Cited by 126Memory and Neural MechanismsNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

Coherent phasic excitation during hippocampal ripples

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Maier, Nikolaus, Tejero-Cantero, Álvaro, Dorrn, Anja L., Winterer, Jochen, Beed, Prateep S., Morris, Genela, Kempter, Richard, Poulet, James F.A. +2 more·2011·Neuron

Abstract

High-frequency hippocampal network oscillations, or "ripples," are thought to be involved in episodic memory. According to current theories, memory traces are represented by assemblies of principal neurons that are activated during ripple-associated network states. Here we performed in vivo and in vitro experiments to investigate the synaptic mechanisms during ripples. We discovered postsynaptic currents that are phase-locked to ripples and coherent among even distant CA1 pyramidal neurons. These fast currents are consistent with excitatory postsynaptic currents (EPSCs) as they are observed at the equilibrium potential of Cl(-), and they display kinetics characteristic of EPSCs. Furthermore, they survived after intracellular blockade of GABAergic transmission and are effective to regulate the timing of action potentials. In addition, our data show a progressive synchronization of phasic excitation and inhibition during the course of ripples. Together, our results demonstrate the presence of phasic excitation during ripples reflecting an exquisite temporal coordination of assemblies of active pyramidal cells.

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Crossref · 10.1016/j.neuron.2011.08.016

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Authors
Maier, N., Tejero-Cantero, Á., Dorrn, A. L., Winterer, J., Beed, P. S., Morris, G., Kempter, R., Poulet, J. F. A., Leibold, C., & Schmitz, D.
Affiliations
  • Charité – Universitätsmedizin Berlin (DE)
  • Ludwig-Maximilians-Universität München (DE)
  • Max Delbrück Center (DE)
  • Bernstein Center for Computational Neuroscience Berlin (DE)
  • Humboldt-Universität zu Berlin (DE)
  • Bernstein Center for Computational Neuroscience Munich (DE)
Corresponding author
Schmitz, Dietmar
Venue
Neuron
Publisher
Elsevier BV
Published
2011-10
Volume
72
Issue
1
Pages
137-152
ISSN
0896-6273 (ISSN-L)
OpenAlex
W1963856990
Cited by
126
References
61
Citations by year
2026: 5 · 2025: 8 · 2024: 8 · 2023: 8 · 2022: 3 · 2021: 7 · 2020: 7 · 2019: 5 · 2018: 14 · 2017: 6 · 2016: 13 · 2015: 12 · 2014: 13 · 2013: 8 · 2012: 7
FWCI
4.87
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
Funders
  • European Research Council (260590)
  • Deutsche Forschungsgemeinschaft (Le-2250/2-1, SFB 618)
  • Bundesministerium für Bildung und Forschung (01GQ0410, 01GQ0440)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
hippocampal ripples, excitatory postsynaptic currents, CA1 pyramidal neurons, network oscillations, episodic memory, synaptic mechanisms, action potential timing, cell assemblies
MeSH terms
Action Potentials, Animals, gamma-Aminobutyric Acid, Hippocampus, Male, Mice, Inbred C57BL, Neural Inhibition, Synaptic Transmission, 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid, Pyramidal Cells, GABA Antagonists, Excitatory Postsynaptic Potentials, Mice, Brain Waves

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