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Cited by 540Motor Control and AdaptationNeural dynamics and brain functionMemory and Neural Mechanisms

Multiple dynamic representations in the motor cortex during sensorimotor learning

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Huber, D., Gutnisky, D. A., Peron, S., O’Connor, D. H., Wiegert, J. S., Tian, L., Oertner, T. G., Looger, L. L. +1 more·2012·Nature
DOI 10.1038/nature11039PMC PMC4601999
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Abstract

The mechanisms linking sensation and action during learning are poorly understood. Layer 2/3 neurons in the motor cortex might participate in sensorimotor integration and learning; they receive input from sensory cortex and excite deep layer neurons, which control movement. Here we imaged activity in the same set of layer 2/3 neurons in the motor cortex over weeks, while mice learned to detect objects with their whiskers and report detection with licking. Spatially intermingled neurons represented sensory (touch) and motor behaviours (whisker movements and licking). With learning, the population-level representation of task-related licking strengthened. In trained mice, population-level representations were redundant and stable, despite dynamism of single-neuron representations. The activity of a subpopulation of neurons was consistent with touch driving licking behaviour. Our results suggest that ensembles of motor cortex neurons couple sensory input to multiple, related motor programs during learning.

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  • The activity of M1 cortical neurons dynamically changes during motor learning.

    “We focused on the primary motor cortex (M1), as the proliferation and differentiation of M1 OPCs is accelerated, and the activity of M1 cortical neurons dynamically changes during motor learning (Huber et al., 2012 ; Masamizu et al., 2014 ; McKenzie et al., 2014 ; Peters, Chen, & Komiyama, 2014 ; Xiao et al., 2016 ).”

    From Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity (2020) · cites this paper as Huber et al., 2012

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Authors
Huber, D., Gutnisky, D. A., Peron, S., O’Connor, D. H., Wiegert, J. S., Tian, L., Oertner, T. G., Looger, L. L., & Svoboda, K.
Affiliations
  • University of Geneva (CH)
  • Howard Hughes Medical Institute (US)
  • University Medical Center Hamburg-Eppendorf (DE)
Corresponding author
Svoboda, K.
ORCID
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2012-04
Volume
484
Issue
7395
Pages
473-478
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/nature11039
PMC
PMC4601999
OpenAlex
W2094933391
Cited by
540
References
6
Citations by year
2026: 12 · 2025: 23 · 2024: 35 · 2023: 36 · 2022: 34 · 2021: 24 · 2020: 45 · 2019: 69 · 2018: 42 · 2017: 44 · 2016: 41 · 2015: 34 · 2014: 37 · 2013: 47 · 2012: 17
FWCI
22.13
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders
Howard Hughes Medical Institute
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
sensorimotor learning, motor cortex, layer 2/3 neurons, population coding, licking behavior, touch, neuronal ensembles, sensorimotor integration, neuroplasticity
MeSH terms
Animals, Behavior, Animal, Hippocampus, Learning, Microscopy, Models, Neurological, Motor Cortex, Neuronal Plasticity, Psychomotor Performance, Tongue, Touch, Vibrissae, Long-Term Potentiation, Mice, Rats, Feedback, Sensory

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