Cited by 294Chemokine receptors and signalingNeurogenesis and neuroplasticity mechanismsAxon Guidance and Neuronal Signaling

The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.

Cxcr7 Controls Neuronal Migration by Regulating Chemokine Responsiveness

Open access

Sánchez-Alcañiz, Juan Antonio, Haege, Sammy, Mueller, Wiebke, Pla, Ramón, Mackay, Fabienne, Schulz, Stefan, López-Bendito, Guillermina, Stumm, Ralf, Marín, Oscar·2011·Neuron

DOI 10.1016/j.neuron.2010.12.006

Open this paper in CoChat — free account Open PDF

Abstract

The chemokine Cxcl12 binds Cxcr4 and Cxcr7 receptors to control cell migration in multiple biological contexts, including brain development, leukocyte trafficking, and tumorigenesis. Both receptors are expressed in the CNS, but how they cooperate during migration has not been elucidated. Here, we used the migration of cortical interneurons as a model to study this process. We found that Cxcr4 and Cxcr7 are coexpressed in migrating interneurons, and that Cxcr7 is essential for chemokine signaling. Intriguingly, this process does not exclusively involve Cxcr7, but most critically the modulation of Cxcr4 function. Thus, Cxcr7 is necessary to regulate Cxcr4 protein levels, thereby adapting chemokine responsiveness in migrating cells. This demonstrates that a chemokine receptor modulates the function of another chemokine receptor by controlling the amount of protein that is made available for signaling at the cell surface.

Integrity signals

Registry

Crossref · 10.1016/j.neuron.2010.12.006

Cites

61 of 61 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

The Role of CXCR7/RDC1 as a Chemokine Receptor for CXCL12/SDF-1 in Prostate Cancer
Wang, J., Shiozawa, Y., Wang, J., Wang, Y., Jung, Y., Pienta, K. J., Mehra, R., Loberg, R. D., & Taichman, R. S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m707465200 · Cited by 457
Retracted
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
Zou, Y.-R., Kottmann, A. H., Kuroda, M., Taniuchi, I., & Littman, D. R. (1998) · Nature · doi:10.1038/31269 · Cited by 2,531
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108
The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
Bleul, C. C., Farzan, M., Choe, H., Parolin, C., Clark‐Lewis, I., Sodroski, J., & Springer, T. A. (1996) · Nature · doi:10.1038/382829a0 · Cited by 1,953
Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice
Ma, Q., Jones, D., Borghesani, P. R., Segal, R. A., Nagasawa, T., Kishimoto, T., Bronson, R. T., & Springer, T. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9448 · Cited by 1,683
The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1
Oberlin, E., Amara, A., Bachelerie, F., Chable-Bessia, C., Virelizier, J., Arenzana‐Seisdedos, F., Schwartz, O., Heard, J., Clark‐Lewis, I., Legler, D. F., et al. (1996) · Nature · doi:10.1038/382833a0 · Cited by 1,652
A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells
Schwenk, F., Baron, U., & Rajewsky, K. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.24.5080 · Cited by 1,289
A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development
Burns, J. M., Summers, B. C., Wang, Y., Melikian, A., Berahovich, R., Miao, Z., Penfold, M. E. T., Sunshine, M. J., Littman, D. R., Kuo, C. J., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052144 · Cited by 1,264
CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment
Burger, J. A., & Kipps, T. J. (2005) · Blood · doi:10.1182/blood-2005-08-3182 · Cited by 1,197

