Cited by 389Cellular transport and secretionNeuroscience and Neuropharmacology ResearchExtracellular vesicles in disease

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The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones

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Imig, Cordelia, Min, Sang-Won, Krinner, Stefanie, Arancillo, Marife, Rosenmund, Christian, Südhof, Thomas C., Rhee, JeongSeop, Brose, Nils, Cooper, Benjamin H.·2014·Neuron

DOI 10.1016/j.neuron.2014.10.009

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Abstract

Synaptic vesicle docking, priming, and fusion at active zones are orchestrated by a complex molecular machinery. We employed hippocampal organotypic slice cultures from mice lacking key presynaptic proteins, cryofixation, and three-dimensional electron tomography to study the mechanism of synaptic vesicle docking in the same experimental setting, with high precision, and in a near-native state. We dissected previously indistinguishable, sequential steps in synaptic vesicle active zone recruitment (tethering) and membrane attachment (docking) and found that vesicle docking requires Munc13/CAPS family priming proteins and all three neuronal SNAREs, but not Synaptotagmin-1 or Complexins. Our data indicate that membrane-attached vesicles comprise the readily releasable pool of fusion-competent vesicles and that synaptic vesicle docking, priming, and trans-SNARE complex assembly are the respective morphological, functional, and molecular manifestations of the same process, which operates downstream of vesicle tethering by active zone components.

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Authors: Imig, C., Min, S.-W., Krinner, S., Arancillo, M., Rosenmund, C., Südhof, T. C., Rhee, J., Brose, N., & Cooper, B. H.
Affiliations: Max Planck Institute of Experimental Medicine (DE)
NeuroCure Cluster of Excellence (DE)
Howard Hughes Medical Institute (US)
Corresponding author: Brose, Nils
Cooper, Benjamin H.
ORCID: Imig, Cordelia
Arancillo, Marife
Rosenmund, Christian
Südhof, Thomas C.
Rhee, JeongSeop
Brose, Nils
Cooper, Benjamin H.
Venue: Neuron
Publisher: Elsevier BV
Published: 2014-10
Volume: 84
Issue: 2
Pages: 416-431
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2014.10.009
OpenAlex: W1996414800
Cited by: 389
References: 104
Citations by year: 2026: 18 · 2025: 24 · 2024: 33 · 2023: 28 · 2022: 42 · 2021: 44 · 2020: 35 · 2019: 39 · 2018: 32 · 2017: 40 · 2016: 27 · 2015: 26 · 2014: 1
FWCI: 15.60
Type: journal article
Language: en
Update notices: erratum (2014-11-19)
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 386 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
GRO (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Funders: Howard Hughes Medical Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords: synaptic vesicle priming, synaptic vesicle docking, active zone, Munc13, synaptotagmin-1, complexin, vesicle tethering, membrane adhesion, readily releasable pool, hippocampal synapses
MeSH terms: Animals, Hippocampus, Membrane Fusion, Synaptic Transmission, Neurons, Synapses, Synaptic Vesicles, SNARE Proteins, Mice

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The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones

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