APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types
Lin, Yuan-Ta, Seo, Jinsoo, Gao, Fan, Feldman, Heather M., Wen, Hsin-Lan, Penney, Jay, Cam, Hugh P., Gjoneska, Elizabeta +13 more·2018·Neuron
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- APOE genotype and sex affect microglial interactions with plaques in Alzheimer’s disease miceStephen, T. L., Cacciottolo, M., Balu, D., Morgan, T. E., LaDu, M. J., Finch, C. E., Pike, C. J. · 2019 · Acta Neuropathologica Communications
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- APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytesde Leeuw, Sherida M., Kirschner, Aron W.T., Lindner, Karina, Rust, Ruslan, Budny, Vanessa, Wolski, Witold E., Gavin, Anne-Claude, Nitsch, Roger M., Tackenberg, Christian · 2022 · Stem Cell Reports
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- Upgrading the Physiological Relevance of Human Brain OrganoidsAshley Del Dosso, Jean‐Paul Urenda, Tuan N. Nguyen, Giorgia Quadrato · 2020 · Neuron
- The cell biology of APOE in the brainWindham, Ian A., Cohen, Sarah · 2024 · Trends in Cell Biology
- Human iPSC-Derived Neural Models for Studying Alzheimer’s Disease: from Neural Stem Cells to Cerebral OrganoidsMartin Barák, Veronika Fedorová, Veronika Pospíšilová, Jan Raška, Simona Vochyánová, Jiří Sedmík, Hana Hříbková, Hana Klímová, Tereza Váňová, Dáša Bohačiaková · 2022 · Stem Cell Reviews and Reports
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- Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s diseaseXian, Xunde, Pohlkamp, Theresa, Durakoglugil, Murat S, Wong, Connie H, Beck, Jürgen K, Lane-Donovan, Courtney, Plattner, Florian, Herz, Joachim · 2018 · eLife
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- Synaptogenic effect of APP -Swedish mutation in familial Alzheimer’s diseaseBo Zhou, Jacqueline G. Lu, Alberto Siddu, Marius Wernig, Thomas Christian Südhof · 2022 · Science Translational Medicine
- APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet sizeWindham, Ian A., Powers, Alex E., Ragusa, Joey V., Wallace, E. Diane, Zanellati, Maria Clara, Williams, Victoria H., Wagner, Colby H., White, Kristen K., Cohen, Sarah · 2024 · Journal of Cell Biology
- Generating microglia from human pluripotent stem cells: novel in vitro models for the study of neurodegenerationAnna M. Speicher, Heinz Wiendl, Sven Guenther Meuth, Matthias Pawlowski · 2019 · Molecular Neurodegeneration
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- Amyloid‐β impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer's diseaseSanchez‐Mico, Maria V., Jimenez, Sebastian, Gomez‐Arboledas, Angela, Muñoz‐Castro, Clara, Romero‐Molina, Carmen, Navarro, Victoria, Sanchez‐Mejias, Elisabeth, Nuñez‐Diaz, Cristina, Sanchez‐Varo, Raquel, Galea, Elena et al. · 2021 · Glia
- CNTN5-/+or EHMT2-/+human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networksÉric Deneault, Muhammad Faheem, Sean H. White, Deivid C. Rodrigues, Song Sun, Wei Wei, Alina Piekna, Tadeo Thompson, Jennifer Howe, Leon Chalil et al. · 2019 · eLife
- Pro-maturational Effects of Human iPSC-Derived Cortical Astrocytes upon iPSC-Derived Cortical NeuronsAnne Hedegaard, Jimena Monzón‐Sandoval, Sarah E. Newey, Emma S. Whiteley, Caleb Webber, Colin J. Akerman · 2020 · Stem Cell Reports
- Genomics of Alzheimer’s disease implicates the innate and adaptive immune systemsYihan Li, Simon Matthew Laws, Luke A. Miles, James S. Wiley, Xin Huang, Colin Louis Masters, Ben J. Gu · 2021 · Cellular and Molecular Life Sciences
- Cholesterol as a key player in amyloid β-mediated toxicity in Alzheimer’s diseaseVladimir Rudajev, Jiřı́ Novotný · 2022 · Frontiers in Molecular Neuroscience
- Roles of ApoE4 on the Pathogenesis in Alzheimer’s Disease and the Potential Therapeutic ApproachesYu-Ying Sun, Zhun Wang, Han‐Chang Huang · 2023 · Cellular and Molecular Neurobiology
