Neuronal correlates of parametric working memory in the prefrontal cortex
Abstract
Humans and monkeys have similar abilities to discriminate the difference in frequency between two mechanical vibrations applied sequentially to the fingertips. A key component of this sensory task is that the second stimulus is compared with the trace left by the first (base) stimulus, which must involve working memory. Where and how is this trace held in the brain? This question was investigated by recording from single neurons in the prefrontal cortex of monkeys while they performed the somatosensory discrimination task. Here we describe neurons in the inferior convexity of the prefrontal cortex whose discharge rates varied, during the delay period between the two stimuli, as a monotonic function of the base stimulus frequency. We describe this as 'monotonic stimulus encoding', and we suggest that the result may generalize: monotonic stimulus encoding may be the basic representation of one-dimensional sensory stimulus quantities in working memory. Thus we predict that other behavioural tasks that require ordinal comparisons between scalar analogue stimuli would give rise to monotonic responses similar to those reported here.
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Two neural populations coupled by reciprocal inhibition exhibit persistent activity that is positively and negatively monotonically tuned to the first frequency f1, as observed in prefrontal neurons.
“Moreover, two such neural populations coupled by reciprocal inhibition exhibit persistent activity that is positively and negatively, respectively, monotonically tuned to the first frequency f1, as observed in prefrontal neurons in this task (Romo et al., 1999; Brody et al., 2003; Miller et al., 2003).”
From Decision Making in Recurrent Neuronal Circuits (2008) · cites this paper as Romo et al., 1999
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- Authors
- Romo, R., Brody, C. D., Hernández, A., & Lemus, L.
- Affiliations
- Universidad Nacional Autónoma de México (MX)
- Corresponding author
- Romo, Ranulfo
- Venue
- Nature
- Published
- 1999-06
- Volume
- 399
- Issue
- 6735
- Pages
- 470-473
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2101620490
- Cited by
- 822
- References
- 27
- Citations by year
- 2026: 26 · 2025: 30 · 2024: 35 · 2023: 35 · 2022: 34 · 2021: 43 · 2020: 36 · 2019: 35 · 2018: 37 · 2017: 42 · 2016: 29 · 2015: 31 · 2014: 34 · 2013: 34 · 2012: 35
- FWCI
- 9.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- working memory, prefrontal cortex, single-unit recording, somatosensory discrimination, ordinal comparison, delay period
- MeSH terms
- Animals, Discrimination Learning, Humans, Macaca mulatta, Memory, Short-Term, Neurons, Prefrontal Cortex
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