APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types
Lin, Yuan-Ta, Seo, Jinsoo, Gao, Fan, Feldman, Heather M., Wen, Hsin-Lan, Penney, Jay, Cam, Hugh P., Gjoneska, Elizabeta, Raja, Waseem K., Cheng, Jemmie, Rueda, Richard, Kritskiy, Oleg, Abdurrob, Fatema, Peng, Zhuyu, Milo, Blerta, Yu, Chung Jong, Elmsaouri, Sara, Dey, Dilip, Ko, Tak, Yankner, Bruce A., Tsai, Li-Huei·2018·Neuron
Cited by (1,002)
Items 301–400 of 1,002
- Fundamental Neurochemistry Review: Microglial immunometabolism in traumatic brain injuryNathan Ryzewski Strogulski, Luis Valmor Portela, Brian M. Polster, David J. Loane · 2023 · Journal of Neurochemistry
- Toxic amyloid-β oligomers induced self-replication in astrocytes triggering neuronal injuryWei Wang, Tingting Hou, Long-fei Jia, Qiaoqi Wu, Meina Quan, Jianping Jia · 2019 · EBioMedicine
- Sex differences in gene expression patterns associated with the APOE4 alleleMichelle Hsu, Mehek Dedhia, Wim E. Crusio, Anna Delprato · 2019 · F1000Research
- Cholesterol Dysmetabolism in Alzheimer’s Disease: A Starring Role for Astrocytes?Staurenghi, Erica, Giannelli, Serena, Testa, Gabriella, Sottero, Barbara, Leonarduzzi, Gabriella, Gamba, Paola · 2021 · Antioxidants
- Astrocytic and neuronal apolipoprotein E isoforms differentially affect neuronal excitabilityKonings, Sabine C., Torres-Garcia, Laura, Martinsson, Isak, Gouras, Gunnar K. · 2021 · Frontiers in Neuroscience
- LilrB3 is a putative cell surface receptor of APOE4Jiayao Zhou, Yumeng Wang, Gaoxingyu Huang, Min Yang, Yumin Zhu, Chen Jin, Dan Jing, Kai Ji, Yigong Shi · 2023 · Cell Research
- Next Generation Precision Medicine: CRISPR-mediated Genome Editing for the Treatment of Neurodegenerative DisordersSudhanshu P. Raikwar, Nidhi Shankar Kikkeri, Ragha Chaitanya Sakuru, Daniyal Saeed, Haris Zahoor, Keerthivaas Premkumar, Shireen Mentor, Ramasamy Thangavel, Iuliia Dubova, Mohammad Ejaz Ahmed et al. · 2019 · Journal of Neuroimmune Pharmacology
- Emerging role of HDL in brain cholesterol metabolism and neurodegenerative disordersTurri, Marta, Marchi, Cinzia, Adorni, Maria Pia, Calabresi, Laura, Zimetti, Francesca · 2022 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- HDL-like-Mediated Cell Cholesterol Trafficking in the Central Nervous System and Alzheimer’s Disease PathogenesisBorràs, Carla, Mercer, Aina, Sirisi, Sònia, Alcolea, Daniel, Escolà-Gil, Joan Carles, Blanco-Vaca, Francisco, Tondo, Mireia · 2022 · International Journal of Molecular Sciences
- Using human induced pluripotent stem cells (hiPSCs) to investigate the mechanisms by which Apolipoprotein E (APOE) contributes to Alzheimer’s disease (AD) riskSreedevi Raman, Nicholas Brookhouser, David A. Brafman · 2020 · Neurobiology of Disease
- Patient-Derived Midbrain Organoids to Explore the Molecular Basis of Parkinson's DiseaseBenjamin Galet, Hélène Cheval, Philippe Ravassard · 2020 · Frontiers in Neurology
- Cholesterol-lowering drugs reduce APP processing to Aβ by inducing APP dimerizationLangness, Vanessa F., van der Kant, Rik, Das, Utpal, Wang, Louie, Chaves, Rodrigo dos Santos, Goldstein, Lawrence S. B. · 2021 · Molecular Biology of the Cell
