Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

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1. Screening of CHCHD10 in a French cohort confirms the involvement of this gene in frontotemporal dementia with amyotrophic lateral sclerosis patients
   Annabelle Chaussenot, Isabelle Le Ber, Samira Ait-El-Mkadem, Agnès Camuzat, Anne Langlois de Septenville, Sylvie Bannwarth, Emmanuelle C. Genin, Valérie Serre, Gaëlle Augé, Alexis Brice et al. · 2014 · Neurobiology of Aging
2. Amyotrophic lateral sclerosis: Current perspectives from basic research to the clinic
   Renzo Mancuso, Xavier Navarro · 2015 · Progress in Neurobiology
3. Repeat associated non-ATG (RAN) translation: new starts in microsatellite expansion disorders
   John Douglas Cleary, Laura P.W. Ranum · 2014 · Current Opinion in Genetics & Development
4. In Vivo Translatome Profiling in Spinal Muscular Atrophy Reveals a Role for SMN Protein in Ribosome Biology
   Paola Bernabò, Toma Tebaldi, Ewout J. N. Groen, Fiona M. Lane, Elena Perenthaler, Francesca Mattedi, Helen J. Newbery, Haiyan Zhou, Paola Zuccotti, Valentina Potrich et al. · 2017 · Cell Reports
5. Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis
   Leeanne McGurk, Jelena Mojsilovic‐Petrovic, Vivianna M. Van Deerlin, James Shorter, Robert Gordon Kalb, V. M. Lee, John Q. Trojanowski, E. B. Lee, Nancy M. Bonini · 2018 · Acta Neuropathologica Communications
6. ATP enhances at low concentrations but dissolves at high concentrations liquid-liquid phase separation (LLPS) of ALS/FTD-causing FUS
   Jian Kang, Liangzhong Lim, Jianxing Song · 2018 · Biochemical and Biophysical Research Communications
7. Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress
   Fabiola Rojas, Nicole Cortés, Sebastián Abarzúa, Agnieszka Dyrda, Brigitte van Zundert · 2014 · Frontiers in Cellular Neuroscience
8. Protein folding alterations in amyotrophic lateral sclerosis
   Sonam Parakh, Julie D. Atkin · 2016 · Brain Research
9. Cytoplasmic poly-GA aggregates impair nuclear import of TDP-43 in C9orf72 ALS/FTLD
   Bahram Khosravi, Hannelore Hartmann, Stephanie May, Christoph Möhl, Helena Ederle, Meike Michaelsen, Martin H. Schludi, Dorothee Dormann, Dieter Edbauer · 2016 · Human Molecular Genetics
10. Tdp-43 cryptic exons are highly variable between cell types
    Yun Ha Jeong, Jonathan P. Ling, Sophie Z. Lin, Aneesh Donde, Kerstin E. Braunstein, Elisa Majounie, Bryan J. Traynor, Katherine D. LaClair, Thomas E. Lloyd, Philip C. Wong · 2017 · Molecular Neurodegeneration
11. ALS/FTD mutant CHCHD10 mice reveal a tissue-specific toxic gain-of-function and mitochondrial stress response
    Corey J. Anderson, Kirsten G. Bredvik, Suzanne R. Burstein, Crystal Davis, Samantha M. Meadows, Jalia Dash, Laure K. Case, Teresa A. Milner, Hibiki Kawamata, Aamir R. Zuberi et al. · 2019 · Acta Neuropathologica
12. Autophagy as a common pathway in amyotrophic lateral sclerosis
    Dao K.H. Nguyen, Ravi Thombre, Jiou Wang · 2018 · Neuroscience Letters
13. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains
    Christian Haenig, Nir Atias, Alexander K. Taylor, Arnon Mazza, Martin H. Schaefer, Jenny Russ, Sean‐Patrick Riechers, Shushant Jain, Maura Coughlin, Jean−Fred Fontaine et al. · 2020 · Cell Reports
14. Protein misfolding and amyloid nucleation through liquid–liquid phase separation
    Semanti Mukherjee, Manisha Poudyal, Kritika Dave, Pradeep Kadu, Samir Kumar Maji · 2024 · Chemical Society Reviews
