Common Brain Mechanisms of Chronic Pain and Addiction

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When Physical and Social Pain Coexist: Insights Into Opioid Therapy

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Neurogenetics and Epigenetics of Loneliness

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Acupuncture Modulation Effect on Pain Processing Patterns in Patients With Migraine Without Aura

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Substance use and common contributors to morbidity: A genetics perspective

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Behavioral, Psychological, Neurophysiological, and Neuroanatomic Determinants of Pain

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Apparent Effects of Opioid Use on Neural Responses to Reward in Chronic Pain

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Novel treatments for chronic pain: moving beyond opioids

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Dopaminergic Modulation of Excitatory Transmission in the Anterior Cingulate Cortex of Adult Mice

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Enhancing Natural Reward Responsiveness Among Opioid Users Predicts Chronic Pain Relief: EEG Analyses From a Trial of Mindfulness-Oriented Recovery Enhancement

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The temporal dynamics of emotion dysregulation in prescription opioid misuse

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Subliminal (latent) processing of pain and its evolution to conscious awareness

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Emotional distress and pain catastrophizing predict cue-elicited opioid craving among chronic pain patients on long-term opioid therapy

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Frequency of the Dopamine Receptor D3 (rs6280) vs. Opioid Receptor µ1 (rs1799971) Polymorphic Risk Alleles in Patients with Opioid Use Disorder: A Preponderance of Dopaminergic Mechanisms?

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Central sensitization of the spino‐parabrachial‐amygdala pathway that outlasts a brief nociceptive stimulus

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Transition from Acute to Chronic Pain: Where Cells, Systems and Society Meet

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Intrathecal delivery of a palmitoylated peptide targeting Y382-384 within the P2X7 receptor alleviates neuropathic pain

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Mechanisms Underlying the Anti-Suicidal Treatment Potential of Buprenorphine

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Pain in an era of armed conflicts: prevention and treatment for warfighters and civilian casualties

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Post-traumatic stress symptoms in pathological gambling: Potential evidence of anti-reward processes

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Pain intensity, e-cigarette dependence, and cessation-related outcomes: The moderating role of pain-related anxiety

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Insights into the Neurobiology of Craving in Opioid Use Disorder

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Should Reward Deficiency Syndrome (RDS) Be Considered an Umbrella Disorder for Mental Illness and Associated Genetic and Epigenetic Induced Dysregulation of Brain Reward Circuitry?

Blum, K., Dennen, C. A., Elman, I., Bowirrat, A., Thanos, P. K., Badgaiyan, R. D., Downs, B. W., Bagchi, D., Baron, D. A., Braverman, E. R., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12101719 · Cited by 19

Abnormal reward system network in primary dysmenorrhea

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“My life is under control with these medications”: an interpretative phenomenological analysis of managing chronic pain with opioids

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D1 receptors in the anterior cingulate cortex modulate basal mechanical sensitivity threshold and glutamatergic synaptic transmission

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Patients' perceptions of the pathways linking chronic pain with problematic substance use

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Multivariate pattern analysis links drug use severity to distributed cortical hypoactivity during emotional inhibitory control in opioid use disorder

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Benzodiazepine Use and Dependence in Relation to Chronic Pain Intensity and Pain Catastrophizing

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Clinical and Neurophysiological Effects of Botulinum Neurotoxin Type A in Chronic Migraine

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Lateral Hypothalamic Orexin Neurons Mediate the Reward Effects of Pain Relief Induced by Electroacupuncture

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Effect of histone deacetylase inhibitor on ethanol withdrawal-induced hyperalgesia in rats

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The omnipresence of autonomic modulation in health and disease

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Why haven't we solved the addiction crisis?

