The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Cux1 and Cux2 Regulate Dendritic Branching, Spine Morphology, and Synapses of the Upper Layer Neurons of the Cortex
Open accessAbstract
Summary Dendrite branching and spine formation determines the function of morphologically distinct and specialized neuronal subclasses. However, little is known about the programs instructing specific branching patterns in vertebrate neurons and whether such programs influence dendritic spines and synapses. Using knockout and knockdown studies combined with morphological, molecular and electrophysiological analysis we show that the homeobox Cux1 and Cux2 are intrinsic and complementary regulators of dendrite branching, spine development and synapse formation in layer II–III neurons of the cerebral cortex. Cux genes control the number and maturation of dendritic spines partly through direct regulation of the expression of Xlr3b and Xlr4b, chromatin remodeling genes previously implicated in cognitive defects. Accordingly, abnormal dendrites and synapses in Cux2−/− mice correlate with reduced synaptic function and defects in working memory. These demonstrate critical roles of Cux in dendritogenesis and highlight novel subclass-specific mechanisms of synapse regulation that contribute to the establishment of cognitive circuits.
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PSD-95 Involvement in Maturation of Excitatory Synapses
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Cingolani, L. A., & Goda, Y. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2373 · Cited by 831
Activity-Dependent Regulation of MEF2 Transcription Factors Suppresses Excitatory Synapse Number
Flavell, S. W., Cowan, C. W., Kim, T.-K., Greer, P. L., Lin, Y., Paradis, S., Griffith, E. C., Hu, L. S., Chen, C., & Greenberg, M. E. (2006) · Science · doi:10.1126/science.1122511 · Cited by 573
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Cited by
Rauch, A., Wieczorek, D., Graf, E., Wieland, T., Endele, S., Schwarzmayr, T., Albrecht, B., Bartholdi, D., Beygo, J., Di Donato, N., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61480-9 · Cited by 1,041
Dendritic Spines: The Locus of Structural and Functional Plasticity
Sala, C., & Segal, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00012.2013 · Cited by 465
Molecular logic of cellular diversification in the mouse cerebral cortex
Di Bella, D. J., Habibi, E., Stickels, R. R., Scalia, G., Brown, J., Yadollahpour, P., Yang, S. M., Abbate, C., Biancalani, T., Macosko, E. Z., et al. (2021) · Nature · doi:10.1038/s41586-021-03670-5 · Cited by 464
The dendritic tree and brain disorders
Kulkarni, V. A., & Firestein, B. L. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.03.005 · Cited by 390
Development, specification, and diversity of callosal projection neurons
Fame, R. M., MacDonald, J. L., & Macklis, J. D. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2010.10.002 · Cited by 381
Metadata
- Authors
- Cubelos, B., Sebastián-Serrano, A., Beccari, L., Calcagnotto, M. E., Cisneros, E., Kim, S., Dopazo, A., Alvarez-Dolado, M., Redondo, J. M., Bovolenta, P., Walsh, C. A., & Nieto, M.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 66
- Issue
- 4
- Pages
- 523-535
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1970876750
- Cited by
- 301
- References
- 9
- FWCI
- 6.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Cux1 and Cux2 Regulate Dendritic Branching, Spine Morphology, and Synapses of the Upper Layer Neurons of the Cortex. https://app.cochat.ai/papers/10.1016/j.neuron.2010.04.038
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- Cubelos, B., Sebastián-Serrano, A., Beccari, L., Calcagnotto, M. E., Cisneros, E., Kim, S., Dopazo, A., Alvarez-Dolado, M., Redondo, J. M., Bovolenta, P., Walsh, C. A., & Nieto, M. (2010). Cux1 and Cux2 Regulate Dendritic Branching, Spine Morphology, and Synapses of the Upper Layer Neurons of the Cortex. Neuron. https://doi.org/10.1016/j.neuron.2010.04.038
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