Vasomotion as a Driving Force for Paravascular Clearance in the Awake Mouse Brain
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Cerebrospinal fluid flow in perivascular spaces is driven forward by dynamic constriction and enlargement of the cerebral arteries, and thereby the perivascular space volume, rather than a steady perivascular space size.
“The data so far indicates that CSF flow in the perivascular spaces (PVSs) is driven forward by dynamic constriction and enlargement of the cerebral arteries, and thereby the PVS volume, rather than a steady PVS size27–31.”
From Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep (2025) · cites this paper as [30]
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“Drainage of soluble waste products from the interstitial fluid (ISF) of the brain seems to be an important process to maintain brain health during aging (Xie et al., 2013; Kress et al., 2014; Benveniste et al., 2019).”
BackgroundInfluentialCerebral Arterial Pulsation Drives Paravascular CSF–Interstitial Fluid Exchange in the Murine Brain
Iliff, J. J., Wang, M., Zeppenfeld, D. M., Venkataraman, A., Plog, B. A., Liao, Y., Deane, R., & Nedergaard, M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1592-13.2013 · Cited by 1,319 · see citing works
Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease
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Self-citationCerebral amyloid angiopathy without and with cerebral hemorrhages: A comparative histological study
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Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep
Hauglund, N. L., Andersen, M., Tokarska, K., Radovanovic, T., Kjaerby, C., Sørensen, F. L., Bojarowska, Z., Untiet, V., Ballestero, S. B., Kolmos, M. G., et al. (2025) · Cell · doi:10.1016/j.cell.2024.11.027 · Cited by 349 · see citing works
Bojarskaite, L., Vallet, A., Bjørnstad, D. M., Gullestad Binder, K. M., Cunen, C., Heuser, K., Kuchta, M., Mardal, K.-A., & Enger, R. (2023) · Nature Communications · doi:10.1038/s41467-023-36643-5 · Cited by 149 · see citing works
Impact of multisession 40Hz tACS on hippocampal perfusion in patients with Alzheimer’s disease
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“…hyperemia), a fundamental homeostatic response of the cerebral microcirculation [15], occurs early in patients with CAA [16–18], whereas Aβ-induced suppression of functional hyperemia and dysfunction of the endothelial regulation of CBF have been linked to CAA in mouse models [13, 19–21].”
InfluentialChronic sleep fragmentation impairs brain interstitial clearance in young wildtype mice
Deng, S., Hu, Y., Chen, S., Xue, Y., Yao, D., Sun, Q., Nedergaard, M., Wang, W., & Ding, F. (2024) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x241230188 · Cited by 52 · see citing works
Plastic vasomotion entrainment
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- Authors
- van Veluw, S. J., Hou, S. S., Calvo-Rodriguez, M., Arbel-Ornath, M., Snyder, A. C., Frosch, M. P., Greenberg, S. M., & Bacskai, B. J.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 105
- Issue
- 3
- Pages
- 549-561.e5
- ISSN
- 0896-6273
- PMC
- PMC7028316
- Cited by
- 514
- References
- 11
- Language
- en
- Licence
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- National Institutes of Health
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