Blum, K., Bowirrat, A., Llanos-Gomez, L., Downs, B. W., Bagchi, D., Barh, D., Modestino, E. J., Baron, D. A., McLaughlin, T., Thanos, P. K., et al. (2022) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2022.120404 · Cited by 21

Mapping the Affective Dimension of Embodiment With the Sensation Manikin: Validation Among Chronic Pain Patients and Modification by Mindfulness-Oriented Recovery Enhancement

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Pain Perception and Modulation: Fundamental Neurobiology and Recent Advances

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Fibromyalgia predicts increased odds of pain-related addiction exacerbation among individuals with pain and opioid use disorder

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Validity of mental and physical stress models

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Epigenetic Alterations in Prescription Opioid Misuse: New Strategies for Precision Pain Management

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Neurophysiological Deficits During Reappraisal of Negative Emotional Stimuli in Opioid Misuse

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Hypoperfusion in nucleus accumbens in chronic migraine using 3D pseudo-continuous arterial spin labeling imaging MRI

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Origin of phantom limb pain: A dynamic network perspective

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Intact responses to non-drug rewards in long-term opioid maintenance treatment

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Individuals requiring orthognathic surgery have more depression and pain than controls

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Chronic Pain, Opioid Use Disorder, and Clinical Management Among Older Adults

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Pramipexole treatment attenuates mechanical hypersensitivity in male rats experiencing chronic inflammatory pain

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Researching Mitigation of Alcohol Binge Drinking in Polydrug Abuse: KCNK13 and RASGRF2 Gene(s) Risk Polymorphisms Coupled with Genetic Addiction Risk Severity (GARS) Guiding Precision Pro-Dopamine Regulation

Blum, K., Brodie, M. S., Pandey, S. C., Cadet, J. L., Gupta, A., Elman, I., Thanos, P. K., Gondré‐Lewis, M. C., Baron, D. A., Kazmi, S., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12061009 · Cited by 15

Opioidergic tone and pain susceptibility: interactions between reward systems and opioid receptors

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Positive Emotion Dysregulation in Opioid Use Disorder and Normalization by Mindfulness-Oriented Recovery Enhancement

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Brain Structure and Function of Chronic Low Back Pain Patients on Long-Term Opioid Analgesic Treatment: A Preliminary Study

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Overlapping Mechanisms of Stress-Induced Relapse to Opioid Use Disorder and Chronic Pain: Clinical Implications

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Auricular nerve stimulation using the NSS-2 BRIDGE device to reduce opioid requirement following laparoscopic Roux-en-Y gastric bypass

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Precision Behavioral Management (PBM) and Cognitive Control as a Potential Therapeutic and Prophylactic Modality for Reward Deficiency Syndrome (RDS): Is There Enough Evidence?

Madigan, M. A., Gupta, A., Bowirrat, A., Baron, D. A., Badgaiyan, R. D., Elman, I., Dennen, C. A., Braverman, E. R., Gold, M. S., & Blum, K. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19116395 · Cited by 16

Understanding the Risks of Long-Term Opioid Therapy for Chronic Pain

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Endorphinergic Enhancement Attenuation of Post-traumatic Stress Disorder (PTSD) via Activation of Neuro-immunological Function in the Face of a Viral Pandemic

Blum, K., Modestino, E. J., Baron, D. A., Brewer, R., Thanos, P. K., Elman, I., Badgaiyan, R. D., Downs, B. W., Bagchi, D., McLaughlin, T., et al. (2021) · Current Psychopharmacologye · doi:10.2174/2211556009999210104221215 · Cited by 15

Network Alterations in Comorbid Chronic Pain and Opioid Addiction: An Exploratory Approach

Smallwood, R. F., Price, L. R., Campbell, J. L., Garrett, A. S., Atalla, S., Monroe, T. B., Aytur, S., Potter, J. S., & Robin, D. A. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00174 · Cited by 13

Pain characteristics and nicotine deprivation as predictors of performance during a laboratory paradigm of smoking cessation.

Powers, J. M., LaRowe, L. R., Heckman, B. W., & Ditre, J. W. (2019) · Psychology of Addictive Behaviors · doi:10.1037/adb0000532 · Cited by 13

Pain‐induced alterations in the dynorphinergic system within the mesocorticolimbic pathway: Implication for alcohol addiction

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Stress and Addiction

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CRF regulates pain sensation by enhancement of corticoaccumbal excitatory synaptic transmission

Zhao, W.-N., Yu, Y., Wang, X., Xia, S.-H., Ma, Y., Tang, H., Tao, M., Li, H., Xu, Z., Yang, J., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02488-7 · Cited by 13

Neuropeptide and cytokine regulation of pain in the context of substance use disorders

Delery, E., & Edwards, S. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108153 · Cited by 12

