The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones

Imig, Cordelia, Min, Sang-Won, Krinner, Stefanie, Arancillo, Marife, Rosenmund, Christian, Südhof, Thomas C., Rhee, JeongSeop, Brose, Nils, Cooper, Benjamin H.·2014·Neuron
DOI 10.1016/j.neuron.2014.10.009

Cited by (389)

Items 301–389 of 389

  1. Presynaptic Cytomatrix Proteins
    Yishi Jin, Rong Grace Zhai · 2023 · Advances in neurobiology
  2. Neuronal synaptic architecture revealed by cryo-correlative light and electron microscopy
    Pei Wang, Buyun Tian, Xiaojun Xu, Huiqin Luan, Yan Zhang, Wenhao Sun, Liqiao Hu, Yuanyuan Li, Yuchen Yao, Weixing Li et al. · 2024 · Biophysics Reports
  3. Independently engaging protein tethers of different length enhance synaptic vesicle trafficking to the plasma membrane
    Manon M. M. Berns, Mirza Yildiz, Stefanie Winkelmann, Alexander M. Walter · 2025 · The Journal of Physiology
  4. Dynamic recruitment of Munc13 primes docked secretory granules for exocytosis
    Santiago Echeverry, Jan Saras, Per-Eric Lund, Johan Dunevall, Nikhil R. Gandasi, Sebastian Barg · 2025 · Cell Reports
  5. Continuum architecture dynamics of vesicle tethering in exocytosis
    Puig-Tintó, Marta, Ortiz, Sebastian, Meek, Sasha, Coray, Raffaele, Betancur, Laura I., Hernández, Altair C., Castellet, Anna, Kramer, Eric, Hoess, Philipp, Mund, Markus et al. · 2026 · Cell
  6. Complexins ☆
    Kerstin Reim · 2017 · Elsevier eBooks
  7. Functional Roles of UNC-13/Munc13 and UNC-18/Munc18 in Neurotransmission
    Frédéric A. Meunier, Zhitao Hu · 2023 · Advances in neurobiology
  8. Maintenance of a central high frequency synapse in the absence of synaptic activity
    Sascha Lessle, Lena Ebbers, Yvette Dörflinger, Simone Hoppe, Michaela Kaiser, Hans Gerd Nothwang, Christoph Körber · 2024 · Frontiers in Cellular Neuroscience
  9. Comprehensive list of preventative migraine headache medications without significant drug–drug interactions
    Jay Dave, Ian Hakkinen, Pengfei Zhang · 2024 · Frontiers in Neurology
  10. A two-pool mechanism of vesicle release in medial habenula terminals underlies GABA B receptor-mediated potentiation
    Peter Koppensteiner, Pradeep Bhandari, Cihan Önal, Carolina Borges-Merjane, Elodie Le Monnier, Yukihiro Nakamura, Tetsushi Sadakata, Makoto Sanbo, Masumi Hirabayashi, Nils Brose et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  11. Adaptive functions correlate with evoked neurotransmitter release in SYT1-associated neurodevelopmental disorder
    Paul Yangho Park, Lauren E. Bleakley, Nadia Saraya, Reem Al‐Jawahiri, Josefine Eck, Marc Anthony Aloi, Holly Melland, Kate Baker, Sarah L. Gordon · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  12. Synergistic regulation of fusion pore opening and dilation by SNARE and synaptotagmin-1
    Kaiju Li, Kaiyu Li, Jiaqi Fan, Xing Zhang, Chengyan Tao, Yijuan Xiang, Lele Cui, Hao Li, Minghan Li, Yanjing Zhang et al. · 2024 · Journal of Molecular Cell Biology
  13. Glutamatergic synaptic resilience to overexpressed human alpha-synuclein
    Patrícia I. Santos, Inés Hojas García-Plaza, Ali Shaib, Jeong Seop Rhee, Abed Alrahman Chouaib, Nils Brose, Silvio O. Rizzoli, James A. Daniel, Tiago F. Outeiro · 2025 · npj Parkinson s Disease
  14. Recent Structural Insights into the Molecular Architecture of Synapses
    Axel T. Brünger, Richard G. Held, Yousuf A. Khan, Jeremy Leitz, Jiahao Liang, Chuchu Wang, K. Ian White · 2026 · Advances in neurobiology
  15. H-Ras induces exuberant de novo dendritic protrusion growth in mature neurons regardless of cell type
    Sarah Krüssel, Ishana Deb, Seungkyu Son, Gabrielle Ewall, Minhyeok Chang, Hey‐Kyoung Lee, Won Do Heo, Hyung‐Bae Kwon · 2024 · iScience
  16. Synaptic Vesicle Recycling at the Developing Presynapse
    Kim, Nawon, Cousin, Michael A. · 2025 · Journal of Neurochemistry
  17. Neddylation regulates the development and function of glutamatergic neurons
