Cited by 488Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorMemory and Neural Mechanisms

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Neurotransmitter roles in synaptic modulation, plasticity and learning in the dorsal striatum

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Lovinger, David M.·2010·Neuropharmacology

DOI 10.1016/j.neuropharm.2010.01.008PMC PMC2849868

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Abstract

The dorsal striatum is a large forebrain region involved in action initiation, timing, control, learning and memory. Learning and remembering skilled movement sequences requires the dorsal striatum, and striatal subregions participate in both goal-directed (action-outcome) and habitual (stimulus-response) learning. Modulation of synaptic transmission plays a large part in controlling input to as well as the output from striatal medium spiny projection neurons (MSNs). Synapses in this brain region are subject to short-term modulation, including allosteric alterations in ion channel function and prominent presynaptic inhibition. Two forms of long-term synaptic plasticity have also been observed in striatum, long-term potentiation (LTP) and long-term depression (LTD). LTP at glutamatergic synapses onto MSNs involves activation of NMDA-type glutamate receptors and D1 dopamine or A2A adenosine receptors. Expression of LTP appears to involve postsynaptic mechanisms. LTD at glutamatergic synapses involves retrograde endocannabinoid signaling stimulated by activation of metabotropic glutamate receptors (mGluRs) and D2 dopamine receptors. While postsynaptic mechanisms participate in LTD induction, maintained expression involves presynaptic mechanisms. A similar form of LTD has also been observed at GABAergic synapses onto MSNs. Studies have just begun to examine the roles of synaptic plasticity in striatal-based learning. Findings to date indicate that molecules implicated in induction of plasticity participate in these forms of learning. Neurotransmitter receptors involved in LTP induction are necessary for proper skill and goal-directed instrumental learning. Interestingly, receptors involved in LTP and LTD at glutamatergic synapses onto MSNs of the "indirect pathway" appear to have important roles in habit learning. More work is needed to reveal if and when synaptic plasticity occurs during learning and if so what molecules and cellular processes, both short- and long-term, contribute to this plasticity.

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Background
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“D1 receptors expressed on Go Neurons play a dual role in cortico-basal ganglia neurotransmission: (i) they show long-term potentiation (LTP) (Lovinger 2010) when D1 receptors are activated by a large amount of DA released in response to unexpected aversive or appetitive events (Matsumoto and Hikosaka 2009; Shen et al.”
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Genetic Reconstruction of Dopamine D1 Receptor Signaling in the Nucleus Accumbens Facilitates Natural and Drug Reward Responses
Gore, B. B., & Zweifel, L. S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5532-12.2013 · Cited by 50
“Infusion of D1R antagonists individually into the prefrontal cortex (Baldwin et al., 2002), dorsal striatum (Lovinger, 2010), amygdala (Berglind et al., 2006, Tye et al., 2010), or nucleus accumbens (NAc; Smith-Roe and Kelley, 2000) disrupts certain aspects of reward.”
Background
Thinking Outside the Box (and Arrow): Current Themes in Striatal Dysfunction in Movement Disorders
Plotkin, J. L., & Goldberg, J. A. (2018) · The Neuroscientist · doi:10.1177/1073858418807887 · Cited by 49
Cannabidiol and Cannabinoid Compounds as Potential Strategies for Treating Parkinson’s Disease and l-DOPA-Induced Dyskinesia
Ferreira‐Junior, N. C., Pereira, M. D. S., Guimarães, F. S., & Bel, E. D. (2019) · Neurotoxicity Research · doi:10.1007/s12640-019-00109-8 · Cited by 53
“nergic neurons of the SNpc, thereby modulating the firing activity of nigral neurons (Lovinger 2010).”
Background
PDE10A Inhibitors—Clinical Failure or Window Into Antipsychotic Drug Action?
Menniti, F. S., Chappie, T. A., & Schmidt, C. J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.600178 · Cited by 49
“In the same vein, different forms of synaptic plasticity are also essential to information processing by MSNs (Calabresi et al., 2007; Surmeier et al., 2009; Wickens, 2009; Lovinger, 2010).”
