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An Embedded Subnetwork of Highly Active Neurons in the Neocortex
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Video abstract Unbiased methods to assess the firing activity of individual neurons in the neocortex have revealed that a large proportion of cells fire at extremely low rates (<0.1 Hz), both in their spontaneous and evoked activity. Thus, firing in neocortical networks appears to be dominated by a small population of highly active neurons. Here, we use a fosGFP transgenic mouse to examine the properties of cells with a recent history of elevated activity. FosGFP-expressing layer 2/3 pyramidal cells fired at higher rates compared to fosGFP(-) neurons, both in vivo and in vitro. Elevated activity could be attributed to increased excitatory and decreased inhibitory drive to fosGFP(+) neurons. Paired-cell recordings indicated that fosGFP(+) neurons had a greater likelihood of being connected to each other. These findings indicate that highly active, interconnected neuronal ensembles are present in the neocortex and suggest these cells may play a role in the encoding of sensory information.
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“likely corresponds to a subset of cortical L2/3 neurons that express IEG c-fos under basal conditions and are preferentially interconnected within the L2/3 network (Yassin et al., 2010)”
From A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation (2021) · cites this paper as Yassin et al., 2010
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Metadata
- Authors
- Yassin, L., Benedetti, B. L., Jouhanneau, J.-S., Wen, J. A., Poulet, J. F. A., & Barth, A. L.
- Affiliations
- Center for the Neural Basis of Cognition (US)
- Max Delbrück Center (DE)
- Corresponding author
- Barth, Alison L.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 68
- Issue
- 6
- Pages
- 1043-1050
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3022325
- OpenAlex
- W2037158512
- Cited by
- 227
- References
- 47
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 10 · 2023: 5 · 2022: 8 · 2021: 12 · 2020: 9 · 2019: 31 · 2018: 16 · 2017: 18 · 2016: 18 · 2015: 24 · 2014: 22 · 2013: 23 · 2012: 12
- FWCI
- 8.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- KiltHub Repository (submittedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- KiltHub Repository
- Funders
- National Institutes of Health (1z01da000171-01)
- National Institute on Drug Abuse (DA 0171-88, R01DA017188)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- neocortex, layer 2/3 pyramidal cells, neuronal ensembles, spontaneous firing rate, neuronal connectivity
- MeSH terms
- Action Potentials, Animals, Animals, Newborn, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Neurons, Neocortex, Mice
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