- Transplantation Strategies to Enhance Maturity and Cellular Complexity in Brain OrganoidsMeiyan Wang, Fred H. Gage, Simon T. Schafer · 2023 · Biological Psychiatry
- Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathyMonica Xiong, Chao Wang, Maud Gratuze, Fareeha Saadi, Xin Bao, Megan E. Bosch, Choonghee Lee, Hong Jiang, Javier Remolina Serrano, Ernesto R. Gonzales et al. · 2023 · Molecular Neurodegeneration
- Exploiting CRISPR Cas9 in Three-Dimensional Stem Cell Cultures to Model DiseaseSneha Gopal, André Lopes Rodrigues, Jonathan S. Dordick · 2020 · Frontiers in Bioengineering and Biotechnology
- Investigating Microglia in Health and Disease: Challenges and OpportunitiesVéronique E. Miron, Josef Priller · 2020 · Trends in Immunology
- Innate Immune System Activation and Neuroinflammation in Down Syndrome and Neurodegeneration: Therapeutic Targets or Partners?Md. Mahiuddin Ahmed, Noah R. Johnson, Timothy D. Boyd, Christina M. Coughlan, Heidi J. Chial, Huntington Potter · 2021 · Frontiers in Aging Neuroscience
- Region Specific Brain Organoids to Study Neurodevelopmental DisordersPraveen Joseph Susaimanickam, Ferdi Rıdvan Kiral, In‐Hyun Park · 2022 · International Journal of Stem Cells
- Human iPSC application in Alzheimer’s disease and tau-related neurodegenerative diseasesTCW, Julia · 2019 · Neuroscience Letters
- What Have Organoids and Assembloids Taught Us About the Pathophysiology of Neuropsychiatric Disorders?Rebecca J. Levy, Sergiu P. Pașca · 2022 · Biological Psychiatry
- Unraveling the Genetic Landscape of Neurological Disorders: Insights into Pathogenesis, Techniques for Variant Identification, and Therapeutic ApproachesZeba Firdaus, Xiaogang Li · 2024 · International Journal of Molecular Sciences
- Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and ADShaowei Wang, Boyang Li, Jie Li, Zhiheng Cai, Cristelle Hugo, Yi Eve Sun, Lu Qian, Julia TCW, Helena Chang Chui, Dante Dikeman et al. · 2025 · Molecular Neurodegeneration
- Pathological Changes in Alzheimer’s Disease Analyzed Using Induced Pluripotent Stem Cell-Derived Human Microglia-Like CellsXu, Mei, Zhang, Lin, Liu, Gang, Jiang, Ning, Zhou, Wenxia, Zhang, Yongxiang · 2019 · Journal of Alzheimer's Disease
- Deconstructing and reconstructing the human brain with regionally specified brain organoidsYangfei Xiang, Bilal Çakır, In‐Hyun Park · 2020 · Seminars in Cell and Developmental Biology
- Invited Review – Understanding cause and effect in Alzheimer's pathophysiology: Implications for clinical trialsDelphine Boche, James A. R. Nicoll · 2020 · Neuropathology and Applied Neurobiology
- Stem Cell Therapies in Alzheimer’s Disease: Applications for Disease ModelingZizhen Si, Xidi Wang · 2021 · Journal of Pharmacology and Experimental Therapeutics
- Cell-Type-Specific High Throughput Toxicity Testing in Human Midbrain OrganoidsHenrik Renner, Katharina Becker, Theresa Kagermeier, Martha Grabos, Farsam Eliat, Patrick S. Günther, Hans Robert Schöler, Jan M. Bruder · 2021 · Frontiers in Molecular Neuroscience
- Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy modelHannah Rickner, Lulu Jiang, Rui Hong, Nicholas K. O’Neill, Chromewell A. Mojica, Benjamin J. Snyder, Lushuang Zhang, Dipan Shaw, Maria Medalla, Benjamin L. Wolozin et al. · 2022 · Nature Communications
