Inhibitory neuron transplantation into adult visual cortex creates a new critical period that rescues impaired vision
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The maturation of inhibitory circuits in juvenile visual cortex triggers a critical period in the development of the visual system. Although several manipulations of inhibition can alter the timing of the critical period, none have demonstrated the creation of a new critical period in adulthood. We developed a transplantation method to reactivate critical period plasticity in the adult visual cortex. Transplanted embryonic inhibitory neurons from the medial ganglionic eminence reinstate ocular dominance plasticity in adult recipients. Transplanted inhibitory cells develop cell-type-appropriate molecular characteristics and visually evoked responses. In adult mice impaired by deprivation during the juvenile critical period, transplantation also recovers both visual cortical responses and performance on a behavioral test of visual acuity. Plasticity and recovery are induced when the critical period would have occurred in the donor animal. These results reveal that the focal reactivation of visual cortical plasticity using inhibitory cell transplantation creates a new critical period that restores visual perception after childhood deprivation.
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The shift in inhibition is likely mediated by PV+ interneurons, which are also thought to regulate sensitive period plasticity in sensory cortex, making them attractive candidates for pubertal regulation of association cortex plasticity.
“This shift in inhibition is likely mediated by PV+ interneurons, which are also thought to regulate sensitive period plasticity in sensory cortex (Davis et al., 2015; de Villers-Sidani et al., 2008; Hensch, 2005; Le Magueresse and Monyer, 2013; Werker and Hensch, 2015), and therefore are attractive candidates for pubertal regulation of association cortex plasticity.”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Davis et al., 2015
Increasing inhibition from PV+ interneurons is implicated in regulating sensitive period plasticity in primary sensory cortices.
“Increasing inhibition from PV+ interneurons is implicated in regulating sensitive period plasticity in primary sensory cortices (Davis et al., 2015; Heimel et al., 2011; Hensch, 2005; Le Magueresse and Monyer, 2013; Werker and Hensch, 2015).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Davis et al., 2015
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- Authors
- Davis, M. F., Figueroa Velez, D. X., Guevarra, R. P., Yang, M. C., Habeeb, M., Carathedathu, M. C., & Gandhi, S. P.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Gandhi, Sunil P.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 86
- Issue
- 4
- Pages
- 1055-1066
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4441572
- OpenAlex
- W2046325420
- Cited by
- 97
- References
- 42
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 7 · 2023: 5 · 2022: 8 · 2021: 5 · 2020: 13 · 2019: 8 · 2018: 6 · 2017: 14 · 2016: 17 · 2015: 5
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- California Institute for Regenerative Medicine (TG2-01152)
- National Institutes of Health (TG2-01152)
- University of California, Irvine
- National Eye Institute (DP2EY024504)
- National Center for Chronic Disease Prevention and Health Promotion (DP2 EY024504-01)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- critical period, adult visual cortex, ocular dominance plasticity, medial ganglionic eminence, visual deprivation, visual acuity recovery, cortical inhibition, visual cortex development
- MeSH terms
- Aging, Animals, Critical Period, Psychological, Evoked Potentials, Visual, Mice, Inbred C57BL, Neural Inhibition, Neuronal Plasticity, Neurons, Sensory Deprivation, Vision, Ocular, Visual Cortex, Dominance, Ocular
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