15. Induction of COX-2-PGE2 synthesis by activation of the MAPK/ERK pathway contributes to neuronal death triggered by TDP-43-depleted microglia
    Q Xia, Qingsong Hu, H Wang, H Yang, Feng Gao, Haigang Ren, D Chen, Chaoying Fu, Li Ping Zheng, Xuechu Zhen et al. · 2015 · Cell Death and Disease
16. FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination
    Kyota Yasuda, Sarah F. Clatterbuck Soper, Meredith E. Jackrel, James Shorter, Stavroula Mili · 2017 · The Journal of Cell Biology
17. Impaired NHEJ repair in amyotrophic lateral sclerosis is associated with TDP-43 mutations
    Anna Konopka, Donna R. Whelan, Md Shafi Jamali, Emma R. Perri, Hamideh Shahheydari, Reka P. Toth, Sonam Parakh, Tina Robinson, Alison Cheong, Prachi M. Mehta et al. · 2020 · Molecular Neurodegeneration
18. Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy
    Kelsey L. Krus, Amy M. Strickland, Yurie Yamada, Laura DeVault, Robert E. Schmidt, A. Joseph Bloom, Jeffrey Milbrandt, Aaron DiAntonio · 2022 · Cell Reports
19. Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export
    Lauren Duan, Benjamin L. Zaepfel, Vasilisa Aksenova, Mary Dasso, Jeffrey D. Rothstein, Petr Kaláb, Lindsey R. Hayes · 2022 · Cell Reports
20. The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?
    Doty, Kevin R., Guillot-Sestier, Marie-Victoire, Town, Terrence · 2015 · Brain Research
21. Role of FET proteins in neurodegenerative disorders
    Francesca Svetoni, Paola Frisone, Maria Paola Paronetto · 2016 · RNA Biology
22. TDP-43 and Tau Oligomers in Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia
    Mauro Montalbano, Salomé McAllen, Filippa Lo Cascio, Urmi Sengupta, Stephanie García, Nemil N. Bhatt, Anna Ellsworth, Eric A. Heidelman, Omar D. Johnson, Samantha D. Doskocil et al. · 2020 · Neurobiology of Disease
23. Molecular structure and interactions within amyloid-like fibrils formed by a low-complexity protein sequence from FUS
    Myungwoon Lee, Ujjayini Ghosh, Kent R. Thurber, Masato Kato, Robert Tycko · 2020 · Nature Communications
24. Focality, stochasticity and neuroanatomic propagation in ALS pathogenesis
    John Ravits · 2014 · Experimental Neurology
25. Advances in molecular pathology, diagnosis, and treatment of amyotrophic lateral sclerosis
    Ilieva, Hristelina, Vullaganti, Mithila, Kwan, Justin · 2023 · BMJ
26. ALS mutant SOD1 interacts with G3BP1 and affects stress granule dynamics
    József Gál, Lisha Kuang, Kelly R. Barnett, Brian Zhu, Susannah Claire Shissler, Konstantin V. Korotkov, Lawrence J. Hayward, Edward J. Kasarskis, Haining Zhu · 2016 · Acta Neuropathologica
27. Cellular stress leads to the formation of membraneless stress assemblies in eukaryotic cells
    Wessel van Leeuwen, Cathérine Rabouille · 2019 · Traffic
28. The established and emerging roles of astrocytes and microglia in amyotrophic lateral sclerosis and frontotemporal dementia
    Rowan A. W. Radford, Marco Morsch, Stephanie L. Rayner, Nicholas James Cole, Dean L. Pountney, Roger S. Chung · 2015 · Frontiers in Cellular Neuroscience
29. Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosis
    Matthew Joseph Fogarty, Paul M. Klenowski, John D. Lee, Joy R. Drieberg-Thompson, Selena E. Bartlett, Shyuan Thieu Ngo, Massimo A. Hilliard, Mark C. Bellingham, Peter G. Noakes · 2016 · Scientific Reports
30. Ageing as a risk factor for ALS/FTD
    Teresa Niccoli, Linda Partridge, Adrian M. Isaacs · 2017 · Human Molecular Genetics