Background
New synaptic and molecular targets for neuroprotection in Parkinson's disease
Calabresi, P., Filippo, M. D., Gallina, A., Wang, Y., Stankowski, J. N., Picconi, B., Dawson, V. L., & Dawson, T. M. (2012) · Movement Disorders · doi:10.1002/mds.25096 · Cited by 47
Mechanisms of acupuncture on vascular dementia—A review of animal studies
Yang, Y., Zhu, W. X., Wang, X., Yang, J., Xiao, L., Liu, Y., Zhang, X., & Liu, C. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.12.001 · Cited by 49
“It has been known that neurotransmitters are closely linked to human learning andmemory (Lovinger, 2010).”
Background
Neuroplasticity in Parkinson’s disease
Popescu, B. O., Batzu, L., Ruiz, P., Tulbă, D., Moro, E., & Santens, P. (2024) · Journal of Neural Transmission · doi:10.1007/s00702-024-02813-y · Cited by 57
“In the indirect pathway plasticity is dominated by LTD, which relies heavily on retrograde endocannabinoid signalling (Lovinger, 2010).”
Influential
Altered motor learning and coordination in mouse models of autism spectrum disorder
Cording, K. R., & Bateup, H. S. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1270489 · Cited by 49
“This prominent form of striatal synaptic depression works through the release of postsynaptic endocannabinoids that act on cortical presynaptic CB1 receptors, ultimately reducing the probability of neurotransmitter release (Kreitzer and Malenka, 2008; Lovinger, 2010).”
Background
Mechanisms of Neuroplasticity and Ethanol's Effects on Plasticity in the Striatum and Bed Nucleus of the Stria Terminalis
Lovinger, D. M. (2015) · Alcohol research · doi:10.35946/arcr.v37.1.08 · Cited by 45
“Long-lasting changes in synaptic function (i.e., synaptic plasticity) have long been thought to contribute to information storage in the nervous system (Kandel et al. 2014; Lovinger 2010).”
Background
Heads for learning, tails for memory: reward, reinforcement and a role of dopamine in determining behavioral relevance across multiple timescales
Baudonnat, M., Huber, A., David, V., & Walton, M. E. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00175 · Cited by 43
“Dopamine has been identified as a strong modulator of these cellular adaptations (Wickens, 2009; Lovinger, 2010).”
Background
FACS Array Profiling Identifies Ecto-5′ Nucleotidase as a Striatopallidal Neuron-Specific Gene Involved in Striatal-Dependent Learning
Ena, S., Backer, J. D., Schiffmann, S. N., & d’Exaerde, A. D. K. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2989-12.2013 · Cited by 43
“It has been demonstrated that the corticostriatal plasticity plays an important role in the acquisition and the consolidation of a learning skill (Costa et al., 2004; Dang et al., 2006; Kheirbek et al., 2009; Yin et al., 2009; Lovinger, 2010).”
Background
Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32
Polito, M., Guiot, E., Gangarossa, G., Longueville, S., Doulazmi, M., Valjent, E., Hervé, D., Girault, J., Paupardin‐Tritsch, D., Castro, L. R., et al. (2015) · eNeuro · doi:10.1523/eneuro.0060-15.2015 · Cited by 45
“The differences observed between medial and lateral striatum likely involve network effects and differences in synaptic plasticity reported between these two striatal subregions (Lovinger, 2010), and further work should precisely show how these spatial differences are related to behavior.”
Background
Alcohol intake enhances glutamatergic transmission from D2 receptor-expressing afferents onto D1 receptor-expressing medium spiny neurons in the dorsomedial striatum
Lu, J., Cheng, Y., Wang, X., Woodson, K., Kemper, W. C., Disney, E., & Wang, J. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0332-9 · Cited by 42
CB1-Dependent Long-Term Depression in Ventral Tegmental Area GABA Neurons: A Novel Target for Marijuana
Friend, L. N., Weed, J., Sandoval, P. J., Nufer, T. M., Ostlund, I., & Edwards, J. G. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0190-17.2017 · Cited by 47
“For example, LTD occurs at glutamatergic inputs onto striatal GABAergic medium spiny neurons, which is dependent on presynaptic CB1 and postsynaptic mGluR activation and eCB synthesis (Adermark et al., 2009; Lovinger, 2010), providing support for our findings.”