    Josefa Torres, Zehra Vural, Maksims Fiošins, Valentin Schwarze, Inés Hojas García-Plaza, Fritz Benseler, Stefan Bonn, Silvio O. Rizzoli, Benjamin H. Cooper, JeongSeop Rhee et al. · 2025 · Communications Biology
  18. Computational methods for ultrastructural analysis of synaptic complexes
    Vladan Lučić · 2022 · Current Opinion in Neurobiology
  19. Complexins: Ubiquitously Expressed Presynaptic Regulators of SNARE-Mediated Synaptic Vesicle Fusion
    Francisco José López-Murcia, Kerstin Reim, Holger Taschenberger · 2023 · Advances in neurobiology
  20. Looking into the Black Box of Synaptic Vesicle Recruitment
    Stefan Hallermann · 2015 · Neuron
  21. Increased synaptic facilitation and exploratory behavior in mice lacking the presynaptic protein Mover
    Julio Viotti, Frederik Wilhelm Ott, Eva Maria Schleicher, Jannek M. Wagner, Yvonne Bouter, Thomas A. Bayer, Thomas Dresbach · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  22. Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons
    Olena Kim, Yuji Okamoto, Nils Brose, Ryuichi Shigemoto, Péter Jónás · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  23. Ultrastructural sublaminar-specific diversity of excitatory synaptic boutons in layer 1 of the adult human temporal lobe neocortex
    Astrid Rollenhagen, Akram Sadeghi, Bernd Walkenfort, Claus Christian Hilgetag, Kurt Sätzler, Joachim H. R. Lübke · 2024 · eLife
  24. Single-Molecule Localization Microscopy of Presynaptic Active Zones in Drosophila melanogaster after Rapid Cryofixation
    Achmed Mrestani, Katharina Lichter, Anna‐Leena Sirén, Manfred Heckmann, Mila Marie Paul, Martin Pauli · 2023 · International Journal of Molecular Sciences
  25. Synaptic vesicle undocking induces low-frequency depression
    Melissa Silva, Federico Francisco Trigo, Isabel Llano, Alain Marty · 2026 · eLife
  26. Visualizing Postsynaptic Density in Excitatory Synapses with Electron Tomography
    Rong Sun, Qiangjun Zhou · 2026 · Advances in neurobiology
  27. The flexible synapse – How mossy fiber architecture adapts to changing needs
    Felicitas Bruentgens, Dietmar Schmitz, Marta Orlando · 2026 · Progress in Neurobiology
  28. Ca2+-phospholipid-dependent regulation of Munc13-1 is essential for post-tetanic potentiation at mossy fiber synapses and supports working memory
    Francisco José López-Murcia, Dilja Krueger‐Burg, Sally Wenger, Tania López-Hernández, Noa Lipstein, Holger Taschenberger, Nils Brose · 2026 · Cell Reports
  29. Encephalopathy-linked UFM1 variants impede neuronal protein translation, development, and function
    Catarina Perdigão, Josefa Torres, H Magnussen, Janina Koch, Elena L. Rudashevskaya, Frederieke Moschref, Maksims Fiošins, Fritz Benseler, Sally Wenger, Tanja Nilsson et al. · 2026 · EMBO Molecular Medicine
  30. A versatile nanobody platform for live and super-resolution imaging of synaptic vesicle dynamics and plasticity in rodent and human neurons
    Rashi Goel, Kristina Jevdokimenko, Ronja Rehm, Jannik Hentze, Paola Agüi‐Gonzalez, Momchil Ninov, Erik Maier, Yin Wu, Felix Lange, Agata Witkowska et al. · 2026 · Journal of Nanobiotechnology
  31. Synapses: Multitasking Global Players in the Brain
    Joachim H. R. Lübke, Astrid Rollenhagen · 2019 · e-Neuroforum
  32. Investigate Synaptic Vesicles Mobility in Neuronal Culture Axons by FRAP Imaging
    Xiao Min Zhang, Fabrice P. Cordelières, Étienne Herzog · 2021 · BIO-PROTOCOL
  33. Complexin Mutants Reveal Partial Segregation between Recycling Pathways That Drive Evoked and Spontaneous Neurotransmission
    Nadezhda S. Sabeva, Richard W. Cho, Alexander Vasin, Agustin Gonzalez, J. Troy Littleton, Maria Bykhovskaia · 2017 · Journal of Neuroscience
  34. SNARE complex assembly and disassembly dynamics in response to Ca2+ current activation in live cells
    Qinghua Fang, Ying Zhao, Dong An, Manfred Lindau · 2025 · Biophysical Journal