31. Transcriptome–pathology correlation identifies interplay between TDP-43 and the expression of its kinase CK1E in sporadic ALS
    Florian Krach, Ranjan Batra, Emily C. Wheeler, Anthony Q. Vu, Ruth Wang, Kasey R. Hutt, Stuart J. Rabin, Michael W. Baughn, Ryan T. Libby, Sandra Díaz-García et al. · 2018 · Acta Neuropathologica
32. RNA-Binding Proteins Hold Key Roles in Function, Dysfunction, and Disease
    Kelaini, Sophia, Chan, Celine, Cornelius, Victoria A, Margariti, Andriana · 2021 · Biology
33. Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS
    Alyssa N. Coyne, Ileana Lorenzini, Ching‐Chieh Chou, Meaghan Torvund, Robert S. Rogers, Alexander Starr, Benjamin L. Zaepfel, Jennifer Levy, Jeffrey Johannesmeyer, Jacob C. Schwartz et al. · 2017 · Cell Reports
34. FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention
    Jack Humphrey, Nicol Birsa, Carmelo Milioto, Martha McLaughlin, Agnieszka M Ule, David Robaldo, Andrea B Eberle, Rahel Kräuchi, Matthew P. Bentham, Anna‐Leigh Brown et al. · 2020 · Nucleic Acids Research
35. Natural Compounds and Autophagy: Allies Against Neurodegeneration
    Alessandra Stacchiotti, Giovanni Corsetti · 2020 · Frontiers in Cell and Developmental Biology
36. Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS
    Prajwal Ciryam, Isabella A. Lambert-Smith, Daniel M. Bean, Rosie Freer, Fernando Cid, Gian Gaetano Tartaglia, Darren N. Saunders, Mark R. Wilson, Stephen G. Oliver, Richard I. Morimoto et al. · 2017 · Proceedings of the National Academy of Sciences
37. The ALS-linked E102Q mutation in Sigma receptor-1 leads to ER stress-mediated defects in protein homeostasis and dysregulation of RNA-binding proteins
    Alice Dreser, Jan Tilmann Vollrath, Antonio S. Sechi, Sonja Johann, Andreas Roos, Alfred Yamoah, Istvan Katona, Saeed Bohlega, Dominik Wiemuth, Yuemin Tian et al. · 2017 · Cell Death and Differentiation
38. Platelets in Neurodegenerative Conditions—Friend or Foe?
    Odette Leiter, Tara L. Walker · 2020 · Frontiers in Immunology
39. Aberrant phase separation and cancer
    Kenzui Taniue, Nobuyoshi Akimitsu · 2021 · FEBS Journal
40. FUS Mutant Human Motoneurons Display Altered Transcriptome and microRNA Pathways with Implications for ALS Pathogenesis
    De Santis, Riccardo, Santini, Laura, Colantoni, Alessio, Peruzzi, Giovanna, de Turris, Valeria, Alfano, Vincenzo, Bozzoni, Irene, Rosa, Alessandro · 2017 · Stem Cell Reports
41. Co-regulation of mRNA translation by TDP-43 and Fragile X Syndrome protein FMRP
    Pritha Majumder, Jen-Fei Chu, Biswanath Chatterjee, Krishna B. S. Swamy, Che-Kun James Shen · 2016 · Acta Neuropathologica
42. A feedback loop between dipeptide-repeat protein, TDP-43 and karyopherin-α mediates C9orf72-related neurodegeneration
    Daniel A. Solomon, Alan Stepto, Wing Hei Au, Yoshitsugu Adachi, Danielle C. Diaper, Rachel Hall, Anjeet Rekhi, Adel Boudi, Paraskevi Tziortzouda, Youn‐Bok Lee et al. · 2018 · Brain
43. Endoplasmic reticulum–mitochondria crosstalk: from junction to function across neurological disorders
    Pabbala Veeresh, Harpreet Kaur, Deepaneeta Sarmah, Leela Mounica, Geetesh Verma, Vignesh Kotian, Radhika Kesharwani, Kiran Kalia, Anupom Borah, Xin Wang et al. · 2019 · Annals of the New York Academy of Sciences
44. TDP-43 Regulates Coupled Dendritic mRNA Transport-Translation Processes in Co-Operation with FMRP and Staufen1: A Mechanistic View
    Jen-Fei Chu, Pritha Majumder, Biswanath Chatterjee, Shih‐Ling Huang, Che-Kun James Shen · 2018 · Cell Reports
