The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Cxcr7 Controls Neuronal Migration by Regulating Chemokine Responsiveness
Open accessAbstract
The chemokine Cxcl12 binds Cxcr4 and Cxcr7 receptors to control cell migration in multiple biological contexts, including brain development, leukocyte trafficking, and tumorigenesis. Both receptors are expressed in the CNS, but how they cooperate during migration has not been elucidated. Here, we used the migration of cortical interneurons as a model to study this process. We found that Cxcr4 and Cxcr7 are coexpressed in migrating interneurons, and that Cxcr7 is essential for chemokine signaling. Intriguingly, this process does not exclusively involve Cxcr7, but most critically the modulation of Cxcr4 function. Thus, Cxcr7 is necessary to regulate Cxcr4 protein levels, thereby adapting chemokine responsiveness in migrating cells. This demonstrates that a chemokine receptor modulates the function of another chemokine receptor by controlling the amount of protein that is made available for signaling at the cell surface.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The confinement of interneurons to each of the three routes of tangential migration involves the chemokine Cxcl12, which is expressed by cells located in each of the routes (Li et al., 2008; López-Bendito et al., 2008; Sánchez-Alcaniz et al., 2011; Stumm et al., 2007; Tiveron et al., 2006; Wang et al., 2011).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Sánchez-Alcaniz et al., 2011
In the citing paper
“chemokine signaling via Cxcl12, which acts as an attractant to keep interneurons within the IZ/SVZ and MZ until they reach appropriate maturity to begin radial migration”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [973]
In the citing paper
“Cxcr7 regulates the local concentrations of Cxcl12 sensed by Cxcr4 and controls Cxcr4 protein levels”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [973]
Citations
Cites
1 retracted
The Role of CXCR7/RDC1 as a Chemokine Receptor for CXCL12/SDF-1 in Prostate Cancer
Wang, J., Shiozawa, Y., Wang, J., Wang, Y., Jung, Y., Pienta, K. J., Mehra, R., Loberg, R. D., & Taichman, R. S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m707465200 · Cited by 457
RetractedCre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
Zou, Y.-R., Kottmann, A. H., Kuroda, M., Taniuchi, I., & Littman, D. R. (1998) · Nature · doi:10.1038/31269 · Cited by 2,531
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108
The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
Bleul, C. C., Farzan, M., Choe, H., Parolin, C., Clark‐Lewis, I., Sodroski, J., & Springer, T. A. (1996) · Nature · doi:10.1038/382829a0 · Cited by 1,953
Ma, Q., Jones, D., Borghesani, P. R., Segal, R. A., Nagasawa, T., Kishimoto, T., Bronson, R. T., & Springer, T. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9448 · Cited by 1,683
Oberlin, E., Amara, A., Bachelerie, F., Chable-Bessia, C., Virelizier, J., Arenzana‐Seisdedos, F., Schwartz, O., Heard, J., Clark‐Lewis, I., Legler, D. F., et al. (1996) · Nature · doi:10.1038/382833a0 · Cited by 1,652
Schwenk, F., Baron, U., & Rajewsky, K. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.24.5080 · Cited by 1,289
Burns, J. M., Summers, B. C., Wang, Y., Melikian, A., Berahovich, R., Miao, Z., Penfold, M. E. T., Sunshine, M. J., Littman, D. R., Kuo, C. J., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052144 · Cited by 1,264
CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment
Burger, J. A., & Kipps, T. J. (2005) · Blood · doi:10.1182/blood-2005-08-3182 · Cited by 1,197
Cited by
Sorted by citations
A guide to chemokines and their receptors
Hughes, C. E., & Nibbs, R. J. B. (2018) · FEBS Journal · doi:10.1111/febs.14466 · Cited by 1,510
Hippocampal GABAergic Inhibitory Interneurons
Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889
Bachelerie, F., Ben‐Baruch, A., Burkhardt, A. M., Combadière, C., Farber, J. M., Graham, G. J., Horuk, R., Sparre‐Ulrich, A. H., Locati, M., Luster, A. D., et al. (2013) · Pharmacological Reviews · doi:10.1124/pr.113.007724 · Cited by 888
The Ins and Outs of the Epithelial to Mesenchymal Transition in Health and Disease
Nieto, M. A. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154036 · Cited by 739
Development and Functional Diversification of Cortical Interneurons
Lim, L., Mi, D., Llorca, A., & Marín, O. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.009 · Cited by 714
“…of interneurons to each of the three routes of tangential migration involves the chemokine Cxcl12, which is expressed by cells located in each of the routes (Li et al., 2008; López-Bendito et al., 2008; Sánchez-Alcañiz et al., 2011; Stumm et al., 2007; Tiveron et al., 2006; Wang et al., 2011).”
Metadata
- Authors
- Sánchez-Alcañiz, J. A., Haege, S., Mueller, W., Pla, R., Mackay, F., Schulz, S., López-Bendito, G., Stumm, R., & Marín, O.
- Affiliations
- Center for Behavioral Brain Sciences (DE)
- Friedrich Schiller University Jena (DE)
- Consejo Superior de Investigaciones Científicas (ES)
- The Alfred Hospital (AU)
- Corresponding author
- Stumm, Ralf
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 69
- Issue
- 1
- Pages
- 77-90
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2142919551
- Cited by
- 290
- References
- 61
- Citations by year
- 2026: 9 · 2025: 6 · 2024: 21 · 2023: 11 · 2022: 9 · 2021: 18 · 2020: 26 · 2019: 18 · 2018: 17 · 2017: 17 · 2016: 4 · 2015: 20 · 2014: 30 · 2013: 34 · 2012: 29
- FWCI
- 17.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 928 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- Ministerio de Ciencia e Innovación
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- CXCR7, CXCR4, CXCL12, chemokine signaling, neuronal migration, cortical interneurons, receptor co-expression, receptor protein levels, brain development
- MeSH terms
- Animals, Cell Movement, Cells, Cultured, Cerebral Cortex, Immunohistochemistry, Interneurons, Mice, Inbred C57BL, Mice, Transgenic, Signal Transduction, In Situ Hybridization, Receptors, CXCR4, Mice, Chemokine CXCL12, Receptors, CXCR
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
