Coherent phasic excitation during hippocampal ripples
Open accessAbstract
High-frequency hippocampal network oscillations, or "ripples," are thought to be involved in episodic memory. According to current theories, memory traces are represented by assemblies of principal neurons that are activated during ripple-associated network states. Here we performed in vivo and in vitro experiments to investigate the synaptic mechanisms during ripples. We discovered postsynaptic currents that are phase-locked to ripples and coherent among even distant CA1 pyramidal neurons. These fast currents are consistent with excitatory postsynaptic currents (EPSCs) as they are observed at the equilibrium potential of Cl(-), and they display kinetics characteristic of EPSCs. Furthermore, they survived after intracellular blockade of GABAergic transmission and are effective to regulate the timing of action potentials. In addition, our data show a progressive synchronization of phasic excitation and inhibition during the course of ripples. Together, our results demonstrate the presence of phasic excitation during ripples reflecting an exquisite temporal coordination of assemblies of active pyramidal cells.
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Key roles for inter-pyramidal cell excitatory synapses within CA1 have been suggested for sharp wave ripple oscillations as well.
“key roles for inter-pyramidal cell excitatory synapses within CA1 have been suggested for sharp wave ripple oscillations as well (Maier et al., 2011).”
From Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit (2016) · cites this paper as Maier et al., 2011
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CA3 hippocampal synaptic plasticity supports ripple physiology during memory consolidation
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Involvement of Mossy Cells in Sharp Wave-Ripple Activity In Vitro
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Mechanisms of neural organization and rhythmogenesis during hippocampal and cortical ripples
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Neuregulin 1 and ErbB4 Kinase Actively Regulate Sharp Wave Ripples in the Hippocampus
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Optogenetics reveals paradoxical network stabilizations in hippocampal CA1 and CA3
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- Authors
- Maier, N., Tejero-Cantero, Á., Dorrn, A. L., Winterer, J., Beed, P. S., Morris, G., Kempter, R., Poulet, J. F. A., Leibold, C., & Schmitz, D.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- Ludwig-Maximilians-Universität München (DE)
- Max Delbrück Center (DE)
- Bernstein Center for Computational Neuroscience Berlin (DE)
- Humboldt-Universität zu Berlin (DE)
- Bernstein Center for Computational Neuroscience Munich (DE)
- Corresponding author
- Schmitz, Dietmar
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 72
- Issue
- 1
- Pages
- 137-152
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1963856990
- Cited by
- 126
- References
- 61
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 8 · 2023: 8 · 2022: 3 · 2021: 7 · 2020: 7 · 2019: 5 · 2018: 14 · 2017: 6 · 2016: 13 · 2015: 12 · 2014: 13 · 2013: 8 · 2012: 7
- FWCI
- 4.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 655 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Funders
- European Research Council (260590)
- Deutsche Forschungsgemeinschaft (Le-2250/2-1, SFB 618)
- Bundesministerium für Bildung und Forschung (01GQ0410, 01GQ0440)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampal ripples, excitatory postsynaptic currents, CA1 pyramidal neurons, network oscillations, episodic memory, synaptic mechanisms, action potential timing, cell assemblies
- MeSH terms
- Action Potentials, Animals, gamma-Aminobutyric Acid, Hippocampus, Male, Mice, Inbred C57BL, Neural Inhibition, Synaptic Transmission, 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid, Pyramidal Cells, GABA Antagonists, Excitatory Postsynaptic Potentials, Mice, Brain Waves
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