- Pathogenesis, therapeutic strategies and biomarker development based on “omics” analysis related to microglia in Alzheimer’s diseaseChao Gao, Xin Shen, Yuyan Tan, Shengdi Chen · 2022 · Journal of Neuroinflammation
- Using induced pluripotent stem cell neuronal models to study neurodegenerative diseasesXinwen Zhang, Di Hu, Yutong Shang, Xin Qi · 2019 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Critical Molecular and Cellular Contributors to Tau PathologyLiqing Song, Evan A. Wells, Anne Skaja Robinson · 2021 · Biomedicines
- Multifaceted Involvement of Microglia in Gray Matter Pathology in Multiple SclerosisFoteini Tsouki, Anna Williams · 2021 · Stem Cells
- Interplay Between Microglia and Alzheimer’s Disease—Focus on the Most Relevant Risks: APOE Genotype, Sex and AgeYanting Chen, Tingting Hong, Feng Chen, Yuanhong Sun, Yan Wang, Lili Cui · 2021 · Frontiers in Aging Neuroscience
- Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on GliaKatrina Albert, Jonna Niskanen, Sara Kälvälä, Šárka Lehtonen · 2021 · International Journal of Molecular Sciences
- Harnessing cerebral organoids for Alzheimer's disease researchAdele Bubnys, Li‐Huei Tsai · 2021 · Current Opinion in Neurobiology
- Experimental Models for the Study of Central Nervous System Infection by SARS-CoV-2Inmaculada Sanclemente-Alamán, Lidia Moreno‐Jiménez, María Soledad Benito‐Martín, Alejandro Arturo Canales-Aguirre, Jordi A. Matías‐Guiu, Jorge Matías‐Guiu, Ulises Gómez‐Pinedo · 2020 · Frontiers in Immunology
- Unlocking Neural Function with 3D In Vitro Models: A Technical Review of Self-Assembled, Guided, and Bioprinted Brain Organoids and Their Applications in the Study of Neurodevelopmental and Neurodegenerative DisordersChiara D’Antoni, Lorenza Mautone, Caterina Sanchini, Lucrezia Tondo, Greta Grassmann, Gianluca Cidonio, Paola Bezzi, Federica Cordella, Silvia Di Angelantonio · 2023 · International Journal of Molecular Sciences
- Astrocytes: The Stars in Neurodegeneration?Katarina Stoklund Dittlau, Kristine Freude · 2024 · Biomolecules
- Comprehensive Overview of Alzheimer’s Disease: Etiological Insights and Degradation StrategiesManish Kumar Singh, Yoonhwa Shin, Songhyun Ju, Sunhee Han, Sung Soo Kim, Insug Kang · 2024 · International Journal of Molecular Sciences
- Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease modelAntara T. Rao, Nuo Chen, Min Joo Kim, Jessica R. Blumenfeld, Oscar Yip, Zherui Liang, David M. Shostak, Yanxia Hao, Maxine R. Nelson, Nicole Koutsodendris et al. · 2024 · Cell stem cell
- The Role of HDL and HDL Mimetic Peptides as Potential Therapeutics for Alzheimer’s DiseaseDustin Chernick, Rui Zhong, Ling Li · 2020 · Biomolecules
- Simplified Brain Organoids for Rapid and Robust Modeling of Brain DiseaseJeongmin Ha, Ji Su Kang, Minhyung Lee, Areum Baek, Seong‐Jun Kim, Sun‐Ku Chung, Mi‐Ok Lee, Janghwan Kim · 2020 · Frontiers in Cell and Developmental Biology
- Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's diseaseGyungah Jun, Yang You, Congcong Zhu, Gaoyuan Meng, Jaeyoon Chung, Rebecca Panitch, Junming Hu, Weiming Xia, David Alan Bennett, Tatiana Foroud et al. · 2022 · Alzheimer s & Dementia
- Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidateNemergut, Michal, Marques, Sérgio M., Uhrik, Lukas, Vanova, Tereza, Nezvedova, Marketa, Gadara, Darshak Chandulal, Jha, Durga, Tulis, Jan, Novakova, Veronika, Planas-Iglesias, Joan et al. · 2023 · Molecular Neurodegeneration
- Astrocytes in Neurodegeneration: Inspiration From GeneticsJingxuan Huang, Chunyu Li, Huifang Shang · 2022 · Frontiers in Neuroscience
- The role of ApoE-mediated microglial lipid metabolism in brain aging and diseaseJui-Hung Jimmy Yen, I-Chen Ivorine Yu · 2023 · Immunometabolism
- More than just risk for Alzheimer’s disease: APOE ε4's impact on the aging brainJustin M. Palmer, Matthew J. Huentelman, Lee Ryan · 2023 · Trends in Neurosciences
- IPSC-NSCs-derived exosomal let-7b-5p improves motor function after spinal cord Injury by modulating microglial/macrophage pyroptosisJie Liu, Guang Kong, Chenlin Lu, Juan Wang, Wenbo Li, Zhengming Lv, Jian Tong, Yuan Liu, Wu Xiong, Haijun Li et al. · 2024 · Journal of Nanobiotechnology
- Modelling Sporadic Alzheimer’s Disease Using Induced Pluripotent Stem CellsHelen A. Rowland, Nigel M. Hooper, Katherine A. B. Kellett · 2018 · Neurochemical Research
- Modeling Alzheimer’s disease with human iPS cells: advancements, lessons, and applicationsSofia Essayan-Perez, Bo Zhou, Amber M. Nabet, Marius Wernig, Yu‐Wen Alvin Huang · 2019 · Neurobiology of Disease
- Apolipoprotein E isoform-dependent effects on the processing of Alzheimer's amyloid-βAmanda B. Chai, Hin Hei Julian Lam, Maaike Kockx, Ingrid C. Gelissen · 2021 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Stem Cell Therapy for Alzheimer’s Disease: A Scoping Review for 2017–2022Yunxiao Duan, Linshuoshuo Lyu, Siyan Zhan · 2023 · Biomedicines
- Microglial APOE3 Christchurch protects neurons from Tau pathology in a human iPSC-based model of Alzheimer’s diseaseSun, Guoqiang George, Wang, Cheng, Mazzarino, Randall C., Perez-Corredor, Paula Andrea, Davtyan, Hayk, Blurton-Jones, Mathew, Lopera, Francisco, Arboleda-Velasquez, Joseph F., Shi, Yanhong · 2024 · Cell Reports
- Tools for studying human microglia: In vitro and in vivo strategiesAnna S. Warden, Claudia Z. Han, Emily A. Hansen, Samantha Trescott, Celina T. Nguyen, Roy Y. Kim, Danielle M. Schafer, Avalon Johnson, Madison Wright, Gabriela Ramírez et al. · 2022 · Brain Behavior and Immunity
- Incorporating microglia‐like cells in human induced pluripotent stem cell‐derived retinal organoidsChichagova, Valeria, Georgiou, Maria, Carter, Madeleine, Dorgau, Birthe, Hilgen, Gerrit, Collin, Joseph, Queen, Rachel, Chung, Git, Ajeian, Jila, Moya‐Molina, Marina et al. · 2023 · Journal of Cellular and Molecular Medicine
- Induced Pluripotent Stem Cells and Organoids in Advancing Neuropathology Research and TherapiesDouglas Bottega Pazzin, Thales Thor Ramos Previato, João Ismael Budelon Gonçalves, Gabriele Zanirati, Fernando Antônio Costa Xavier, Jaderson Costa DaCosta, Daniel Rodrigo Marinowic · 2024 · Cells
- Strategies for modeling aging and age-related diseasesD. Jothi, Linda Anna Michelle Kulka · 2024 · npj Aging
