Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease
Open accessAbstract
Transgenic mice carrying disease-linked forms of genes associated with Alzheimer disease often demonstrate deposition of the beta-amyloid as senile plaques and cerebral amyloid angiopathy. We have characterized the natural history of beta-amyloid deposition in APPswe/PS1dE9 mice, a particularly aggressive transgenic mouse model generated with mutant transgenes for APP (APPswe: KM594/5NL) and PS1 (dE9: deletion of exon 9). Ex vivo histochemistry showed Abeta deposition by 4 months with a progressive increase in plaque number up to 12 months and a similar increase of Abeta levels. In vivo multiphoton microscopy at weekly intervals showed increasing beta-amyloid deposition as CAA and plaques. Although first appearing at an early age, CAA progressed at a significantly slower rate than in the Tg2576 mice. The consistent and early onset of beta-amyloid accumulation in the APPswe/PS1dE9 model confirms its utility for studies of biochemical and pathological mechanisms underlying beta-amyloid deposition, as well as exploring new therapeutic treatments.
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Human APOE alleles targeted to APPSW/PS1dE9 mice reproduce their differential effect on the magnitude of Aβ plaque load but do not delay onset of Aβ deposition compared to APPSW/PS1dE9 mice expressing native murine apoE.
“As previously shown, human APOE alleles targeted to APPSW/PS1dE9 mice reproduce their differential effect on the magnitude of Aβ plaque load [13] but do not delay onset of Aβ deposition compared to APPSW/PS1dE9 mice expressing native murine apoE [14].”
From Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice (2014) · cites this paper as [14]
The APP/PS1 line represents a Tg model with enhanced disease phenotype, whereby the first plaques are detected by thioflavin-S at the age of 4 months.
“The APP SW /PS1 dE9 line represents a Tg model with enhanced disease phenotype, whereby the first plaques are detected by thioflavin-S at the age of 4 months.54”
From Blocking the Interaction between Apolipoprotein E and Aβ Reduces Intraneuronal Accumulation of Aβ and Inhibits Synaptic Degeneration (2013) · cites this paper as [54]
Cites
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210 · see citing works
Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126 · see citing works
Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., et al. (1996) · Nature Medicine · doi:10.1038/nm0896-864 · Cited by 2,599 · see citing works
Evans, D. A. (1989) · JAMA · doi:10.1001/jama.262.18.2551 · Cited by 1,627 · see citing works
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
Lewis, J., Dickson, D. W., Lin, W.-L., Chisholm, L., Corral, A., Jones, G., Yen, S.-H., Sahara, N., Skipper, L., Yager, D., et al. (2001) · Science · doi:10.1126/science.1058189 · Cited by 1,611 · see citing works
Jankowsky, J. L., Fadale, D. J., Anderson, J., Xu, G. M., Gonzales, V., Jenkins, N. A., Copeland, N. G., Lee, M. K., Younkin, L. H., Wagner, S. L., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh019 · Cited by 1,575 · see citing works
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.-H., Mistl, C., Rothacher, S., Ledermann, B., Bürki, K., Frey, P., Paganetti, P. A., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13287 · Cited by 1,507 · see citing works
Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1
Duff, K., Eckman, C., Zehr, C., Yu, X., Prada, C.-M., Pérez‐Tur, J., Hutton, M., Buée, L., Harigaya, Y., Yager, D., et al. (1996) · Nature · doi:10.1038/383710a0 · Cited by 1,453 · see citing works
Self-citationHolcomb, L., Gordon, M. N., McGowan, E., Yu, X., Benkovic, S., Jantzen, P., Wright, K., Saad, I., Mueller, R., Morgan, D., et al. (1998) · Nature Medicine · doi:10.1038/nm0198-097 · Cited by 1,386 · see citing works
Self-citationO'Brien, J. T., Erkinjuntti, T., Reisberg, ., Román, G. C., Pantoni, L., Bowler, J., Ballard, C., DeCarli, C., Gorelick, P., Rockwood, K., et al. (2014) · International Journal of Stroke · doi:10.1111/ijs.12374_18 · Cited by 1,165 · see citing works
O'Brien, J. T., Erkinjuntti, T., Reisberg, B., Roman, G., Sawada, T., Pantoni, L., Bowler, J. V., Ballard, C., DeCarli, C., Gorelick, P. B., et al. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00305-3 · Cited by 1,139 · see citing works
Kawarabayashi, T., Younkin, L. H., Saido, T. C., Shoji, M., Ashe, K. H., & Younkin, S. G. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-02-00372.2001 · Cited by 1,053 · see citing works
