The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Dorsal Horn Circuits for Persistent Mechanical Pain
Open accessAbstract
Persistent mechanical hypersensitivity that occurs in the setting of injury or disease remains a major clinical problem largely because the underlying neural circuitry is still not known. Here we report the functional identification of key components of the elusive dorsal horn circuit for mechanical allodynia. We show that the transient expression of VGLUT3 by a discrete population of neurons in the deep dorsal horn is required for mechanical pain and that activation of the cells in the adult conveys mechanical hypersensitivity. The cells, which receive direct low threshold input, point to a novel location for circuit initiation. Subsequent analysis of c-Fos reveals the circuit extends dorsally to nociceptive lamina I projection neurons, and includes lamina II calretinin neurons, which we show also convey mechanical allodynia. Lastly, using inflammatory and neuropathic pain models, we show that multiple microcircuits in the dorsal horn encode this form of pain.
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“The Maf dorsal, the excitatory family was comprised of Excit-5, Excit-6, and Excit-7 which expressed markers of neurons involved in light touch46,48,50,56,57.”
From A harmonized atlas of mouse spinal cord cell types and their spatial organization (2021) · cites this paper as [56]
In the citing paper
“The Prkcg dorsal, excitatory family was comprised of Excit-3 and Excit-4 and likely corresponded to neurons involved in light static touch and allodynic pain in pathological situations46,48–56.”
From A harmonized atlas of mouse spinal cord cell types and their spatial organization (2021) · cites this paper as [56]
In the citing paper
“The Sox5 dorsal, the excitatory family was comprised of Excit-14, Excit-15, Excit-16, Excit-17, Excit-18, and Excit-19, and expressed markers suggestive of a role in coping pain and mechanical nociception46,52,56,63–67.”
From A harmonized atlas of mouse spinal cord cell types and their spatial organization (2021) · cites this paper as [56]
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Citations
Cites
Pain mechanisms: a new theory.
Melzack, R., & Wall, P. D. (1965) · Science · doi:10.1126/science.150.3699.971 · Cited by 11,108
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
Melzack, R., & Wall, P. D. (1996) · Pain Forum · doi:10.1016/s1082-3174(96)80062-6 · Cited by 2,786
Neuronal circuitry for pain processing in the dorsal horn
Todd, A. J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2947 · Cited by 1,475
Coding of pleasant touch by unmyelinated afferents in humans
Löken, L. S., Wessberg, J., Morrison, I., McGlone, F., & Olausson, H. (2009) · Nature Neuroscience · doi:10.1038/nn.2312 · Cited by 1,120
Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms
von Hehn, C. A., Baron, R., & Woolf, C. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.008 · Cited by 824
Central mechanisms of pathological pain
Kuner, R. (2010) · Nature Medicine · doi:10.1038/nm.2231 · Cited by 795
The development of nociceptive circuits
Fitzgerald, M. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1701 · Cited by 778
P AIN M ECHANISMS : Labeled Lines Versus Convergence in Central Processing
Craig, A. D. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131022 · Cited by 765
The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons
Li, L., Rutlin, M. L., Abraira, V. E., Cassidy, C., Kus, L., Gong, S., Jankowski, M. P., Luo, W., Heintz, N., Koerber, H. R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.11.027 · Cited by 760
Cited by
Sorted by citations
Neuropathic Pain: From Mechanisms to Treatment
Finnerup, N. B., Kuner, R., & Jensen, T. S. (2020) · Physiological Reviews · doi:10.1152/physrev.00045.2019 · Cited by 1,727
Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential
Inoue, K., & Tsuda, M. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2018.2 · Cited by 908
Neural circuits for pain: Recent advances and current views
Peirs, C., & Seal, R. P. (2016) · Science · doi:10.1126/science.aaf8933 · Cited by 501
Self-citationHäring, M., Zeisel, A., Hochgerner, H., Rinwa, P., Jakobsson, J. E. T., Lönnerberg, P., La Manno, G., Sharma, N., Borgius, L., Kiehn, O., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0141-1 · Cited by 470
Neuropathic Pain: Central vs. Peripheral Mechanisms
Meacham, K., Shepherd, A. J., Mohapatra, D. P., & Haroutounian, S. (2017) · Current Pain and Headache Reports · doi:10.1007/s11916-017-0629-5 · Cited by 462
Metadata
- Authors
- Peirs, C., Williams, S.-P. G., Zhao, X., Walsh, C. E., Gedeon, J. Y., Cagle, N. E., Goldring, A. C., Hioki, H., Liu, Z., Marell, P. S., & Seal, R. P.
- Affiliations
- University of Pittsburgh (US)
- Kyoto University (JP)
- Corresponding author
- Seal, Rebecca P.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 87
- Issue
- 4
- Pages
- 797-812
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4562334
- OpenAlex
- W2169382112
- Cited by
- 327
- References
- 51
- Citations by year
- 2026: 19 · 2025: 17 · 2024: 21 · 2023: 30 · 2022: 34 · 2021: 34 · 2020: 40 · 2019: 36 · 2018: 36 · 2017: 34 · 2016: 22 · 2015: 3
- FWCI
- 23.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, cc-by)
- Funders
- National Institutes of Health (UL1TR000005)
- Japan Society for the Promotion of Science (15K14333, 15H01430)
- National Institute of Neurological Disorders and Stroke (NS084191, T32NS007433, R21NS084191)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- dorsal horn, mechanical allodynia, mechanical hypersensitivity, VGLUT3, glutamate uptake, lamina II, nociceptive circuits, neuropathic pain, inflammatory pain, chronic pain
- MeSH terms
- Animals, Hyperalgesia, Nerve Net, Organ Culture Techniques, Pain, Touch, Mice, Knockout, Amino Acid Transport Systems, Acidic, Mice, Spinal Cord Dorsal Horn
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