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Cited by 117Neuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanismsVisual perception and processing mechanisms

Neuregulin-1/ErbB4 Signaling Regulates Visual Cortical Plasticity

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Sun, Yanjun, Ikrar, Taruna, Davis, Melissa F., Gong, Nian, Zheng, Xiaoting, Luo, Z. David, Lai, Cary, Mei, Lin +3 more·2016·Neuron
DOI 10.1016/j.neuron.2016.08.033PMC PMC5310354
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Abstract

Experience alters cortical networks through neural plasticity mechanisms. During a developmental critical period, the most dramatic consequence of occluding vision through one eye (monocular deprivation) is a rapid loss of excitatory synaptic inputs to parvalbumin-expressing (PV) inhibitory neurons in visual cortex. Subsequent cortical disinhibition by reduced PV cell activity allows for excitatory ocular dominance plasticity. However, the molecular mechanisms underlying critical period synaptic plasticity are unclear. Here we show that brief monocular deprivation during the critical period downregulates neuregulin-1(NRG1)/ErbB4 signaling in PV neurons, causing retraction of excitatory inputs to PV neurons. Exogenous NRG1 rapidly restores excitatory inputs onto deprived PV cells through downstream PKC-dependent activation and AMPA receptor exocytosis, thus enhancing PV neuronal inhibition to excitatory neurons. NRG1 treatment prevents the loss of deprived eye visual cortical responsiveness in vivo. Our findings reveal molecular, cellular, and circuit mechanisms of NRG1/ErbB4 in regulating the initiation of critical period visual cortical plasticity.

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  • Sensory manipulations or drug treatments that inhibit PV cells may result in PV-mediated cortical disinhibition that creates a permissive state for ODP in the presence of visual experience.

    “Sensory manipulations or drug treatments that inhibit PV cells may result in PV-mediated cortical disinhibition that creates a permissive state for ODP to occur in the presence of visual experience (Kuhlman et al., 2013;Gu et al., 2016;Sun et al., 2016;Grieco et al., 2020;Sadahiro et al., 2020).”

    From Psychedelics and Neural Plasticity: Therapeutic Implications (2022) · cites this paper as Sun et al., 2016

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Cited by

Sorted by citations

Authors
Sun, Y., Ikrar, T., Davis, M. F., Gong, N., Zheng, X., Luo, Z. D., Lai, C., Mei, L., Holmes, T. C., Gandhi, S. P., & Xu, X.
Affiliations
  • University of California, Irvine (US)
  • Indiana University Bloomington (US)
  • Augusta University (US)
Corresponding author
Xu, Xiangmin
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2016-10
Volume
92
Issue
1
Pages
160-173
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2016.08.033
PMC
PMC5310354
OpenAlex
W2520836933
Cited by
117
References
11
Citations by year
2026: 7 · 2025: 9 · 2024: 5 · 2023: 10 · 2022: 13 · 2021: 9 · 2020: 18 · 2019: 14 · 2018: 18 · 2017: 12 · 2016: 2
FWCI
8.63
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Institute of Mental Health (R01MH105427)
  • National Institute on Drug Abuse (R00DA023700)
  • National Eye Institute (DP2EY024504)
  • National Cancer Institute (P30CA062203)
  • National Institute of General Medical Sciences (R01GM107405, R01GM102965)
  • National Institute of Neurological Disorders and Stroke (R01NS078434)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Keywords
neuregulin-1, ERBB4 signaling, visual cortical plasticity, critical period, monocular deprivation, ocular dominance, parvalbumin interneurons, cortical disinhibition, PKC signaling, visual cortex
MeSH terms
Animals, Critical Period, Psychological, Female, Male, Neural Inhibition, Neuronal Plasticity, Neurons, Parvalbumins, Sensory Deprivation, Visual Cortex, Down-Regulation, Neuregulin-1, Dominance, Ocular, Mice, Receptor, ErbB-4

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