Show all 61 references

Sorted by citations

A guide to chemokines and their receptors
Hughes, C. E., & Nibbs, R. J. B. (2018) · FEBS Journal · doi:10.1111/febs.14466 · Cited by 1,510
Hippocampal GABAergic Inhibitory Interneurons
Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889
International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors
Bachelerie, F., Ben‐Baruch, A., Burkhardt, A. M., Combadière, C., Farber, J. M., Graham, G. J., Horuk, R., Sparre‐Ulrich, A. H., Locati, M., Luster, A. D., et al. (2013) · Pharmacological Reviews · doi:10.1124/pr.113.007724 · Cited by 888
The Ins and Outs of the Epithelial to Mesenchymal Transition in Health and Disease
Nieto, M. A. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154036 · Cited by 739
Development and Functional Diversification of Cortical Interneurons
Lim, L., Mi, D., Llorca, A., & Marín, O. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.009 · Cited by 714
“…of interneurons to each of the three routes of tangential migration involves the chemokine Cxcl12, which is expressed by cells located in each of the routes (Li et al., 2008; López-Bendito et al., 2008; Sánchez-Alcañiz et al., 2011; Stumm et al., 2007; Tiveron et al., 2006; Wang et al., 2011).”
Immunoneuropsychiatry — novel perspectives on brain disorders
Pape, K., Tamouza, R., Leboyer, M., & Zipp, F. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0174-4 · Cited by 461
Immune regulation by atypical chemokine receptors
Nibbs, R. J. B., & Graham, G. J. (2013) · Nature reviews. Immunology · doi:10.1038/nri3544 · Cited by 413
Transcriptional co-regulation of neuronal migration and laminar identity in the neocortex
Kwan, K. Y., Šestan, N., & Anton, E. S. (2012) · Development · doi:10.1242/dev.069963 · Cited by 414
The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease
Döring, Y., Pawig, L., Weber, C., & Noels, H. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00212 · Cited by 293
Arl13b in Primary Cilia Regulates the Migration and Placement of Interneurons in the Developing Cerebral Cortex
Higginbotham, H., Eom, T.-Y., Mariani, L. E., Bachleda, A., Hirt, J., Ghukasyan, V., Cusack, C. L., Lai, C., Caspary, T., & Anton, E. S. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.09.019 · Cited by 260
Excitatory projection neuron subtypes control the distribution of local inhibitory interneurons in the cerebral cortex
Lodato, S., Rouaux, C., Quast, K. B., Jantrachotechatchawan, C., Studer, M., Hensch, T. K., & Arlotta, P. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.015 · Cited by 244
Chemokines in chronic pain: cellular and molecular mechanisms and therapeutic potential
Jiang, B., Liu, T., & Gao, Y. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107581 · Cited by 242
Neural progenitor cells orchestrate microglia migration and positioning into the developing cortex
Arnò, B., Grassivaro, F., Rossi, C., Bergamaschi, A., Castiglioni, V., Furlan, R., Greter, M., Favaro, R., Comı, G., Becher, B., et al. (2014) · Nature Communications · doi:10.1038/ncomms6611 · Cited by 250
Current status of chemokines in the adult CNS
Goazigo, A. R.-L., Steenwinckel, J. V., Rostène, W. H., & Parsadaniantz, S. M. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.02.001 · Cited by 244
Cellular and molecular mechanisms controlling the migration of neocortical interneurons
Marín, Ó. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12225 · Cited by 224
Microglia induce the transformation of A1/A2 reactive astrocytes via the CXCR7/PI3K/Akt pathway in chronic post-surgical pain
Li, T., Liu, T., Chen, X., Li, L., Feng, M., Zhang, Y., Wan, L., Zhang, C., & Yao, W. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01891-5 · Cited by 207
CXCR7 impact on CXCL12 biology and disease
Sánchez-Martı́n, L., Sánchez‐Mateos, P., & Cabañas, C. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.10.004 · Cited by 206
Scavenging of CXCL12 by CXCR7 promotes tumor growth and metastasis of CXCR4-positive breast cancer cells
Luker, K. E., Lewin, S. A., Mihalko, L. A., Schmidt, B. T., Winkler, J. S., Coggins, N. L., Thomas, D. G., & Luker, G. D. (2012) · Oncogene · doi:10.1038/onc.2011.633 · Cited by 214
Generation and Dynamics of an Endogenous, Self-Generated Signaling Gradient across a Migrating Tissue
Venkiteswaran, G., Lewellis, S. W., Wang, J., Reynolds, E., Nicholson, C., & Knaut, H. (2013) · Cell · doi:10.1016/j.cell.2013.09.046 · Cited by 186
Integration of GABAergic interneurons into cortical cell assemblies: lessons from embryos and adults
Bartolini, G., Ciceri, G., & Marín, O. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.014 · Cited by 185
