The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD
Open accessAbstract
Stress granules (SGs) form during cellular stress and are implicated in neurodegenerative diseases such as amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). To yield insights into the role of SGs in pathophysiology, we performed a high-content screen to identify small molecules which alter SG properties in proliferative cells and human iPSC-derived motor neurons (iPS-MNs). One major class of active molecules contained extended planar aromatic moieties, suggesting a potential to intercalate in nucleic acids. Accordingly, we show that several hit compounds can prevent the RNA-dependent recruitment of the ALS-associated RNA-binding proteins (RBPs) TDP-43, FUS and HNRNPA2B1 into SGs. We further demonstrate that transient SG formation contributes to persistent accumulation of TDP-43 into cytoplasmic puncta and that our hit compounds can reduce this accumulation in iPS-MNs from ALS patients. We propose that compounds with planar moieties represent a promising starting point to develop small molecule therapeutics for treating ALS/FTD.
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Modulating biomolecular condensates: a novel approach to drug discovery
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Metadata
- Authors
- Fang, M. Y., Markmiller, S., Vu, A. Q., Javaherian, A., Dowdle, W. E., Jolivet, P., Bushway, P. J., Castello, N. A., Baral, A., Chan, M. Y., Linsley, J. W., Linsley, D., Mercola, M., Finkbeiner, S., Lecuyer, E., Lewcock, J. W., & Yeo, G. W.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2019-09
- Volume
- 103
- Issue
- 5
- Pages
- 802-819.e11
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2954699006
- Cited by
- 282
- References
- 97
- FWCI
- 16.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD. https://app.cochat.ai/papers/10.1016/j.neuron.2019.05.048
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- Fang, M. Y., Markmiller, S., Vu, A. Q., Javaherian, A., Dowdle, W. E., Jolivet, P., Bushway, P. J., Castello, N. A., Baral, A., Chan, M. Y., Linsley, J. W., Linsley, D., Mercola, M., Finkbeiner, S., Lecuyer, E., Lewcock, J. W., & Yeo, G. W. (2019). Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD. Neuron. https://doi.org/10.1016/j.neuron.2019.05.048
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
