Genetic Differences in Response to Novelty and Spatial Memory Using a Two-Trial Recognition Task in Mice
Abstract
A two-trial memory task, based on a free-choice exploration paradigm in a Y-maze, was previously developed to study recognition processes in Sprague-Dawley rats. Because this paradigm avoids the use of electric shock or deprivation that may have nonspecific effects and does not require learning of a rule, it may be particularly useful for studying memory in mice. Four inbred strains (Balb/cByJ, DBA/2J, C57BL/6J, and SJL/J), an F1 hybrid (C57BL/6 x SJL/J), and one outbred strain (CD1) were used to validate this task in mice and to characterize a strain distribution in response to novelty and working memory. Exploration was measured with a short (2 min) intertrial interval (ITI) between acquisition and retrieval, while memory was examined with longer intervals (30 min, 1 h, and 2 h). A study of the time course of the response to novelty revealed varying degrees of preference and/or habituation to novelty among the different strains, with CD1 exhibiting a very high response to novelty and others showing lower (C57 x SJL hybrids) to complete absence (SJL) of exploration of novelty. Memory span, assessed with increasing ITIs, varied widely among strains from 30 min (C57 x SJL hybrids) to at least 2 h (C57 and BALB). Such demonstrated sensitivity to a wide range of behavioral phenotypes supports the use of this spatial memory task as an effective tool for the study of genetic influences on the response to novelty and recognition processes in mice.
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Downregulation of AMPA receptors (GluR1) after juvenile BPA exposure suggests a lower regulative capability to control synaptic plasticity in the hippocampus.
“the downregulation of AMPA receptors (GluR1) (Figure 5B) suggests that there is a lower regulative capability to control synaptic plasticity in the hippocampus after juvenile BPA exposure.30”
From Bisphenol A Impairs Synaptic Plasticity by Both Pre‐ and Postsynaptic Mechanisms (2017) · cites this paper as [30]
The two-trial Y-maze delayed alternation task is a specific and sensitive test of spatial recognition memory in rodents.
“The two-trial Y-maze delayed alternation task is a specific and sensitive test of spatial recognition memory in rodents (47, 48).”
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- Authors
- Dellu, F., Contarino, A., Simon, H., Koob, G. F., & Gold, L. H.
- Affiliations
- Scripps Research Institute (US)
- Centre National de la Recherche Scientifique (FR)
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 2000-01
- Volume
- 73
- Issue
- 1
- Pages
- 31-48
- ISSN
- 1074-7427 (ISSN-L)
- OpenAlex
- W2087607255
- Cited by
- 303
- References
- 2
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 13 · 2023: 14 · 2022: 15 · 2021: 14 · 2020: 15 · 2019: 9 · 2018: 13 · 2017: 14 · 2016: 14 · 2015: 11 · 2014: 17 · 2013: 15 · 2012: 13
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Learning and Memory (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH47680, P50MH047680)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- novelty response, spatial memory, working memory, inbred mouse strains, C57BL/6J mice, BALB/cByJ, DBA/2J, ICR mice, F1 hybrids, Y-maze, intertrial interval, memory span
- MeSH terms
- Animals, Arousal, Choice Behavior, Exploratory Behavior, Genotype, Male, Mice, Inbred Strains, Orientation, Reaction Time, Mental Recall, Retention, Psychology, Species Specificity, Maze Learning, Mice, Rats
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