The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
DISC1 Regulates New Neuron Development in the Adult Brain via Modulation of AKT-mTOR Signaling through KIAA1212
Open accessAbstract
Disrupted-in-schizophrenia 1 (DISC1), a susceptibility gene for major mental illnesses, regulates multiple aspects of embryonic and adult neurogenesis. Here, we show that DISC1 suppression in newborn neurons of the adult hippocampus leads to overactivated signaling of AKT, another schizophrenia susceptibility gene. Mechanistically, DISC1 directly interacts with KIAA1212, an AKT binding partner that enhances AKT signaling in the absence of DISC1, and DISC1 binding to KIAA1212 prevents AKT activation in vitro. Functionally, multiple genetic manipulations to enhance AKT signaling in adult-born neurons in vivo exhibit similar defects as DISC1 suppression in neuronal development that can be rescued by pharmacological inhibition of mammalian target of rapamycin (mTOR), an AKT downstream effector. Our study identifies the AKT-mTOR signaling pathway as a critical DISC1 target in regulating neuronal development and provides a framework for understanding how multiple susceptibility genes may functionally converge onto a common pathway in contributing to the etiology of certain psychiatric disorders.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Synaptic dysfunction and abnormal behaviors have been documented in mice harboring Disc1 mutations (Clapcote et al., 2007; Kim et al., 2009)”
From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Kim et al., 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
AKT/PKB signaling: navigating downstream
Manning, B. D., & Cantley, L. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.009 · Cited by 6,115
Maehama, T., & Dixon, J. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13375 · Cited by 3,104
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007
ADULT NEUROGENESIS IN THE MAMMALIAN CENTRAL NERVOUS SYSTEM
Ming, G., & Song, H. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.051804.101459 · Cited by 1,891
Self-citationNeuregulin 1 and Susceptibility to Schizophrenia
Stefánsson, H., Pétursson, H., Sigurðsson, E., Steinthórsdóttir, V., Bjornsdottir, S., Sigmundsson, T., Ghosh, S., Brynjolfsson, J., Gunnarsdottir, S., Ivarsson, O., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/342734 · Cited by 1,671
Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo
Jin, K., Zhu, Y., Sun, Y., Mao, X. O., Xie, L., & Greenberg, D. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182296499 · Cited by 1,507
Adult neurogenesis and functional plasticity in neuronal circuits
Lledo, P., Alonso, M., & Grubb, M. S. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1867 · Cited by 1,425
Álvarez-Buylla, A., & Lim, D. A. (2004) · Neuron · doi:10.1016/s0896-6273(04)00111-4 · Cited by 1,348
GABA regulates synaptic integration of newly generated neurons in the adult brain
Ge, S., Goh, E. L. K., Sailor, K. A., Kitabatake, Y., Ming, G., & Song, H. (2005) · Nature · doi:10.1038/nature04404 · Cited by 1,303
Self-citationKohn, A. D., Summers, S. A., Birnbaum, M. J., & Roth, R. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.49.31372 · Cited by 1,284
Flagged first, then by citations
Cited by
Sorted by citations
The physiology, signaling, and pharmacology of dopamine receptors
Beaulieu, J.-M., & Gainetdinov, R. R. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.002642 · Cited by 2,763
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651
Self-citationHydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain
Guo, J. U., Su, Y., Zhong, C., Ming, G., & Song, H. (2011) · Cell · doi:10.1016/j.cell.2011.03.022 · Cited by 1,404
Self-citationMaternal immune activation: Implications for neuropsychiatric disorders
Estes, M. L., & McAllister, A. K. (2016) · Science · doi:10.1126/science.aag3194 · Cited by 1,206
In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics
Bonaguidi, M. A., Wheeler, M. A., Shapiro, J. S., Stadel, R. P., Sun, G. J., Ming, G.-L., & Song, H. (2011) · Cell · doi:10.1016/j.cell.2011.05.024 · Cited by 831
Self-citationLipton, J. O., & Şahin, M. (2014) · Neuron · doi:10.1016/j.neuron.2014.09.034 · Cited by 771