- Exploring human brain development and disease using assembloidsSih‐Rong Wu, Tomasz Jan Nowakowski · 2025 · Neuron
- Microglial phagocytosis in Alzheimer diseaseBrown, Guy C., St George-Hyslop, Peter, Paolicelli, Rosa C., Lemke, Greg · 2026 · Nature Reviews Neurology
- Microglia in Alzheimer's Disease: A Role for Ion ChannelsLaura Thei, Jennifer L. Imm, Eleni Kaisis, Mark L. Dallas, Talitha L. Kerrigan · 2018 · Frontiers in Neuroscience
- Astrocytes in Neuropathologies Affecting the Frontal CortexUlla‐Kaisa Peteri, Mikael Niukkanen, Maija L. Castrén · 2019 · Frontiers in Cellular Neuroscience
- Optogenetics in the Era of Cerebral OrganoidsZahra Shiri, Susan Simorgh, Somayeh Naderi, Hossein Baharvand · 2019 · Trends in biotechnology
- Endosomal-Lysosomal Processing of Neurodegeneration-Associated Proteins in AstrocytesWong, Ching-On · 2020 · International Journal of Molecular Sciences
- Current and future applications of induced pluripotent stem cell-based models to study pathological proteins in neurodegenerative disordersAurélie de Rus Jacquet, Hélèna L. Denis, Francesca Cicchetti, Melanie Alpaugh · 2021 · Molecular Psychiatry
- Astrocytic expression of the Alzheimer’s disease risk allele, ApoEε4, potentiates neuronal tau pathology in multiple preclinical modelsAngela Marie Jablonski, Lee Warren, Marija Usenovic, Heather H. Zhou, Jonathan A. Sugam, Sophie Parmentier‐Batteur, Bhavya Voleti · 2021 · Scientific Reports
- Combining NGN2 programming and dopaminergic patterning for a rapid and efficient generation of hiPSC-derived midbrain neuronsRazan Sheta, Maxime Teixeira, Walid Idi, Marion Pierre, Aurélie de Rus Jacquet, Vincent Émond, Cornelia E. Zorca, Benoît Vanderperre, Thomas M. Durcan, Edward A. Fon et al. · 2022 · Scientific Reports
- ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cellsJiyeon Lee, Haeryung Lee, Hyein G. Lee, Miram Shin, Min-Gi Shin, Jinsoo Seo, Eun Jeong Lee, Sun Ah Park, Soochul Park · 2023 · Nature Communications
- The application of in vitro ‐derived human neurons in neurodegenerative disease modelingGary X. D’Souza, Shannon E. Rose, Allison Knupp, Daniel A. Nicholson, Christopher Dirk Keene, Jessica E. Young · 2020 · Journal of Neuroscience Research
- If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?Lezanne Ooi, Mirella Dottori, Anthony L. Cook, Martin Engel, Vini Gautam, Alexandra Grubman, Damián Hernández, Anna Elizabeth King, Simon Maksour, Helena Targa Dias Anastacio et al. · 2020 · The Neuroscientist
- Brain organoids: Human 3D models to investigate neuronal circuits assembly, function and dysfunctionMonica Tambalo, Simona Lodato · 2020 · Brain Research
- Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer’s DiseaseJuan Antonio García‐León, Laura Cáceres-Palomo, Elisabeth Sánchez‐Mejías, Marina Mejias‐Ortega, Cristina Nuñez‐Diaz, Juan José Fernandez-Valenzuela, Raquel Maria Sanchez-Varo, José Carlos Dávila, Javier Vitórica, Antonia Gutiérrez · 2020 · International Journal of Molecular Sciences
- Brain organoids: building higher-order complexity and neural circuitry modelsGulimiheranmu Maisumu, Stephanie Michelle Willerth, Michael W. Nestor, Ben Waldau, Stefan Schülke, Francesco V. Nardi, Osama Ahmed, You Zhou, Madel Durens, Bo Liang et al. · 2025 · Trends in biotechnology