Result
A Bayesian context fear learning algorithm/automaton
Krasne, F., Cushman, J. D., & Fanselow, M. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00112 · Cited by 39
“Reviews: Kenney and Gould, 2008; Lovinger, 2010; Lisman et al., 2011; Hawkins, 2013).”
Striatal Cholinergic Interneurons: How to Elucidate Their Function in Health and Disease
Mallet, N. P., Leblois, A., Maurice, N., & Beurrier, C. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01488 · Cited by 43
“Cholinergic modulation of long-term corticostriatal plasticity has been addressed in excellent reviews (Lovinger, 2010; Lerner and Kreitzer, 2011) and will not be further discussed here.”
Background
Endocannabinoid-Specific Impairment in Synaptic Plasticity in Striatum of Huntington's Disease Mouse Model
Sepers, M. D., Smith-Dijak, A., LeDue, J. M., Kołodziejczyk, K., Mackie, K., & Raymond, L. A. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1739-17.2017 · Cited by 39
“This long-term decrease in synaptic efficacy [long-term depression (LTD)] at corticostriatal synapses is involved in motor skill, instrumental and response learning (Lovinger, 2010).”
Background
Endocannabinoids in striatal plasticity
Lovinger, D. M., & Mathur, B. N. (2011) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(11)70041-4 · Cited by 41
“As with LTD at glutamatergic striatal synapses, the bulk of evidence supports retrograde eCB signaling, CB1 activation, and synergism between CB1 and presynaptic activity in eCB-LTD at GABAergic synapses in striatum [6].”
BackgroundInfluential
Distinct representation of cue-outcome association by D1 and D2 neurons in the ventral striatum’s olfactory tubercle
Martiros, N., Kapoor, V., Kim, S. E., & Murthy, V. N. (2022) · eLife · doi:10.7554/elife.75463 · Cited by 41
Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving
Li, X., Witonsky, K. R., Lofaro, O. M., Surjono, F., Zhang, J., Bossert, J. M., & Shaham, Y. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2873-17.2018 · Cited by 42
“These data support the notion that striatal function and striatal-dependent learned behaviors depend on an interaction between dopamine and glutamate transmission (O’Donnell, 2003; Sesack et al., 2003; Lovinger, 2010; Shiflett and Balleine, 2011).”
BackgroundResult
Cocaine-induced neuroadaptations in the dorsal striatum: Glutamate dynamics and behavioral sensitization
Parikh, V., Naughton, S. X., Shi, X., Kelley, L. K., Yegla, B., Tallarida, C. S., Rawls, S. M., & Unterwald, E. M. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.05.016 · Cited by 42
Vulnerability factors in anxiety: Strain and sex differences in the use of signals associated with non-threat during the acquisition and extinction of active-avoidance behavior
Beck, K. D., Jiao, X., Ricart, T. M., Myers, C. E., Minor, T. R., Pang, K. C. H., & Servatius, R. J. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.05.002 · Cited by 42
Abnormal striatal plasticity in a DYT11/SGCE myoclonus dystonia mouse model is reversed by adenosine A2A receptor inhibition
Maltese, M., Martella, G., Imbriani, P., Schuermans, J., Billion, K., Sciamanna, G., Farook, F., Ponterio, G., Tassone, A., Santoro, M., et al. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.08.007 · Cited by 39
“Paired-pulse facilitation was assessed by presenting two stimuli, which evoked EPSPs at about 50% of maximal amplitude, with an interstimulus interval of 50 ms.”
BackgroundInfluential
Functional interaction between pre‐synaptic α6β2 ‐containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum
Garção, P., Szabó, E. C., Wopereis, S., de Castro, A. A., Tomé, Â. R., Prediger, R. D., Cunha, R. A., Agostinho, P. M., & Köfalvi, A. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12234 · Cited by 40
“Accordingly, the dopaminergic system is crucial in different functions processed through striatal circuits, such as locomotor activity, habit formation or associative and mnemonic functions (Wickens et al., 2007; Dagher and Robbins, 2009; Lovinger, 2010; Cools, 2011).”
