Cited by 2,310Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and TherapyNuclear Receptors and Signaling

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The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

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Pickrell, Alicia M., Youle, Richard J.·2015·Neuron

DOI 10.1016/j.neuron.2014.12.007PMC PMC4764997

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Abstract

Understanding the function of genes mutated in hereditary forms of Parkinson's disease yields insight into disease etiology and reveals new pathways in cell biology. Although mutations or variants in many genes increase the susceptibility to Parkinson's disease, only a handful of monogenic causes of parkinsonism have been identified. Biochemical and genetic studies reveal that the products of two genes that are mutated in autosomal recessive parkinsonism, PINK1 and Parkin, normally work together in the same pathway to govern mitochondrial quality control, bolstering previous evidence that mitochondrial damage is involved in Parkinson's disease. PINK1 accumulates on the outer membrane of damaged mitochondria, activates Parkin's E3 ubiquitin ligase activity, and recruits Parkin to the dysfunctional mitochondrion. Then, Parkin ubiquitinates outer mitochondrial membrane proteins to trigger selective autophagy. This review covers the normal functions that PINK1 and Parkin play within cells, their molecular mechanisms of action, and the pathophysiological consequences of their loss.

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Authors: Pickrell, A. M., & Youle, R. J.
Affiliations: National Institutes of Health (US)
Corresponding author: Youle, Richard J.
ORCID: Pickrell, Alicia M.
Youle, Richard J.
Venue: Neuron
Publisher: Elsevier BV
Published: 2015-01
Volume: 85
Issue: 2
Pages: 257-273
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2014.12.007
PMC: PMC4764997
OpenAlex: W2082425146
Cited by: 2,310
References: 212
Citations by year: 2026: 268 · 2025: 234 · 2024: 177 · 2023: 175 · 2022: 228 · 2021: 261 · 2020: 239 · 2019: 197 · 2018: 178 · 2017: 174 · 2016: 123 · 2015: 54
FWCI: 23.21
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 385 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of General Medical Sciences
National Institute of Neurological Disorders and Stroke (Z01NS002859)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords: PINK1, Parkin, Parkinson's disease, mitochondrial quality control, mitochondrial damage, E3 ubiquitin ligase, selective autophagy, mitophagy, autosomal recessive parkinsonism, mitochondrial outer membrane
MeSH terms: PTEN-Induced Putative Kinase, Humans, Mitochondria, Parkinson Disease, Protein Kinases, Parkinsonian Disorders, Ubiquitin-Protein Ligases, Proteolysis, Mitophagy

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The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

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