Tetrabenazine, a vesicular monoamine transporter-2 inhibitor, attenuates morphine-induced hyperlocomotion in mice through alteration of dopamine and 5-hydroxytryptamine turnover in the cerebral cortex

Kitanaka, N., Kitanaka, J., Hall, F. S., Kandori, T., Murakami, A., Muratani, K., Nakano, T., Uhl, G. R., & Takemura, M. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.07.002 · Cited by 12

Treating Opioid Dependence: Pain Medicine Physiology of Tolerance and Addiction

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Prevalence and associated factors of myofascial pain in orthognathic patients with skeletal class II malocclusion

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Evolutionary Mismatch, Emotional Homeostasis, and “Emotional Addiction”: A Unifying Model of Psychological Dysfunction

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Inflammatory Pain Alters Dopaminergic Modulation of Excitatory Synapses in the Anterior Cingulate Cortex of Mice

Darvish-Ghane, S., Lyver, B., Facciol, A., Chatterjee, D., & Martin, L. J. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.07.010 · Cited by 10

Una revisión sobre la eficacia del tratamiento cognitivo conductual para el abordaje de la comorbilidad de dolor crónico y el consumo problemático de sustancias

Barrios, V., Cesan, M., Cieplicki, N., & Rosales, M. G. (2021) · NeuroTarget · doi:10.47924/neurotarget20217 · Cited by 11

We need to talk: The urgent conversation on chronic pain, mental health, prescribing patterns and the opioid crisis

Battaglia, M., Groenewald, C. B., Campbell, F. A., Scaini, S., Koninck, Y. D., Stinson, J., & Quinn, P. D. (2023) · Journal of Psychopharmacology · doi:10.1177/02698811221144635 · Cited by 10

How to Combat the Global Opioid Crisis.

Catherine Dennen, A., Blum, K., Eric Braverman, R., Bowirrat, A., Gold, M. S., Elman, I., Panayotis Thanos, K., Baron, D. A., Gupta, A., Edwards, D., et al. (2023) · PubMed · Cited by 11

Contextual processing and its alterations in patients with addictive disorders

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Comprehensive treatment for patients with chronic pain in a 12-step based substance use disorder program

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GluA1 in Central Amygdala Promotes Opioid Use and Reverses Inhibitory Effect of Pain

Hou, Y.-Y., Cai, Y.-Q., & Pan, Z. Z. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.11.032 · Cited by 11

Unveiling the link between chronic pain and misuse of opioids and cannabis

Dagher, M., Alayoubi, M., Sigal, G. H., & Cahill, C. M. (2024) · Journal of Neural Transmission · doi:10.1007/s00702-024-02765-3 · Cited by 11

Brain-behaviour correlates of habitual motivation in chronic back pain

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Pharmacological treatment of pain among persons with opioid addiction: A systematic review and meta‐analysis with implications for drug development

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Mechanisms Underlying Unconscious Processing and Their Alterations in Post-traumatic Stress Disorder: Neuroimaging of Zero Monetary Outcomes Contextually Framed as “No Losses” vs. “No Gains”

Elman, I., Upadhyay, J., Lowen, S. B., Karunakaran, K. D., Albanese, M. A., & Borsook, D. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.604867 · Cited by 11

Left to themselves: Time to target chronic pain in childhood rare diseases

Sieberg, C. B., Lebel, A., Silliman, E., Holmes, S. A., Borsook, D., & Elman, I. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.03.008 · Cited by 11

Overcoming reward deficiency syndrome by the induction of “dopamine homeostasis” instead of opioids for addiction: illusion or reality?

Blum, K., Soni, D., Badgaiyan, R. D., & Baron, D. A. (2022) · Journal of Osteopathic Medicine · doi:10.1515/jom-2021-0026 · Cited by 11

Nicotine, alcohol, and caffeine use among individuals with untreated obstructive sleep apnea

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Alcohol amplifies cingulate cortex signaling and facilitates immobilization-induced hyperalgesia in female rats

Cucinello‐Ragland, J. A., Mitchell‐Cleveland, R., Trimble, W. B., Urbina, A. P., Yeh, A. Y., Edwards, K. N., Molina, P. E., Peter, L. S., & Edwards, S. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136119 · Cited by 9

“Preaddiction” construct and reward deficiency syndrome: genetic link via dopaminergic dysregulation

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