  35. Electrophysiological Analysis of the Synaptic Vesicle Priming Process
    Dennis Nestvogel · 2017 · eDiss (Georg-August-Universität Göttingen)
  36. Correlating Synaptic Ultrastructure and Function at the Nanoscale
    Lydia Maus, Bekir Altas, JeongSeop Rhee, Nils Brose, Cordelia Imig, Benjamin H. Cooper · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  37. The presynaptic protein Mover is heterogeneously expressed across brain areas and synapse types
    Rebecca Wallrafen · 2019
  38. Mover affects a subpool of primed synaptic vesicles in the mouse calyx of Held
    Hermes Pofantis · 2019
  39. Editorial: Quantifying and controlling the nano-architecture of neuronal synapses
    Xiaobing Chen, Thomas Kuner, Thomas A. Blanpied · 2022 · Frontiers in Synaptic Neuroscience
  40. Nanoscale organization and dynamics of SNARE proteins in the presynaptic membranes
    Dragomir Milovanović · 2015 · eDiss (Georg-August-Universität Göttingen)
  41. Biochemical characterization of presynaptic membrane protein complexes
    Momchil Ninov · 2017 · eDiss (Georg-August-Universität Göttingen)
  42. Satnav for cells: Destination membrane fusion
    Matthew G. Holt · 2017 · Cell Calcium
  43. Molecular physiology of signal transmission along the auditory pathway
    Tanvi Butola · 2017 · eDiss (Georg-August-Universität Göttingen)
  44. Regulation of the neuronal SNARE-complex by accessory proteins
    Shrutee Jakhanwal · 2018 · eDiss (Georg-August-Universität Göttingen)
  45. Ultrastructural Analysis of the Role of Voltage-Gated Calcium Channel Intracellular Domains in Synaptic Vesicle Tethering at Presynaptic Terminals
    Robert Chen · 2017 · TSpace (University of Toronto)
  46. Synaptotagmins ensure speed and efficiency of inhibitory neurotransmitter release
    Chen, Chong · 2018 · Institute of Science and Technology Austria
  47. Evidence for Synaptic Vesicle Binding by the C-terminal of a Short Splice CaV2.1 Calcium Channel
    Christine A. Snidal · 2018 · TSpace (University of Toronto)
  48. Morphological Studies of Synaptic Vesicle Recycling at the Inner Hair Cell Ribbon Synapse
    Jana Kroll · 2020 · eDiss (Georg-August-Universität Göttingen)
  49. Diversity of excitatory release sites
    M. R. Karlocai, Judit Herédi, Tünde Benedek, Noémi Holderith, A. Lorincz, Z. Nusser · 2021 · bioRxiv
  50. VAMP2 AND SYNAPTOTAGMINS ARE RELATIVELY IMMOBILE ON CHROMAFFIN GRANULE MEMBRANES: IMPLICATIONS FOR MEMBRANE FUSION AND FUSION PORE EXPANSION
    Prabhodh S. Abbineni, Joseph S. Briguglio, Edwin R. Chapman, Ronald W. Holz, Daniel Axelrod · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  51. Resolving the Ultrastructural Organization of Synaptic Vesicle Pools at Hippocampal Mossy Fiber and Schaffer Collateral Synapses
    Lydia Maus · 2021
  52. Neuromodulation, Short-Term and Long-Term Plasticity in Corticothalamic and Hippocampal Neuronal Networks
    Sofie Sundberg · 2018
  53. Spatially Resolved Hydration Statistical Mechanics at Biomolecular Surfaces from Atomistic Simulations
    Leonard P. Heinz · 2021
  54. Conformational Change of Syntaxin-3b in Regulating SNARE Complex Assembly in the Ribbon Synapses
    Claire Gething, Joshua Ferrar, Bishal Misra, Giovanni Howells, Ucheor Brandon Choi · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  55. DYNAMICS OF NEUROMUSCULAR TRANSMISSION REPRODUCED BY CALCIUM-DEPENDENT SERIAL TRANSITIONS IN THE VESICLE FUSION COMPLEX
    Alejandro Martínez-Valencia, Guillermo Ramı́rez-Santiago, Francisco F. De‐Miguel · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  56. Reconstructing essential active zone functions within a synapse
    Chao Tan, Shan Shan H. Wang, Giovanni de Nola, Pascal S. Kaeser · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  57. Faculty Opinions recommendation of Synaptotagmin-1 enables frequency coding by suppressing asynchronous release in a temperature dependent manner.