The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease
Selkoe, D. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01363-4 · Cited by 862 · see citing works
Co-expression of multiple transgenes in mouse CNS: a comparison of strategies
Jankowsky, J. L., Slunt, H. H., Ratovitski, T., Jenkins, N. A., Copeland, N. G., & Borchelt, D. (2001) · Biomolecular Engineering · doi:10.1016/s1389-0344(01)00067-3 · Cited by 819 · see citing works
Alzheimer disease and cerebrovascular pathology: an update
Jellinger, K. A. (2002) · Journal of Neural Transmission · doi:10.1007/s007020200068 · Cited by 680 · see citing works
Herreman, A., Hartmann, D., Annaert, W. G., Säftig, P., Craessaerts, K., Serneels, L., Umans, L., Schrijvers, V., Checler, F., Vanderstichele, H., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.11872 · Cited by 518 · see citing works
Savonenko, A. V., Xu, G. M., Melnikova, T., Morton, J. L., Gonzales, V., Wong, M. P., Price, D. L., Tang, F., Markowska, A. L., & Borchelt, D. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.10.022 · Cited by 396 · see citing works
Raber, J., Wong, D., Buttini, M., Orth, M., Bellosta, S., Pitas, R. E., Mahley, R. W., & Mucke, L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10914 · Cited by 364 · see citing works
Racke, M. M., Boone, L. I., Hepburn, D. L., Parsadainian, M., Bryan, M. T., Ness, D. K., Piroozi, K. S., Jordan, W. H., Brown, D. D., Hoffman, W. P., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4337-04.2005 · Cited by 320 · see citing works
Hyman, B., Marzloff, K., & Arriagada, P. (1993) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199311000-00006 · Cited by 294 · see citing works
Spontaneous Hemorrhagic Stroke in a Mouse Model of Cerebral Amyloid Angiopathy
Winkler, D. T., Bondolfi, L., Herzig, M. C., Jann, L., Calhoun, M. E., Wiederhold, K., Tolnay, M., Staufenbiel, M., & Jucker, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01619.2001 · Cited by 287 · see citing works
Hyman, B. T., West, H. L., Rebeck, G. W., Buldyrev, S. V., Mantegna, R. N., Ukleja, M., Havlin, S., & Stanley, H. E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.8.3586 · Cited by 212 · see citing works
Transgenic models of Alzheimer’s disease: Learning from animals
Spires‐Jones, T. L., & Hyman, B. T. (2005) · NeuroRx · doi:10.1602/neurorx.2.3.423 · Cited by 209 · see citing works
Christie, R. H., Bacskai, B. J., Zipfel, W. R., Williams, R. M., Kajdasz, S. T., Webb, W. W., & Hyman, B. T. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-03-00858.2001 · Cited by 197 · see citing works
Self-citationRichards, J., Higgins, G., Ouagazzal, A., Ozmen, L., Kew, J., Bohrmann, B., Malherbe, P., Brockhaus, M., Loetscher, H., Czech, C., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-26-08989.2003 · Cited by 197 · see citing works
The Cerebral β-Amyloid Angiopathies: Hereditary and Sporadic
Zhang-Nunes, S., Maat–Schieman, M. L. C., van Duinen, S. G., Roos, R. A. C., Frosch, M. P., & Greenberg, S. M. (2006) · Brain Pathology · doi:10.1111/j.1750-3639.2006.tb00559.x · Cited by 195 · see citing works
Self-citationAPP processing and amyloid deposition in mice haplo-insufficient for presenilin 1
Jankowsky, J. L., Slunt, H. H., Gonzales, V., Jenkins, N. A., Copeland, N. G., & Borchelt, D. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.09.008 · Cited by 189 · see citing works
McLellan, M. E., Kajdasz, S. T., Hyman, B. T., & Bacskai, B. J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-06-02212.2003 · Cited by 174 · see citing works
Self-citationNicoll, J. A. R., Yamada, M., Frackowiak, J., Mazur‐Kolecka, B., & Weller, R. O. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.02.003 · Cited by 159 · see citing works
Weller, R. O., Massey, A., Kuo, Y., & Roher, A. E. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06356.x · Cited by 151 · see citing works
Christie, R. H., Yamada, M., Moskowitz, M. A., & Hyman, B. T. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64053-9 · Cited by 137 · see citing works
Siman, R., Reaume, A. G., Savage, M. J., Trusko, S., Lin, Y.-G., Scott, R. W., & Flood, D. G. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08717.2000 · Cited by 133 · see citing works
Mouse Models of Alzheimer's Disease: Insight into Treatment
German, D., & Eisch, A. (2004) · Reviews in the Neurosciences · doi:10.1515/revneuro.2004.15.5.353 · Cited by 116 · see citing works
