forkhead domain transcription factor Foxp1 plays a critical role in defining the columnar identity of motor neurons at each axial position. Using genetic manipulations, we demonstrate that Foxp1 establishes the pattern of LIM-HD protein expression, and accordingly organizes motor axon projections, their connectivity with peripheral targets, and the establishment of motor pools. These functions of Foxp1 act in accordance with the rostrocaudal pattern provided by Hox proteins along the length of the spinal cord, suggesting a model by which motor neuron diversity is achieved through the coordinated actions of Foxp1 and Hox proteins.
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1 retracted
Expression of Oct-6, a POU III Domain Transcription Factor, in Schizophrenia
Ilia, M., Beasley, C. L., Meijer, D., Kerwin, R. W., Cotter, D., Everall, I., & Price, J. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.7.1174 · Cited by 24
RetractedNeuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089
Directed Differentiation of Embryonic Stem Cells into Motor Neurons
Wichterle, H., Lieberam, I., Porter, J. A., & Jessell, T. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00835-8 · Cited by 1,728
Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes
Tsuchida, T., Ensini, M., Morton, S. B., Baldassare, M., Edlund, T., Jessell, T. M., & Pfaff, S. L. (1994) · Cell · doi:10.1016/0092-8674(94)90027-2 · Cited by 1,004
A mitogen gradient of dorsal midline Wnts organizes growth in the CNS
Megason, S. G., & McMahon, A. P. (2002) · Development · doi:10.1242/dev.129.9.2087 · Cited by 683
Novitch, B. G., Chen, A. I., & Jessell, T. M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00407-x · Cited by 615
Self-citationRequirement for the Homeobox Gene Hb9 in the Consolidation of Motor Neuron Identity
Arber, S., Han, B., Mendelsohn, M., Smith, M., Jessell, T. M., & Sockanathan, S. (1999) · Neuron · doi:10.1016/s0896-6273(01)80026-x · Cited by 609
Hox10 and Hox11 Genes Are Required to Globally Pattern the Mammalian Skeleton
Wellik, D. M., & Capecchi, M. R. (2003) · Science · doi:10.1126/science.1085672 · Cited by 586
Self-citationArea Patterning of the Mammalian Cortex
O'Leary, D. D. M., Chou, S.-J., & Sahara, S. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.010 · Cited by 583
Transcriptional Codes and the Control of Neuronal Identity
Shirasaki, R., & Pfaff, S. L. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142916 · Cited by 523
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Hox Genes: Choreographers in Neural Development, Architects of Circuit Organization
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Delile, J., Rayon, T., Melchionda, M., Edwards, A., Briscoe, J., & Sagner, A. (2019) · Development · doi:10.1242/dev.173807 · Cited by 356
Motor neurons and the generation of spinal motor neuron diversity
Stifani, N. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00293 · Cited by 351
Identification of neural oscillations and epileptiform changes in human brain organoids
Samarasinghe, R. A., Miranda, O. A., Buth, J. E., Mitchell, S., Ferando, I., Watanabe, M., Allison, T. F., Kurdian, A., Fotion, N. N., Gandal, M. J., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00906-5 · Cited by 281
Self-citationMaking sense out of spinal cord somatosensory development
Lai, H. C., Seal, R. P., & Johnson, J. E. (2016) · Development · doi:10.1242/dev.139592 · Cited by 188
Metadata
- Authors
- Rousso, D. L., Gaber, Z. B., Wellik, D., Morrisey, E. E., & Novitch, B. G.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 59
- Issue
- 2
- Pages
- 226-240
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2043905106
- Cited by
- 254
- References
- 65
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Rousso, D. L., Gaber, Z. B., Wellik, D., Morrisey, E. E., & Novitch, B. G. (2008). Coordinated Actions of the Forkhead Protein Foxp1 and Hox Proteins in the Columnar Organization of Spinal Motor Neurons. Neuron. https://doi.org/10.1016/j.neuron.2008.06.025
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
