The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior
Open accessAbstract
DREADDs are chemogenetic tools widely used to remotely control cellular signaling, neuronal activity and behavior. Here we used a structure-based approach to develop a new Gi coupled DREADD using the kappa-opioid receptor as template (KORD) that is activated by the pharmacologically inert ligand salvinorin B (SALB). Activation of virally-expressed KORD in several neuronal contexts robustly attenuated neuronal activity and modified behaviors. Additionally, co-expression of the KORD and the Gq coupled M3-DREADD within the same neuronal population facilitated the sequential and bi-directional remote control of behavior. The availability of DREADDs activated by different ligands provides enhanced opportunities for investigating diverse physiological systems using multiplexed chemogenetic actuators.
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Self-citationRapid, reversible activation of AgRP neurons drives feeding behavior in mice
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Self-citationDeconstruction of a neural circuit for hunger
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Automated design of ligands to polypharmacological profiles
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Metadata
- Authors
- Vardy, E., Robinson, J. E., Li, C., Olsen, R. H. J., DiBerto, J. F., Giguere, P. M., Sassano, F. M., Huang, X.-P., Zhu, H., Urban, D. J., White, K. L., Rittiner, J. E., Crowley, N. A., Pleil, K. E., Mazzone, C. M., Mosier, P. D., Song, J., Kash, T. L., Malanga, C. J., Krashes, M. J., & Roth, B. L.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 86
- Issue
- 4
- Pages
- 936-946
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1999772617
- Cited by
- 380
- References
- 6
- FWCI
- 16.91
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vardy, E., Robinson, J. E., Li, C., Olsen, R. H. J., DiBerto, J. F., Giguere, P. M., Sassano, F. M., Huang, X.-P., Zhu, H., Urban, D. J., White, K. L., Rittiner, J. E., Crowley, N. A., Pleil, K. E., Mazzone, C. M., Mosier, P. D., Song, J., Kash, T. L., Malanga, C. J., . . . Roth, B. L. (2015). A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Neuron. https://doi.org/10.1016/j.neuron.2015.03.065
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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