Background
Biological bases for a possible effect of cannabidiol in Parkinson’s disease
Ferreira‐Junior, N. C., Campos, A. C., Guimarães, F. S., Bel, E. A. D., Zimmermann, P. M. D. R., Brum, L., Hallak, J. E. C., Crippa, J. A. S., & Zuardi, A. W. (2019) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2019-0460 · Cited by 44
Effect of dietary supplementation of ginger and turmeric rhizomes on ectonucleotidases, adenosine deaminase and acetylcholinesterase activities in synaptosomes from the cerebral cortex of hypertensive rats
Akinyemi, A. J., Thomé, G. R., Morsch, V. M., Stefanello, N., da Costa, P., Cardoso, A. M., Goularte, J. F., Belló‐Klein, A., Akindahunsi, A. A., Oboh, G., et al. (2015) · Journal of Applied Biomedicine · doi:10.1016/j.jab.2015.06.001 · Cited by 38
“…lead to a fast ACh degradation and subsequent reduction of stimulation of ACh receptors causing undesirable effect on cholinergic neurotransmission as well progressive cognitive impairment and other neurological dysfunctions seen in hypertensive patients (Kuhad and Chopra, 2007; Lovinger, 2010).”
BackgroundInfluential
Excitotoxicity Triggered by Neonatal Monosodium Glutamate Treatment and Blood–Brain Barrier Function
Gudiño‐Cabrera, G., Ureña‐Guerrero, M. E., Rivera-Cervantes, M. C., Feria‐Velasco, A., & Beas‐Zárate, C. (2014) · Archives of Medical Research · doi:10.1016/j.arcmed.2014.11.014 · Cited by 38
Opioidergic Interactions between Striatal Projection Neurons
Blomeley, C. P., & Bracci, E. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1775-11.2011 · Cited by 38
“Endocannabinoids play an important role in the control of glutamatergic inputs to MSNs (Lovinger, 2010).”
Background
Negative allosteric modulation of mGlu5 receptor rescues striatal D2 dopamine receptor dysfunction in rodent models of DYT1 dystonia
Sciamanna, G., Ponterio, G., Tassone, A., Maltese, M., Madeo, G., Martella, G., Poli, S. M., Schirinzi, T., Bonsi, P., & Pisani, A. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.06.013 · Cited by 37
The interactive role of cannabinoid and vanilloid systems in hippocampal synaptic plasticity in rats
Tahmasebi, L., Komaki‬, A., Karamian, R., Shahidi, ‬., Sarihi, A., Salehi, I., & Nikkhah, A. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.063 · Cited by 37
Putamen volume predicts real‐time fMRI neurofeedback learning success across paradigms and neurofeedback target regions
Zhao, Z., Yao, S., Zweerings, J., Zhou, X., Zhou, F., Kendrick, K. M., Chen, H., Mathiak, K., & Becker, B. (2021) · Human Brain Mapping · doi:10.1002/hbm.25336 · Cited by 37
Exogenous BDNF facilitates strategy set-shifting by modulating glutamate dynamics in the dorsal striatum
D'Amore, D. E., Tracy, B. A., & Parikh, V. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.07.033 · Cited by 39
Applied neurophysiology of the horse; implications for training, husbandry and welfare
McBride, S. D., Parker, M. O., Roberts, K., & Hemmings, A. (2017) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2017.02.014 · Cited by 43
“This process is achieved through LTP as a result of phasic dopamine released and activation of D1 dopamine receptors on MSNs within the striatum (both ventral and dorsal) (Surmeier et al., 2007; Lovinger, 2010).”
Background
Amygdala-Cortical Control of Striatal Plasticity Drives the Acquisition of Goal-Directed Action
Fisher, S. D., Ferguson, L. A., Bertran-Gonzalez, J., & Balleine, B. W. (2020) · Current Biology · doi:10.1016/j.cub.2020.08.090 · Cited by 36
The Enemy within: Propagation of Aberrant Corticostriatal Learning to Cortical Function in Parkinson’s Disease
Beeler, J. A., Petzinger, G. M., & Jakowec, M. W. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00134 · Cited by 36
“DOPAMINE REGULATES CORTICAL FILTERING THROUGH THE BASAL GANGLIA Bidirectional corticostriatal plasticity is regulated by dopamine (31, 33, 34, 37, 43), widely believed to encode positive and negative reward prediction errors (RPEs) by firing bursts of action potentials or pausing tonic activity, respectively (44, 45).”