Gao, R., & Penzes, P. (2015) · Current Molecular Medicine · doi:10.2174/1566524015666150303003028 · Cited by 516
“Many of these candidates - such as DISC1, NRXN1, NLGN3-4, SHANK3, and CNTNAP2 - encode for synaptic proteins (NRXN1, NLGN3-4, and SHANK3, see ASD at the Glutamatergic Circuit) or molecules involved with neuronal development (DISC1 [261], CNTNAP2 [258, 262]) and thus support the existence of shared biologic pathways be…”
BackgroundSynaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3
Wang, X., McCoy, P. A., Rodriguiz, R. M., Pan, Y., Je, H. S., Roberts, A. C., Kim, C. J., Berrios, J., Colvin, J. S., Bousquet-Moore, D., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr212 · Cited by 537
Duan, X., Qiao, M., Bei, F., Kim, I.-J., He, Z., & Sanes, J. R. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.017 · Cited by 518
Self-citationNeuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision
Song, J., Zhong, C., Bonaguidi, M. A., Sun, G. J., Hsu, D., Gu, Y., Meletis, K., Huang, Z. J., Ge, S., Enikolopov, G., et al. (2012) · Nature · doi:10.1038/nature11306 · Cited by 534
Self-citationModeling Autism by SHANK Gene Mutations in Mice
Jiang, Y.-H., & Ehlers, M. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.016 · Cited by 488
Linking neurodevelopmental and synaptic theories of mental illness through DISC1
Brandon, N. J., & Sawa, A. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3120 · Cited by 431
Functions and dysfunctions of adult hippocampal neurogenesis
Christian, K. M., Song, H., & Ming, G.-L. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014134 · Cited by 362
Self-citationmTOR complexes in neurodevelopmental and neuropsychiatric disorders
Costa-Mattioli, M., & Monteggia, L. M. (2013) · Nature Neuroscience · doi:10.1038/nn.3546 · Cited by 367
Goriely, A., & Wilkie, A. O. M. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.12.017 · Cited by 365
Gelernter, J. E., Kranzler, H. R., Sherva, R., Almasy, L. A., Koesterer, R., Smith, A. H., Anton, R. F., Preuss, U. W., Ridinger, M., Rujescu, D., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.145 · Cited by 375
mTOR in Brain Physiology and Pathologies
Bockaert, J., & Marin, P. (2015) · Physiological Reviews · doi:10.1152/physrev.00038.2014 · Cited by 381
Duric, V., Banasr, M., Stockmeier, C. A., Simen, A. A., Newton, S. S., Overholser, J. C., Jurjus, G. J., Dieter, L., & Duman, R. S. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000016 · Cited by 304
Pleiotropic Effects of GLP-1 and Analogs on Cell Signaling, Metabolism, and Function
Rowlands, J., Heng, J., Newsholme, P., & Carlessi, R. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00672 · Cited by 302
“In addition, analysis of patients with psychiatric illnesses has revealed an alteration to crucial intracellular signaling pathways including the AKT/GSK3 (glycogen synthase kinase) pathway (269, 270).”
BackgroundResultPersonalized medicine in psychiatry: problems and promises
Ozomaro, U., Wahlestedt, C., & Nemeroff, C. B. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-132 · Cited by 270
Martínez‐Cerdeño, V. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22417 · Cited by 256
Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons
Griesi-Oliveira, K., Acab, A., Gupta, A. R., Sunaga, D. Y., Chailangkarn, T., Nicol, X., Nunez, Y., Walker, M. F., Murdoch, J. D., Sanders, S. J., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.141 · Cited by 236
Self-citationHippocampal neurogenesis as a target for the treatment of mental illness: A critical evaluation
DeCarolis, N. A., & Eisch, A. J. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.12.013 · Cited by 259
NMDA hypofunction as a convergence point for progression and symptoms of schizophrenia
Snyder, M. A., & Gao, W. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00031 · Cited by 254
Doblado, L., Lueck, C., Rey, C., Samhan-Arias, A. K., Priéto, I., Stacchiotti, A., & Monsalve, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083903 · Cited by 238
Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus
Song, J., Sun, J., Moss, J., Wen, Z., Sun, G. J., Hsu, D., Zhong, C., Davoudi, H., Christian, K. M., Toni, N., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3572 · Cited by 223