45. Molecular Mechanisms Underlying TDP-43 Pathology in Cellular and Animal Models of ALS and FTLD
    Alistair Wood, Yuval Gurfinkel, Nicole Polain, Wesley G. Lamont, Sarah Lyn Rea · 2021 · International Journal of Molecular Sciences
46. Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer’s disease
    Tracy L. Young‐Pearse, Hyo Lee, Yi‐Chen Hsieh, Vicky Chou, Dennis J. Selkoe · 2023 · Trends in Neurosciences
47. Degeneration of proprioceptive sensory nerve endings in mice harboring amyotrophic lateral sclerosis–causing mutations
    Sydney V. Doss, Zachary Kemp, Theo Hatzipetros, Fernando G. Vieira, Gregorio Valdez · 2015 · The Journal of Comparative Neurology
48. 3′UTR Length-Dependent Control of SynGAP Isoform α2 mRNA by FUS and ELAV-like Proteins Promotes Dendritic Spine Maturation and Cognitive Function
    Satoshi Yokoi, Tsuyoshi Udagawa, Yusuke Fujioka, Daiyu Honda, Haruo Okado, Hirohisa Watanabe, Masahisa Katsuno, Shinsuke Ishigaki, Gen Sobue · 2017 · Cell Reports
49. Excitatory Dendritic Mitochondrial Calcium Toxicity: Implications for Parkinson’s and Other Neurodegenerative Diseases
    Manish Verma, Zachary P. Wills, Charleen T. Chu · 2018 · Frontiers in Neuroscience
50. Fused in Sarcoma: Properties, Self-Assembly and Correlation with Neurodegenerative Diseases
    Chen Chen, Xiufang Ding, Nimrah Akram, Song Xue, Shizhong Luo · 2019 · Molecules
51. Nuclear pore complexes — a doorway to neural injury in neurodegeneration
    Coyne, Alyssa N., Rothstein, Jeffrey D. · 2022 · Nature Reviews Neurology
52. Phase to Phase with TDP-43
    Yulong Sun, Avijit Chakrabartty · 2017 · Biochemistry
53. Genetics insight into the amyotrophic lateral sclerosis/frontotemporal dementia spectrum
    Ai-Ling Ji, Xia Zhang, Weiwei Chen, Wenjuan Huang · 2017 · Journal of Medical Genetics
54. Optineurin in amyotrophic lateral sclerosis: Multifunctional adaptor protein at the crossroads of different neuroprotective mechanisms
    Andrea Markovinović, Raffaello Cimbro, Tereza Ljutić, Jasna Križ, Boris Rogelj, Ivana Munitić · 2017 · Progress in Neurobiology
55. Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions
    Miguel Mompeán, Valentina C. Romano, David Pantoja‐Uceda, Cristiana Stuani, Francisco Ernesto Baralle, Emanuele Buratti, Douglas V. Laurents · 2017 · Journal of Biological Chemistry
56. Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity
    Elke Bogaert, Steven Boeynaems, Masato Kato, Lin E. Guo, Thomas R. Caulfield, Jolien Steyaert, Wendy Scheveneels, Nathalie Wilmans, Wanda Haeck, Nicole Hersmus et al. · 2018 · Cell Reports
57. Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum
    Karch, Celeste M., Wen, Natalie, Fan, Chun C., Yokoyama, Jennifer S., Kouri, Naomi, Ross, Owen A., Höglinger, Gunter, Müller, Ulrich, Ferrari, Raffaele, Hardy, John et al. · 2018 · JAMA Neurology
58. Increased prevalence of autoimmune disease within C9 and FTD/MND cohorts: Completing the picture
    Miller, Zachary A., Sturm, Virginia E., Camsari, Gamze Balci, Karydas, Anna, Yokoyama, Jennifer S., Grinberg, Lea T., Boxer, Adam L., Rosen, Howard J., Rankin, Katherine P., Gorno-Tempini, Maria Luisa et al. · 2016 · Neurology Neuroimmunology & Neuroinflammation
59. Chaperones in Neurodegeneration
    Iris Lindberg, James Shorter, R. Luke Wiseman, Fabrizio Chiti, Chad A. Dickey, Pamela J. McLean · 2015 · Journal of Neuroscience
60. Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation and inclusion formation
    Lei-Lei Jiang, Jian Zhao, Xiao-Fang Yin, Wen-Tian He, Hui Yang, Meixia Che, Hong-Yu Hu · 2016 · Scientific Reports
61. Loss of TDP‐43 oligomerization or RNA binding elicits distinct aggregation patterns
    Manuela Pérez‐Berlanga, Vera I. Wiersma, Aurélie Zbinden, Laura De Vos, Ulrich Wagner, Chiara Foglieni, Izaskun Mallona, Katharina M Betz, Antoine Cléry, Julien Weber et al. · 2023 · The EMBO Journal
62. RNA binding proteins and the pathological cascade in ALS/FTD neurodegeneration
    Daisuke Ito, Mami Hatano, Norihiro Suzuki · 2017 · Science Translational Medicine
63. An Intramolecular Salt Bridge Linking TDP43 RNA Binding, Protein Stability, and TDP43-Dependent Neurodegeneration
    Brittany N. Flores, Xingli Li, Ahmed Mujtaba Malik, Jose Martinez, Asim A. Beg, Sami J. Barmada · 2019 · Cell Reports
64. Promiscuous Roles of Autophagy and Proteasome in Neurodegenerative Proteinopathies
    Fiona Limanaqi, Francesca Biagioni, Stefano Gambardella, Pietro Familiari, Alessandro Frati, Francesco Fornai · 2020 · International Journal of Molecular Sciences
65. Neuroinflammation in motor neuron disease
    Fumito Endo, Okiru Komine, Koji Yamanaka · 2016 · Clinical and Experimental Neuroimmunology
66. Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation
    Alyssa N. Coyne, Shizuka B. Yamada, Bhavani Bagevalu Siddegowda, Patricia S. Estes, Benjamin L. Zaepfel, Jeffrey Johannesmeyer, Donovan B. Lockwood, Linh Thuy Pham, Michael P. Hart, Joel A. Cassel et al. · 2015 · Human Molecular Genetics
67. Extracellular Vesicles as Innovative Tool for Diagnosis, Regeneration and Protection against Neurological Damage
    Pavle R. Anđjus, Maja Kosanović, Katarina D. Milicevic, Mukesh Gautam, Seppo Juhani Vainio, Denis Jagečić, Elena N. Kozlova, Augustas Pivoriūnas, Juan Carlos Chachques, Mirena Sakaj et al. · 2020 · International Journal of Molecular Sciences
68. Cortical Function in Asymptomatic Carriers and Patients WithC9orf72Amyotrophic Lateral Sclerosis
    Nimeshan Geevasinga, Parvathi Menon, Garth A. Nicholson, Karl Ng, James Howells, Jillian J. Kril, Con Yiannikas, Matthew C. Kiernan, Steve Vucic · 2015 · JAMA Neurology
69. TDP‐43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons
    Benjamin M. Schwenk, Hannelore Hartmann, Alperen Serdaroglu, Martin H. Schludi, Daniel Hornburg, Felix Meissner, Denise Orozco, Alessio Vittorio Colombo, Sabina Tahirović, Meike Michaelsen et al. · 2016 · The EMBO Journal
70. Targeting RNA-Mediated Toxicity in C9orf72 ALS and/or FTD by RNAi-Based Gene Therapy
    Raygene Martier, Jolanda M.P. Liefhebber, Ana García‐Osta, Jana Miniarikova, Mar Cuadrado‐Tejedor, María Espelosin, Susana Ursúa, Harald Petry, Sander J. H. van Deventer, Melvin M. Evers et al. · 2019 · Molecular Therapy — Nucleic Acids
71. Targeting stress granules: A novel therapeutic strategy for human diseases
    Fei Wang, Juan Li, Shengjie Fan, Zhigang Jin, Cheng Huang · 2020 · Pharmacological Research
72. Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons
    Cristián Arredondo, Carolina Cefaliello, Agnieszka Dyrda, Nur Jury, Pablo Martínez, Iván Darío Parrado Díaz, Armando Amaro, Hélène Tran, Danna Morales, Marı́a Pertusa et al. · 2022 · Neuron
73. TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domain
    Mauricio Budini, Valentina C. Romano, Zainuddin Quadri, Emanuele Buratti, Francisco Ernesto Baralle · 2014 · Human Molecular Genetics
