APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

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  19. Human iPSC application in Alzheimer’s disease and tau-related neurodegenerative diseases
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  26. Stem Cell Therapies in Alzheimer’s Disease: Applications for Disease Modeling
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  30. Using induced pluripotent stem cell neuronal models to study neurodegenerative diseases
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  59. Microglial phagocytosis in Alzheimer disease
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  60. Microglia in Alzheimer's Disease: A Role for Ion Channels
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  61. Astrocytes in Neuropathologies Affecting the Frontal Cortex
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  80. Alzheimer’s in a dish – induced pluripotent stem cell-based disease modeling
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  88. TRPV1 alleviates APOE4-dependent microglial antigen presentation and T cell infiltration in Alzheimer's disease
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