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Vasoactive Intestinal Polypeptide-Expressing Interneurons in the Hippocampus Support Goal-Oriented Spatial Learning
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Diverse computations in the neocortex are aided by specialized GABAergic interneurons (INs), which selectively target other INs. However, much less is known about how these canonical disinhibitory circuit motifs contribute to network operations supporting spatial navigation and learning in the hippocampus. Using chronic two-photon calcium imaging in mice performing random foraging or goal-oriented learning tasks, we found that vasoactive intestinal polypeptide-expressing (VIP+), disinhibitory INs in hippocampal area CA1 form functional subpopulations defined by their modulation by behavioral states and task demands. Optogenetic manipulations of VIP+ INs and computational modeling further showed that VIP+ disinhibition is necessary for goal-directed learning and related reorganization of hippocampal pyramidal cell population dynamics. Our results demonstrate that disinhibitory circuits in the hippocampus play an active role in supporting spatial learning. VIDEO ABSTRACT.
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“Place fields uniformly tiled the available space (Fig. 1c), with a slight over-representation of the reward’s position and of prominent tactile cues on the belt (see also refs. 39–41).”
From Place and behavioral modulation of hippocampal neurons during immobility (2026) · cites this paper as [41]
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Metadata
- Authors
- Turi, G. F., Li, W.-K., Chavlis, S., Pandi, I., O’Hare, J., Priestley, J. B., Grosmark, A. D., Liao, Z., Ladow, M., Zhang, J. F., Zemelman, B. V., Poirazi, P., & Losonczy, A.
- Affiliations
- Columbia University (US)
- Mortimer B. Zuckerman Mind Brain Behavior Institute (US)
- FORTH Institute of Molecular Biology and Biotechnology (GR)
- University of Crete (GR)
- The University of Texas at Austin (US)
- Corresponding author
- Poirazi, Panayiota
- Losonczy, Attila
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 101
- Issue
- 6
- Pages
- 1150-1165.e8
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC6428605
- OpenAlex
- W2913259775
- Cited by
- 218
- References
- 82
- Citations by year
- 2026: 26 · 2025: 35 · 2024: 34 · 2023: 33 · 2022: 30 · 2021: 27 · 2020: 22 · 2019: 9
- FWCI
- 12.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (1R01MH100631)
- National Institute of Neurological Disorders and Stroke (1U19NS104590, 1R01NS094668)
- Zegar Family Foundation Award
- Kavli Foundation (NYSTEM-C029157, S10 OD018464)
- NIMH (F32MH118716)
- Revson Foundation
- NINDS (U01NS094330, U01NS099720)
- ERC Starting Grant dEMORY (ERC-2012-StG-311435)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- vasoactive intestinal peptide, GABAergic interneurons, hippocampal CA1, goal-directed learning, spatial learning, spatial navigation, two-photon calcium imaging, optogenetics, computational modeling, foraging behavior, behavioral state
- MeSH terms
- Animals, Appetitive Behavior, Goals, Hippocampus, Interneurons, Neural Inhibition, Vasoactive Intestinal Peptide, Pyramidal Cells, Neocortex, Mice, CA1 Region, Hippocampal, Optogenetics, Spatial Learning
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