CXCL12 modulation of CXCR4 and CXCR7 activity in human glioblastoma stem-like cells and regulation of the tumor microenvironment
Würth, R., Bajetto, A., Harrison, J. K., Barbieri, F., & Florio, T. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00144 · Cited by 172
Development and specification of GABAergic cortical interneurons
Kelsom, C., & Lu, W. (2013) · Cell & Bioscience · doi:10.1186/2045-3701-3-19 · Cited by 193
All Roads Lead to Directional Cell Migration
Shellard, A., & Mayor, R. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.08.002 · Cited by 168
MIF interacts with CXCR7 to promote receptor internalization, ERK1/2 and ZAP‐70 signaling, and lymphocyte chemotaxis
Alampour‐Rajabi, S., Bounkari, O. E., Rot, A., Müller‐Newen, G., Bachelerie, F., Gawaz, M., Weber, C., Schober, A., & Bernhagen, J. (2015) · The FASEB Journal · doi:10.1096/fj.15-273904 · Cited by 175
The biochemistry and biology of the atypical chemokine receptors
Graham, G. J., Locati, M., Mantovani, A., Rot, A., & Thelen, M. (2012) · Immunology Letters · doi:10.1016/j.imlet.2012.04.004 · Cited by 163
Chemokines in CNS injury and repair
Järve, A., & Müller, H. W. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1427-3 · Cited by 160
Dlx1&2-Dependent Expression of Zfhx1b (Sip1, Zeb2) Regulates the Fate Switch between Cortical and Striatal Interneurons
McKinsey, G. L., Lindtner, S., Trzcinski, B., Visel, A., Pennacchio, L. A., Huylebroeck, D., Higashi, Y., & Rubenstein, J. L. R. (2013) · Neuron · doi:10.1016/j.neuron.2012.11.035 · Cited by 153
CX3CR1 deficiency alters hippocampal-dependent plasticity phenomena blunting the effects of enriched environment
Maggi, L. (2011) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2011.00022 · Cited by 149
Integrative Mechanisms of Oriented Neuronal Migration in the Developing Brain
Evsyukova, I. Y., Plestant, C., & Anton, E. S. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122400 · Cited by 151
We have got you ‘covered’: how the meninges control brain development
Siegenthaler, J. A., & Pleasure, S. J. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.12.005 · Cited by 145
Chemokine signaling in development and disease
Wang, J., & Knaut, H. (2014) · Development · doi:10.1242/dev.101071 · Cited by 145
The Role of Chemokines in the Pathophysiology of Major Depressive Disorder
Milenkovic, V. M., Stanton, E. H., Nothdurfter, C., Rupprecht, R., & Wetzel, C. H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092283 · Cited by 149
The Role of SDF-1/CXCR4/CXCR7 in Neuronal Regeneration after Cerebral Ischemia
Cheng, X., Wang, H., Zhang, X., Zhao, S., Zhou, Z., Mu, X., Zhao, C., & Teng, W. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00590 · Cited by 139
Neurochemokines: a menage a trois providing new insights on the functions of chemokines in the central nervous system
Rostène, W. H., Dansereau, M., Godefroy, D., Steenwinckel, J. V., Goazigo, A. R.-L., Parsadaniantz, S. M., Apartis, E., Hunot, S., Beaudet, N., & Sarret, P. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07371.x · Cited by 133
Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position
Vogt, D., Hunt, R. F., Mandal, S., Sandberg, M., Silberberg, S. N., Nagasawa, T., Yang, Z., Baraban, S. C., & Rubenstein, J. L. R. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.030 · Cited by 129
Building the posterior lateral line system in zebrafish
Chitnis, A. B., Nogare, D. D., & Matsuda, M. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20962 · Cited by 122
Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1
van den Berghe, V., Stappers, E., Vandesande, B., Dimidschstein, J., Kroes, R., Francis, A., Conidi, A., Lesage, F., Dries, R., Cazzola, S., et al. (2013) · Neuron · doi:10.1016/j.neuron.2012.11.009 · Cited by 120
The Role of Selected Chemokines and Their Receptors in the Development of Gliomas
Groblewska, M., Litman‐Zawadzka, A., & Mroczko, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103704 · Cited by 121
Neuronal migration disorders: Focus on the cytoskeleton and epilepsy
Stouffer, M. A., Golden, J. A., & Francis, F. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.08.003 · Cited by 123
Platelet‐derived CXCL12 (SDF‐1α): basic mechanisms and clinical implications
Chatterjee, M., & Gawaz, M. (2013) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12404 · Cited by 106
C6 cell line: the gold standard in glioma research.
Giakoumettis, D., Κritis, A., & Foroglou, N. (2018) · PubMed Central · Cited by 106
Cxcr4 regulation of interneuron migration is disrupted in 22q11.2 deletion syndrome