- Human iNSC-derived brain organoid model of lysosomal storage disorder in Niemann–Pick disease type CSeung‐Eun Lee, Nari Shin, Myung Geun Kook, Dasom Kong, Nam Gyo Kim, Soon Won Choi, Kyung‐Sun Kang · 2020 · Cell Death and Disease
- Crosstalk between Different DNA Repair Pathways Contributes to Neurodegenerative DiseasesSwapnil Gupta, Panpan You, Tanima SenGupta, Hilde Loge Nilsen, Kulbhushan Sharma · 2021 · Biology
- Neuroimmune mechanisms underlying Alzheimer’s disease: Insights into central and peripheral immune cell crosstalkYuqing Liu, Yejun Tan, Zheyu Zhang, Hongli Li, Min Yi, Zhen Zhang, Shan Hui, Weijun Peng · 2022 · Ageing Research Reviews
- CRISPR/Cas9 system and its applications in nervous system diseasesHaibin Jiang, Meng-Yan Tang, Zidi Xu, Yanan Wang, Mopu Li, Shuyin Zheng, Jianghu Zhu, Zhenlang Lin, Min Zhang · 2023 · Genes & Diseases
- Elevated expression of the retrotransposon LINE-1 drives Alzheimer’s disease-associated microglial dysfunctionNainika Roy, Imdadul Haq, Jason C. Ngo, David A. Bennett, Andrew F. Teich, Philip L. De Jager, Marta Olah, Falak Sher · 2024 · Acta Neuropathologica
- Advancements in CRISPR/Cas systems for disease treatmentYangsong Xu, Hao Le, Qinjie Wu, Ning Wang, Changyang Gong · 2025 · Acta Pharmaceutica Sinica B
- The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseasesFeringa, Femke M., Koppes-den Hertog, Sascha J., Wang, Lian Y., Derks, Rico J. E., Kruijff, Iris, Erlebach, Lena, Heijneman, Jorin, Miramontes, Ricardo, Pömpner, Nadine, Blomberg, Niek et al. · 2025 · Nature Metabolism
- Alzheimer’s in a dish – induced pluripotent stem cell-based disease modelingde Leeuw, Sherida, Tackenberg, Christian · 2019 · Translational Neurodegeneration
- PDE inhibition in distinct cell types to reclaim the balance of synaptic plasticityBen Rombaut, Sofie Kessels, Melissa Schepers, Assia Tiane, Dean Paes, Yevgeniya Solomina, Elisabeth Piccart, Daniël van den Hove, Bert Brône, Jos Prickaerts et al. · 2020 · Theranostics
- APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer’s diseaseBrookhouser, Nicholas, Raman, Sreedevi, Frisch, Carlye, Srinivasan, Gayathri, Brafman, David A. · 2021 · Molecular Psychiatry
- APOE4 Affects Basal and NMDAR-Mediated Protein Synthesis in Neurons by Perturbing Calcium HomeostasisSarayu Ramakrishna, Vishwaja Jhaveri, Sabine C Konings, Bharti Nawalpuri, Sumita Chakraborty, Bjørn Holst, Benjamin Schmid, Gunnar K. Gouras, Kristine Freude, Ravi Sondekoppa Muddashetty · 2021 · Journal of Neuroscience
- Redefining microglia states: Lessons and limits of human and mouse models to study microglia states in neurodegenerative diseasesYvanka de Soysa, Martine Therrien, Alicia C. Walker, Beth Stevens · 2022 · Seminars in Immunology
- A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD miceBalu, Deebika, Valencia-Olvera, Ana C., Nguyen, Austin, Patnam, Mehul, York, Jason, Peri, Francesco, Neumann, Frank, LaDu, Mary Jo, Tai, Leon M. · 2023 · Alzheimer's Research & Therapy
- Integration of iPSC-Derived Microglia into Brain Organoids for Neurological ResearchMuhammad Asif Mrza, Jitian He, Youwei Wang · 2024 · International Journal of Molecular Sciences