74. Endoplasmic reticulum and mitochondria in diseases of motor and sensory neurons: a broken relationship?
    Nathalie Bernard‐Marissal, Roman Chrast, Bernard Laurent Schneider · 2018 · Cell Death and Disease
75. Nucleocytoplasmic transport defects in neurodegeneration — Cause or consequence?
    Saskia Hutten, Dorothee Dormann · 2019 · Seminars in Cell and Developmental Biology
76. Motor cortex transcriptome reveals microglial key events in amyotrophic lateral sclerosis
    Oriol Dols‐Icardo, Víctor Montal, Sònia Sirisi, Gema López‐Pernas, Laura Cervera‐Carles, Marta Querol‐Vilaseca, Laia Muñoz, Olivia Belbin, Daniel Andres Alcolea, Laura Molina‐Porcel et al. · 2020 · Neurology Neuroimmunology & Neuroinflammation
77. Oxytosis/Ferroptosis in Neurodegeneration: the Underlying Role of Master Regulator Glutathione Peroxidase 4 (GPX4)
    Nawab John Dar, Urmilla John, Nargis Bano, Sameera Khan, Shahnawaz Ali Bhat · 2023 · Molecular Neurobiology
78. Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS–FTD-linked UBQLN2 mutations
    Nhat T. T. Le, Lydia Chang, Irina Kovlyagina, Polymnia Georgiou, Nathaniel Safren, Kerstin E. Braunstein, Mark D. Kvarta, Adam M. Van Dyke, Tara A. LeGates, Thomas Philips et al. · 2016 · Proceedings of the National Academy of Sciences
79. Cell-autonomous requirement of TDP-43, an ALS/FTD signature protein, for oligodendrocyte survival and myelination
    Jia Wang, Wan Yun Ho, Kenneth Lim, Jia Feng, Greg Tucker‐Kellogg, Klaus‐Armin Nave, Shuo‐Chien Ling · 2018 · Proceedings of the National Academy of Sciences
80. Proteomics Approaches for Biomarker and Drug Target Discovery in ALS and FTD
    Hedl, Thomas J., San Gil, Rebecca, Cheng, Flora, Rayner, Stephanie L., Davidson, Jennilee M., De Luca, Alana, Villalva, Maria D., Ecroyd, Heath, Walker, Adam K., Lee, Albert · 2019 · Frontiers in Neuroscience
81. Neurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neurons
    Julie Vérièpe, Lucresse Fossouo, J. Alex Parker · 2015 · Nature Communications
82. Rab8, POSH, and TAK1 regulate synaptic growth in a Drosophila model of frontotemporal dementia
    Ryan J. H. West, Yubing Lu, Bruno Marie, Fen‐Biao Gao, Sean T. Sweeney · 2015 · The Journal of Cell Biology