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- Apolipoprotein E in Alzheimer’s disease: molecular insights and therapeutic opportunitiesBelaidi, Abdel Ali, Bush, Ashley I., Ayton, Scott · 2025 · Molecular Neurodegeneration
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- Precision Nutrition for Alzheimer’s Prevention in ApoE4 CarriersNicholas G. Norwitz, Nabeel Saif, Ingrid Estrada Ariza, Richard Isaacson · 2021 · Nutrients
- Sex-dependent effect of <i>APOE</i> on Alzheimer's disease and other age-related neurodegenerative disordersGamache, Julia, Yun, Young, Chiba-Falek, Ornit · 2020 · Disease Models & Mechanisms
- Application of Human Brain Organoids—Opportunities and Challenges in Modeling Human Brain Development and Neurodevelopmental DiseasesSoo-hyun Kim, Mi‐Yoon Chang · 2023 · International Journal of Molecular Sciences
- <i>APOE</i>
ε4 associates with microglial activation independently of Aβ plaques and tau tanglesFerrari-Souza, João Pedro, Lussier, Firoza Z., Leffa, Douglas T., Therriault, Joseph, Tissot, Cécile, Bellaver, Bruna, Ferreira, Pâmela C. L., Malpetti, Maura, Wang, Yi-Ting, Povala, Guilherme et al. · 2023 · Science Advances
- Understanding the Role of ApoE Fragments in Alzheimer’s DiseaseSonia Sanz Muñoz, Brett Garner, Lezanne Ooi · 2018 · Neurochemical Research
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- Limitations of human brain organoids to study neurodegenerative diseases: a manual to surviveUrrestizala-Arenaza, Nerea, Cerchio, Sonia, Cavaliere, Fabio, Magliaro, Chiara · 2024 · Frontiers in Cellular Neuroscience
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- Astrocytic propagation of Tau in the context of Alzheimer's diseaseFleeman, Rebecca M., Proctor, Elizabeth A. · 2021 · Frontiers in Cellular Neuroscience
- PICALM Rescues Endocytic Defects Caused by the Alzheimer’s Disease Risk Factor APOE4Narayan, Priyanka, Sienski, Grzegorz, Bonner, Julia M., Lin, Yuan-Ta, Seo, Jinsoo, Baru, Valeriya, Haque, Aftabul, Milo, Blerta, Akay, Leyla A., Graziosi, Agnese et al. · 2020 · Cell Reports
- Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylationSaroja, Sivaprakasam R., Gorbachev, Kirill, Julia, TCW, Goate, Alison M., Pereira, Ana C. · 2022 · Proceedings of the National Academy of Sciences
- Opportunities and challenges for the use of induced pluripotent stem cells in modelling neurodegenerative diseaseYi‐Ying Wu, Feng‐Lan Chiu, Chan-Shien Yeh, Hung‐Chih Kuo · 2019 · Open Biology
- Cerebral organoids derived from patients with Alzheimer’s disease with PSEN1/2 mutations have defective tissue patterning and altered developmentTereza Váňová, Jiří Sedmík, Jan Raška, Kateřina Amruz Černá, Petr Tauš, Veronika Pospisilova, Markéta Nezvedová, Veronika Fedorová, Sona Kadakova, Hana Klímová et al. · 2023 · Cell Reports
- Chimeric cerebral organoids reveal the essentials of neuronal and astrocytic APOE4 for Alzheimer’s tau pathologyHuang, Shichao, Zhang, Zhen, Cao, Junwei, Yu, Yongchun, Pei, Gang · 2022 · Signal Transduction and Targeted Therapy
- Association of
<i>APOE</i>
Genotype With Heterogeneity of Cognitive Decline Rate in Alzheimer DiseaseQian, Jing, Betensky, Rebecca A., Hyman, Bradley T., Serrano-Pozo, Alberto · 2021 · Neurology
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- Control of Astrocyte Quiescence and Activation in a Synthetic Brain HydrogelSualyneth Galarza, Alfred J. Crosby, ChangHui Pak, Shelly R. Peyton · 2020 · Advanced Healthcare Materials
- Application of CRISPR/Cas9 in Alzheimer’s DiseaseLikui Lu, Yu Xi, Yongle Cai, Miao Sun, Hao Yang · 2021 · Frontiers in Neuroscience
- Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaquesPranav Preman, Julia TCW, Sara Calafate, An Snellinx, María Alfonso-Triguero, Nikky Corthout, Sebastian Munck, Dietmar Rudolf Thal, Alison Goate, Bart De Strooper et al. · 2021 · Molecular Neurodegeneration
- Neuron-astrocyte omnidirectional signaling in neurological health and diseaseDhruba Pathak, Krishnan Sriram · 2023 · Frontiers in Molecular Neuroscience