Self-citationRibosomal Protein S6 Phosphorylation in the Nervous System: From Regulation to Function
Biever, A., Valjent, E., & Puighermanal, E. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00075 · Cited by 227
AKT/GSK3 signaling pathway and schizophrenia
Emamian, E. S. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00033 · Cited by 227
Interplay between DISC1 and GABA Signaling Regulates Neurogenesis in Mice and Risk for Schizophrenia
Kim, J., Liu, C. Y., Zhang, F., Duan, X., Wen, Z., Song, J., Feighery, E. L., Lu, B., Rujescu, D., Clair, D. S., et al. (2012) · Cell · doi:10.1016/j.cell.2011.12.037 · Cited by 212
Self-citationTet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair
Yu, H., Su, Y., Shin, J., Zhong, C., Guo, J. U., Weng, Y., Gao, F., Geschwind, D. H., Coppola, G., Ming, G., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4008 · Cited by 199
Self-citationRoles of PI3K/AKT/GSK3/mTOR Pathway in Cell Signaling of Mental Illnesses
Kitagishi, Y., Kobayashi, M., Kikuta, K., & Matsuda, S. (2012) · Depression Research and Treatment · doi:10.1155/2012/752563 · Cited by 197
DISC1-binding proteins in neural development, signalling and schizophrenia
Bradshaw, N., & Porteous, D. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.12.027 · Cited by 221
Wnt Signaling: Role in Alzheimer Disease and Schizophrenia
Inestrosa, N. C., Montecinos-Oliva, C., & Fuenzalida, M. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9417-5 · Cited by 192
Adult Neurogenesis and Psychiatric DisordersPreprint
Kang, E., Wen, Z., Song, H., Christian, K. M., & Ming, G. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019026 · Cited by 189
Self-citationNeuroplasticity signaling pathways linked to the pathophysiology of schizophrenia
Balu, D. T., & Coyle, J. T. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.005 · Cited by 185
Genetics of human brain development
Zhou, Y. F., Song, H., & Ming, G. (2023) · Nature Reviews Genetics · doi:10.1038/s41576-023-00626-5 · Cited by 195
Self-citationKang, Y., Zhou, Y., Li, Y., Han, Y., Xu, J., Niu, W., Li, Z., Liu, S., Feng, H., Huang, W., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00913-6 · Cited by 168
Role of mTOR Complexes in Neurogenesis
Licausi, F., & Hartman, N. W. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051544 · Cited by 172
Next-Generation Treatments for Mental Disorders
Insel, T. R. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004873 · Cited by 164
DISC1 regulates neurogenesis via modulating kinetochore attachment of Ndel1/Nde1 during mitosis
Ye, F., Kang, E., Yu, C., Qian, X.-Y., Jacob, F., Yu, C., Mao, M., Poon, R. Y., Kim, J., Song, H.-J., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.10.010 · Cited by 13
Self-citationBeyond cAMP: the regulation of Akt and GSK3 by dopamine receptors
Beaulieu, J. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00038 · Cited by 165
Wnt7a Regulates Multiple Steps of Neurogenesis
Qu, Q., Sun, G., Murai, K., Ye, P., Li, W., Asuelime, G. E., Cheung, Y.-T., & Shi, Y. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00325-13 · Cited by 158
Bao, H., Asrican, B., Li, W., Gu, B., Wen, Z., Lim, S.-A., Haniff, I., Ramakrishnan, C., Deisseroth, K., Philpot, B., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.10.003 · Cited by 151
Ayhan, Y., Abazyan, B., Nomura, J., Kim, R., Ladenheim, B., Krasnova, I. N., Sawa, A., Margolis, R. L., Cadet, J. L., Mori, S., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2009.144 · Cited by 148
Dixdc1 Is a Critical Regulator of DISC1 and Embryonic Cortical Development
Singh, K. K., Ge, X., Mao, Y., Drane, L., Meletis, K., Samuels, B. A., & Tsai, L. (2010) · Neuron · doi:10.1016/j.neuron.2010.06.002 · Cited by 142
Wang, Q., Charych, E. I., Pulito, V., Lee, J., Graziane, N., Crozier, R., Revilla-Sánchez, R., Kelly, M. P., Dunlop, A. J., Murdoch, H., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.87 · Cited by 164
Neurogenesis in the adult hippocampus: history, regulation, and prospective roles
Fares, J., Diab, Z. B., Nabha, S. M., & Fares, Y. (2018) · International Journal of Neuroscience · doi:10.1080/00207454.2018.1545771 · Cited by 145
Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesis
Kim, P. M., Duan, X., Huang, A. S., Liu, C. Y., Ming, G., Song, H., & Snyder, S. H. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914706107 · Cited by 138
Self-citationDISC1 at 10: connecting psychiatric genetics and neuroscience
Porteous, D. J., Millar, J. K., Brandon, N. J., & Sawa, A. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.09.002 · Cited by 140
Kuroda, K., Yamada, S., Tanaka, M., Iizuka, M., Yano, H., Mori, D., Tsuboi, D., Nishioka, T., Namba, T., Iizuka, Y., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr400 · Cited by 138
DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness
Soares, D. C., Carlyle, B. C., Bradshaw, N. J., & Porteous, D. J. (2011) · ACS Chemical Neuroscience · doi:10.1021/cn200062k · Cited by 129
Laufer, B. I., Mantha, K., Kleiber, M. L., Chater‐Diehl, E., Addison, S. M. F., & Singh, S. M. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.010975 · Cited by 134
Common DISC1 Polymorphisms Disrupt Wnt/GSK3β Signaling and Brain Development
Singh, K. K., Rienzo, G. D., Drane, L., Mao, Y., Flood, Z., Madison, J. M., Ferreira, M. A. R., Bergen, S. E., King, C. R., Sklar, P. B., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.030 · Cited by 125
Zhang, H., Kang, E., Wang, Y., Yang, C., Yu, H., Wang, Q., Chen, Z.-Y., Zhang, C., Christian, K. M., Song, H., et al. (2016) · Nature Communications · doi:10.1038/ncomms11773 · Cited by 119
Self-citationThe impact of Disrupted-in-Schizophrenia 1 (DISC1) on the dopaminergic system: a systematic review
Dahoun, T., Trossbach, S. V., Brandon, N., Korth, C., & Howes, O. (2017) · Translational Psychiatry · doi:10.1038/tp.2016.282 · Cited by 118
Modeling psychiatric disorders at the cellular and network levels
Brennand, K. J., Simone, A., Tran, N., & Gage, F. H. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.20 · Cited by 119
Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool
Zhou, Y. F., Bond, A. M., Shade, J. E., Zhu, Y., Davis, C.-H. O., Wang, X., Su, Y., Yoon, K., Phan, A. T., Chen, W. J., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.08.005 · Cited by 114
Self-citationKassai, H., Sugaya, Y., Noda, S., Nakao, K., Maeda, T., Kano, M., & Aiba, A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.04.048 · Cited by 107
DISC1 genetics, biology and psychiatric illness
Thomson, P. A., Malavasi, E. L. V., Grünewald, E., Soares, D. C., Borkowska, M., & Millar, J. K. (2012) · Frontiers in Biology · doi:10.1007/s11515-012-1254-7 · Cited by 112
Functional Role of Adult Hippocampal Neurogenesis as a Therapeutic Strategy for Mental Disorders
Jun, H., Hussaini, S. M. Q., Rigby, M. J., & Jang, M. (2012) · Neural Plasticity · doi:10.1155/2012/854285 · Cited by 112
Self-citationMurai, K., Sun, G., Ye, P., Tian, E., Su, Y., Cui, Q., Sun, G., Trinh, D. V., Sun, O., Hong, T., et al. (2016) · Nature Communications · doi:10.1038/ncomms10965 · Cited by 108
Self-citationmTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders
Ryskalin, L., Limanaqi, F., Frati, A., Busceti, C. L., & Fornai, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082226 · Cited by 110
Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression
Zeng, Y., Yao, B., Shin, J., Lin, L., Kim, N., Song, Q., Liu, S., Su, Y., Guo, J. U., Huang, L., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.11.020 · Cited by 102
Self-citationOrtiz-López, L. I., Márquez‐Valadez, B., Gómez‐Sánchez, A., Silva‐Lucero, M., Torres-Pérez, M. O., Tellez-Ballesteros, R. I., Ichwan, M., Meraz‐Ríos, M. A., Kempermann, G., & Ramírez-Rodríguez, G. B. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.02.040 · Cited by 103
A Dopamine D2 Receptor-DISC1 Protein Complex may Contribute to Antipsychotic-Like Effects
Su, P., Li, S., Chen, S., Lipina, T. V., Wang, M., Lai, T. K. Y., Lee, F. H. F., Zhang, H., Zhai, D., Ferguson, S. S. G., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.11.007 · Cited by 104
Interaction between FEZ1 and DISC1 in Regulation of Neuronal Development and Risk for Schizophrenia
Kang, E., Burdick, K. E., Kim, J. Y., Duan, X., Guo, J. U., Sailor, K. A., Jung, D.-E., Ganesan, S., Choi, S., Pradhan, D. A., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.032 · Cited by 104
