The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Postsynaptic Complexin Controls AMPA Receptor Exocytosis during LTP
Open accessAbstract
Long-term potentiation (LTP) is a compelling synaptic correlate of learning and memory. LTP induction requires NMDA receptor (NMDAR) activation, which triggers SNARE-dependent exocytosis of AMPA receptors (AMPARs). However, the molecular mechanisms mediating AMPAR exocytosis induced by NMDAR activation remain largely unknown. Here, we show that complexin, a protein that regulates neurotransmitter release via binding to SNARE complexes, is essential for AMPAR exocytosis during LTP but not for the constitutive AMPAR exocytosis that maintains basal synaptic strength. The regulated postsynaptic AMPAR exocytosis during LTP requires binding of complexin to SNARE complexes. In hippocampal neurons, presynaptic complexin acts together with synaptotagmin-1 to mediate neurotransmitter release. However, postsynaptic synaptotagmin-1 is not required for complexin-dependent AMPAR exocytosis during LTP. These results suggest a complexin-dependent molecular mechanism for regulating AMPAR delivery to synapses, a mechanism that is surprisingly similar to presynaptic exocytosis but controlled by regulators other than synaptotagmin-1.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Numerous studies have shown that blocking postsynaptic exocytosis by a variety of means blocks LTP/sLTP (195, 249, 250, 332–338).”
From Synaptic memory and CaMKII (2023) · cites this paper as [333]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Long-Term Potentiation--A Decade of Progress?
Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729
Self-citationAMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588
Self-citationSüdhof, T. C. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131412 · Cited by 2,491
Self-citationSNAREpins: Minimal Machinery for Membrane Fusion
Weber, T., Zemelman, B. V., McNew, J. A., Westermann, B., Gmachl, M., Parlati, F., Söllner, T. H., & Rothman, J. E. (1998) · Cell · doi:10.1016/s0092-8674(00)81404-x · Cited by 2,481
Membrane Fusion: Grappling with SNARE and SM Proteins
Südhof, T. C., & Rothman, J. E. (2009) · Science · doi:10.1126/science.1161748 · Cited by 2,027
Self-citationGermline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors
Lois, C., Hong, E. J., Pease, S., Brown, E. J., & Baltimore, D. (2002) · Science · doi:10.1126/science.1067081 · Cited by 1,992
Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse
Geppert, M., Goda, Y., Hammer, R. E., Li, C., Rosahl, T. W., Stevens, C. F., & Südhof, T. C. (1994) · Cell · doi:10.1016/0092-8674(94)90556-8 · Cited by 1,483
Self-citationSynaptic plasticity and addiction
Kauer, J. A., & Malenka, R. C. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2234 · Cited by 1,397
Self-citationPDZ Domains and the Organization of Supramolecular Complexes
Sheng, M., & Sala, C. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1 · Cited by 1,211
AMPA receptor trafficking at excitatory synapses
Bredt, D. S., & Nicoll, R. A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00640-8 · Cited by 1,150
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–133 of 133
Der molekulare Mechanismus der Neurotransmitterfreisetzung und Nervenzell‐Synapsen (Nobel‐Aufsatz)
Südhof, T. C. (2014) · Angewandte Chemie · doi:10.1002/ange.201406359 · Cited by 3
Self-citationA High-content Assay for Monitoring AMPA Receptor Trafficking
Ghane, M. A., Yakout, D. W., & Mabb, A. M. (2019) · Journal of Visualized Experiments · doi:10.3791/59048 · Cited by 3
Visual deprivation modifies glutamate receptor expression in visual and auditory centers.
Zhou, Y., Yin, M., Xia, C., Wang, X., Wu, H., & Ji, Y. (2019) · Europe PMC (PubMed Central) · Cited by 3
Extracellular Remodeling by Lysosomes: An Inside-Out Mechanism of Spine Plasticity
Evans, P. R., & Yasuda, R. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.025 · Cited by 2
La machinerie moléculaire de sécrétion des neurotransmetteurs
Südhof, T. C. (2015) · Biologie Aujourd hui · doi:10.1051/jbio/2015012 · Cited by 2
Self-citationAdding a piece to the LTP jigsaw
Tse, M. T. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3207 · Cited by 2
Neurophysiology and signaling pathways
Matić, I. S., & Zivkovic, V. I. (2017) · Medicinski casopis · doi:10.5937/mckg51-14006 · Cited by 1
Datumetine exposure alters hippocampal neurotransmitters system in C57BL/6 mice
Ishola, A. O., Imam, A., & Ajao, M. S. (2020) · Drug and Chemical Toxicology · doi:10.1080/01480545.2020.1776315 · Cited by 2
AMPA receptors in synaptic plasticity and learning and memory
Kim, K., & Park, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15754-7.00056-0 · Cited by 1
Regulation of Exocytosis by Complexin
Shin, O. (2015) · Journal of Biochemistry and Molecular Biology Research · doi:10.17554/j.issn.2313-7177.2015.01.6 · Cited by 1
Localising Receptors and Channels Across the Dendritic Arbour
Bikbaev, A. F., Duménieu, M., Lopez‐Rojas, J., & Heine, M. (2016) · Springer eBooks · doi:10.1007/978-4-431-56050-0_16 · Cited by 1
Central Glutamatergic-Purinergic System Importance in Brain/Neural Plasticity
Kania, B. F., Wrońska, D., & Zieba, D. A. (2017) · Journal of Behavioral and Brain Science · doi:10.4236/jbbs.2017.77019 · Cited by 1
A High-content Assay for Monitoring AMPA Receptor Trafficking
Ghane, M. A., Yakout, D. W., & Mabb, A. M. (2019) · Journal of Visualized Experiments · doi:10.3791/59048-v · Cited by 1
Neurophysiological mechanisms of plasticity induced in adult brain
Popova, D. (2015) · Työväentutkimus Vuosikirja · Cited by 1
Vadakkan, K. I. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/085589 · Cited by 1
Functional Roles of Group II Metabotropic Glutamate Receptors in the Hippocampal CA1 Network
Rosenberg, N. (2015) · Repository for Publications and Research Data (ETH Zurich) · doi:10.3929/ethz-a-010553902
Varga, E. (2015) · SZTE Repository of Dissertations (University of Szeged) · doi:10.14232/phd.2588
Coward, L. A. (2013) · Springer eBooks · doi:10.1007/978-94-007-7107-9_5
Structure and Function Relationship of Syntaxin-1 in Neurotransmitter Release
Park, S. (2015) · TSpace (University of Toronto)
Labrecque, S. (2012) · Corpus Université Laval (Université Laval)
AMPA receptor trafficking in the developing and mature glutamatergic synapse
Catsburg, L. A. E., & MacGillavry, H. D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-823672-7.00023-5
Rab10 inactivation promotes AMPAR trafficking and spine enlargement during long-term potentiation
Wang, J., Nishiyama, J., Parra-Bueno, P., Okaz, E., Oz, G., Liu, X., Watabe, T., Suponitsky-Kroyter, I., McGraw, T. E., Szatmari, E. M., et al. (2025) · eLife · doi:10.7554/elife.103879.3
Gamaleldin, M., Yu, N., Diedrich, J. K., Ma, Y., Wienand, A., McClatchy, D. B., Nykjær, A., Nabavi, S., & Yates, J. R. (2024) · Journal of Proteome Research · doi:10.1021/acs.jproteome.4c00180
Rab10 inactivation promotes AMPAR trafficking and spine enlargement during long-term potentiationPreprint
Wang, J., Nishiyama, J., Parra-Bueno, P., Okaz, E., Oz, G., Liu, X., Watabe, T., Suponitsky-Kroyter, I., McGraw, T. E., Szatmari, E. M., et al. (2024) · eLife · doi:10.7554/elife.103879
Rab10 inactivation promotes AMPAR insertion and spine enlargement during long-term potentiationPreprint
Wang, J., Nishiyama, J., Parra-Bueno, P., Okaz, E., Oz, G., Liu, X., Watabe, T., Suponitsky-Kroyter, I., McGraw, T. E., Szatmari, E. M., et al. (2024) · eLife · doi:10.7554/elife.103879.1
Rab10 inactivation promotes AMPAR trafficking and spine enlargement during long-term potentiationPreprint
Wang, J., Nishiyama, J., Parra-Bueno, P., Okaz, E., Oz, G., Liu, X., Watabe, T., Suponitsky-Kroyter, I., McGraw, T. E., Szatmari, E. M., et al. (2025) · eLife · doi:10.7554/elife.103879.2 · Cited by 1
Wang, Z., Wong, L., & Sajikumar, S. (2025) · PNAS Nexus · doi:10.1093/pnasnexus/pgaf241
Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor
Wang, Y., Deng, Y., Xia, N. M., Sugita, S., & Gao, S. (2026) · Advanced Science · doi:10.1002/advs.202520721
Role of vSNAREs in post-synaptic AMPAR trafficking, glutamatergic transmisson and plasticity
Bakr, M. (2020) · theses.fr (ABES) · doi:10.70675/32528bd6ze209z428fzbe94z1a44fc665a82 · Cited by 1
Tropea, M. R., Aceto, G., Trovato, R. C., Nicitra, E., Santuccio, N., Intili, G., D’Ascenzo, M., & Puzzo, D. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1840697
Two Pleckstrin homology domains scaffold SNAP-47-containing SNARE complexesPreprint
Alickovic, I., Wise, M., Tela, R., Fausnaught, C., Lee, L., Beasley, C., Carr, C., Carr, C., Schwindt, L., & Peters, J. J. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.15.759244
Metadata
- Authors
- Ahmad, M., Polepalli, J. S., Goswami, D., Yang, X., Kaeser-Woo, Y. J., Südhof, T. C., & Malenka, R. C.
- Affiliations
- Stanford Medicine (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Malenka, Robert C.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 73
- Issue
- 2
- Pages
- 260-267
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3269030
- OpenAlex
- W2085433160
- Cited by
- 133
- References
- 51
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 4 · 2021: 9 · 2020: 10 · 2019: 8 · 2018: 15 · 2017: 11 · 2016: 12 · 2015: 18 · 2014: 10 · 2013: 13 · 2012: 3
- FWCI
- 5.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH06334, R01MH063394, P50MH086403, P50 MH0864)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- complexin, long-term potentiation, SNARE complex, NMDA receptor activation, synaptotagmin-1, hippocampal neurons, neurotransmitter release regulation
- MeSH terms
- Animals, Exocytosis, Nerve Tissue Proteins, Synaptic Transmission, Neurons, Long-Term Potentiation, Receptors, AMPA, Excitatory Postsynaptic Potentials, Protein Transport, Adaptor Proteins, Vesicular Transport, SNARE Proteins, Synaptotagmin I, Mice, CA1 Region, Hippocampal, Post-Synaptic Density
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