Increased Aβ42(43) from cell lines expressing presenilin 1 mutations
Mehta, N. D., Refolo, L. M., Eckman, C., Sanders, S., Yager, D., Perez‐Tur, J., Younkin, S., Duff, K., Hardy, J., & Hutton, M. (1998) · Annals of Neurology · doi:10.1002/ana.410430217 · Cited by 101 · see citing works
Wengenack, T. M., Whelan, S. L., Curran, G. L., Duff, K., & Poduslo, J. F. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00388-2 · Cited by 97 · see citing works
Expression of APP in transgenic mice: a Comparison of neuron-specific promoters
Andrä, K., Abramowski, D., Duke, M., Probst, A., Wiederhold, K.-H., Bürki, K., Goedert, M., Sommer, B., & Staufenbiel, M. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(95)02066-7 · Cited by 95 · see citing works
Savonenko, A. V., Xu, G. M., Price, D. L., Borchelt, D., & Markowska, A. L. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(02)00012-8 · Cited by 82 · see citing works
Kinetics of Cerebral Amyloid Angiopathy Progression in a Transgenic Mouse Model of Alzheimer Disease
Robbins, E. M., Betensky, R. A., Domnitz, S. B., Purcell, S. M., Garcı́a-Alloza, M., Greenberg, C., Rebeck, G. W., Hyman, B. T., Greenberg, S. M., Frosch, M. P., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3854-05.2006 · Cited by 78 · see citing works
Self-citationMatrix metalloproteinase-9 in cerebral-amyloid-angiopathy-related hemorrhage
Lee, J., Yin, K., Hsin, I., Chen, S., Fryer, J. D., Holtzman, D. M., Hsu, C. Y., & Xu, J. (2004) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2004.11.041 · Cited by 67 · see citing works
Progression of Cerebral Amyloid Angiopathy in Transgenic Mouse Models of Alzheimer Disease
Domnitz, S. B., Robbins, E. M., Hoang, A. W., Garcı́a-Alloza, M., Hyman, B. T., Rebeck, G. W., Greenberg, S. M., Bacskai, B. J., & Frosch, M. P. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000171644.00180.fc · Cited by 65 · see citing works
Self-citationSelkoe, D. J. (2006) · Nature Medicine · doi:10.1038/nm0706-758 · Cited by 53 · see citing works
Amyloid at the blood vessel wall
Hardy, J., & Cullen, K. M. (2006) · Nature Medicine · doi:10.1038/nm0706-756 · Cited by 40 · see citing works
Liu, L., Herukka, S., Minkeviciene, R., vanGroen, T., & Tanila, H. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.08.005 · Cited by 36 · see citing works
Mouse Models of Human Neurodegenerative Disorders
Bloom, F. E., Reilly, J. F., Redwine, J. M., Wu, C.-C., Young, W. G., & Morrison, J. H. (2005) · Archives of Neurology · doi:10.1001/archneur.62.2.185 · Cited by 35 · see citing works
Cerebrovascular disease and the pathophysiology of Alzheimer's disease. Implications for therapy.
Weller, R. O., Cohen, N. R., & Nicoll, J. A. R. (2004) · PubMed · Cited by 35 · see citing works
Borchelt, D., Lee, M. K., Gonzales, V., Slunt, H. H., Ratovitski, T., Jenkins, N. A., Copeland, N. G., Price, D. L., & Sisodia, S. S. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00280-9 · Cited by 21 · see citing works
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Sperling, R. A., Jack, C. R., Black, S. E., Frosch, M. P., Greenberg, S. M., Hyman, B. T., Scheltens, P., Carrillo, M. C., Thies, W., Bednar, M. M., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.05.2351 · Cited by 857 · see citing works
Self-citationSynchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice
Kuchibhotla, K. V., Lattarulo, C. R., Hyman, B. T., & Bacskai, B. J. (2009) · Science · doi:10.1126/science.1169096 · Cited by 729 · see citing works
Self-citationKoronyo-Hamaoui, M., Koronyo, Y., Ljubimov, A. V., Miller, C. A., Ko, M. K., Black, K. L., Schwartz, M., & Farkas, D. L. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.06.020 · Cited by 672 · see citing works
Garcı́a-Alloza, M., Borrelli, L. A., Rozkalne, A., Hyman, B. T., & Bacskai, B. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04613.x · Cited by 663 · see citing works
Self-citationAmyloid β-Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy
Minkeviciene, R., Rheims, S., Dobszay, M. B., Zilberter, M. Y., Hartikainen, J., Fülöp, L., Penke, B., Zilberter, Y., Harkany, T., Pitkänen, A., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5215-08.2009 · Cited by 656 · see citing works
Kuchibhotla, K. V., Goldman, S. T., Lattarulo, C. R., Wu, H.-Y., Hyman, B. T., & Bacskai, B. J. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.008 · Cited by 614 · see citing works
Self-citationVasomotion as a Driving Force for Paravascular Clearance in the Awake Mouse Brain
