The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
An Embedded Subnetwork of Highly Active Neurons in the Neocortex
Open accessAbstract
Video abstract Unbiased methods to assess the firing activity of individual neurons in the neocortex have revealed that a large proportion of cells fire at extremely low rates (<0.1 Hz), both in their spontaneous and evoked activity. Thus, firing in neocortical networks appears to be dominated by a small population of highly active neurons. Here, we use a fosGFP transgenic mouse to examine the properties of cells with a recent history of elevated activity. FosGFP-expressing layer 2/3 pyramidal cells fired at higher rates compared to fosGFP(-) neurons, both in vivo and in vitro. Elevated activity could be attributed to increased excitatory and decreased inhibitory drive to fosGFP(+) neurons. Paired-cell recordings indicated that fosGFP(+) neurons had a greater likelihood of being connected to each other. These findings indicate that highly active, interconnected neuronal ensembles are present in the neocortex and suggest these cells may play a role in the encoding of sensory information.
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“likely corresponds to a subset of cortical L2/3 neurons that express IEG c-fos under basal conditions and are preferentially interconnected within the L2/3 network (Yassin et al., 2010)”
From A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation (2021) · cites this paper as Yassin et al., 2010
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Expression of c- fos Protein in Brain: Metabolic Mapping at the Cellular Level
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Cellular and network mechanisms of rhythmic recurrent activity in neocortex
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Internal brain state regulates membrane potential synchrony in barrel cortex of behaving mice
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A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation
Yao, Z., van Velthoven, C. T. J., Nguyen, T. N., Goldy, J., Sedeno-Cortes, A. E., Baftizadeh, F., Bertagnolli, D., Casper, T., Chiang, M., Crichton, K., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.021 · Cited by 1,065
The log-dynamic brain: how skewed distributions affect network operations
Buzsáki, G., & Mizuseki, K. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3687 · Cited by 1,019
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Metadata
- Authors
- Yassin, L., Benedetti, B. L., Jouhanneau, J.-S., Wen, J. A., Poulet, J. F. A., & Barth, A. L.
- Affiliations
- Center for the Neural Basis of Cognition (US)
- Max Delbrück Center (DE)
- Corresponding author
- Barth, Alison L.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 68
- Issue
- 6
- Pages
- 1043-1050
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3022325
- OpenAlex
- W2037158512
- Cited by
- 227
- References
- 47
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 10 · 2023: 5 · 2022: 8 · 2021: 12 · 2020: 9 · 2019: 31 · 2018: 16 · 2017: 18 · 2016: 18 · 2015: 24 · 2014: 22 · 2013: 23 · 2012: 12
- FWCI
- 8.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- KiltHub Repository (submittedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- KiltHub Repository
- Funders
- National Institutes of Health (1z01da000171-01)
- National Institute on Drug Abuse (DA 0171-88, R01DA017188)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- neocortex, layer 2/3 pyramidal cells, neuronal ensembles, spontaneous firing rate, neuronal connectivity
- MeSH terms
- Action Potentials, Animals, Animals, Newborn, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Neurons, Neocortex, Mice
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