    Edwin R. Chapman, Jason Vevea · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  58. Influence of T-Bar on Calcium Concentration Impacting Release Probability
    Markus M. Knodel, Ranjita Dutta Roy, Gabriel Wittum · 2022 · Frontiers in Computational Neuroscience
  59. Syntaxin Habc is required to open Unc18 to template SNARE assembly
    Leonardo A Parra‐Rivas, Mark T. Palfreyman, Thien N. Vu, Erik M. Jørgensen · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  60. The activation of mGluR4 rescues parallel fiber LTP, motor learning and social behavior in a mouse model of Fragile X Syndrome
    Ricardo Martín, Alberto Samuel Suárez-Pinilla, Nuria García-Font, M. Luisa Laguna-Luque, Juan Carlos López, María Jesús Oset‐Gasque, Agnès Gruart, Jose Maria Delgado-Garcia, Magdalena Torres, José Sánchez‐Prieto · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  61. Faculty Opinions recommendation of Complexin cooperates with Bruchpilot to tether synaptic vesicles to the active zone cytomatrix.
    J. Troy Littleton, Karen Leopold · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  62. A role for synapsin 2a oligomerization in maintaining a reserve pool of synaptic vesicles
    Minchuan Zhang · 2022 · DR-NTU (Nanyang Technological University)
  63. Release site plasticity via Unc13A regulatory domains mediates synaptic short-term facilitation and homeostatic potentiation
    Meida Jusyte, Natalie Blaum, Mathias A. Böhme, Manon M. M. Berns, Alix E. Bonard, Janus RL Kobbersmed, Alexander M. Walter · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  64. PIP 2 electrostatically triggers vesicle fusion: arresting full SNARE assembly and vesicle fusion by PIP 2 -masking
    Houda Yasmine Ali Moussa, Kyung Chul Shin, Janarthanan Ponraj, Sung Hyun Park, One‐Sun Lee, Said A Mansour, Yongsoo Park · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  65. Excitation-Secretion Coupling of Dense-Core Vesicle Release
    Cirkovic, Valentina · 2023 · eDiss (Georg-August-Universität Göttingen)
  66. Exuberant de novo dendritic spine growth in mature neurons
    Sarah Krüssel, Ishana Deb, Seungkyu Son, Gabrielle Ewall, Minhyeok Chang, Hey‐Kyoung Lee, Won Do Heo, Hyung‐Bae Kwon · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  67. Differential Regulation of Excitatory vs Inhibitory Synaptic Release by Complexin/CPX-1 and CAPS/UNC-31 at the C. elegans Neuromuscular Junctions
    Ya Wang, Chun Hin Chow, Mengjia Huang, Randa Higazy, Neeraja Ramakrishnan, Cuntai Zhang, Shuzo Sugita, Shangbang Gao · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  68. Quantitative molecular physiology at active zones of calyceal synapses of the auditory pathway
    Theocharis Alvanos · 2023 · eDiss (Georg-August-Universität Göttingen)
  69. Single residues in the complexin N-terminus exhibit distinct phenotypes in synaptic vesicle fusion
    Estelle Toulmé, Jacqueline Murach, Simon Bärfuss, Jana Kroll, Jörg Malsam, Thorsten Trimbuch, Melissa A. Herman, Thomas H. Söllner, Christian Rosenmund · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  70. Ultrastructural sublaminar-specific diversity of excitatory synaptic boutons in layer 1 of the adult human temporal lobe neocortex
    Astrid Rollenhagen, Akram Sadeghi, Bernd Walkenfort, Claus Christian Hilgetag, Kurt Sätzler, Joachim H. R. Lübke · 2025 · eLife
  71. Mutations of Single Residues in the Complexin N-terminus Exhibit Distinct Phenotypes in Synaptic Vesicle Fusion