van Veluw, S. J., Hou, S. S., Calvo-Rodríguez, M., Arbel‐Ornath, M., Snyder, A. C., Frosch, M. P., Greenberg, S. M., & Bacskai, B. J. (2019) · Neuron · doi:10.1016/j.neuron.2019.10.033 · Cited by 492 · see citing works
Self-citationApoE4 Accelerates Early Seeding of Amyloid Pathology
Liu, C.-C., Zhao, N., Fu, Y., Wang, N., Linares, C., Tsai, C.-W., & Bu, G. (2017) · Neuron · doi:10.1016/j.neuron.2017.11.013 · Cited by 451 · see citing works
REVIEW: Curcumin and Alzheimer’s disease
Hamaguchi, T., Ono, K., & Yamada, M. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00147.x · Cited by 450 · see citing works
Alzheimer disease models and human neuropathology: similarities and differences
Duyckaerts, C. J., Potier, M., & Delatour, B. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0312-8 · Cited by 441 · see citing works
Shaftel, S. S., Kyrkanides, S., Olschowka, J. A., Miller, J.-N. H., Johnson, R. E., & O’Banion, M. K. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31450 · Cited by 433 · see citing works
Calvo-Rodríguez, M., Hou, S. S., Snyder, A. C., Kharitonova, E. K., Russ, A., Das, S., Fan, Z., Muzikansky, A., Garcı́a-Alloza, M., Serrano‐Pozo, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16074-2 · Cited by 432 · see citing works
Self-citationKim, T., Vidal, G. S., Djurisic, M., William, C. M., Birnbaum, M. E., Garcia, K. C., Hyman, B. T., & Shatz, C. J. (2013) · Science · doi:10.1126/science.1242077 · Cited by 410 · see citing works
Gowrishankar, S., Yuan, P., Wu, Y., Schrag, M., Paradise, S., Grutzendler, J., De Camilli, P., & Ferguson, S. M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510329112 · Cited by 406 · see citing works
Zhang, X., Tian, Y., Zeng, L., Tian, X., Sun, H., Liu, H. S., Moore, A. V., & Ran, C. (2013) · Journal of the American Chemical Society · doi:10.1021/ja405239v · Cited by 359 · see citing works
Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors
Zelcer, N., Khanlou, N., Clare, R., Jiang, Q., Reed-Geaghan, E. G., Landreth, G. E., Vinters, H. V., & Tontonoz, P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701096104 · Cited by 358 · see citing works
Bennett, R. E., Robbins, A. B., Hu, M., Cao, X., Betensky, R. A., Clark, T., Das, S., & Hyman, B. T. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1710329115 · Cited by 299 · see citing works
Self-citationLonnemann, N., Hosseini, S., Marchetti, C., Skouras, D. B., Stefanoni, D., D’Alessandro, A., Dinarello, C. A., & Korte, M. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2009680117 · Cited by 298 · see citing works
Toledo, E. M., & Inestrosa, N. C. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.72 · Cited by 290 · see citing works
Ding, M., Shen, Y., Wang, P., Xie, Z., Xu, S., Zhu, Z., Wang, Y., Lyu, Y., Dewei, W., Xu, L., et al. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2641-5 · Cited by 279 · see citing works
The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β
Wu, X., Lu, Y., Dong, Y., Zhang, G., Zhang, Y., Xu, Z., Culley, D. J., Crosby, G. J., Marcantonio, E. R., Tanzi, R. E., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.11.002 · Cited by 261 · see citing works
Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer’s disease mouse models
Arbel‐Ornath, M., Hudry, E., Eikermann‐Haerter, K., Hou, S. S., Gregory, J. L., Zhao, L., Betensky, R. A., Frosch, M. P., Greenberg, S. M., & Bacskai, B. J. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1145-2 · Cited by 256 · see citing works
Self-citationUnger, M. S., Li, E., Scharnagl, L., Poupardin, R., Altendorfer, B., Mrowetz, H., Hutter-Paier, B., Weiger, T. M., Heneka, M. T., Attems, J., et al. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.05.070 · Cited by 248 · see citing works
da Silva, S. V., Haberl, M. G., Zhang, P., Bethge, P., Lemos, C., Gonçalves, N., Gorlewicz, A., Malézieux, M., Gonçalves, F. Q., Grosjean, N., et al. (2016) · Nature Communications · doi:10.1038/ncomms11915 · Cited by 242 · see citing works
Bäuerl, C., Collado, M. C., Diaz Cuevas, A., Viña, J., & Pérez Martínez, G. (2018) · Letters in Applied Microbiology · doi:10.1111/lam.12882 · Cited by 238 · see citing works
Zhang, X., Tian, Y., Zhang, C. M., Tian, X., Ross, A., Moir, R. D., Sun, H., Tanzi, R. E., Moore, A. V., & Ran, C. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1505420112 · Cited by 227 · see citing works