- Challenges and Future Perspectives in Modeling Neurodegenerative Diseases Using Organ‐on‐a‐Chip TechnologyFrancesca Michela Pramotton, Sarah Spitz, Roger Dale Kamm · 2024 · Advanced Science
- TRPV1 alleviates APOE4-dependent microglial antigen presentation and T cell infiltration in Alzheimer's diseaseJia Lu, Kexin Wu, Xudong Sha, Jiayuan Lin, Hongzhuan Chen, Zhihua Yu · 2024 · Translational Neurodegeneration
- APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microgliaPreman, Pranav, Moechars, Daan, Fertan, Emre, Wolfs, Leen, Serneels, Lutgarde, Shah, Disha, Lamote, Jochen, Poovathingal, Suresh, Snellinx, An, Mancuso, Renzo et al. · 2024 · EMBO Molecular Medicine
- Growing Glia: Cultivating Human Stem Cell Models of Gliogenesis in Health and DiseaseSamantha N. Lanjewar, Steven A. Sloan · 2021 · Frontiers in Cell and Developmental Biology
- The Application of Brain Organoid Technology in Stroke Research: Challenges and ProspectsGuini Song, Min Zhao, Han‐Min Chen, Xiangyue Zhou, Cameron Lenahan, Yibo Ou, Yue He · 2021 · Frontiers in Cellular Neuroscience
- Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteinsFote, Gianna M., Geller, Nicolette R., Efstathiou, Nikolaos E., Hendricks, Nathan, Vavvas, Demetrios G., Reidling, Jack C., Thompson, Leslie M., Steffan, Joan S. · 2022 · Journal of Cell Science
- Human microglial models to study HIV infection and neuropathogenesis: a literature overview and comparative analysesStephanie B. H. Gumbs, Raphael Kübler, Lavina Gharu, Pauline J. Schipper, Anne L. Borst, Gijsje J. L. Snijders, Paul R. Ormel, Amber Berdenis van Berlekom, Annemarie M. J. Wensing, Lot D. de Witte et al. · 2022 · Journal of NeuroVirology
- Opportunities and challenges in delivering biologics for Alzheimer’s disease by low-intensity ultrasoundLiyu Chen, Esteban Cruz, Lotta E. Oikari, Pranesh Padmanabhan, Jae Hee Song, Jürgen Götz · 2022 · Advanced Drug Delivery Reviews
- A new perspective on Alzheimer’s disease: m6A modificationLei Xia, Fan Zhang, Yulu Li, Yuemi Mo, Lingqiu Zhang, Qianhua Li, Minghuang Luo, Xiaotao Hou, Zhengcai Du, Jiagang Deng et al. · 2023 · Frontiers in Genetics
- Induced pluripotent stem cell-derived macrophages as a platform for modelling human diseaseSatish Kumar Tiwari, Wei Jie Wong, Marco Moreira, Claudia Pasqualini, Florent Ginhoux · 2024 · Nature reviews. Immunology
- Trends and challenges of AAV-delivered gene editing therapeutics for CNS disorders: Implications for neurodegenerative diseaseBoris Kantor, Bernadette O’Donovan, Ornit Chiba‐Falek · 2025 · Molecular Therapy — Nucleic Acids
- Stem cell models of human synapse development and degenerationEmily S. Wilson, Karen Litwa · 2018 · Molecular Biology of the Cell
- An Overview of Astrocyte Responses in Genetically Induced Alzheimer’s Disease Mouse ModelsFokion Spanos, Shane Antony Liddelow · 2020 · Cells
- iPSC-Derived Microglia for Modeling Human-Specific DAMP and PAMP Responses in the Context of Alzheimer’s DiseaseIvanna Ihnatovych, Barbara G. Birkaya, Emily Notari, Kinga Szigeti · 2020 · International Journal of Molecular Sciences