Visualization of changes in presynaptic function during long-term synaptic plasticity

Zakharenko, Stanislav S.; Zablow, Leonard; Siegelbaum, Steven A.

doi:10.1038/89498

Cited by 305Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

Visualization of changes in presynaptic function during long-term synaptic plasticity

Zakharenko, Stanislav S., Zablow, Leonard, Siegelbaum, Steven A.·2001·Nature Neuroscience

DOI 10.1038/89498

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Abstract

Controversy exists regarding the site of modification of synaptic transmission during long-term plasticity in the mammalian hippocampus. Here we used a fluorescent marker of presynaptic activity, FM 1-43, to directly image changes in presynaptic function during both short-term and long-term forms of plasticity at presynaptic boutons of CA3-CA1 excitatory synapses in acute hippocampal slices. We demonstrated enhanced presynaptic function during long-term potentiation (LTP) induced either chemically (with tetraethylammonium), or by high-frequency (200-Hz) electrical stimulation. Both of these forms of LTP required activation of L-type voltage-gated calcium channels and NMDA receptors in the postsynaptic CA1 neuron. These results thus implied that a long-lasting increase in the efficacy of synaptic transmission is likely to depend, at least in part, on enhanced transmitter release from the presynaptic neuron.

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Destaining curves of FM1-43 were superimposable before and after tetanic induction of NMDAR-dependent LTP in CA1 neurons at 50-100 Hz.
“Just as with MK-801, the destaining curves were superimposable before and after tetanic induction of NMDAR-dependent LTP in CA1 neurons at 50 -100 Hz (Zakharenko et al. 2001).”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Zakharenko et al. 2001
At CA1 excitatory synapses, both NMDAR-dependent and NMDAR-independent forms of LTP can coexist under certain conditions.
“There is even evidence that at CA1 excitatory synapses both NMDAR-dependent and NMDAR-independent forms of LTP can coexist under certain conditions (49–51).”
From Synaptic memory and CaMKII (2023) · cites this paper as [50]
With intense induction protocols for LTP, a component of LTP requires the activation of VDCCs.
“with intense induction protocols for LTP a component of LTP requires the activation of VDCCs (49–51, 193, 196).”
From Synaptic memory and CaMKII (2023) · cites this paper as [50]

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Authors: Zakharenko, S. S., Zablow, L., & Siegelbaum, S. A.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Siegelbaum, Steven A.
ORCID: Zakharenko, Stanislav S.
Siegelbaum, Steven A.
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2001-07
Volume: 4
Issue: 7
Pages: 711-717
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/89498
OpenAlex: W1488440012
Cited by: 305
References: 49
Citations by year: 2026: 2 · 2025: 1 · 2024: 6 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 10 · 2019: 5 · 2018: 2 · 2017: 20 · 2016: 10 · 2015: 10 · 2014: 13 · 2013: 15 · 2012: 14
FWCI: 7.00
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: long-term potentiation, presynaptic function, synaptic plasticity, hippocampus, CA3-CA1 synapses, FM1-43, presynaptic terminals, neurotransmitter release, L-type calcium channels, NMDA receptor, tetraethylammonium, high-frequency stimulation, short-term plasticity
MeSH terms: Quaternary Ammonium Compounds, Animals, Electric Stimulation, Fluorescent Dyes, Hippocampus, Microscopy, Fluorescence, Neuronal Plasticity, Pyridinium Compounds, Presynaptic Terminals, Long-Term Potentiation, Microscopy, Confocal, Excitatory Postsynaptic Potentials, Mice, In Vitro Techniques

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Visualization of changes in presynaptic function during long-term synaptic plasticity

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