The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System
Open accessAbstract
SUMMARY Ventral tegmental area (VTA) dopamine (DA) neurons play a central role in mediating motivated behaviors, but the circuitry through which they signal positive and negative motivational stimuli is incompletely understood. Using in-vivo fiber photometry, we simultaneously recorded activity in DA terminals in different nucleus accumbens (NAc) subnuclei during an aversive and reward conditioning task. We find that DA terminals in the ventral NAc medial shell (vNAcMed) are excited by unexpected aversive outcomes and to cues that predict them, whereas DA terminals in other NAc subregions are persistently depressed. Excitation to reward-predictive cues dominated in the NAc lateral shell and was largely absent in the vNAcMed. Moreover, we demonstrate that glutamatergic (VGLUT2-expressing) neurons in the lateral hypothalamus represent a key afferent input for providing information about aversive outcomes to vNAcMed-projecting DA neurons. Collectively, we reveal the distinct functional contributions of separate mesolimbic DA subsystems and their afferent pathways underlying motivated behaviors.
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Cites
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Self-citationLateral habenula as a source of negative reward signals in dopamine neurons
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Matthews, G. A., & Tye, K. M. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14016 · Cited by 273
Physiology and Pathophysiology of Itch
Cevikbas, F., & Lerner, E. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00017.2019 · Cited by 282
Dopamine release in the nucleus accumbens core signals perceived saliency
Kutlu, M. G., Zachry, J. E., Melugin, P. R., Cajigas, S. A., Chevee, M. F., Kelly, S. J., Kutlu, B., Tian, L., Siciliano, C. A., & Calipari, E. S. (2021) · Current Biology · doi:10.1016/j.cub.2021.08.052 · Cited by 238
Self-citationImaging neurotransmitter and neuromodulator dynamics in vivo with genetically encoded indicators
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Metadata
- Authors
- de Jong, J. W., Afjei, S. A., Pollak Dorocic, I., Peck, J. R., Liu, C., Kim, C. K., Tian, L., Deisseroth, K., & Lammel, S.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 101
- Issue
- 1
- Pages
- 133-151.e7
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2902477192
- Cited by
- 511
- References
- 30
- FWCI
- 16.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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- de Jong, J. W., Afjei, S. A., Pollak Dorocic, I., Peck, J. R., Liu, C., Kim, C. K., Tian, L., Deisseroth, K., & Lammel, S. (2019). A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System. Neuron. https://doi.org/10.1016/j.neuron.2018.11.005
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