Cited by 303Pain Mechanisms and TreatmentsNeurotransmitter Receptor Influence on BehaviorPain Management and Treatment

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Common Brain Mechanisms of Chronic Pain and Addiction

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Elman, Igor, Borsook, David·2016·Neuron

DOI 10.1016/j.neuron.2015.11.027

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Abstract

While chronic pain is considered by some to be a CNS disease, little is understood about underlying neurobiological mechanisms. Addiction models have heuristic value in this regard, because both pain and addictive disorders are characterized by impaired hedonic capacity, compulsive drug seeking, and high stress. In drug addiction such symptomatology has been attributed to reward deficiency, impaired inhibitory control, incentive sensitization, aberrant learning, and anti-reward allostatic neuroadaptations. Here we propose that similar neuroadaptations exist in chronic pain patients.

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See all 303

Authors: Elman, I., & Borsook, D.
Affiliations: Wright State University (US)
Boston Children's Hospital (US)
Corresponding author: Elman, Igor
ORCID: Elman, Igor
Borsook, David
Venue: Neuron
Publisher: Elsevier BV
Published: 2016-01
Volume: 89
Issue: 1
Pages: 11-36
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2015.11.027
OpenAlex: W2228504785
Cited by: 303
References: 294
Citations by year: 2026: 13 · 2025: 26 · 2024: 33 · 2023: 24 · 2022: 37 · 2021: 38 · 2020: 34 · 2019: 36 · 2018: 30 · 2017: 18 · 2016: 14
FWCI: 3.83
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 371 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (K24NS064050)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: chronic pain, addiction, neural adaptation, incentive sensitization, inhibitory control, compulsive drug seeking, hedonic capacity, stress
MeSH terms: Animals, Brain, Humans, Reward, Behavior, Addictive, Substance-Related Disorders, Drug-Seeking Behavior, Chronic Pain

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Common Brain Mechanisms of Chronic Pain and Addiction

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