Self-citationExtracellular and Intracellular Signaling for Neuronal Polarity
Namba, T., Funahashi, Y., Nakamuta, S., Xu, C., Takano, T., & Kaibuchi, K. (2015) · Physiological Reviews · doi:10.1152/physrev.00025.2014 · Cited by 105
Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice
Kvajo, M., McKellar, H., Drew, L., Lepagnol-Bestel, A.-M., Xiao, L., Levy, R. J., Blazeski, R., Arguello, P. A., Lacefield, C., Mason, C. A., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114113108 · Cited by 103
Cognition and Reward Circuits in Schizophrenia: Synergistic, Not Separate
Robison, A. J., Thakkar, K. N., & Diwadkar, V. A. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.09.021 · Cited by 104
Deregulated mTOR-mediated translation in intellectual disability
Troca-Marín, J. A., Alves-Sampaio, A., & Montesinos, M. L. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.01.005 · Cited by 109
Zhou, M., Li, W., Huang, S., Song, J., Kim, J. Y., Tian, X., Kang, E., Sano, Y., Liu, C. M., Balaji, J., et al. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.033 · Cited by 102
Self-citationБычков, Э. Р., Ahmed, M. R., & Gurevich, E. V. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000118 · Cited by 99
In vivo imaging of adult human hippocampal neurogenesis: progress, pitfalls and promise
Ho, N. F., Hooker, J. M., Sahay, A., Holt, D. J., & Roffman, J. L. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.8 · Cited by 100
Cell-autonomous inactivation of the reelin pathway impairs adult neurogenesis in the hippocampus
Teixeira, C. M., Kron, M. M., Masachs, N., Zhang, H., Lagace, D. C., Martinez, A., Reillo, I., Duan, X., Bosch, C., Pujadas, L., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1857-12.2012 · Cited by 97
Self-citationThe Role of the Eukaryotic Translation Initiation Factor 4E (eIF4E) in Neuropsychiatric Disorders
Amorim, I. S., Lach, G., & Gkogkas, C. G. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00561 · Cited by 96
A central role for the acid sphingomyelinase/ceramide system in neurogenesis and major depression
Gulbins, E., Walter, S., Becker, K. A., Halmer, R., Liu, Y., Reichel, M., Edwards, M. J., Müller, C. P., Fassbender, K. C., & Kornhuber, J. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13145 · Cited by 97
Frontier of Epilepsy Research - mTOR signaling pathway
Cho, C. (2011) · Experimental & Molecular Medicine · doi:10.3858/emm.2011.43.5.032 · Cited by 93
Genetic and pharmacological evidence for schizophrenia‐related Disc1 interaction with GSK‐3
Lipina, T. V., Kaidanovich‐Beilin, O., Patel, S., Wang, M., Clapcote, S. J., Liu, F., Woodgett, J. R., & Roder, J. (2010) · Synapse · doi:10.1002/syn.20839 · Cited by 92
Stevens, H. E. (2010) · Frontiers in Neuroscience · doi:10.3389/fnins.2010.00059 · Cited by 90
Zhang, Z., Wang, W., Zhong, P., Liu, S. J., Long, J. Z., Zhao, L., Gao, H., Cravatt, B. F., & Liu, Q. (2015) · Hippocampus · doi:10.1002/hipo.22344 · Cited by 89
Functional Implications of miR-19 in the Migration of Newborn Neurons in the Adult Brain
Han, J., Kim, H. J., Schafer, S. T., Paquola, A. C. M., Clemenson, G. D., Toda, T., Oh, J., Pankonin, A. R., Lee, B. S., Johnston, S. T., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.05.034 · Cited by 89
Garza-Lombó, C., & Gonsebatt, M. E. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00157 · Cited by 90
Neurogenesis in neurological and psychiatric diseases and brain injury: From bench to bedside
Ruan, L., Lau, B. W.-M., Wang, J., Huang, L., Zhuge, Q., Wang, B. Z., Jin, K., & So, K. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.12.006 · Cited by 89
Ochneva, A., Zorkina, Y., Abramova, O. V., Pavlova, O., Ushakova, V. M., Morozova, A. Y., Zubkov, E. A., Ka, P., Gurina, O. I., & Chekhonin, V. P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214498 · Cited by 89
Ali, T., Hao, Q., Ullah, N., Rahman, S. U., Shah, F. A., He, K., Zheng, C., Li, W., Murtaza, I., Yang, L., et al. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00096 · Cited by 84
Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice
Lipina, T. V., Wang, M., Liu, F., & Roder, J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.02.020 · Cited by 83
Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models
Samsom, J., & Wong, A. H. C. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00013 · Cited by 88
Czesak, M., François, B. L., Millar, A., Deria, M., Daigle, M., Visvader, J. E., Anisman, H., & Albert, P. R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.293027 · Cited by 82
Bradshaw, N., Soares, D., Carlyle, B., Ogawa, F., Davidson-Smith, H., Christie, S., Mackie, S., Thomson, P., Porteous, D., & Millar, J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5410-10.2011 · Cited by 95
Woo, Y., Seo, H.-J., McIntyre, R., & Bahk, W.-M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17010080 · Cited by 79
Hester, M. S., & Danzer, S. C. (2014) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2013.12.022 · Cited by 81
GIV/Girdin Transmits Signals from Multiple Receptors by Triggering Trimeric G Protein Activation
Garcia‐Marcos, M., Ghosh, P., & Farquhar, M. G. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r114.613414 · Cited by 78
Neural mechanisms underlying GABAergic regulation of adult hippocampal neurogenesis
Catavero, C. M., Bao, H., & Song, J. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2668-y · Cited by 76
Cellular dynamics of neuronal migration in the hippocampus
Hayashi, K., Kubo, K., Kitazawa, A., & Nakajima, K. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00135 · Cited by 80
G-Protein-Coupled Receptors in Adult Neurogenesis
Doze, V. A., & Perez, D. M. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.004762 · Cited by 75
Garone, C., Giorgio, F. D., & Carli, S. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05041-w · Cited by 80
Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein–Aurora A pathway
Inaba, H., Goto, H., Kasahara, K., Kumamoto, K., Yonemura, S., Inoko, A., Yamano, S., Wanibuchi, H., He, D., Goshima, N., et al. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201507046 · Cited by 74
Disrupted-in-Schizophrenia 1 (DISC1) Is Necessary for the Correct Migration of Cortical Interneurons
Steinecke, A., Gampe, C., Valkova, C., Kaether, C., & Bolz, J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5036-11.2012 · Cited by 69
Wang, Y., Kaneko, N., Asai, N., Enomoto, A., Isotani-Sakakibara, M., Kato, T., Asai, M., Murakumo, Y., Ota, H., Hikita, T., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1130-11.2011 · Cited by 72
Self-citationAge-related cognitive decline: Can neural stem cells help us?
Artegiani, B., & Calegari, F. (2012) · Aging · doi:10.18632/aging.100446 · Cited by 70
Metadata
- Authors
- Kim, J. Y., Duan, X., Liu, C. Y., Jang, M.-H., Guo, J. U., Pow-anpongkul, N., Kang, E., Song, H., & Ming, G.-L.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Ming, Guo-li
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 63
- Issue
- 6
- Pages
- 761-773
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3075620
- OpenAlex
- W2067961999
- Cited by
- 319
- References
- 71
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 11 · 2023: 8 · 2022: 15 · 2021: 12 · 2020: 11 · 2019: 14 · 2018: 20 · 2017: 12 · 2016: 23 · 2015: 32 · 2014: 24 · 2013: 26 · 2012: 32
- FWCI
- 10.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG 024984, R01AG024984)
- National Institute of Mental Health (MH084018, P20MH084018)
- National Institute of Neurological Disorders and Stroke (NS 048271, R01NS047344, NS 047344, R01NS048271, R37NS047344, R56NS047344)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD069184)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- DISC1, Akt signaling, mTOR signaling, adult neurogenesis, adult hippocampus, newborn neurons, schizophrenia risk genes, protein-protein interaction
- MeSH terms
- Analysis of Variance, Animals, Animals, Newborn, Cell Movement, Cells, Cultured, Female, Hippocampus, Humans, Immunosuppressive Agents, Mice, Inbred C57BL, Nerve Tissue Proteins, Neurons, Pregnancy, Protein Binding, Transfection, Signal Transduction, Gene Expression Regulation, Developmental, Sirolimus, RNA Interference, Immunoprecipitation, Green Fluorescent Proteins, Oncogene Protein v-akt, Mice, Adult Stem Cells, Neurogenesis, Gene Knockdown Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
