Cited by 748Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsDementia and Cognitive Impairment Research

Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease

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Garcia-Alloza, Monica, Robbins, Elissa M., Zhang-Nunes, Sandy X., Purcell, Susan M., Betensky, Rebecca A., Raju, Susan, Prada, Claudia, Greenberg, Steven M. +2 more·2006·Neurobiology of Disease

Abstract

Transgenic mice carrying disease-linked forms of genes associated with Alzheimer disease often demonstrate deposition of the beta-amyloid as senile plaques and cerebral amyloid angiopathy. We have characterized the natural history of beta-amyloid deposition in APPswe/PS1dE9 mice, a particularly aggressive transgenic mouse model generated with mutant transgenes for APP (APPswe: KM594/5NL) and PS1 (dE9: deletion of exon 9). Ex vivo histochemistry showed Abeta deposition by 4 months with a progressive increase in plaque number up to 12 months and a similar increase of Abeta levels. In vivo multiphoton microscopy at weekly intervals showed increasing beta-amyloid deposition as CAA and plaques. Although first appearing at an early age, CAA progressed at a significantly slower rate than in the Tg2576 mice. The consistent and early onset of beta-amyloid accumulation in the APPswe/PS1dE9 model confirms its utility for studies of biochemical and pathological mechanisms underlying beta-amyloid deposition, as well as exploring new therapeutic treatments.

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Crossref · 10.1016/j.nbd.2006.08.017

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Authors
Garcia-Alloza, M., Robbins, E. M., Zhang-Nunes, S. X., Purcell, S. M., Betensky, R. A., Raju, S., Prada, C., Greenberg, S. M., Bacskai, B. J., & Frosch, M. P.
Affiliations
Harvard University (US)
Corresponding author
Frosch, Matthew P.
Venue
Neurobiology of Disease
Publisher
Elsevier BV
Published
2006-12
Volume
24
Issue
3
Pages
516-524
ISSN
0969-9961 (ISSN-L)
OpenAlex
W2005719973
Cited by
744
References
46
Citations by year
2026: 36 · 2025: 28 · 2024: 39 · 2023: 28 · 2022: 41 · 2021: 46 · 2020: 53 · 2019: 43 · 2018: 57 · 2017: 44 · 2016: 45 · 2015: 49 · 2014: 47 · 2013: 51 · 2012: 42
FWCI
10.38
Type
journal article
Language
en
Open access
Locations
  • Neurobiology of Disease (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Chinese Academy of Agricultural Sciences
  • National Institutes of Health
  • National Institute on Aging (R01AG021084, AG021084, R01AG020570, AG 020570)
  • National Institute of Biomedical Imaging and Bioengineering (EB 000768, R01EB000768)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
amyloid-beta deposition, APP/PS1 mice, Alzheimer's disease, transgenic mouse model, amyloid plaques, cerebral amyloid angiopathy, multiphoton microscopy, Tg2576 mice
MeSH terms
Age Factors, Alzheimer Disease, Animals, Brain, Disease Models, Animal, Mice, Neurologic Mutants, Mice, Transgenic, Tissue Distribution, Amyloid beta-Protein Precursor, Mice, Plaque, Amyloid

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