α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton
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Genetics and neuropathology strongly link α-synuclein aggregation and neurotoxicity to the pathogenesis of Parkinson's disease and related α-synucleinopathies. Here we describe a new Drosophila model of α-synucleinopathy based on widespread expression of wild-type human α-synuclein, which shows robust neurodegeneration, early-onset locomotor deficits, and abundant α-synuclein aggregation. We use results of forward genetic screening and genetic analysis in our new model to demonstrate that α-synuclein expression promotes reorganization of the actin filament network and consequent mitochondrial dysfunction through altered Drp1 localization. Similar changes are present in a mouse α-synucleinopathy model and in postmortem brain tissue from patients with α-synucleinopathy. Importantly, we provide evidence that the interaction of α-synuclein with spectrin initiates pathological alteration of the actin cytoskeleton and downstream neurotoxicity. These findings suggest new therapeutic approaches for α-synuclein induced neurodegeneration.
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Mitochondrial degeneration has been implicated in a-synucleinopathy and a-syn transgenic flies show abnormal mitochondrial morphology.
“Mitochondrial degeneration has been implicated in a-synucleinopathy (13,25) and a-syn transgenic flies show abnormal mitochondrial morphology (16).”
From Enhanced mTORC1 signaling and Protein Synthesis in Parkinson’s Disease Pathogenesis Disease Pathogenesis (2022) · cites this paper as [16]
The Drosophila Syb-QF2> a-syn model exhibits robust pathologic a-syn induced degeneration.
“The Drosophila Syb-QF2> a-syn model, which exhibits robust pathologic a-syn induced degeneration (16), showed a significant increase in P-S129 a-syn and d4EBP phosphorylation that was reduced by feeding the flies, the mTOR inhibitor, rapamycin (Figures 3C and3D).”
From Enhanced mTORC1 signaling and Protein Synthesis in Parkinson’s Disease Pathogenesis Disease Pathogenesis (2022) · cites this paper as [16]
Familial Parkinson's disease-linked genes such as LRRK2, Parkin, SNCA, and DJ-1, as well as Parkinson's-like phenotypes resulting from genetic deletion of a catalytic ETC complex I subunit, reinforce the role of mitochondrial dysfunction in Parkinson's disease.
“and reinforced by recent studies on familial PD-linked genes such as,leucine-rich repeat kinase 2 (LRRK2), Parkin, synuclein alpha (SNCA), and DJ-1, as well as PD-like phenotypes resulting from genetic deletion of a catalytic ETC complex I subunit.184–187”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [187]
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- Authors
- Ordonez, D. G., Lee, M. K., & Feany, M. B.
- Affiliations
- Brigham and Women's Hospital (US)
- University of Minnesota (US)
- ORCID
- Lee, Michael K.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 97
- Issue
- 1
- Pages
- 108-124.e6
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC5755717
- OpenAlex
- W2771082365
- Cited by
- 227
- References
- 66
- Citations by year
- 2026: 11 · 2025: 20 · 2024: 31 · 2023: 24 · 2022: 30 · 2021: 41 · 2020: 31 · 2019: 26 · 2018: 13
- FWCI
- 13.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Science Foundation (DGE1745303, DGE1144152)
- National Institutes of Health (R01-NS086074, R01-NS092093, R01-AG044113, R01-NS083391)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- alpha-synuclein, Parkinson's disease, synucleinopathies, spectrin, actin cytoskeleton, mitochondrial dysfunction, Drp1, mitochondrial fission, Drosophila model, neurodegeneration, alpha-synuclein aggregation, locomotor deficits, forward genetic screen
- MeSH terms
- Aged, Aged, 80 and over, Animals, Cytoskeletal Proteins, Disease Models, Animal, Drosophila melanogaster, Female, Humans, Male, Actin Cytoskeleton, Middle Aged, Mitochondria, Nerve Degeneration, Spectrin, GTP-Binding Proteins, Lewy Body Disease, alpha-Synuclein
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