A Role for the Locus Coeruleus in Hippocampal CA1 Place Cell Reorganization during Spatial Reward Learning
Open accessAbstract
During spatial learning, hippocampal (HPC) place maps reorganize to represent new goal locations, but little is known about the circuit mechanisms facilitating these changes. Here, we examined how neuromodulation via locus coeruleus (LC) projections to HPC area CA1 (LC-CA1) regulates the overrepresentation of CA1 place cells near rewarded locations. Using two-photon calcium imaging, we monitored the activity of LC-CA1 fibers in the mouse dorsal HPC. We find that the LC-CA1 projection signals the translocation of a reward, predicting behavioral performance on a goal-oriented spatial learning task. An optogenetic stimulation mimicking this LC-CA1 activity induces place cell reorganization around a familiar reward, while its inhibition decreases the degree of overrepresentation around a translocated reward. Our results show that LC acts in conjunction with other factors to induce goal-directed reorganization of HPC representations and provide a better understanding of the role of neuromodulatory actions on HPC place map plasticity.
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Stimulation of locus coeruleus neurons enhances hippocampus-dependent memory.
“Notably, stimulation of locus coeruleus neurons, presumably releasing noradrenaline or dopamine, enhances hippocampus-dependent memory [105–108].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [108]
The Discussion (page unavailable) says local, unilateral LC–CA1 stimulation produced place-cell enrichment when paired with a reward, but did not produce a behavioral effect. The paper therefore does not show that its stimulation enhanced hippocampus-dependent memory; it reports a change in hippocampal representation instead. (LLM, conf=0.87)
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- Gauthier, Jeffrey L, Tank DW, 2018 A Dedicated Population for Reward Coding in the Hippocampus. Neuron 99, 1– 15. 30008297 PMC7023678
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Entorhinal cortex–hippocampal circuit connectivity in health and disease
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The little brain and the seahorse: Cerebellar-hippocampal interactions
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Cartographers of the Cognitive Map: Locus Coeruleus Is Part of the Guild
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Mechanisms of experience-dependent place-cell referencing in hippocampal area CA1
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Learning, Fast and Slow: Single- and Many-Shot Learning in the Hippocampus
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Self-citationThe shallow cognitive map hypothesis: A hippocampal framework for thought disorder in schizophrenia
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Neural circuit dynamics of drug-context associative learning in the mouse hippocampus
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Locus Coeruleus in Non-Mammalian Vertebrates
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Full field-of-view virtual reality goggles for mice
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Place cells are nonrandomly clustered by field location in CA1 hippocampus
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Reward Expectation Reduces Representational Drift in the HippocampusPreprint
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Multiple long-range projections convey position information to the agranular retrosplenial cortex
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Hippocampal contextualization of social rewards in mice
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Predictive coding of reward in the hippocampus
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Contextual memory engrams, and the neuromodulatory influence of the locus coeruleus
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Elucidating a locus coeruleus-dentate gyrus dopamine pathway for operant reinforcement
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Spatial localization of hippocampal replay requires dopamine signalingPreprint
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Single-trial dynamics of hippocampal spatial representations are modulated by reward value
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Brain-wide presynaptic networks of functionally distinct cortical neurons
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Whole-brain afferent input mapping to functionally distinct brainstem noradrenaline cell types
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Learning to predict future locations with internally generated theta sequences
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How prediction error drives memory updating: role of locus coeruleus–hippocampal interactions
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Recurrent connectivity shapes spatial coding in hippocampal CA3 subregions
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Self-citationMoculus: an immersive virtual reality system for mice incorporating stereo vision
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An Intranet of Things approach for adaptable control of behavioral and navigation-based experimentsPreprint
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Signatures of Rapid Synaptic Learning in the Hippocampus During Novel ExperiencesPreprint
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Stimulus-dependent dopamine dynamics from locus coeruleus axons
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- Authors
- Kaufman, A. M., Geiller, T., & Losonczy, A.
- Affiliations
- Mortimer B. Zuckerman Mind Brain Behavior Institute (US)
- Corresponding author
- Losonczy, Attila
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 105
- Issue
- 6
- Pages
- 1018-1026.e4
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC7265133
- OpenAlex
- W3002023792
- Cited by
- 193
- References
- 53
- Citations by year
- 2026: 31 · 2025: 34 · 2024: 41 · 2023: 27 · 2022: 25 · 2021: 23 · 2020: 11 · 2019: 1
- FWCI
- 11.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 382 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Foundation for the National Institutes of Health
- Kavli Foundation
- National Science Foundation (DGE-1644869, 1F31MH117870-01A1)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- locus coeruleus, hippocampal CA1, place cells, neuromodulation, goal-directed learning, optogenetic stimulation
- MeSH terms
- Place Cells, Animals, Female, Locus Coeruleus, Male, Mice, Transgenic, Neural Inhibition, Neural Pathways, Reward, Mice, CA1 Region, Hippocampal, Optogenetics, Spatial Learning
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