Jiwaji, Z., Tiwari, S. S., Avilés-Reyes, R. X., Hooley, M., Hampton, D., Torvell, M., Johnson, D. A., McQueen, J., Baxter, P., Sabari-Sankar, K., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27702-w · Cited by 223 · see citing works
Wang, Y., Thomas, P., Zhong, J., Bi, F., Kosaraju, S. L., Pollard, A., Fenech, M. F., & Zhou, X. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9000-x · Cited by 221 · see citing works
Trimethylated chitosan-conjugated PLGA nanoparticles for the delivery of drugs to the brain
Wang, Z. H., Wang, Z., Sun, C., Wang, C. Y., Jiang, T., & Wang, S. L. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.09.104 · Cited by 214 · see citing works
Pedrós, I., Petrov, D., Allgaier, M., Sureda, F. X., Barroso, E., Beas‐Zárate, C., Auladell, C., Pallàs, M., Vázquez‐Carrera, M., Casadesús, G., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.05.025 · Cited by 203 · see citing works
Wang, D., Li, S., Wu, W., Zhu, X., Wang, Y., & Yuan, H. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1343-x · Cited by 196 · see citing works
Ji, M., Arbel, M., Zhang, L., Freudiger, C. W., Hou, S. S., Lin, D., Yang, X., Bacskai, B. J., & Xie, X. S. (2018) · Science Advances · doi:10.1126/sciadv.aat7715 · Cited by 194 · see citing works
Self-citationLu, Y., Wu, X., Dong, Y., Xu, Z., Zhang, Y., & Xie, Z. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181d94de1 · Cited by 193 · see citing works
Mori, T., Koyama, N., Guillot‐Sestier, M., Tan, J., & Town, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055774 · Cited by 189 · see citing works
Cerebrovascular lesions induce transient -amyloid deposition
Garcia-Alloza, M., Gregory, J., Kuchibhotla, K. V., Fine, S., Wei, Y., Ayata, C., Frosch, M. P., Greenberg, S. M., & Bacskai, B. J. (2011) · Brain · doi:10.1093/brain/awr300 · Cited by 187 · see citing works
Self-citationNeprilysin: An Enzyme Candidate to Slow the Progression of Alzheimer's Disease
El‐Amouri, S. S., Zhu, H., Yu, J., Marr, R. A., Verma, I. M., & Kindy, M. S. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070620 · Cited by 188 · see citing works
Mitochondrial alterations near amyloid plaques in an Alzheimer’s disease mouse model
Xie, H., Guan, J., Borrelli, L. A., Xu, J., Serrano-Pozo, A., & Bacskai, B. J. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1836-13.2013 · Cited by 185 · see citing works
“In the transgenic (Tg) mice (APPswe:PSEN1dE9), the levels of A increase with age and A plaques are observed at 4 months of age, accumulating progressively afterward (Garcia-Alloza et al., 2006).”
BackgroundSelf-citationElevated labile Cu is associated with oxidative pathology in Alzheimer disease
James, S., Volitakis, I., Adlard, P. A., Duce, J. A., Masters, C. L., Cherny, R. A., & Bush, A. I. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.446 · Cited by 184 · see citing works
Liu, C.-C., Zhao, N., Yamaguchi, Y., Cirrito, J. R., Kanekiyo, T., Holtzman, D. M., & Bu, G. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad3650 · Cited by 180 · see citing works
Mori, T., Rezai-Zadeh, K. P., Koyama, N., Arendash, G. W., Yamaguchi, H., Kakuda, N., Horikoshi‐Sakuraba, Y., Tan, J., & Town, T. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.294025 · Cited by 179 · see citing works
Neuroprotective Role of Trans-Resveratrol in a Murine Model of Familial Alzheimer's Disease
Porquet, D., Griñán‐Ferré, C., Ferrer, I., Camins, A., Sanfeliu, C., del Valle, J., & Pallàs, M. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140444 · Cited by 178 · see citing works
Amyloid Deposition and Inflammation in APPswe/PS1dE9 Mouse Model of Alzheimers Disease
Ruan, L., Kang, Z., Pei, G., & Le, Y. (2009) · Current Alzheimer Research · doi:10.2174/156720509790147070 · Cited by 169 · see citing works
Johnstone, D. M., Moro, C., Stone, J., Benabid, A., & Mitrofanis, J. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00500 · Cited by 171 · see citing works
The Second Activating Glucokinase Mutation (A456V)
Christesen, H. T., Jacobsen, B. B., Odili, S., Buettger, C. W., Cuesta-Muñoz, A. L., Hansen, T. F., Brusgaard, K., Massa, O., Magnuson, M. A., Shiota, C., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1240 · Cited by 171 · see citing works
Tapia‐Rojas, C., Aránguiz, F. C., Varela‐Nallar, L., & Inestrosa, N. C. (2015) · Brain Pathology · doi:10.1111/bpa.12255 · Cited by 168 · see citing works
Garcia, K. O., Ornellas, F. M., Martin, P. K. M., Patti, C. L., Mello, L. E., Frussa‐Filho, R., Han, S. W., & Longo, B. M. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00030 · Cited by 168 · see citing works
