The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Cooperative and Competitive Spreading Dynamics on the Human Connectome
Open accessAbstract
Increasingly detailed data on the network topology of neural circuits create a need for theoretical principles that explain how these networks shape neural communication. Here we use a model of cascade spreading to reveal architectural features of human brain networks that facilitate spreading. Using an anatomical brain network derived from high-resolution diffusion spectrum imaging (DSI), we investigate scenarios where perturbations initiated at seed nodes result in global cascades that interact either cooperatively or competitively. We find that hub regions and a backbone of pathways facilitate early spreading, while the shortest path structure of the connectome enables cooperative effects, accelerating the spread of cascades. Finally, competing cascades become integrated by converging on polysensory associative areas. These findings show that the organizational principles of brain networks shape global communication and facilitate integrative function.
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“simulation experiments using structure-function models have predicted that even purely focal and transient perturbations in activity should result in diffuse network reorganization that affects distant brain systems (Alstott et al., 2009; Honey and Sporns, 2008; Misic et al., 2015).”
From Development of large-scale functional networks from birth to adulthood: A guide to the neuroimaging literature (2017) · cites this paper as Misic et al., 2015
In the citing paper
“Even the best-performing SC-FC models generally account for less than 50% of the variance in FC across the brain in both humans and non-human primates (Grayson et al., 2016; Messe et al., 2014; Misic et al., 2015).”
From Development of large-scale functional networks from birth to adulthood: A guide to the neuroimaging literature (2017) · cites this paper as Misic et al., 2015
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Complex network measures of brain connectivity: Uses and interpretations
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Self-citationThe organization of the human cerebral cortex estimated by intrinsic functional connectivity
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Communication dynamics in complex brain networks
Avena-Koenigsberger, A., Misic, B., & Sporns, O. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.149 · Cited by 856
Self-citationLinking Structure and Function in Macroscale Brain Networks
Suárez, L. E., Markello, R. D., Betzel, R. F., & Mišić, B. (2020) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2020.01.008 · Cited by 769
Self-citationGraph theory methods: applications in brain networks
Sporns, O. (2018) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2018.20.2/osporns · Cited by 671
Self-citationThe modular and integrative functional architecture of the human brain
Bertolero, M. A., Yeo, B. T. T., & D’Esposito, M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510619112 · Cited by 572
Brain networks and cognitive architectures
Petersen, S. E., & Sporns, O. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.027 · Cited by 553
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Metadata
- Authors
- Mišić, B., Betzel, R. F., Nematzadeh, A., Goñi, J., Griffa, A., Hagmann, P., Flammini, A., Ahn, Y.-Y., & Sporns, O.
- Affiliations
- Indiana University Bloomington (US)
- Centre Hospitalier Universitaire Vaudois (CH)
- Corresponding author
- Sporns, Olaf
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 86
- Issue
- 6
- Pages
- 1518-1529
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2155847838
- Cited by
- 342
- References
- 74
- Citations by year
- 2026: 14 · 2025: 17 · 2024: 32 · 2023: 51 · 2022: 37 · 2021: 31 · 2020: 35 · 2019: 25 · 2018: 36 · 2017: 34 · 2016: 24 · 2015: 6
- FWCI
- 20.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- National Institute on Aging (P30AG010133, P30 AG-10133)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › Complex Network Analysis Techniques
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- human connectome, global cascades, brain network architecture, diffusion spectrum imaging, hub regions, neural communication, network topology
- MeSH terms
- Adult, Brain, Competitive Behavior, Cooperative Behavior, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Models, Neurological, Neural Pathways, Oxygen, Nonlinear Dynamics, Young Adult, Diffusion Tensor Imaging, Connectome
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