Meechan, D. W., Tucker, E. S., Maynard, T. M., & LaMantia, A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211507109 · Cited by 105
Ubiquitination of CXCR7 Controls Receptor Trafficking
Canals, M., Scholten, D. J., de Munnik, S., Han, M. K. L., Smit, M. J., & Leurs, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034192 · Cited by 105
Decision making during interneuron migration in the developing cerebral cortex
Guo, J., & Anton, E. S. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.12.001 · Cited by 104
Decoy Receptor CXCR7 Modulates Adrenomedullin-Mediated Cardiac and Lymphatic Vascular Development
Klein, K. R., Karpinich, N. O., Espenschied, S. T., Willcockson, H. H., Dunworth, W. P., Hoopes, S. L., Kushner, E. J., Bautch, V. L., & Caron, K. M. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.07.012 · Cited by 113
The role of CXCR7 on the adhesion, proliferation and angiogenesis of endothelial progenitor cells
Dai, X., Tan, Y., Cai, S., Xiong, X., Wang, L., Ye, Q., Yan, X., Ma, K., & Cai, L. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01301.x · Cited by 103
Role of Atypical Chemokine Receptors in Microglial Activation and Polarization
Salvi, V., Sozio, F., Sozzani, S., & Prete, A. D. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00148 · Cited by 99
CXCR4 and CXCR7 Signaling Pathways: A Focus on the Cross-Talk Between Cancer Cells and Tumor Microenvironment
Santagata, S., Ieranò, C., Trotta, A. M., Capiluongo, A., Auletta, F., Guardascione, G., & Scala, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.591386 · Cited by 107
Endothelial expression of CXCR 7 and the regulation of systemic CXCL 12 levels
Berahovich, R., Zabel, B. A., Lewén, S., Walters, M. J., Ebsworth, K., Wang, Y., Jaén, J. C., & Schall, T. J. (2013) · Immunology · doi:10.1111/imm.12176 · Cited by 106
Endocytic trafficking of chemokine receptors
Marchese, A. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2013.11.011 · Cited by 103
Relevance of the CXCR4/CXCR7-CXCL12 axis and its effect in pathophysiological conditions
Huynh, C., Dingemanse, J., zu Schwabedissen, H. E. M., & Sidharta, P. N. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105092 · Cited by 96
Rapid Uptake and Degradation of CXCL12 Depend on CXCR7 Carboxyl-terminal Serine/Threonine Residues
Hoffmann, F., Müller, W., Schütz, D., Penfold, M. E. T., Wong, Y. H., Schulz, S., & Stumm, R. K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.335679 · Cited by 96
Self-citation
New insights in chemokine signaling
Legler, D. F., & Thelen, M. (2018) · F1000Research · doi:10.12688/f1000research.13130.1 · Cited by 91
The CXCL12/CXCR4/ACKR3 Axis in the Tumor Microenvironment: Signaling, Crosstalk, and Therapeutic Targeting
Smit, M. J., Schlecht‐Louf, G., Neves, M., van den Bor, J., Penela, P., Siderius, M. H., Bachelerie, F., & Mayor, F. (2020) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010919-023340 · Cited by 92
Polyfunctionality of the CXCR4/CXCL12 axis in health and disease: Implications for therapeutic interventions in cancer and immune‐mediated diseases
Britton, C., Poznansky, M. C., & Reeves, P. (2021) · The FASEB Journal · doi:10.1096/fj.202001273r · Cited by 88
Biased signaling pathways via CXCR3 control the development and function of CD4+ T cell subsets
Karin, N., Wildbaum, G., & Thelen, M. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.2mr0915-441r · Cited by 92
Targeting SDF-1/CXCR4 to inhibit tumour vasculature for treatment of glioblastomas
Tseng, D., Vasquez-Medrano, D. A., & Brown, J. M. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.169 · Cited by 87
Early Developmental Disturbances of Cortical Inhibitory Neurons: Contribution to Cognitive Deficits in Schizophrenia
Volk, D. W., & Lewis, D. A. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu111 · Cited by 86
CXCR7 prevents excessive CXCL12-mediated downregulation of CXCR4 in migrating cortical interneurons
Abe, P., Mueller, W., Schütz, D., Mackay, F., Thelen, M., Zhang, P., & Stumm, R. K. (2014) · Development · doi:10.1242/dev.104224 · Cited by 85
Self-citation
CXCL12 Enhances Human Neural Progenitor Cell Survival Through a CXCR7‐ and CXCR4‐Mediated Endocytotic Signaling Pathway
Zhu, B., Xu, D., Deng, X., Chen, Q., Huang, Y., Peng, H., Li, Y., Jia, B., Thoreson, W. B., Ding, W., et al. (2012) · Stem Cells · doi:10.1002/stem.1239 · Cited by 85
Production and organization of neocortical interneurons
Sultan, K. T., Brown, K. N., & Shi, S.-H. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00221 · Cited by 83
ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin
Saaber, F., Schütz, D., Miess, E., Abe, P., Desikan, S., Kumar, P. A., Balk, S., Huang, K., Beaulieu, J., Schulz, S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.049 · Cited by 83
Self-citation
Serotonin receptor 3A controls interneuron migration into the neocortex
Murthy, S. S., Niquille, M., Hurni, N., Limoni, G., Frazer, S. L., Chameau, P. J. P., van Hooft, J. A., Vitalis, T., & Dayer, A. G. (2014) · Nature Communications · doi:10.1038/ncomms6524 · Cited by 83
CXCR4 and CXCR7 transduce through mTOR in human renal cancer cells
Ieranò, C., Santagata, S., Napolitano, M., Guardia, F., Grimaldi, A., Antignani, E., Botti, G., Consales, C., Riccio, A., Nanayakkara, M., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.269 · Cited by 85
Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons
Yang, S., Edman, L. C., Sánchez‐Alcañiz, J. A., Fritz, N., Bonilla, S., Hecht, J. H., Uhlén, P., Pleasure, S. J., Villaescusa, C., Marín, Ó., et al. (2013) · Development · doi:10.1242/dev.098145 · Cited by 83
Self-citation
Neurons on the Move: Migration and Lamination of Cortical Interneurons
Faux, C. H., Rakić, S., Andrews, W. D., & Britto, J. M. (2012) · Neurosignals · doi:10.1159/000334489 · Cited by 88
Development of Cortical Interneurons
Chu, J., & Anderson, S. A. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.171 · Cited by 80
Neuregulin 3 Mediates Cortical Plate Invasion and Laminar Allocation of GABAergic Interneurons
Bartolini, G., Sánchez-Alcañiz, J. A., Osório, C., Valiente, M., García-Frigola, C., & Marín, O. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.089 · Cited by 74
Self-citation
Hierarchical Organization of Multi-Site Phosphorylation at the CXCR4 C Terminus
Mueller, W., Schütz, D., Nagel, F., Schulz, S., & Stumm, R. K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064975 · Cited by 74
Self-citation
CXCL12 Signaling in the Tumor Microenvironment
Portella, L., Bello, A. M., & Scala, S. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-62658-7_5 · Cited by 72
Discovery of Potent and Orally Bioavailable Macrocyclic Peptide–Peptoid Hybrid CXCR7 Modulators
Boehm, M., Beaumont, K. C., Jones, R., Kalgutkar, A. S. S., Zhang, L., Atkinson, K. A., Bai, G., Brown, J. A., Eng, H. F., Goetz, G. H., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01028 · Cited by 72
CXCR7 Mediates Neural Progenitor Cells Migration to CXCL12 Independent of CXCR4
Chen, Q., Zhang, M., Li, Y., Xu, D., Wang, Y., Song, A., Zhu, B., Huang, Y., & Zheng, J. (2015) · Stem Cells · doi:10.1002/stem.2022 · Cited by 70
Tangential migration of glutamatergic neurons and cortical patterning during development: Lessons from Cajal‐Retzius cells
Barber, M., & Pierani, A. (2015) · Developmental Neurobiology · doi:10.1002/dneu.22363 · Cited by 76
Atypical Chemokine Receptor 3 (ACKR3): A Comprehensive Overview of its Expression and Potential Roles in the Immune System
Koenen, J., Bachelerie, F., Balabanian, K., Schlecht‐Louf, G., & Gallego, C. (2019) · Molecular Pharmacology · doi:10.1124/mol.118.115329 · Cited by 74
Cellular and subcellular localization of CXCL12 and CXCR4 in rat nociceptive structures: physiological relevance
Goazigo, A. R.-L., Rivat, C., Kitabgi, P., Pohl, M., & Parsadaniantz, S. M. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08179.x · Cited by 69
Minireview: Ubiquitination-regulated G Protein-Coupled Receptor Signaling and Trafficking
Alonso, V., & Friedman, P. A. (2013) · Molecular Endocrinology · doi:10.1210/me.2012-1404 · Cited by 73
CXCR7 Protein Expression in Human Adult Brain and Differentiated Neurons
Shimizu, S., Brown, M., Sengupta, R., Penfold, M. E. T., & Meucci, O. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020680 · Cited by 67
A negative-feedback loop maintains optimal chemokine concentrations for directional cell migration
Lau, S., Feitzinger, A. A., Venkiteswaran, G., Wang, J., Lewellis, S. W., Koplinski, C. A., Peterson, F. C., Volkman, B. F., Meier‐Schellersheim, M., & Knaut, H. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0465-4 · Cited by 67
Interneuron, interrupted: molecular pathogenesis of ARX mutations and X-linked infantile spasms
Olivetti, P. R., & Noebels, J. L. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.04.006 · Cited by 66
SDF‐1α induces differential trafficking of CXCR4‐CXCR7 involving cyclophilin A, CXCR7 ubiquitination and promotes platelet survival
Chatterjee, M., Seizer, P., Borst, O., Schönberger, T., Mack, A. F., Geisler, T., Langer, H. F., May, A. E., Vogel, S., Lang, F. J. W., et al. (2014) · The FASEB Journal · doi:10.1096/fj.14-249730 · Cited by 65
CXCR4, but not CXCR7, Discriminates Metastatic Behavior in Non–Small Cell Lung Cancer Cells