Volianskis, A., Køstner, R., Mølgaard, M., Hass, S., & Jensen, M. S. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.08.005 · Cited by 167 · see citing works
Purushothuman, S., Johnstone, D. M., Nandasena, C., Mitrofanis, J., & Stone, J. (2014) · Alzheimer s Research & Therapy · doi:10.1186/alzrt232 · Cited by 167 · see citing works
Yang, H., Xie, Z., Wei, L. F., Yang, H. N., Yang, S. N., Zhu, Z., Wang, P., Zhao, C., & Bi, J. Z. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt227 · Cited by 166 · see citing works
Neuroprotective Activity of Hypericum perforatum and Its Major Components
Oliveira, A. I., Pinho, C., Sarmento, B. F. C. C., & Dias, A. C. P. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.01004 · Cited by 159 · see citing works
Viayna, E., Sola, I., Bartolini, M., Simone, A. D., Tapia‐Rojas, C., Serrano, F. G., Sabaté, R., Juárez‐Jiménez, J., Pérez, B., Luque, F. J., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm401824w · Cited by 156 · see citing works
Vepsäläinen, S., Koivisto, H., Pekkarinen, E., Mäkinen, P., Dobson, G., McDougall, G. J., Stewart, D., Haapasalo, A., Karjalainen, R. O., Tanila, H., et al. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.07.006 · Cited by 150 · see citing works
Darvesh, S., Cash, M. K., Reid, G. A., Martin, E. V., Mitnitski, A., & Geula, C. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31823cc7a6 · Cited by 151 · see citing works
CXCR3 promotes plaque formation and behavioral deficits in an Alzheimer’s disease model
Krauthausen, M., Kummer, M. P., Zimmermann, J., Reyes-Irisarri, E., Terwel, D., Bulic, B., Heneka, M. T., & Müller, M. (2014) · Journal of Clinical Investigation · doi:10.1172/jci66771 · Cited by 147 · see citing works
Cancino, G. I., Toledo, E. M., Leal, N. R., Hernández, D. E., Yévenes, L. F., Inestrosa, N. C., & Alvarez, A. R. (2008) · Brain · doi:10.1093/brain/awn125 · Cited by 147 · see citing works
Zhang, R., Xue, G., Wang, S., Zhang, L., Shi, C., & Xie, X. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120151 · Cited by 146 · see citing works
Wan, J., Fu, A. K. Y., Ip, F. C. F., Ng, H., Hugon, J., Page, G., Wang, J. H.-C., Lai, K., Wu, Z., & Ip, N. Y. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0519-10.2010 · Cited by 143 · see citing works
Liu, H., Zhao, G., Zhang, H., & Li-de, S. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.08.008 · Cited by 141 · see citing works
Hoeijmakers, L., Ruigrok, S. R., Amelianchik, A., Ivan, D., van Dam, A.-M., Lucassen, P. J., & Korosi, A. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.12.023 · Cited by 138 · see citing works
Differential cell proliferation in the cortex of the appsweps1de9 alzheimer's disease mouse model
Kamphuis, W., Orre, M., Kooijman, L., Dahmen, M., & Hol, E. M. (2012) · Glia · doi:10.1002/glia.22295 · Cited by 137 · see citing works
Šalković‐Petrišić, M., Barilar, J. O., Brückner, M. K., Hoyer, S., Arendt, T., & Riederer, P. F. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-011-0651-4 · Cited by 136 · see citing works
Increased brain iron coincides with early plaque formation in a mouse model of Alzheimer's disease
Leskovjan, A. C., Kretlow, A., Lanzirotti, A., Barrea, R. A., Vogt, S., & Miller, L. M. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.11.073 · Cited by 134 · see citing works
O’Leary, T. P., & Brown, R. E. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.01.039 · Cited by 134 · see citing works
Kostylev, M. A., Kaufman, A. C., Nygaard, H. B., Patel, P., Haas, L. T., Gunther, E. C., Vortmeyer, A., & Strittmatter, S. M. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.643577 · Cited by 133 · see citing works
Praet, J., Manyakov, N. V., Muchene, L., Mai, Z., Terzopoulos, V., de Backer, S., Torremans, A., Guns, P.-J., Van De Casteele, T., Bottelbergs, A., et al. (2018) · Alzheimer's Research & Therapy · doi:10.1186/s13195-017-0329-8 · Cited by 133 · see citing works
Frost, J. L., Le, K. X., Cynis, H., Ekpo, E., Kleinschmidt, M., Palmour, R. M., Ervin, F. R., Snigdha, S., Cotman, C. W., Saido, T. C., et al. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.05.005 · Cited by 132 · see citing works
Guo, H., Cheng, Y., Wang, C., Wu, J., Zou, Z., Niu, B., Yu, H. M., Wang, H., & Xu, J. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.004 · Cited by 133 · see citing works