83. Neuroinflammation in motor neuron disease.
    Okiru Komine, Koji Yamanaka · 2015 · Europe PMC (PubMed Central)
84. Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis
    Shuo‐Chien Ling, Somasish Ghosh Dastidar, Seiya Tokunaga, Wan Yun Ho, Kenneth Lim, Hristelina S. Ilieva, Philippe A. Parone, Sheue-Houy Tyan, Tsemay M. Tse, Jer‐Cherng Chang et al. · 2019 · eLife
85. Combating deleterious phase transitions in neurodegenerative disease
    April L. Darling, James Shorter · 2021 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
86. Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis
    Sebum Lee, Yulei Shang, Stephanie Redmond, Anatoly Urisman, Amy A. Tang, Kathy H. Li, Alma L. Burlingame, Ryan A. Pak, Ana Jovičić, Aaron D. Gitler et al. · 2016 · Neuron
87. Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism
    Erin G. Conlon, Delphine Fagegaltier, Phaedra Agius, Julia Davis‐Porada, James A. Gregory, Isabel Hubbard, Kristy Kang, Duyang Kim, Hemali P. Phatnani, Justin Y. Kwan et al. · 2018 · eLife
88. ATP binds and inhibits the neurodegeneration-associated fibrillization of the FUS RRM domain
    Jian Kang, Liangzhong Lim, Jianxing Song · 2019 · Communications Biology
89. U1 snRNP is mislocalized in ALS patient fibroblasts bearing NLS mutations in FUS and is required for motor neuron outgrowth in zebrafish
    Yong Yu, Binkai Chi, Wei Xia, Jaya Pal Gangopadhyay, Tomohiro Yamazaki, Marlene E. Winkelbauer-Hurt, Shanye Yin, Yoan Eliasse, Edward Adams, Christopher E. Shaw et al. · 2015 · Nucleic Acids Research
90. TDP-43 functions within a network of hnRNP proteins to inhibit the production of a truncated human SORT1 receptor
    Fatemeh Mohagheghi, Mercedes Prudencio, Cristiana Stuani, Casey N. Cook, Karen R. Jansen‐West, Dennis W. Dickson, Leonard Petrucelli, Emanuele Buratti · 2015 · Human Molecular Genetics
91. Neuronal ribonucleoprotein granules: Dynamic sensors of localized signals
    Nadia Formicola, Jeshlee Vijayakumar, Florence Besse · 2019 · Traffic
92. Preclinical progression of neurodegenerative diseases.
    Masahisa Katsuno, Kentaro Sahashi, Yohei Iguchi, Atsushi Hashizume · 2018 · Europe PMC (PubMed Central)
93. The clinical trial landscape in amyotrophic lateral sclerosis—Past, present, and future
    Heike J. Wobst, Korrie L. Mack, Dean G. Brown, Nicholas J. Brandon, James Shorter · 2020 · Medicinal Research Reviews
94. The human motor cortex microcircuit: insights for neurodegenerative disease
    Peter McColgan, Julie Joubert, Sarah J. Tabrizi, Geraint E. Rees · 2020 · Nature reviews. Neuroscience
95. Polystyrene nanoparticles trigger aberrant condensation of TDP-43 and amyotrophic lateral sclerosis-like symptoms
    Hang Sun, Bingwei V. Yang, Qiong Li, Xiaokang Zhu, Erqun Song, Cong Liu, Yang Song, Guibin Jiang · 2024 · Nature Nanotechnology
96. Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis
    Daniel Jutzi, Sébastien Campagne, Ralf Schmidt, Stefan Reber, Jonas Mechtersheimer, Foivos Gypas, Christoph Schweingruber, Martino Colombo, Christine von Schroetter, Fionna E. Loughlin et al. · 2020 · Nature Communications
97. Overexpression of ferroptosis defense enzyme Gpx4 retards motor neuron disease of SOD1G93A mice
    Liuji Chen, Ren Na, Kirsten Danae McLane, Cody S. Thompson, Ju Gao, Xinglong Wang, Qitao Ran · 2021 · Scientific Reports
98. ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs
    Yueh-Lin Tsai, Tristan H. Coady, Lei Lü, Dinghai Zheng, Isabel Alland, Bin Tian, Neil A. Shneider, James L. Manley · 2020 · Genes & Development
99. Preserving Lysosomal Function in the Aging Brain: Insights from Neurodegeneration
    Peng, Wesley, Minakaki, Georgia, Nguyen, Maria, Krainc, Dimitri · 2019 · Neurotherapeutics
100. FUS interacts with nuclear matrix-associated protein SAFB1 as well as Matrin3 to regulate splicing and ligand-mediated transcription
     Atsushi Yamaguchi, Keisuke Takanashi · 2016 · Scientific Reports