Background
Combined Amperometry and Electrochemical Cytometry Reveal Differential Effects of Cocaine and Methylphenidate on Exocytosis and the Fraction of Chemical Release
Zhu, W., Gu, C., Dunevall, J., Ren, L., Zhou, X., & Ewing, A. G. (2019) · Angewandte Chemie · doi:10.1002/ange.201813717 · Cited by 36
Dopamine D1 receptors and phosphorylation of dopamine- and cyclic AMP-regulated phosphoprotein-32 in the medial preoptic area are involved in experience-induced enhancement of male sexual behavior in rats.
McHenry, J. A., Bell, G. A., Parrish, B. P., & Hull, E. M. (2012) · Behavioral Neuroscience · doi:10.1037/a0028707 · Cited by 35
“D1 receptors act synergistically with NMDA glutamate receptors in other brain regions to facilitate learning and synaptic plasticity (Lovinger, 2010; Sarantis, Matsokis, & Angelatou, 2009; Scott & Aperia, 2009; Smith-Roe & Kelley, 2000).”
Updating temporal expectancy of an aversive event engages striatal plasticity under amygdala control
Dallérac, G. M., Graupner, M., Knippenberg, J., Martinez, R. C. R., Tavares, T. F., Tallot, L., Massioui, N. E., Verschueren, A., Höhn, S., Boulanger-Bertolus, J., et al. (2017) · Nature Communications · doi:10.1038/ncomms13920 · Cited by 35
Toward a Unifying Account of Dopamine’s Role in Cost-Benefit Decision Making
Soutschek, A., Jetter, A., & Tobler, P. N. (2022) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2022.02.010 · Cited by 33
“Because D2R activation suppresses activation in the inhibitory indirect path, stronger D2R signaling also energizes behavior by suppressing the inhibitory influence of the indirect path on cortical activity (13,14).”
Background
Striatum‐dependent habits are insensitive to both increases and decreases in reinforcer value in mice
Quinn, J. J., Pittenger, C., Lee, A. S., Pierson, J. L., & Taylor, J. R. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12106 · Cited by 32
“…behavior depends upon corticostriatal systems (Yin & Knowlton, 2006; Hitchcott et al., 2007; Wickens et al., 2007; Grahn et al., 2008; Hil ario & Costa, 2008; Kubota et al., 2009; Pennartz et al., 2009; Balleine & O’Doherty, 2010; Lovinger, 2010; Corbit et al., 2012; Lingawi & Balleine, 2012).”
Background
Low‐frequency‐induced synaptic potentiation: A paradigm shift in the field of memory‐related plasticity mechanisms?
Habib, D., & Dringenberg, H. C. (2009) · Hippocampus · doi:10.1002/hipo.20611 · Cited by 35
Endocannabinoid Modulation of Dopaminergic Motor Circuits
Morera‐Herreras, T., Miguélez, C., Aristieta, A., Ruíz-Ortega, J. Á., & Ugedo, L. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00110 · Cited by 35
“Using different LTD induction paradigms it has been described that this form of plasticity is mostly controlled by endocannabinoids (Shen et al., 2008; Lovinger, 2010).”
Impaired Formation of Stimulus–Response, But Not Action–Outcome, Associations in Rats with Methamphetamine-Induced Neurotoxicity
Son, J., Latimer, C., & Keefe, K. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.131 · Cited by 33
“On the other hand, numerous studies indicate that DA signaling in striatum has a crucial role underlying instrumental conditioning (Darvas and Palmiter, 2009; Lovinger, 2010; Robinson et al, 2007; Schultz, 2007; Surmeier et al, 2007).”
Background
Modeling Intracellular Signaling Underlying Striatal Function in Health and Disease
Nair, A. G., Gutierrez‐Arenas, O., Eriksson, O., Jauhiainen, A., Blackwell, K. T., & Kotaleski, J. H. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-397897-4.00013-9 · Cited by 32
Cyclic AMP and Afferent Activity Govern Bidirectional Synaptic Plasticity in Striatopallidal Neurons
Augustin, S. M., Beeler, J. A., McGehee, D. S., & Zhuang, X. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3906-13.2014 · Cited by 34
“…by postsynaptic and presynaptic mechanisms, respectively (Choi and Lovinger, 1997; Gerdeman et al., 2002; Ronesi et al., 2004), these data support the idea that these two forms of plasticity are not mutually exclusive and coexist within the same cell, as was speculated recently (Lovinger, 2010).”