Zhang, Q., Ma, C., Chin, L., & Li, L. (2020) · Science Advances · doi:10.1126/sciadv.abc5802 · Cited by 127 · see citing works
Sierksma, A. S. R., van den Hove, D., Pfau, F., Philippens, M., Bruno, O., Fedele, E., Ricciarelli, R., Steinbusch, H. W. M., Vanmierlo, T., & Prickaerts, J. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.09.015 · Cited by 125 · see citing works
Rapid β-Amyloid Deposition and Cognitive Impairment After Cholinergic Denervation in APP/PS1 Mice
Ramos‐Rodríguez, J. J., Pacheco‐Herrero, M., Thyssen, D. H., Murillo-Carretero, M. I., Berrocoso, E., Spires‐Jones, T. L., Bacskai, B. J., & Garcı́a-Alloza, M. (2013) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318288a8dd · Cited by 125 · see citing works
Self-citationMemantine lowers amyloid‐β peptide levels in neuronal cultures and in APP/PS1 transgenic mice
Alley, G. M., Bailey, J. A., Chen, D., Ray, B., Puli, L., Tanila, H., Banerjee, P., & Lahiri, D. K. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22172 · Cited by 124 · see citing works
Smoking exacerbates amyloid pathology in a mouse model of Alzheimer’s disease
Moreno‐González, I., Estrada, L. D., Sánchez‐Mejías, E., & Soto, C. A. (2013) · Nature Communications · doi:10.1038/ncomms2494 · Cited by 123 · see citing works
Mei, X., Ezan, P., Giaume, C., & Koulakoff, A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.001 · Cited by 119 · see citing works
Zhang, X., Cai, Y., Xiong, K., Cai, H., Luo, X., Feng, J., Clough, R. W., Struble, R. G., Patrylo, P. R., & Yan, X. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.07017.x · Cited by 117 · see citing works
Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 mice
Serrano, F. G., Tapia‐Rojas, C., Carvajal, F. J., Hancke, J. L., Cerpa, W. F., & Inestrosa, N. C. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-61 · Cited by 117 · see citing works
Bernstein, K. E., Koronyo, Y., Salumbides, B. C., Sheyn, J., Pelissier, L., Lopes, D. H. J., Shah, K. H., Bernstein, E. A., Fuchs, D.-T. S., Yu, J. J.-Y., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci66541 · Cited by 117 · see citing works
In vivo molecular imaging of neuroinflammation in Alzheimer's disease
Chaney, A. M., Williams, S. R., & Boutin, H. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14615 · Cited by 116 · see citing works
Optogenetic stimulation of dentate gyrus engrams restores memory in Alzheimer's disease mice
Perusini, J. N., Cajigas, S. A., Cohensedgh, O., Lim, S. C., Pavlova, I. P., Donaldson, Z. R., & Denny, C. A. (2017) · Hippocampus · doi:10.1002/hipo.22756 · Cited by 115 · see citing works
Nikolic, W. V., Hou, H., Town, T., Zhu, Y., Giunta, B. N., Sanberg, C. D., Zeng, J., Luo, D., Ehrhart, J. C., Mori, T., et al. (2008) · Stem Cells and Development · doi:10.1089/scd.2008.0018 · Cited by 114 · see citing works
Intracellular pathways underlying the effects of lithium
Pasquali, L., Busceti, C. L., Fulceri, F., Paparelli, A., & Fornai, F. (2010) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32833da5da · Cited by 112 · see citing works
Liang, B., Duan, B.-Y., Zhou, X., Gong, J., & Luo, Z. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.117960 · Cited by 109 · see citing works
Jackson, R. J., Rudinskiy, N., Herrmann, A. G., Croft, S., Kim, J. M., Petrova, V., Ramos‐Rodríguez, J. J., Pitstick, R., Wegmann, S., Garcı́a-Alloza, M., et al. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13442 · Cited by 109 · see citing works
Cytokine-producing microglia have an altered beta-amyloid load in aged APP/PS1 Tg mice
Babcock, A. A., Ilkjær, L., Clausen, B. H., Villadsen, B., Dissing-Olesen, L., Bendixen, A. T. M., Lyck, L., Lambertsen, K. L., & Finsen, B. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.006 · Cited by 107 · see citing works
The impact of curcumin and its modified formulations on Alzheimer's disease
Farkhondeh, T., Samarghandian, S., Pourbagher‐Shahri, A. M., & Sedaghat, M. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28411 · Cited by 109 · see citing works
Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice
Xu, Z., Dong, Y., Wang, H., Culley, D. J., Marcantonio, E. R., Crosby, G. J., Tanzi, R. E., Zhang, Y., & Xie, Z. (2014) · Scientific Reports · doi:10.1038/srep03766 · Cited by 106 · see citing works
Reduction of the cerebrovascular volume in a transgenic mouse model of Alzheimer's disease
Bourasset, F., Ouellet, M., Tremblay, C., Julien, C., Minh, T. N., Oddo, S., LaFerla, F. M., & Calon, F. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.01.006 · Cited by 105 · see citing works