Choi, Y. H., Burdick, M. D., Strieter, B. A., Mehrad, B., & Strieter, R. M. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-12-0334 · Cited by 65
Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function
Pai, E. L.-L., Vogt, D. L., Clemente-Perez, A., McKinsey, G. L., Cho, F. S., Hu, J. S., Wimer, M., Paul, A., Darbandi, S. F., Pla, R., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.031 · Cited by 66
Self-citation
CXCL12 Signaling in the Development of the Nervous System
Mithal, D. S., Banisadr, G., & Miller, R. J. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9336-x · Cited by 63
Emerging roles of atypical chemokine receptor 3 (ACKR3) in normal development and physiology
Quinn, K. E., Mackie, D. I., & Caron, K. M. (2018) · Cytokine · doi:10.1016/j.cyto.2018.02.024 · Cited by 61
The peculiarities of the SDF-1/CXCL12 system: in some cells, CXCR4 and CXCR7 sing solos, in others, they sing duets
Puchert, M., & Engele, J. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1747-y · Cited by 60
Endothelial CXCR7 regulates breast cancer metastasis
Stacer, A. C., Fenner, J., Cavnar, S. P., Xiao, A., Zhao, S. G., Chang, S. L., Salomonnson, A., Luker, G. D., & Luker, G. D. (2015) · Oncogene · doi:10.1038/onc.2015.236 · Cited by 62
Secreted CXCL12 (SDF-1) forms dimers under physiological conditions
Ray, P., Lewin, S. A., Mihalko, L. A., Lesher‐Pérez, S. C., Takayama, S., Luker, K. E., & Luker, G. D. (2011) · Biochemical Journal · doi:10.1042/bj20111341 · Cited by 66
Attractive guidance: How the chemokine SDF1/CXCL12 guides different cells to different locations
Lewellis, S. W., & Knaut, H. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.03.009 · Cited by 58
CXCL12/CXCR4/CXCR7 Chemokine Axis in the Central Nervous System: Therapeutic Targets for Remyelination in Demyelinating Diseases
Chu, T., Shields, L. B. E., Zhang, Y. P., Feng, S., Shields, C. B., & Cai, J. (2017) · The Neuroscientist · doi:10.1177/1073858416685690 · Cited by 61
Regulation of CNS precursor function by neuronal chemokines
Watson, A. E. S., Goodkey, K., Footz, T. K., & Voronova, A. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134533 · Cited by 57
MIF and CXCL12 in Cardiovascular Diseases: Functional Differences and Similarities
van der Vorst, E. P. C., Döring, Y., & Weber, C. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00373 · Cited by 57
Prenatal ontogeny as a susceptibility period for cortical GABA neuron disturbances in schizophrenia
Volk, D. W., & Lewis, D. A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.06.008 · Cited by 56
Identification of Arx targets unveils new candidates for controlling cortical interneuron migration and differentiation
Friocourt, G. (2011) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2011.00028 · Cited by 59
SDF and GABA interact to regulate axophilic migration of GnRH neurons
Casoni, F., Hutchins, B. I., Donohue, D. E., Fornaro, M., Condie, B. G., & Wray, S. (2012) · Journal of Cell Science · doi:10.1242/jcs.101675 · Cited by 58
The role of CXCR4 signaling in the migration of transplanted oligodendrocyte progenitors into the cerebral white matter
Banisadr, G., Frederick, T. J., Freitag, C. M., Ren, D., Jung, H., Miller, S. D., & Miller, R. J. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.05.019 · Cited by 57
Effects of the chemokine CXCL12 and combined internalization of its receptors CXCR4 and CXCR7 in human MCF-7 breast cancer cells
Hattermann, K., Holzenburg, E., Hans, F., Lucius, R., Held‐Feindt, J., & Mentlein, R. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1823-y · Cited by 55
Modulation of Neuroinflammation in the Central Nervous System: Role of Chemokines and Sphingolipids
Gualtierotti, R., Guarnaccia, L., Beretta, M., Navone, S. E., Campanella, R., Riboni, L., Rampini, P. M., & Marfia, G. (2017) · Advances in Therapy · doi:10.1007/s12325-016-0474-7 · Cited by 58
Interneuron development and dysfunction
Yang, J., Yang, X. W., & Tang, K. (2021) · FEBS Journal · doi:10.1111/febs.15872 · Cited by 54
Reelin and CXCL12 regulate distinct migratory behaviors during the development of the dopaminergic system
Bodea, G. O., Spille, J.-H., Abe, P., Sentürk, A., Acker‐Palmer, A., Stumm, R. K., Kubitscheck, U., & Blaess, S. (2014) · Development · doi:10.1242/dev.099937 · Cited by 57
Self-citation
The relevance of the chemokine receptor ACKR3/CXCR7 on CXCL12-mediated effects in cancers with a focus on virus-related cancers
Freitas, C., Desnoyer, A., Meuris, F., Bachelerie, F., Balabanian, K., & Machelon, V. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.04.006 · Cited by 54