    Estelle Toulmé, Jacqueline Murach, Simon Bärfuss, Jana Kroll, Jörg Malsam, Thorsten Trimbuch, Melissa A. Herman, Thomas H. Söllner, Christian Rosenmund · 2024 · Journal of Neuroscience
  72. Readily Releasable Pool
    Sina Zobel, Christian Rosenmund · 2024 · Neuromethods
  73. A Technique to Perform Structure–Function Analysis of Synapses
    Carolin Wichmann, Susann Michanski · 2024 · Neuromethods
  74. Synaptic Function
    Dimitri Michael Kullmann, Kirill E. Volynski · 2025 · Oxford University Press eBooks
  75. Nanobinders for Synaptotagmin 1 enable the analysis of synaptic vesicle dynamics in rodent and human models
    Rashi Goel, Kristina Jevdokimenko, Ronja Rehm, Jannik Hentze, Paola Agüi‐Gonzalez, Momchil Ninov, Felix Lange, Agata Witkowska, Svenja Bolz, Francesca Pennacchietti et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  76. Ultrastructural sublaminar-specific diversity of excitatory synaptic boutons in layer 1 of the adult human temporal lobe neocortex
    Astrid Rollenhagen, Akram Sadeghi, Bernd Walkenfort, Claus Christian Hilgetag, Kurt Sätzler, Joachim H. R. Lübke · 2025 · eLife
  77. Ultrastructural sublaminar-specific diversity of excitatory synaptic boutons in layer 1 of the adult human temporal lobe neocortex
    Astrid Rollenhagen, Akram Sadeghi, Bernd Walkenfort, Claus Christian Hilgetag, Kurt Sätzler, Joachim H. R. Lübke · 2025 · eLife
  78. Acute ethanol inhibits asynchronous glutamate release from mouse basolateral amygdala synapses
    B. Parrish, Brian A. McCool · 2026 · Neuropharmacology
  79. Huntingtin functions in the regulation of axonal transport : consequences on neuronal network homeostasis and behavior, in health and disease
    Hélène Vitet · 2020 · theses.fr (ABES)
  80. Synaptic vesicle undocking induces low frequency depression
    Melissa Silva, Federico Francisco Trigo, Isabel Llano, Alain Marty · 2026 · eLife
  81. Synaptic vesicle undocking induces low-frequency depression
    Melissa Silva, Federico Francisco Trigo, Isabel Llano, Alain Marty · 2026 · eLife
  82. Selective, genetically induced increase in synaptic vesicle priming
    Mohammad Aldahabi, Flóra Bálint, Andrea Lőrincz, Noa Lipstein, Nils Brose, Zoltán Nusser · 2026 · Science Advances
  83. Ultrastructural and molecular analysis of cortico-striatal dopamine hub synapses
    Paul Lapios · 2024 · theses.fr (ABES)
  84. Membrane Merger Dynamics in Exocytosis and Endocytosis
    Xiaoli Guo, Chung Yu Chan, Ling‐Gang Wu · 2026 · Advances in experimental medicine and biology
  85. Nociceptor-enriched CAPS1 isoform couples to Ca V 2.2 channels and underlies inflammatory pain hypersensitivity
    Melissa Daeschner, Emilio Román Mustafá, Andi N. Morgan, Quiana Mosley, Eduardo Javier López Soto · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  86. The Synaptic Vesicle Priming Protein Munc13 Mediates Evoked Somatodendritic Dopamine Release
    Joseph J. Lebowitz, Aditi Banerjee, Gillian E. Handy, John T. Williams, Pascal S. Kaeser · 2026 · Journal of Neuroscience
  87. Munc18 reprograms the intrinsic neuronal SNARE complex assembly pathway
    Vicky Vishvakarma, Edwin R. Chapman · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  88. Engineered proteins to restore and enhance neurotransmitter release
    Morven Chin, Ke Yang, Ricardo López C., Chao Tan, Pascal S. Kaeser · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  89. Caracterização ultraestrutural das células imunorreativas a 5-bromo-2-deoxiuridina (BRDU) na zona ventricular e sub-ventricular adulta e de sua relação com o peptideo regulador CART.
    Carlos Alexandre dos Santos Haemmerle · 2015