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Cited by 230Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

Local Dendritic Activity Sets Release Probability at Hippocampal Synapses

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Branco, Tiago, Staras, Kevin, Darcy, Kevin J., Goda, Yukiko·2008·Neuron
DOI 10.1016/j.neuron.2008.07.006PMC PMC6390949
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Abstract

The arrival of an action potential at a synapse triggers neurotransmitter release with a limited probability, p(r). Although p(r) is a fundamental parameter in defining synaptic efficacy, it is not uniform across all synapses, and the mechanisms by which a given synapse sets its basal release probability are unknown. By measuring p(r) at single presynaptic terminals in connected pairs of hippocampal neurons, we show that neighboring synapses on the same dendritic branch have very similar release probabilities, and p(r) is negatively correlated with the number of synapses on the branch. Increasing dendritic depolarization elicits a homeostatic decrease in p(r), and equalizing activity in the dendrite significantly reduces its variability. Our results indicate that local dendritic activity is the major determinant of basal release probability, and we suggest that this feedback regulation might be required to maintain synapses in their operational range.

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  • Synapses onto the same dendrite tend to have similar Pr, and there is an inverse relationship between synapse number and Pr onto individual dendrites, suggesting that this regulation happens in a quasi-local manner as a result of the degree of dendritic depolarization.

    “Synapses onto the same dendrite tended to have similar P r , and there was an inverse relationship between synapse number and P r onto individual dendrites, suggesting that this regulation happens in a”

    From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Branco et al. 2008

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  • There is compelling evidence that homeostatic modulation of neurotransmitter release probability can happen at the level of individual dendritic branches.

    “On the presynaptic side, there is compelling evidence that homeostatic modulation of neurotransmitter release probability (P r ) can happen at the level of individual dendritic branches.”

    From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Branco et al. 2008

  • Enhanced synaptic activity reduces Pr in cultured hippocampal neurons through a mechanism local to particular dendrites.

    “Enhanced synaptic activity was observed to reduce P r in cultured hippocampal neurons, through a mechanism that was local to particular dendrites (Branco et al. 2008).”

    From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Branco et al. 2008

  • This quasi-local (dendrite-wide) form of presynaptic homeostasis has been suggested to prevent synaptic saturation owing to strong depolarization from summed inputs onto a dendrite, by reducing Pr when postsynaptic activation rises too high.

    “This quasi-local (dendrite-wide) form of presynaptic homeostasis has been suggested to prevent synaptic saturation owing to strong depolarization from summed inputs onto a dendrite, by reducing P r when postsynaptic activation rises too high (Branco et al. 2008).”

    From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Branco et al. 2008

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Cited by

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Authors
Branco, T., Staras, K., Darcy, K. J., & Goda, Y.
Affiliations
MRC Laboratory for Molecular Cell Biology (GB)
Corresponding author
  • Branco, Tiago
  • Goda, Yukiko
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2008-08
Volume
59
Issue
3
Pages
475-485
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2008.07.006
PMC
PMC6390949
OpenAlex
W2100701643
Cited by
230
References
5
Citations by year
2026: 5 · 2025: 3 · 2024: 6 · 2023: 7 · 2022: 3 · 2021: 14 · 2020: 14 · 2019: 13 · 2018: 17 · 2017: 14 · 2016: 12 · 2015: 14 · 2014: 16 · 2013: 19 · 2012: 27
FWCI
6.63
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
Funders
  • Wellcome Trust (068718)
  • National Institutes of Health
  • Medical Research Council
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
release probability, synaptic transmission, hippocampus, dendritic activity, presynaptic terminals, synaptic homeostasis, dendritic depolarization, synaptic efficacy, paired-pulse depression, dendritic branching
MeSH terms
Action Potentials, Quaternary Ammonium Compounds, Animals, Animals, Newborn, Cells, Cultured, Dendrites, Electric Stimulation, Hippocampus, Image Processing, Computer-Assisted, Models, Neurological, Neurons, Probability, Pyridinium Compounds, Synapses, Patch-Clamp Techniques, Excitatory Postsynaptic Potentials, Microscopy, Electron, Transmission, Rats

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