Background
Striatal cholinergic interneurons and D2 receptor-expressing GABAergic medium spiny neurons regulate tardive dyskinesia
Bordia, T., Zhang, D., Perez, X. A., & Quik, M. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.09.009 · Cited by 32
“Neurotransmitter systems in the striatum that may play a role include the cholinergic one (Deffains and Bergman, 2015; Kelley and Roberts, 2004; Lovinger, 2010).”
BDNF Controls Bidirectional Endocannabinoid Plasticity at Corticostriatal Synapses
Gangarossa, G., Siaume‐Perez, S., Dembitskaya, Y., Prokin, I., Berry, H., & Venance, L. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz081 · Cited by 33
547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates
Li, M., Wu, S., Zhang, J.-J., Tian, H.-Y., Shao, Y., Wang, Z., Irwin, D. M., Li, J., Hu, X., & Wu, D. (2019) · Genome biology · doi:10.1186/s13059-019-1866-1 · Cited by 32
High intensity VNS disrupts VNS-mediated plasticity in motor cortex
Morrison, R. A., Danaphongse, T. T., Abe, S. T., Stevens, M. E., Ezhil, V., Seyedahmadi, A., Adcock, K. S., Rennaker, R. L., Kilgard, M. P., & Hays, S. A. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147332 · Cited by 32
Loss of Tsc1 from striatal direct pathway neurons impairs endocannabinoid-LTD and enhances motor routine learning
Benthall, K. N., Cording, K. R., Agopyan-Miu, A. H. C. W., Wong, C. D., Chen, E. Y., & Bateup, H. S. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109511 · Cited by 33
“that mediate endocannabinoid-LTD (eCB-LTD), a prominent form of striatal synaptic depression (Kreitzer and Malenka, 2008; Lovinger, 2010).”
Background
Striatum expresses region-specific plasticity consistent with distinct memory abilities
Siaume‐Perez, S., Cui, Y., Vignoud, G., Perrin, E., Mendes, A., Zheng, Z., Touboul, J. D., & Venance, L. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110521 · Cited by 32
Differential regulation of CaV1.2 channels by cAMP-dependent protein kinase bound to A-kinase anchoring proteins 15 and 79/150
Fuller, M. D., Fu, Y., Scheuer, T., & Catterall, W. A. (2014) · The Journal of General Physiology · doi:10.1085/jgp.201311075 · Cited by 33

Authors: Lovinger, D. M.
Affiliations: National Institutes of Health (US)
Corresponding author: Lovinger, David M.
ORCID: Lovinger, David M.
Venue: Neuropharmacology
Publisher: Elsevier BV
Published: 2010-06
Volume: 58
Issue: 7
Pages: 951-961
ISSN: 0028-3908 (ISSN-L)
DOI: 10.1016/j.neuropharm.2010.01.008
PMC: PMC2849868
OpenAlex: W2086614467
Cited by: 488
References: 150
Citations by year: 2026: 10 · 2025: 19 · 2024: 28 · 2023: 21 · 2022: 37 · 2021: 32 · 2020: 27 · 2019: 32 · 2018: 30 · 2017: 39 · 2016: 25 · 2015: 38 · 2014: 30 · 2013: 39 · 2012: 29
FWCI: 3.43
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism (Z01AA000407)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: dorsal striatum, synaptic plasticity, long-term potentiation, long-term depression, medium spiny neurons, glutamatergic synapses, GABAergic synapses, NMDA receptor, dopamine D1 receptor, adenosine A2A receptor, dopamine D2 receptor, metabotropic glutamate receptors, retrograde endocannabinoid signaling, presynaptic inhibition, allosteric modulation, operant conditioning, habit learning, goal-directed learning, indirect pathway, neurotransmitter receptors
MeSH terms: Animals, Corpus Striatum, Learning, Neuronal Plasticity, Synapses, Neurotransmitter Agents

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Neurotransmitter roles in synaptic modulation, plasticity and learning in the dorsal striatum

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