Authors: Sánchez-Alcañiz, J. A., Haege, S., Mueller, W., Pla, R., Mackay, F., Schulz, S., López-Bendito, G., Stumm, R., & Marín, O.
Affiliations: Center for Behavioral Brain Sciences (DE)
Friedrich Schiller University Jena (DE)
Consejo Superior de Investigaciones Científicas (ES)
The Alfred Hospital (AU)
Corresponding author: Stumm, Ralf
ORCID: Pla, Ramón
Mackay, Fabienne
Schulz, Stefan
Stumm, Ralf
Venue: Neuron
Publisher: Elsevier BV
Published: 2011-01
Volume: 69
Issue: 1
Pages: 77-90
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2010.12.006
OpenAlex: W2142919551
Cited by: 290
References: 61
Citations by year: 2026: 9 · 2025: 6 · 2024: 21 · 2023: 11 · 2022: 9 · 2021: 18 · 2020: 26 · 2019: 18 · 2018: 17 · 2017: 17 · 2016: 4 · 2015: 20 · 2014: 30 · 2013: 34 · 2012: 29
FWCI: 17.92
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 928 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Funders: Ministerio de Ciencia e Innovación
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Keywords: CXCR7, CXCR4, CXCL12, chemokine signaling, neuronal migration, cortical interneurons, receptor co-expression, receptor protein levels, brain development
MeSH terms: Animals, Cell Movement, Cells, Cultured, Cerebral Cortex, Immunohistochemistry, Interneurons, Mice, Inbred C57BL, Mice, Transgenic, Signal Transduction, In Situ Hybridization, Receptors, CXCR4, Mice, Chemokine CXCL12, Receptors, CXCR

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cxcr7 Controls Neuronal Migration by Regulating Chemokine Responsiveness

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks