Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

Ling, Shuo-Chien, Polymenidou, Magdalini, Cleveland, Don W.·2013·Neuron
DOI 10.1016/j.neuron.2013.07.033

Cited by (1,002)

Items 401–500 of 1,002

  1. Circulating Metabolites as Potential Biomarkers for Neurological Disorders—Metabolites in Neurological Disorders
    Amanda Donatti, Amanda Morato do Canto, Alexandre B. Godoi, Douglas C. da Rosa, Íscia Lopes‐Cendes · 2020 · Metabolites
  2. Disruption of ER‐mitochondria tethering and signalling in C9orf72‐associated amyotrophic lateral sclerosis and frontotemporal dementia
    Patricia Gómez‐Suaga, Gábor M. Mórotz, Andrea Markovinović, Sandra M. Martín‐Guerrero, Elisavet Preza, Natalia Arias, Keith Mayl, Afra Aabdien, Vesela Gesheva, Agnes Lumi Nishimura et al. · 2022 · Aging Cell
  3. Advances in Proteomic and Metabolomic Profiling of Neurodegenerative Diseases
    Artur Francisco Schumacher Schuh, Andrei Bieger, Wyllians Vendramini Borelli, Makayla K. Portley, Paula Saffie Awad, Sara Bandrés‐Ciga · 2022 · Frontiers in Neurology
  4. TDP-43 Regulates the Microprocessor Complex Activity During In Vitro Neuronal Differentiation
    Valerio Di Carlo, Elena Grossi, Pietro Laneve, Mariangela Morlando, Stefano Dini Modigliani, Monica Ballarino, Irene Bozzoni, Elisa Caffarelli · 2013 · Molecular Neurobiology
  5. Selective degeneration of a physiological subtype of spinal motor neuron in mice with SOD1-linked ALS
    Muhamed Hadzipasic, Babak Tahvildari, Maria Nagy, Minjuan Bian, Arthur L. Horwich, David A. McCormick · 2014 · Proceedings of the National Academy of Sciences
  6. Current Advances and Limitations in Modeling ALS/FTD in a Dish Using Induced Pluripotent Stem Cells
    Wenting Guo, Laura Fumagalli, Robert Ciarán Prior, Ludo Van Den Bosch · 2017 · Frontiers in Neuroscience
  7. Deciphering lipid dysregulation in ALS: from mechanisms to translational medicine
    Ira Agrawal, Yong Shan Lim, Shi‐Yan Ng, Shuo‐Chien Ling · 2022 · Translational Neurodegeneration
  8. Limbic-predominant age-related TDP43 encephalopathy (LATE) neuropathological change in neurodegenerative diseases
    Sukriti Nag, Julie A. Schneider · 2023 · Nature Reviews Neurology
  9. Phase separation and pathologic transitions of RNP condensates in neurons: implications for amyotrophic lateral sclerosis, frontotemporal dementia and other neurodegenerative disorders
    Aditi Naskar, Asima Nayak, Muthu Raj Salaikumaran, Sonali S. Vishal, Pallavi P. Gopal · 2023 · Frontiers in Molecular Neuroscience
  10. Fishing for causes and cures of motor neuron disorders
    Shunmoogum A. Patten, Gary A.B. Armstrong, Alexandra Lissouba, Edor Kabashi, J. Alex Parker, Pierre Drapeau · 2014 · Disease Models & Mechanisms
  11. TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons
    Miriam Annika Vogt, Zahra Ehsaei, Philip Knuckles, Adrian Higginbottom, Michaela S. Helmbrecht, Tilo Kunath, Kevin C. Eggan, Luis A. Williams, Pamela J. Shaw, Wolfgang Wurst et al. · 2018 · Scientific Reports
  12. Reactivation of nonsense-mediated mRNA decay protects against C9orf72 dipeptide-repeat neurotoxicity
    Wangchao Xu, Puhua Bao, Xin Jiang, Haifang Wang, Meiling Qin, Ruiqi L. Wang, Tao Wang, Yi An Yang, Ileana Lorenzini, Lujian Liao et al. · 2019 · Brain
  13. Ibudilast enhances the clearance of SOD1 and TDP-43 aggregates through TFEB-mediated autophagy and lysosomal biogenesis: The new molecular mechanism of ibudilast and its implication for neuroprotective therapy
    Chen, Yanming, Wang, Hongfeng, Ying, Zheng, Gao, Qingzhi · 2020 · Biochemical and Biophysical Research Communications
  14. Screening a UK amyotrophic lateral sclerosis cohort provides evidence of multiple origins of the C9orf72 expansion
    Pietro Fratta, James M. Polke, Jia Newcombe, Sarah Mizielinska, Tammaryn Lashley, Mark Poulter, Jon A. Beck, Elisavet Preza, Anny Devoy, Katie C. L. Sidle et al. · 2014 · Neurobiology of Aging
  15. Immunoprecipitation and mass spectrometry defines an extensive RBM45 protein–protein interaction network
    Yang Li, Mahlon A. Collins, Jiyan An, Rachel Geiser, Tony J. Tegeler, Kristine A. Tsantilas, Krystine Garcia, Patrick Pirrotte, Robert P. Bowser · 2016 · Brain Research
  16. Asparagine endopeptidase is an innovative therapeutic target for neurodegenerative diseases
    Zhen-Tao Zhang, Manling Xie, K. Ye · 2016 · Expert opinion on therapeutic targets
  17. A Case for Microtubule Vulnerability in Amyotrophic Lateral Sclerosis: Altered Dynamics During Disease
    Jayden A. Clark, Elise J. Yeaman, Catherine A. Blizzard, Jyoti A. Chuckowree, Tracey C. Dickson · 2016 · Frontiers in Cellular Neuroscience
  18. MicroRNA Metabolism and Dysregulation in Amyotrophic Lateral Sclerosis
    Paola Rinchetti, Mafalda Rizzuti, Irene Faravelli, Stefania Paola Corti · 2017 · Molecular Neurobiology
  19. From nucleation to widespread propagation: A prion-like concept for ALS
    Zuzanna Maniecka, Magdalini Polymenidou · 2015 · Virus Research
  20. TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination
    Wan Yun Ho, Jer‐Cherng Chang, Kenneth Lim, Amaury Cazenave‐Gassiot, Aivi T. Nguyen, Juat Chin Foo, Sneha Muralidharan, Ashley Viera-Ortiz, Sarah J.M. Ong, Jin Hui Hor et al. · 2021 · The Journal of Cell Biology
  21. Targeting phosphoglycerate kinase 1 with terazosin improves motor neuron phenotypes in multiple models of amyotrophic lateral sclerosis
    Helena Chaytow, Emily Carroll, David Gordon, Yu-Ting Huang, Dinja van der Hoorn, Hannah Louise Smith, Thomas Becker, Catherina Gwynne Becker, Kiterie M. E. Faller, Kevin Talbot et al. · 2022 · EBioMedicine
  22. RNA granules in neuronal plasticity and disease
    Karl E. Bauer, Bruna R. de Queiroz, Michael A. Kiebler, Florence Besse · 2023 · Trends in Neurosciences
  23. Reversible Behavioral Phenotypes in a Conditional Mouse Model of TDP-43 Proteinopathies
    Julio A. Alfieri, Natalia S. Pino, Lionel Muller Igaz · 2014 · Journal of Neuroscience
  24. The role of SIGMAR1 gene mutation and mitochondrial dysfunction in amyotrophic lateral sclerosis
    Kohji Fukunaga, Yasuharu Shinoda, Hideaki Tagashira · 2014 · Journal of Pharmacological Sciences
  25. Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?
    Zhiqiang Deng, Patricia Sheehan, Shi Chen, Zhenyu Yue · 2017 · Molecular Neurodegeneration
  26. MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology
    Javier H. Jara, Mukesh Gautam, Nuran Koçak, Edward F. Xie, Qinwen Mao, Eileen H. Bigio, P. Hande Özdi̇nler · 2019 · Journal of Neuroinflammation
  27. ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration
    Seiji Watanabe, Kotaro Oiwa, Yuri Murata, Okiru Komine, Akira Sobue, Fumito Endo, Eiki Takahashi, Koji Yamanaka · 2020 · Molecular Brain
  28. DNA Damage and Repair Deficiency in ALS/FTD-Associated Neurodegeneration: From Molecular Mechanisms to Therapeutic Implication
    Haibo Wang, Manohar M. Kodavati, Gavin Wayne Britz, Muralidhar L. Hegde · 2021 · Frontiers in Molecular Neuroscience
  29. RNA dysregulation in neurodegenerative diseases
    Yini Li, Shuying Sun · 2025 · The EMBO Journal
  30. Intrinsic disorder in proteins involved in amyotrophic lateral sclerosis
    Nikolas Santamaria, Marwa Alhothali, Maria Belen Harreguy Alfonso, Leonid Breydo, Vladimir Nikolaevich Uversky · 2016 · Cellular and Molecular Life Sciences
  31. Protein Quality Control and the Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Continuum
    Hamideh Shahheydari, Audrey Ragagnin, Adam K. Walker, Reka P. Toth, Marta Vidal, Cyril Jones Jagaraj, Emma R. Perri, Anna Konopka, Jessica M. Sultana, Julie D. Atkin · 2017 · Frontiers in Molecular Neuroscience
  32. Protein aggregation in cell biology: An aggregomics perspective of health and disease
    Dezerae Cox, Candice Raeburn, Xiaojing Sui, Danny M. Hatters · 2018 · Seminars in Cell and Developmental Biology
  33. Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function
    Eva‐Maria Hock, Zuzanna Maniecka, Marián Hruška-Plocháň, Stefan Reber, Florent Laferrière, Sonu Sahadevan, Helena Ederle, Lauren M. Gittings, Lucas Pelkmans, Luc Dupuis et al. · 2018 · Cell Reports
  34. Aggresome formation and liquid–liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43
    Seiji Watanabe, Hidekazu Inami, Kotaro Oiwa, Yuri Murata, Shohei Sakai, Okiru Komine, Akira Sobue, Yohei Iguchi, Masahisa Katsuno, Koji Yamanaka · 2020 · Cell Death and Disease
  35. Multifaceted Genes in Amyotrophic Lateral Sclerosis-Frontotemporal Dementia
    Ramya Ranganathan, Shaila Haque, Kayesha Coley, Stephanie R. Shepheard, Johnathan Cooper‐Knock, Janine Kirby · 2020 · Frontiers in Neuroscience
  36. Huntington’s disease-specific mis-splicing unveils key effector genes and altered splicing factors
    Ainara Elorza, Yamile Márquez, Jorge Rubén Cabrera, Jose L. Sanchez‐Trincado, María Santos‐Galindo, Ivó H. Hernández, Sara Picó, Juan Ignacio Díaz‐Hernandéz, Ramón García‐Escudero, Manuel Irimia et al. · 2021 · Brain
  37. A common gene expression signature in Huntington’s disease patient brain regions
    Andreas Neueder, Gillian P. Bates · 2014 · BMC Medical Genomics
  38. ALS-linked mutations in ubiquilin-2 or hnRNPA1 reduce interaction between ubiquilin-2 and hnRNPA1
    Kathleen M. Gilpin, Lydia Chang, Mervyn J. Monteiro · 2015 · Human Molecular Genetics
  39. Frontotemporal dementia: insights into the biological underpinnings of disease through gene co-expression network analysis
    Raffaele Ferrari, Paola Forabosco, Jana Vandrovcová, Juan Antonio Botía, Sebastian Guelfi, Jason D. Warren, Parastoo Momeni, Michael E. Weale, Mina Ryten, John Hardy · 2016 · Molecular Neurodegeneration
  40. RRM domain of ALS/FTD-causing FUS characteristic of irreversible unfolding spontaneously self-assembles into amyloid fibrils
    Yimei Lu, Liangzhong Lim, Jianxing Song · 2017 · Scientific Reports
  41. PURA, the Gene Encoding Pur-alpha, Member of an Ancient Nucleic Acid-binding Protein Family with Mammalian Neurological Functions
    D. C. Daniel, E. Johnson · 2017 · Gene
  42. Twin CHCH Proteins, CHCHD2, and CHCHD10: Key Molecules of Parkinson’s Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia
    Yuzuru Imai, Hongrui Meng, Kahori Shiba‐Fukushima, Nobutaka Hattori · 2019 · International Journal of Molecular Sciences
  43. ALS and FTD: Where RNA metabolism meets protein quality control
    Jessica Mandrioli, Laura Mediani, Simon Alberti, Serena Carra · 2019 · Seminars in Cell and Developmental Biology
  44. C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis
    Qiang Shao, Mei Yang, Liang Chen, Li Ma, Wei Zhang, Zhiwen Jiang, Jun Luo, Jae‐Kyung Lee, Chengyu Liang, Jian‐Fu Chen · 2019 · Autophagy
  45. RNA-mediated toxicity in C9orf72 ALS and FTD
    Zachary T. McEachin, Janani Parameswaran, Nisha Raj, Gary Jonathan Bassell, Jie Jiang · 2020 · Neurobiology of Disease
  46. The role of DNA damage response in amyotrophic lateral sclerosis
    Yu Sun, Annabel J. Curle, Arshad M. Haider, Gabriel Balmus · 2020 · Essays in Biochemistry
  47. Diagnostics of Amyotrophic Lateral Sclerosis: Up to Date
    Ivana Štětkářová, Edvard Ehler · 2021 · Diagnostics
  48. Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice
    Chunxing Yang, Tao Qiao, Jia Hui Yu, Hongyan Wang, Yansu Guo, Johnny S. Salameh, Jake Metterville, Sepideh Parsi, Issa Olakunle Yusuf, Robert H. Brown et al. · 2022 · PLoS ONE
  49. Blood biomarkers in ALS : challenges, applications and novel frontiers
    Ellie Sturmey, Andrea Malaspina · 2022 · Acta Neurologica Scandinavica
  50. Endoplasmic reticulum stress and its role in various neurodegenerative diseases
    Rimaljot Singh, Navpreet Kaur, Vinay Choubey, Neelima Dhingra, Tanzeer Kaur · 2023 · Brain Research
  51. Failure to Deliver and Translate—New Insights into RNA Dysregulation in ALS
    Alyssa N. Coyne, Benjamin L. Zaepfel, Daniela C. Zarnescu · 2017 · Frontiers in Cellular Neuroscience
  52. Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration
    Ahmed Yousef, John L. Robinson, David John Irwin, Matthew D. Byrne, Linda K. Kwong, Edward B. Lee, Yan Xu, Sharon Xiangwen Xie, Lior Rennert, EunRan R. Suh et al. · 2017 · Acta Neuropathologica Communications
  53. R-Loops in Motor Neuron Diseases
    Martina G. L. Perego, Michela Maria Taiana, Nereo Bresolin, Giacomo P. Comi, Stefania Paola Corti · 2018 · Molecular Neurobiology
  54. Artificial MicroRNAs Targeting C9orf72 Can Reduce Accumulation of Intra-nuclear Transcripts in ALS and FTD Patients
    Raygene Martier, Jolanda M.P. Liefhebber, Jana Miniarikova, Tom van der Zon, Jolanda Snapper, Iris C. R. M. Kolder, Harald Petry, Sander J. H. van Deventer, Melvin M. Evers, Pavlina S. Konstantinova · 2019 · Molecular Therapy — Nucleic Acids
  55. TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes
    Thomas J. LaRocca, Andrea Mariani, Linda R. Watkins, Christopher D. Link · 2019 · Neurobiology of Disease
  56. Prion-Like Proteins in Phase Separation and Their Link to Disease
    Macy L. Sprunger, Meredith E. Jackrel · 2021 · Biomolecules
  57. Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43
    Sean S. Keating, Adekunle T. Bademosi, Rebecca San Gil, Adam K. Walker · 2023 · Cellular and Molecular Life Sciences
  58. A model of human neural networks reveals NPTX2 pathology in ALS and FTLD
    Marián Hruška-Plocháň, Vera I. Wiersma, Katharina M. Betz, Izaskun Mallona, Silvia Ronchi, Zuzanna Maniecka, Eva‐Maria Hock, Elena Tantardini, Florent Laferrière, Sonu Sahadevan et al. · 2024 · Nature
  59. Antisense Oligonucleotide Therapy for the Treatment of C9ORF72 ALS/FTD Diseases
    Giulietta Maria Riboldi, Chiara Zanetta, Michela Ranieri, Monica Nizzardo, Chiara Simone, Francesca Magri, Nereo Bresolin, Giacomo P. Comi, Stefania Paola Corti · 2014 · Molecular Neurobiology
  60. There Is an Inclusion for That: Material Properties of Protein Granules Provide a Platform for Building Diverse Cellular Functions
    Daniel Kaganovich · 2017 · Trends in Biochemical Sciences
  61. The Study of Language in the Amyotrophic Lateral Sclerosis - Frontotemporal Spectrum Disorder: a Systematic Review of Findings and New Perspectives
    Marta Pinto‐Grau, Orla M. Hardiman, Niall P Pender · 2018 · Neuropsychology Review
  62. Imaging Biomarkers for the Diagnosis and Prognosis of Neurodegenerative Diseases. The Example of Amyotrophic Lateral Sclerosis
    Miguel Mazón, Juan Francisco Vazquez-Costa, Amadeo Ten‐Esteve, Luis Martí‐Bonmatí · 2018 · Frontiers in Neuroscience
  63. The multifaceted role of kinases in amyotrophic lateral sclerosis: genetic, pathological and therapeutic implications
    Wenting Guo, Tijs Vandoorne, Jolien Steyaert, Kim A. Staats, Ludo Van Den Bosch · 2020 · Brain
  64. Expression of FSHD‐related DUX4‐FL alters proteostasis and induces TDP‐43 aggregation
    Sachiko T. Homma, Mary Lou Beermann, Frederick M. Boyce, Jeffrey B. Miller · 2015 · Annals of Clinical and Translational Neurology
  65. RNA–protein interactions in unstable microsatellite diseases
    Apoorva Mohan, Marianne Goodwin, Maurice S. Swanson · 2014 · Brain Research
  66. Nuclear transport dysfunction: a common theme in amyotrophic lateral sclerosis and frontotemporal dementia
    Ana Jovičić, Joseph West Paul, Aaron D. Gitler · 2016 · Journal of Neurochemistry
  67. C9orf72: At the intersection of lysosome cell biology and neurodegenerative disease
    Joseph Amick, Shawn M. Ferguson · 2017 · Traffic
  68. Cerebrospinal Fluid TAR DNA-Binding Protein 43 Combined with Tau Proteins as a Candidate Biomarker for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Spectrum Disorders
    Mara Bourbouli, Michael Rentzos, Anastasia M. Bougea, Vasiliki Zouvelou, Vasilios C. Constantinides, Ioannis V. Zaganas, Ioannis Evdokimidis, Elisabeth N. Kapaki, George P. Paraskevas · 2017 · Dementia and Geriatric Cognitive Disorders
  69. The impact of histone post-translational modifications in neurodegenerative diseases
    Samantha N. Cobos, Seth A. Bennett, Mariana P. Torrente · 2018 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  70. A directional 3D neurite outgrowth model for studying motor axon biology and disease
    Xandor M. Spijkers, Svetlana Pasteuning-Vuhman, Jennifa C. Dorleijn, Paul Vulto, Nienke R. Wevers, R. Jeroen Pasterkamp · 2021 · Scientific Reports
  71. Longitudinal diffusion imaging across the <i>C9orf72</i> clinical spectrum
    Floeter, Mary Kay, Danielian, Laura E, Braun, Laura E, Wu, Tianxia · 2018 · Journal of Neurology, Neurosurgery &amp; Psychiatry
  72. The Complex Mechanisms by Which Neurons Die Following DNA Damage in Neurodegenerative Diseases
    Sina Shadfar, Mariana G. Brocardo, Julie D. Atkin · 2022 · International Journal of Molecular Sciences
  73. Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72 -ALS iPSC-derived microglia contributes to neurodegeneration
    Poulomi Banerjee, Arpan R. Mehta, Raja Sekhar Nirujogi, James D. Cooper, Owen G. James, Jyoti Nanda, James Longden, Karen Burr, Karina McDade, Andrea Salzinger et al. · 2023 · Science Advances
  74. KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury
    Jesse D. Lai, Joshua E. Berlind, Gabriella Fricklas, Cecilia Lie, Jean‐Paul Urenda, Kelsey Lam, Naomi S. Sta Maria, Russell E. Jacobs, Violeta L. Yu, Zhen Zhao et al. · 2024 · Cell stem cell
  75. Worming forward: amyotrophic lateral sclerosis toxicity mechanisms and genetic interactions in Caenorhabditis elegans
    Martine Therrien, J. Alex Parker · 2014 · Frontiers in Genetics
  76. Resting state fMRI correlates of Theory of Mind impairment in amyotrophic lateral sclerosis
    Francesca Trojsi, Federica Di Nardo, Gabriella Santangelo, Mattia Siciliano, Cinzia Femiano, Carla Passaniti, Giuseppina Caiazzo, Michele Fratello, Mario Cirillo, Maria Rosaria Monsurrò et al. · 2017 · Cortex
  77. Transcription elongation factor AFF2/FMR2 regulates expression of expanded GGGGCC repeat-containing C9ORF72 allele in ALS/FTD
    Yeliz Yuva-Aydemir, Sandra Almeida, Gopinath Krishnan, Tania F. Gendron, Fen‐Biao Gao · 2019 · Nature Communications
  78. Nuclear Periphery Takes Center Stage: The Role of Nuclear Pore Complexes in Cell Identity and Aging
    Ukrae H Cho, Martin W. Hetzer · 2020 · Neuron
  79. Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation
    Eugénie Ansseau, Jocelyn O. Eidahl, Céline Lancelot, Alexandra Tassin, Christel Mattéotti, Cassandre Yip, Jian Liu, Baptiste Leroy, Céline Hubeau, Cécile Gerbaux et al. · 2016 · PLoS ONE
  80. Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
    Avital Licht-Murava, Samantha M. Meadows, Fernando Palaguachi, Soomin C. Song, Yaron Bram, Constance Q. Zhou, Stephanie Jackvony, Robert E. Schwartz, Robert C. Froemke, Adam L. Orr et al. · 2023 · Science Advances
  81. hnRNP A1 dysfunction alters RNA splicing and drives neurodegeneration in multiple sclerosis (MS)
    Hannah E. Salapa, P. Thibault, Cole D. Libner, Yu-Lian Ding, Joseph P. Clarke, C. Denomy, Catherine Hutchinson, Hashim M. Abidullah, S. A. Hammond, Landon Pastushok et al. · 2024 · Nature Communications
  82. Network Analyses Reveal Novel Aspects of ALS Pathogenesis
    Mario Sanhueza, Andrea Chai, Colin Smith, Brett A. McCray, T. Ian Simpson, J. Paul Taylor, Giuseppa Pennetta · 2015 · PLoS Genetics
  83. Rac1 at the crossroad of actin dynamics and neuroinflammation in Amyotrophic Lateral Sclerosis
    Nadia Dâ€TMAmbrosi, Simona Rossi, Valeria Gerbino, Mauro Cozzolino · 2014 · Frontiers in Cellular Neuroscience
  84. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration–associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways
    Tao Wang, Xin Jiang, Gang Chen, Jin Xu · 2014 · Neurobiology of Aging
  85. RNA Granules and Diseases: A Case Study of Stress Granules in ALS and FTLD
    Alexander C. Fan, Anthony K. L. Leung · 2016 · Advances in experimental medicine and biology
  86. ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization
    Gijs H.P. Tazelaar, Steven Boeynaems, Mathias De Decker, Joke J.F.A. van Vugt, Lindy Kool, Hendrik Stephan Goedee, Russell Lewis McLaughlin, William Sproviero, Alfredo Iacoangeli, Matthieu Moisse et al. · 2020 · Brain Communications
  87. Drosophila Glia: Models for Human Neurodevelopmental and Neurodegenerative Disorders
    Taejoon Kim, Bokyeong Song, Im‐Soon Lee · 2020 · International Journal of Molecular Sciences
  88. Reversible Kinetic Trapping of FUS Biomolecular Condensates
    Sayantan Chatterjee, Yelena Kan, Mateusz Brzeziński, Kaloian Koynov, Roshan Mammen Regy, Anastasia C. Murthy, Kathleen A. Burke, Jasper J. Michels, Jeetain Mittal, Nicolas Lux Fawzi et al. · 2021 · Advanced Science
  89. Preclinical evaluation of WVE-004, an investigational stereopure oligonucleotide for the treatment of C9orf72-associated ALS or FTD
    Yuanjing Liu, Amy Andreucci, Naoki Iwamoto, Yuan Yin, Hailin Yang, Fangjun Liu, Alexey Bulychev, Xiao Shelley Hu, Xuena Lin, Sarah D. Lamore et al. · 2022 · Molecular Therapy — Nucleic Acids
  90. Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD
    Gopinath Krishnan, Denitza Raitcheva, Daniel A. Bartlett, Mercedes Prudencio, Diane M. McKenna-Yasek, Catherine L. Douthwright, Björn Oskarsson, Shafeeq S. Ladha, Oliver D. King, Sami J. Barmada et al. · 2022 · Nature Communications
  91. Molecular Dissection of TDP-43 as a Leading Cause of ALS/FTLD
    Yoshitaka Tamaki, Makoto Urushitani · 2022 · International Journal of Molecular Sciences
  92. Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes
    Eliana Lauranzano, Silvia Pozzi, Laura Pasetto, Riccardo Stucchi, Tania Massignan, Katia Paolella, Melissa Mombrini, Giovanni Nardo, Christian Lunetta, Massimo Corbo et al. · 2015 · Brain
  93. The Emerging Roles of MicroRNAs in the Pathogenesis of Frontotemporal Dementia–Amyotrophic Lateral Sclerosis (FTD-ALS) Spectrum Disorders
    Eduardo Gascon, Fen‐Biao Gao · 2014 · Journal of Neurogenetics
  94. The Genetics of Monogenic Frontotemporal Dementia
    Leonel Tadao Takada · 2015 · Dementia & Neuropsychologia
  95. Lost in Translation: Evidence for Protein Synthesis Deficits in ALS/FTD and Related Neurodegenerative Diseases
    Erik M. Lehmkuhl, Daniela C. Zarnescu · 2018 · Advances in neurobiology
  96. Phosphorylation of nuclear Tau is modulated by distinct cellular pathways
    Giorgio Ulrich, Agnese Salvadè, Paul J. Boersema, Tito Calí, Chiara Foglieni, Martina Sola, Paola Picotti, Stéphanie Papin, Paolo Paganetti · 2018 · Scientific Reports
  97. A standard operating procedure for King’s ALS clinical staging
    Rubika Balendra, Ahmad Al Khleifat, Ton Fang, Ammar Al‐Chalabi · 2019 · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
  98. The Autophagy Signaling Pathway: A Potential Multifunctional Therapeutic Target of Curcumin in Neurological and Neuromuscular Diseases
    Lorena Perrone, Tiziana Squillaro, Filomena Napolitano, Chiara Terracciano, Simone Sampaolo, Mariarosa Anna Beatrice Melone · 2019 · Nutrients
  99. A Systematic Review of Genotype–Phenotype Correlation across Cohorts Having Causal Mutations of Different Genes in ALS
    Owen Connolly, Laura Le Gall, Gavin McCluskey, Colette G. Donaghy, William John Duddy, Stéphanie Duguez · 2020 · Journal of Personalized Medicine
  100. Liquid–Liquid Phase Separation Enhances TDP-43 LCD Aggregation but Delays Seeded Aggregation
    Donya Pakravan, Emiel Michiels, Anna Bratek‐Skicki, Mathias De Decker, Joris Van Lindt, David Alsteens, Sylvie Derclaye, Philip Van Damme, Joost W. H. Schymkowitz, Frédéric Rousseau et al. · 2021 · Biomolecules