Shrivastava, A. N., Kowalewski, J. M., Renner, M. L., Bousset, L., Koulakoff, A., Melki, R., Giaume, C., & Triller, A. (2013) · Glia · doi:10.1002/glia.22548 · Cited by 107 · see citing works
Amyloid-β oligomers stimulate microglia through a tyrosine kinase dependent mechanism
Manocha, G. D., Floden, A. M., & Combs, C. K. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.10.027 · Cited by 104 · see citing works
He, D., Wu, H., Wei, Y., Liu, W., Huang, F., Shi, H., Zhang, B., Wu, X., & Wang, C. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.10.037 · Cited by 105 · see citing works
Yi, C., Ezan, P., Fernández, P., Schmitt, J., Sáez, J. C., Giaume, C., & Koulakoff, A. (2017) · Glia · doi:10.1002/glia.23182 · Cited by 104 · see citing works
Huang, J., van Zijl, P. C. M., Han, X., Dong, C. M., Cheng, G. W., Tse, K., Knutsson, L., Chen, L., Lai, J. H. C., Wu, E. X., et al. (2020) · Science Advances · doi:10.1126/sciadv.aba3884 · Cited by 103 · see citing works
Alzheimer's disease pathophysiology in the Retina
Gaire, B. P., Koronyo, Y., Fuchs, D.-T. S., Shi, H., Rentsendorj, A., Danziger, R., Vit, J., Mirzaei, N., Doustar, J., Sheyn, J., et al. (2024) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2024.101273 · Cited by 102 · see citing works
Harrison, F. E., Hosseini, A. H., McDonald, M. P., & May, J. M. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.06.006 · Cited by 103 · see citing works
Li, Y., Yang, J., Liu, H., Yang, J., Du, L., Feng, H., Tian, Y., Cao, J., & Ran, C. (2017) · Chemical Science · doi:10.1039/c7sc02050c · Cited by 102 · see citing works
Bian, Y., Chen, Y., Wang, X., Cui, G., Ung, C. O. L., Lu, J., Cong, W., Tang, B.-Q., & Lee, S. M. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.09.002 · Cited by 102 · see citing works
Retromer disruption promotes amyloidogenic APP processing
Sullivan, C. P., Jay, A. G., Stack, E. C., Pakaluk, M., Wadlinger, E., Fine, R. E., Wells, J. M., & Morin, P. J. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.04.002 · Cited by 100 · see citing works
Behavior of neural stem cells in the Alzheimer brain
Waldau, B., & Shetty, A. K. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8053-y · Cited by 99 · see citing works
Whitesell, J. D., Buckley, A. R., Knox, J. E., Kuan, L., Graddis, N., Pelos, A., Mukora, A., Wakeman, W., Bohn, P., Ho, A., et al. (2019) · Journal of Comparative Neurology · doi:10.1002/cne.24555 · Cited by 99 · see citing works
Curcumin as a Therapeutic Agent in Dementia: A Mini Systematic Review of Human Studies
Brondino, N., Re, S., Boldrini, A., Cuccomarino, A. F., Lanati, N., Barale, F., & Politi, P. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/174282 · Cited by 99 · see citing works
Guo, H.-S., Cheng, Y. F., Wu, J., Wang, C. M., Wang, H., Zhang, C., Qiu, Z. K., & Xu, J. P. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.01.058 · Cited by 97 · see citing works
- Authors
- Garcia-Alloza, M., Robbins, E. M., Zhang-Nunes, S. X., Purcell, S. M., Betensky, R. A., Raju, S., Prada, C., Greenberg, S. M., Bacskai, B. J., & Frosch, M. P.
- Affiliations
- Harvard University (US)
- Corresponding author
- Frosch, Matthew P.
- ORCID
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 24
- Issue
- 3
- Pages
- 516-524
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2005719973
- Cited by
- 744
- References
- 46
- Citations by year
- 2026: 36 · 2025: 28 · 2024: 39 · 2023: 28 · 2022: 41 · 2021: 46 · 2020: 53 · 2019: 43 · 2018: 57 · 2017: 44 · 2016: 45 · 2015: 49 · 2014: 47 · 2013: 51 · 2012: 42
- FWCI
- 10.38
- Type
- journal article
- Language
- en
- Open access
- green
- doaj.org
- Licence
- Locations
- Neurobiology of Disease (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Chinese Academy of Agricultural Sciences
- National Institutes of Health
- National Institute on Aging (R01AG021084, AG021084, R01AG020570, AG 020570)
- National Institute of Biomedical Imaging and Bioengineering (EB 000768, R01EB000768)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- amyloid-beta deposition, APP/PS1 mice, Alzheimer's disease, transgenic mouse model, amyloid plaques, cerebral amyloid angiopathy, multiphoton microscopy, Tg2576 mice
- MeSH terms
- Age Factors, Alzheimer Disease, Animals, Brain, Disease Models, Animal, Mice, Neurologic Mutants, Mice, Transgenic, Tissue Distribution, Amyloid beta-Protein Precursor, Mice, Plaque, Amyloid
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