Cited by 195Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

A Role for the Locus Coeruleus in Hippocampal CA1 Place Cell Reorganization during Spatial Reward Learning

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Kaufman, Alexandra Mansell, Geiller, Tristan, Losonczy, Attila·2020·Neuron

Abstract

During spatial learning, hippocampal (HPC) place maps reorganize to represent new goal locations, but little is known about the circuit mechanisms facilitating these changes. Here, we examined how neuromodulation via locus coeruleus (LC) projections to HPC area CA1 (LC-CA1) regulates the overrepresentation of CA1 place cells near rewarded locations. Using two-photon calcium imaging, we monitored the activity of LC-CA1 fibers in the mouse dorsal HPC. We find that the LC-CA1 projection signals the translocation of a reward, predicting behavioral performance on a goal-oriented spatial learning task. An optogenetic stimulation mimicking this LC-CA1 activity induces place cell reorganization around a familiar reward, while its inhibition decreases the degree of overrepresentation around a translocated reward. Our results show that LC acts in conjunction with other factors to induce goal-directed reorganization of HPC representations and provide a better understanding of the role of neuromodulatory actions on HPC place map plasticity.

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  • Stimulation of locus coeruleus neurons enhances hippocampus-dependent memory.

    “Notably, stimulation of locus coeruleus neurons, presumably releasing noradrenaline or dopamine, enhances hippocampus-dependent memory [105–108].”

    From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [108]

    The Discussion (page unavailable) says local, unilateral LC–CA1 stimulation produced place-cell enrichment when paired with a reward, but did not produce a behavioral effect. The paper therefore does not show that its stimulation enhanced hippocampus-dependent memory; it reports a change in hippocampal representation instead. (LLM, conf=0.87)

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Research works printed but not linked: 1

  1. Gauthier, Jeffrey L, Tank DW, 2018 A Dedicated Population for Reward Coding in the Hippocampus. Neuron 99, 1– 15. 30008297 PMC7023678

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Authors
Kaufman, A. M., Geiller, T., & Losonczy, A.
Affiliations
Mortimer B. Zuckerman Mind Brain Behavior Institute (US)
Corresponding author
Losonczy, Attila
Venue
Neuron
Publisher
Elsevier BV
Published
2020-03
Volume
105
Issue
6
Pages
1018-1026.e4
ISSN
0896-6273 (ISSN-L)
OpenAlex
W3002023792
Cited by
193
References
53
Citations by year
2026: 31 · 2025: 34 · 2024: 41 · 2023: 27 · 2022: 25 · 2021: 23 · 2020: 11 · 2019: 1
FWCI
11.48
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Foundation for the National Institutes of Health
  • Kavli Foundation
  • National Science Foundation (DGE-1644869, 1F31MH117870-01A1)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
locus coeruleus, hippocampal CA1, place cells, neuromodulation, goal-directed learning, optogenetic stimulation
MeSH terms
Place Cells, Animals, Female, Locus Coeruleus, Male, Mice, Transgenic, Neural Inhibition, Neural Pathways, Reward, Mice, CA1 Region, Hippocampal, Optogenetics, Spatial Learning

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