Plastic vasomotion entrainment
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Abstract
The presence of global synchronization of vasomotion induced by oscillating visual stimuli was identified in the mouse brain. Endogenous autofluorescence was used and the vessel ‘shadow’ was quantified to evaluate the magnitude of the frequency-locked vasomotion. This method allows vasomotion to be easily quantified in non-transgenic wild-type mice using either the wide-field macro-zoom microscopy or the deep-brain fiber photometry methods. Vertical stripes horizontally oscillating at a low temporal frequency (0.25 Hz) were presented to the awake mouse, and oscillatory vasomotion locked to the temporal frequency of the visual stimulation was induced not only in the primary visual cortex but across a wide surface area of the cortex and the cerebellum. The visually induced vasomotion adapted to a wide range of stimulation parameters. Repeated trials of the visual stimulus presentations resulted in the plastic entrainment of vasomotion. Horizontally oscillating visual stimulus is known to induce horizontal optokinetic response (HOKR). The amplitude of the eye movement is known to increase with repeated training sessions, and the flocculus region of the cerebellum is known to be essential for this learning to occur. Here, we show a strong correlation between the average HOKR performance gain and the vasomotion entrainment magnitude in the cerebellar flocculus. Therefore, the plasticity of vasomotion and neuronal circuits appeared to occur in parallel. Efficient energy delivery by the entrained vasomotion may contribute to meeting the energy demand for increased coordinated neuronal activity and the subsequent neuronal circuit reorganization.
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Vascular dilation and constriction regulate the initial step of glucose and oxygen delivery.
“For example, vascular dilation and constriction regulate the initial step of glucose and oxygen delivery2,14.”
From Energy paradox in REM sleep: balancing supply and consumption in brain metabolism (2026) · cites this paper as [2]
The 0.05-0.2 Hz band corresponds to the established frequency range of spontaneous vessel diameter oscillations (vasomotion) reported in rodents.
“Importantly, the 0.05–0.2 Hz band corresponds to the established frequency range of spontaneous vessel diameter oscillations (vasomotion) reported in rodents2,43.”
From Energy paradox in REM sleep: balancing supply and consumption in brain metabolism (2026) · cites this paper as [2]
Fluorescence emitted from parenchymal cells is attenuated by overlying blood vessels, which appear as shadows in wide-field images.
“Our earlier studies showed that fluorescence emitted from parenchymal cells is attenuated by overlying blood vessels, which therefore appear as shadows in wide-field images2,4,36.”
From Energy paradox in REM sleep: balancing supply and consumption in brain metabolism (2026) · cites this paper as [2]
Blood vessels spontaneously dilate and constrict (vasomotion) and change their diameter in response to nearby neuronal activity (functional hyperemia).
“It has been shown that blood vessels spontaneously dilate and constrict (vasomotion) and change their diameter in response to nearby neuronal activity (functional hyperemia)2.”
From Energy paradox in REM sleep: balancing supply and consumption in brain metabolism (2026) · cites this paper as [2]
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- Authors
- Sasaki, D., Imai, K., Ikoma, Y., & Matsui, K.
- Affiliations
- Tohoku University (JP)
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2024-04-17
- Volume
- 13
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W4394880402
- Cited by
- 6
- References
- 68
- Citations by year
- 2026: 3 · 2025: 3
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- Funders
- Japan Society for the Promotion of Science (22KJ0262, 22K15218, 20H05896, 23H04659, 18H05110, 20H05046, 19H03338, 22H02713)
- Research Foundation for Opto-Science and Technology
- Takeda Science Foundation
- NOVARTIS Foundation
- Uehara Memorial Foundation
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Keywords
- vasomotion, entrainment, plasticity, visual stimulation, cerebellar flocculus, primary visual cortex, cerebellum, cerebral blood flow, energy delivery
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