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Flow of Cortical Activity Underlying a Tactile Decision in Mice
Open accessAbstract
Perceptual decisions involve distributed cortical activity. Does information flow sequentially from one cortical area to another, or do networks of interconnected areas contribute at the same time? Here we delineate when and how activity in specific areas drives a whisker-based decision in mice. A short-term memory component temporally separated tactile "sensation" and "action" (licking). Using optogenetic inhibition (spatial resolution, 2 mm; temporal resolution, 100 ms), we surveyed the neocortex for regions driving behavior during specific behavioral epochs. Barrel cortex was critical for sensation. During the short-term memory, unilateral inhibition of anterior lateral motor cortex biased responses to the ipsilateral side. Consistently, barrel cortex showed stimulus-specific activity during sensation, whereas motor cortex showed choice-specific preparatory activity and movement-related activity, consistent with roles in motor planning and movement. These results suggest serial information flow from sensory to motor areas during perceptual decision making.
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“Hence, peak 4 is likely to reflect participation of the primary somatosensory cortex in motor preparatory activity, often observed in higher motor cortices (12–14).”
From Neural correlates of perceptual decision-making in the primary somatosensory cortex (2026) · cites this paper as [12]
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“Serial transformation of sensory inputs along bottom–up hierarchical pathways has been observed in rodents engaged in whisker-discrimination tasks (8, 9) with an increasingly stronger association with perceptual choice in S2 (10, 11) and premotor areas (12–14) rather than whisker-related wS1 (9).”
From Neural correlates of perceptual decision-making in the primary somatosensory cortex (2026) · cites this paper as [12]
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“Therefore, this global regulation is unlikely to originate directly from frontal cortical premotor areas (12–14) since frontal cortices have a high degree of symmetry for both ipsilateral and contralateral projections (59).”
From Neural correlates of perceptual decision-making in the primary somatosensory cortex (2026) · cites this paper as [12]
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“The functional impact of motor feedback signals to sensory cortex is likewise only beginning to be explored (Guo et al., 2014; Lee et al., 2013; Schneider et al., 2014; Zagha et al., 2013).”
Metadata
- Authors
- Guo, Z. V., Li, N., Huber, D., Ophir, E., Gutnisky, D., Ting, J. T., Feng, G., & Svoboda, K.
- Affiliations
- Howard Hughes Medical Institute (US)
- McGovern Institute for Brain Research (US)
- Corresponding author
- Svoboda, Karel
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 81
- Issue
- 1
- Pages
- 179-194
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3984938
- OpenAlex
- W2040707073
- Cited by
- 715
- References
- 0
- Citations by year
- 2026: 65 · 2025: 56 · 2024: 74 · 2023: 84 · 2022: 60 · 2021: 64 · 2020: 69 · 2019: 62 · 2018: 57 · 2017: 47 · 2016: 32 · 2015: 27 · 2014: 18
- FWCI
- 14.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- perceptual decision making, barrel cortex, anterior lateral motor cortex, short-term memory, optogenetic inhibition, sensorimotor integration, mice
- MeSH terms
- Channelrhodopsins, Action Potentials, Afferent Pathways, Animals, Cerebral Cortex, Conditioning, Operant, Decision Making, Discrimination, Psychological, Female, Male, Mice, Transgenic, Motion Perception, Nerve Net, Neurons, Photic Stimulation, Touch, Vibrissae, Green Fluorescent Proteins, Vesicular Inhibitory Amino Acid Transport Proteins, Mice
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